Relapsed Myeloma: Navigating Post-BCMA Therapy Failure
From HemeTalks: Conversations in Hematology Education by American Society of Hematology
August 21, 2025 · 23 min · Season 4 · Episode 13
About this episode
The episode discusses treatment strategies for relapsed multiple myeloma following BCMA-targeted therapy failure.
Join us for an insightful discussion with Drs. Natalia Neparidze and Saad Z. Usmani as we explore treatment strategies for relapsed multiple myeloma following BCMA-targeted therapy failure. With CAR T-cell therapy and bispecific antibodies revolutionizing myeloma treatment, clinicians are now faced with new challenges as patients relapse after BCMA-directed therapies. Through the case of a 62-year-old woman who relapsed one year post-BCMA CAR T-cell therapy, we will discuss mechanisms of resistance, treatment sequencing, and the role of novel agents like selinexor-pomalidomide-dexamethasone. This episode will provide hematologists with practical strategies to navigate post-BCMA treatment failure and optimize patient outcomes. Learning Objectives Understand mechanisms of resistance and progression following BCMA-targeted therapy. Explore non-BCMA treatment options, including alternative targets and novel agents. Recognize key factors influencing treatment selection and patient management.
People in this episode
Guests: Dr. Natalia Neparidze, Dr. Saad Z. Usmani
Topics covered
- relapsed myeloma
- BCMA therapy failure
- treatment strategies
- CAR T-cell therapy
- novel agents
- patient management
Keywords
- relapsed myeloma
- BCMA-targeted therapy
- treatment sequencing
- mechanisms of resistance
- novel agents
- patient outcomes
Mentioned in this episode
Organizations: American Society of Hematology
Products: CAR T-cell therapy, bispecific antibodies, selinexor-pomalidomide-dexamethasone
Places: BCMA, multiple myeloma
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- TTP Today: Diagnosis, Management & Evolving Therapies · May 7, 2026 · 20 min
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- New Horizons in Smoldering Multiple Myeloma · March 19, 2026 · 26 min
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