53. Histamine Intolerance vs MCAS: How To Tell The Difference

53. Histamine Intolerance vs MCAS: How To Tell The Difference

July 6, 2026 · 16 min · Episode 53

About this episode

Joanne explains the difference between histamine intolerance and MCAS, highlighting their overlapping symptoms and distinct underlying mechanisms.

Many people with flushing, hives, anxiety, brain fog, digestive issues, food sensitivities, and heart palpitations are told they have either histamine intolerance or Mast Cell Activation Syndrome (MCAS). While these conditions can look remarkably similar, they have very different underlying mechanisms—and understanding those differences is often the key to finding the right treatment. In this episode, Joanne explains the difference between histamine intolerance and MCAS, why symptoms overlap,...

People in this episode

Host: Joanne Kennedy

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Keywords

Mentioned in this episode

Organizations: Mast Cell Activation Syndrome, histamine intolerance

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