About this episode

The episode discusses GLP-1 drugs and novel peptide discovery in relation to obesity and metabolic health.

Send us Fan Mail Endogenous peptide diversity, GLP-1 drugs, and methods for novel peptide discovery. TOPICS DISCUSSED: Peptide Structure & Production: Short amino acid chains (3-50 residues) cleaved from larger precursors by PCSK enzymes, stored in dense-core vesicles, and released upon stimuli rather than acting as folded enzymes like proteins.Tissue-Specific Processing: The same precursor yields different peptides by tissue; preproglucagon produces glucagon in pancreas but GLP-1 in gut ...

People in this episode

Host: Nick Jikomes

Guest: Katrin Svensson

Mentioned in this episode

Organizations: PCSK, GLP-1, preproglucagon

Places: pancreas, gut

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