Why SIBO Comes Back After Rifaximin (3 Reasons Symptoms Return After Antibiotics)

Why SIBO Comes Back After Rifaximin (3 Reasons Symptoms Return After Antibiotics)

March 31, 2026 · 32 min

About this episode

Alyssa discusses why symptoms of SIBO often return after treatment with rifaximin and explores the underlying reasons for this pattern.

Send us Fan Mail If you’ve taken antibiotics like rifaximin for SIBO and found yourself right back where you started, you’re not alone. This is one of the most common patterns we see in practice, and it’s also one of the most frustrating. In this episode, Alyssa breaks down what’s actually happening beneath the surface when symptoms return, and why repeating the same approach often leads to the same outcome. You’ll learn how different SIBO patterns behave, why treatment sometimes only s...

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