The Gut Fungiome

The Gut Fungiome

From The Lab Report by Genova Diagnostics, Inc

December 11, 2025 · 29 min · Season 1 · Episode 339

About this episode

This episode explores the gut mycobiome, focusing on the roles of yeast in health and disease.

The gut microbiome is more than just bacteria. It encompasses all organisms and genetic material including yeast, viruses, and archaea. It is a common belief that yeast in the GI tract needs to be eradicated. But not so fast. In this episode, we focus on the mycobiome. We examine the dual roles of commensal and pathogenic yeast species within the GI tract, exploring how they influence immune signaling, metabolic function, and mucosal integrity. We also discuss emerging evidence linking fungal dysbiosis to conditions such as Inflammatory Bowel Disease, cancer, and systemic inflammation. If you’re interested in the clinical science behind how yeast can support health – or contribute to disease - this episode explores a topic often overlooked in longevity medicine. Today on The Lab Report: 4:00 The Gut Mycobiome – needs a new name 6:40 Yeast vs. Bacteria 9:00 Development of the commensal mycobiome 11:00 The important role of yeast & their metabolites 15:25 Candida and Malassezia 18:45 Saccharomyces 21:05 Dietary influences and fermented foods 23:30 Question of the Day If yeast grows out in culture on the GI Effects, what next? Additional Resources: GI Effects…

People in this episode

Hosts: Michael Chapman, Patti Devers

Topics covered

  • gut microbiome
  • mycobiome
  • yeast
  • immune signaling
  • metabolic function
  • fungal dysbiosis
  • longevity medicine

Keywords

  • gut fungiome
  • mycobiome
  • yeast
  • fungal dysbiosis
  • immune signaling
  • metabolic function
  • GI tract
  • health
  • disease
  • longevity medicine

Mentioned in this episode

Organizations: Candida, Malassezia, Saccharomyces, GI Effects, Microbiomix

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