E150 | Histamine Overload In Perimenopause

E150 | Histamine Overload In Perimenopause

March 12, 2026 · 24 min · Season 2 · Episode 150

About this episode

This episode discusses how histamine intolerance and mast cell activation can mimic symptoms of perimenopause, particularly in high-achieving women.

Share Your Thoughts! Wine starts making you anxious, your sleep breaks at 2 a.m., your heart races for no clear reason, and suddenly your body feels “reactive” to everything. If you’ve been told it’s just perimenopause, we want to offer a more useful lens: histamine intolerance and mast cell activation can mimic a huge list of midlife hormone symptoms, and they often show up hardest in high-achieving, chronically stressed women. We unpack what histamine actually does beyond seasonal allergie...

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