Building a Better Barrier: Modeling the Human Gut Epithelium
From The Stem Cell Report with Janet Rossant by ISSCR
November 19, 2025 · 43 min · Season 4 · Episode 8
About this episode
The episode discusses the human intestinal epithelial barrier and its variability among individuals, focusing on the impact of culture conditions on cell type composition and gene expression.
The human intestinal epithelial barrier comprises diverse proliferative, secretory and absorptive cell types that facilitate nutrient digestion and absorption and protect against harmful environmental agents. The barrier and its function can vary between individuals due to genetic differences thus impact processes such as digestion, drug metabolism, and drug sensitivity. Our guests today investigated the effect of diverse culture conditions on the cell type composition, gene expression profil...
People in this episode
Host: Janet Rossant
Topics covered
- human gut epithelium
- intestinal barrier
- cell types
- gene expression
- nutrient absorption
- drug metabolism
Keywords
- intestinal epithelial barrier
- cell types
- gene expression
- nutrient digestion
- drug sensitivity
Mentioned in this episode
Organizations: ISSCR
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