About this episode

This episode discusses the modeling of the blood-brain barrier using human stem-cell-based models to understand disease impacts on its integrity.

The blood-brain barrier (BBB), formed by brain endothelial cells, pericytes, and astrocytes, is organized into a neurovascular unit that regulates the exchange of proteins between blood circulation and brain parenchyma. Human stem-cell-based models using brain endothelial cells are a powerful tool to investigate how disease-related conditions might affect the blood-brain barrier integrity. However, the cell type composition is critical to faithfully model transcytosis across the blood-brain b...

People in this episode

Host: Janet Rossant

Mentioned in this episode

Organizations: ISSCR

Places: blood-brain barrier, brain, brain endothelial cells, brain parenchyma

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