Tuning the X

About this episode

This episode explores the role of m6A in regulating X chromosome dosage compensation and its implications in development and disease.

Epigenetic regulation of gene expression is an important mechanism in development and disease. N6-methyladenosine (m6A) is one of the most prevalent epigenetic modifications for RNA and has been shown to play critical roles in processes such as embryo development, cancer, and stress responses. Our guests today investigate how m6A regulates X chromosome dosage compensation to ensure proper balance of gene expression from X chromosomes between sexes. X-chromosome dosage compensation is accompli...

People in this episode

Host: Janet Rossant

Topics covered

• epigenetic regulation
• gene expression
• X chromosome
• dosage compensation
• development
• disease

Keywords

• epigenetics
• m6A
• X chromosome
• gene expression
• dosage compensation
• embryo development
• cancer
• stress responses

Mentioned in this episode

Organizations: ISSCR

Books & works: N6-methyladenosine (m6A)

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