Cancer Neuroscience, Tumor Organoids, and Understanding the Role of the Nervous System in Human Glioblastoma

About this episode

This episode explores the influence of neurons on the progression of glioblastomas and their interactions with tumor cells.

The role of neuronal influences on cancer pathogenesis and progression is increasingly appreciated in the nervous system. Neurons have been shown to enhance the proliferation and migration of gliomas, a glial-derived tumor of the CNS, via diffusible paracrine factors or synaptic inputs onto tumor cells. In glioblastomas, a highly aggressive glioma, mostly glutamatergic inputs have been identified. While the potential for glioblastomas to receive projections from neurons of other neurotransmit...

People in this episode

Host: Janet Rossant

Topics covered

• cancer neuroscience
• tumor organoids
• nervous system
• glioblastoma
• tumor progression
• neuronal influences

Keywords

• glioblastoma
• cancer pathogenesis
• neurons
• tumor cells
• glial-derived tumor
• CNS
• paracrine factors
• synaptic inputs

Mentioned in this episode

Organizations: ISSCR

Books & works: glioblastomas, gliomas

Places: CNS

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