
MICRO:11 - Microdosed Psilocybin, Synaptic Plasticity, and Compulsion with Dr. Mikael Palner
From Adventures Through The Mind by James W. Jesso
November 28, 2025 · 12 min · Episode 202
About this episode
Dr. Mikael Palner discusses the effects of psilocybin microdosing on synaptic plasticity and its implications for stress resiliency and compulsive behaviors.
Dr. Mikael Palner discusses how psilocybin microdosing alters synaptic plasticity in rats and how these brain changes align with shifts in stress resiliancy and compulsive behaviors. He then discusses how these data line up with emerging reports on low-dose psilocybin as helpful in cases of OCD, and hypothesizes a plausible biological basis. ... This is a clip from 'Microdosing Psilocybin; Effects on Stress Resiliency and Compulsive Behaviours | Dr. Mikael Palner ~ ATTMind Podcast 194" FULL INTERVIEW Listen on iTunes Listen/Watch on Spotify Watch on Youtube Read the show notes SUPPORT THE PODCAST 🥰 Support ATTMind and join the community on Patreon Other options Toss me a tip on PayPal: https://www.paypal.com/biz/fund?id=383635S3BKJVS Buy some merchandise: https://www.jameswjesso.com/shop/ More Options: https://www.jameswjesso.com/support Connect with Me Bluesky: https://bsky.app/profile/jameswjesso.bsky.social Instagram: https://www.instagram.com/attmindpodcast/ Newsletter: https://www.jameswjesso.com/newsletter Substack: https://substack.com/@jameswjesso LinkedIn: https://t.me/jameswjesso
People in this episode
Host: James W. Jesso
Guest: Dr. Mikael Palner
Topics covered
- psilocybin
- microdosing
- synaptic plasticity
- compulsive behaviors
- OCD
- stress resiliency
Keywords
- psilocybin
- microdosing
- synaptic plasticity
- OCD
- compulsive behaviors
- stress resiliency
Mentioned in this episode
Books & works: Microdosing Psilocybin; Effects on Stress Resiliency and Compulsive Behaviours | Dr. Mikael Palner ~ ATTMind Podcast 194
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