
45 | Overtime: A Conversation With Dr. David Fajgenbaum
From Alive Again by iHeartPodcasts
March 3, 2026 · 1h 12m · Season 1 · Episode 45
About this episode
Dr. David Fajgenbaum shares his incredible journey of survival and determination in the face of a rare disease.
Today’s guest is Dr. David Fajgenbaum, survivor, scientist, physician, and disease hunter. Dr. Fajgenbaum is a world-renowned physician-scientist, bestselling author, inspirational speaker, and survivor on a mission to save lives by using AI and relentless hope to unlock hidden cures. At 25 years old, Dr. David Fajgenbaum was told he had hours to live. A rare immune disorder called Idiopathic Multicentric Castleman Disease was shutting down his organs. He received last rites. He said goodbye to his family. And then — against all odds — he survived. Not once. Five times. With no effective treatments available, he turned my desperation into determination— As both patient and scientist, David made a radical decision: if no cure existed, he would chase one himself—even if it meant experimenting on his own body. What followed wasn’t just recovery. It was transformation. In this episode of Alive Again , David recounts what it feels like to grieve everyone you love all at once — to prepare for death while still conscious. He describes the strange emotional flip from despair to overwhelming gratitude when the chemotherapy began to…
People in this episode
Guest: Dr. David Fajgenbaum
Topics covered
- survival
- medicine
- AI
- personal transformation
- disease research
Keywords
- survivor
- physician-scientist
- cure
- chemotherapy
- transplant drug
Mentioned in this episode
Organizations: iHeartPodcasts
Books & works: Alive Again
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