Mice on Magic Mushrooms

Mice on Magic Mushrooms

From Altered States by PRX

November 5, 2025 · 25 min · Season 2 · Episode 7

About this episode

This episode explores the effects of psychedelics on mice and what it reveals about consciousness and mental health.

How do you know if a mouse is on a psychedelic? It might just shake its head. This behavior, known as the head-twitch response, signals whether a molecule is a psychedelic-like hallucinogen. Head twitch is one tool used by pharmaceutical companies racing to develop new mental health drugs. But does a mouse experience an altered state like a human? Do animals have mystical experiences? And what can we really learn about the brain, or even human consciousness, from these unwitting rodent psychonauts? For a transcript of this episode, please visit this link.

Topics covered

  • psychedelics
  • mental health
  • animal behavior
  • hallucinogens
  • consciousness

Keywords

  • psychedelics
  • mice
  • head-twitch response
  • mental health drugs
  • animal consciousness

Mentioned in this episode

Organizations: PRX

Products: magic mushrooms

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