BaladoCritique - club de lecture médical
by Dr Luc Lanthier et collaborateurs
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Recent episodes
BC 078 – Traitement intensif ciblant le cholestérol-LDL dans la maladie cardiovasculaire athérosclérotique (étude Ez-PAVE)
May 20, 2026
Unknown duration
BC 077 – Comparaison des risques hémorragiques entre le rivaroxaban et l’apixaban dans le traitement de la maladie thromboembolique (étude COBRRA)
Apr 27, 2026
Unknown duration
BC 076 – Seuils de D-dimères ajustés en fonction de l’âge pour exclure une thrombose veineuse profonde (étude ADJUST-DVT)
Mar 20, 2026
Unknown duration
BC 075 – Traitement médical ou par revascularisation dans la sténose carotidienne asymptomatique (étude CREST-2)
Jan 24, 2026
Unknown duration
BC 074 – Évolocumab chez les patients à risque cardiovasculaire élevé (étude VESALIUS-CV)
Dec 17, 2025
Unknown duration
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| Date | Episode | Description | Length | ||||||
|---|---|---|---|---|---|---|---|---|---|
| 5/20/26 | BC 078 – Traitement intensif ciblant le cholestérol-LDL dans la maladie cardiovasculaire athérosclérotique (étude Ez-PAVE) | Dans cette 78e baladodiffusion, les Drs Luc Lanthier et Pierre-Nicolas Perron discutent de traitement intensif de la dyslipidémie, en plus de réviser la littérature médicale d’avril 2026. Quiz clinique (1 min51), présentation principale (2 min 23), critique (16 min 30), retour sur le cas clinique (22 min 25), autres articles (24 min 32), réponse au quiz clinique (27 min 32). Référence principale : Lee YJ, Lee SJ, Kim JW, Lee SH, Kim GS, Park JH, et al; Ez-PAVE Investigators. Intensive LDL Cholesterol Targeting in Atherosclerotic Cardiovascular Disease. N Engl J Med. 2026;394(14):1365-1375. PubMed PMID: 41910315. Articles associés : Probstfield JL, Branch KRH. Paving the Road toward Targeted Lipid Lowering. N Engl J Med. 2026 Apr 9;394(14):1443-1444. PubMed PMID: 41910324. Mach F, Koskinas KC, Roeters van Lennep JE, Tokgözoğlu L, Badimon L, Baigent C, et al; ESC/EAS Scientific Document Group. 2025 Focused Update of the 2019 ESC/EAS Guidelines for the management of dyslipidaemias. Eur Heart J. 2025;46(42):4359-4378. PubMed PMID: 40878289. Marston NA, Bohula EA, Bhatia AK, De Ferrari GM, Leiter LA, Nicolau JC, et al; VESALIUS-CV Investigators. Evolocumab to Reduce First Major Cardiovascular Events in Patients Without Known Significant Atherosclerosis and With Diabetes: Results From the VESALIUS-CV Trial. JAMA. 2026;335(16):1400-1407. PubMed PMID: 41903215. Cannon CP, Braunwald E, McCabe CH, Rader DJ, Rouleau JL, Belder R, Joyal SV, Hill KA, Pfeffer MA, Skene AM; Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial Infarction 22 Investigators. Intensive versus moderate lipid lowering with statins after acute coronary syndromes. N Engl J Med. 2004;350(15):1495-504. PubMed PMID: 15007110. LaRosa JC, Grundy SM, Waters DD, Shear C, Barter P, Fruchart JC, et al; Treating to New Targets (TNT) Investigators. Intensive lipid lowering with atorvastatin in patients with stable coronary disease. N Engl J Med. 2005;352(14):1425-35. PubMed PMID: 15755765. Cannon CP, Blazing MA, Giugliano RP, McCagg A, White JA, Theroux P, et al; IMPROVE-IT Investigators. Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes. N Engl J Med. 2015;372(25):2387-97. PubMed PMID: 26039521. Sabatine MS, Giugliano RP, Keech AC, Honarpour N, Wiviott SD, Murphy SA, Kuder JF, Wang H, Liu T, Wasserman SM, Sever PS, Pedersen TR; FOURIER Steering Committee and Investigators. Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease. N Engl J Med. 2017;376(18):1713-1722. PubMed PMID: 28304224. Schwartz GG, Steg PG, Szarek M, Bhatt DL, Bittner VA, Diaz R, et al; ODYSSEY OUTCOMES Committees and Investigators. Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome. N Engl J Med. 2018;379(22):2097-2107. PubMed PMID: 30403574. Autres articles d’intérêt récent : Landmesser U, Skurk C, Kirchhof P, Lewalter T, Hartung J, Rroku A, et al; CLOSURE-AF Trial Investigators. Left Atrial Appendage Closure or Medical Therapy in Atrial Fibrillation. N Engl J Med. 2026;394(13):1270-1280. PubMed PMID: 41849741. Choi KH, Kang D, Kim W, Doh JH, Kim J, Park YH, et al; SMART-DECISION Investigators. Discontinuation of Beta-Blocker Therapy after Myocardial Infarction. N Engl J Med. 2026;394(13):1302-1312. PubMed PMID: 41910427. Sharma M, Dong Q, Hirano T, Kasner SE, Saver JL, Masjuan J, et al; OCEANIC-STROKE Investigators. Asundexian for Secondary Stroke Prevention. N Engl J Med. 2026;394(15):1467-1479. PubMed PMID: 41985132. Butler CC, Pinto AD, Harris V, Holmes J, Rahman NM, Cureton L, et al; PANORAMIC Trial and CanTreatCOVID Trial Collaborative Groups. Oral Nirmatrelvir-Ritonavir for Covid-19 in Higher-Risk Outpatients. N Engl J Med. 2026;394(16):1583-1594. PubMed PMID: 42019019. Guides de pratique : Prescott HC, Antonelli M, Alhazzani W, et al. Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2026. Crit Care Med. 2026;54(4):725-812. PubMed PMID: 41869847. Blumenthal RS, Morris PB, Gaudino M, et al. 2026 ACC/AHA/AACVPR/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Dyslipidemia: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2026;153(17):e1154-e1276. PubMed PMID: 41824552. Références du quiz clinique : Öberg J, Buchwald P, Nilsson A, Nilson B, Inghammar M. Risk and prognosis of colorectal cancer following bacteraemia with Streptococcus bovis–Streptococcus equinus complex: A Swedish nationwide retrospective cohort study. Epidemiol Infect. 2025;154:e2. PubMed PMID: 41449806. Abdulamir AS, Hafidh RR, Abu Bakar F. The association of Streptococcus bovis/gallolyticus with colorectal tumors: the nature and the underlying mechanisms of its etiological role. J Exp Clin Cancer Res. 2011;30(1):11. PubMed PMID: 21247505. | — | ||||||
| 4/27/26 | BC 077 – Comparaison des risques hémorragiques entre le rivaroxaban et l’apixaban dans le traitement de la maladie thromboembolique (étude COBRRA) | Dans cette 77e baladodiffusion, les Drs Alexandre Mutchmore et Geneviève LeTemplier discutent du traitement de l’embolie pulmonaire, en plus de réviser la littérature médicale de mars 2026. Quiz clinique (2 min 04), présentation principale (2 min 50), critique (21 min 43), retour sur le cas clinique (31 min 08), autres articles (33 min 45), réponse au quiz clinique (38 min 00). Référence principale : Castellucci LA, Chen VM, Kovacs MJ, Lazo-Langner A, Greenstreet P, Kahn S, et al; COBRRA Trial Investigators. Bleeding Risk with Apixaban vs. Rivaroxaban in Acute Venous Thromboembolism. N Engl J Med. 2026;394(11):1051-1060. PubMed PMID: 41812192. Articles associés : Moores LK. The COBRRA Trial – Ending the Venous Thromboembolism Safety Toss-up. N Engl J Med. 2026;394(11):1123-1124. PubMed PMID: 41812199. EINSTEIN Investigators; Bauersachs R, Berkowitz SD, Brenner B, Buller HR, Decousus H, Gallus AS, et al. Oral rivaroxaban for symptomatic venous thromboembolism. N Engl J Med. 2010;363(26):2499-510. PubMed PMID: 21128814. Agnelli G, Buller HR, Cohen A, Curto M, Gallus AS, Johnson M, et al; AMPLIFY Investigators. Oral apixaban for the treatment of acute venous thromboembolism. N Engl J Med. 2013;369(9):799-808. PubMed PMID: 23808982. Stevens SM, Woller SC, Baumann Kreuziger L, Bounameaux H, Doerschug K, Geersing GJ, et al. Executive Summary: Antithrombotic Therapy for VTE Disease: Second Update of the CHEST Guideline and Expert Panel Report. Chest. 2021;160(6):2247-2259. PubMed PMID: 34352279. Ortel TL, Neumann I, Ageno W, Beyth R, Clark NP, Cuker A, et al. American Society of Hematology 2020 guidelines for management of venous thromboembolism: treatment of deep vein thrombosis and pulmonary embolism. Blood Adv. 2020 ;4(19):4693-4738. PubMed PMID: 33007077. Autres articles d’intérêt récent : Heerspink HJL, Birkenfeld AL, Cherney DZI, Colhoun HM, Groop PH, Ji L, Jongs N, Mathieu C, Pratley RE, Rosas SE, Rossing P, Skyler JS, Tuttle KR, Lawatscheck R, Brinker M, Scheerer MF, Russell J, Schloemer P, McGill JB; FINE-ONE Investigators. Finerenone in Type 1 Diabetes and Chronic Kidney Disease. N Engl J Med. 2026;394(10):947-957. PubMed PMID: 41780000. Azizi M, Brown JM, Dwyer JP, Flack JM, Jones ESW, Kurlyandskaya R, Li H, Birve F, Lihn AS, Perl S, Schlaich MP, Shibata H, Wang JG, Williams B; Bax24 investigators. Effect of baxdrostat on ambulatory blood pressure in patients with resistant hypertension (Bax24): a phase 3, randomised, double-blind, placebo-controlled trial. Lancet. 2026;407(10532):988-999. PubMed PMID: 41794437. Zhang Y, Liu Y, Li Y, Li Y, Gu X, Kang JH, Eliassen AH, Wang M, Rimm EB, Willett WC, Hu FB, Stampfer MJ, Wang DD. Coffee and Tea Intake, Dementia Risk, and Cognitive Function. JAMA. 2026;335(11):961-974. PubMed PMID: 41661604. Rosenstock J, Yabe D, Cox D, Li J, Denning M, Wu WS, Liu R, Zhao Y; ACHIEVE-3 Investigators. Efficacy and safety of once-daily oral orforglipron compared with oral semaglutide in adults with type 2 diabetes (ACHIEVE-3): a multinational, multicentre, non-inferiority, open-label, randomised, phase 3 trial. Lancet. 2026;407(10534):1147-1160. PubMed PMID: 41765029. Guides de pratique : Bajaj JS, Jakab SS, Jesudian AB, Rahimi RS, Duarte-Rojo A, Chen PH, Wong RJ, Tapper EB, Tandon P. ACG Clinical Guideline: Hepatic Encephalopathy. Am J Gastroenterol. 2026;121(3):588-618. PubMed PMID: 41773757. Creager MA, Barnes GD, Giri J, Mukherjee D, Jones WS, Burnett AE, Carman T, Casanegra AI, Castellucci LA, Clark SM, Cushman M, de Wit K, Eaves JM, Fang MC, Goldberg JB, Henkin S, Johnston-Cox H, Kadavath S, Kadian-Dodov D, Keeling WB, Klein AJP, Li J, McDaniel MC, Moores LK, Piazza G, Prenger KS, Pugliese SC, Ranade M, Rosovsky RP, Russo F, Secemsky EA, Sista AK, Tefera L, Weinberg I, Westafer LM, Young MN. 2026 AHA/ACC/ACCP/ACEP/CHEST/SCAI/SHM/SIR/SVM/SVN Guideline for the Evaluation and Management of Acute Pulmonary Embolism in Adults: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2026;153(12):e977-e1051. PubMed PMID: 41712677. Référence du quiz clinique : Abramson BL, Al-Omran M, Anand SS, Albalawi Z, Coutinho T, de Mestral C, et al. Canadian Cardiovascular Society 2022 Guidelines for Peripheral Arterial Disease. Can J Cardiol. 2022;38(5):560-587. PubMed PMID: 35537813. | — | ||||||
| 3/20/26 | BC 076 – Seuils de D-dimères ajustés en fonction de l’âge pour exclure une thrombose veineuse profonde (étude ADJUST-DVT) | Dans cette 76e baladodiffusion, les Drs Alexandre Mutchmore et Luc Lanthier discutent de diagnostic de la thrombose veineuse profonde, en plus de réviser la littérature médicale de janvier et février 2026. Quiz clinique (1 min 45), présentation principale (2 min 15), critique (23 min 10), retour sur le cas clinique (30 min 25), autres articles (31 min 48), réponse au quiz clinique (36 min 55). Référence principale : Le Gal G, Robert-Ebadi H, Thiruganasambandamoorthy V, Moustafa F, Penaloza A, Catella J, et al. Age-Adjusted D-Dimer Cutoff Levels to Rule Out Deep Vein Thrombosis. JAMA. 2026;335(5):416-24. PubMed PMID: 41490105. Articles associés : Righini M, Van Es J, Den Exter PL, Roy PM, Verschuren F, Ghuysen A, et al. Age-adjusted D-dimer cutoff levels to rule out pulmonary embolism: the ADJUST-PE study. JAMA. 2014;311(11):1117-24. PubMed PMID: 24643601. Ujueta F, Piazza G. Like a Fine Wine-Aging the D-Dimer to Improve Value and Clinical Efficiency. JAMA. 2026;335(5):403-4. PubMed PMID: 41490683. Lim W, Le Gal G, Bates SM, Righini M, Haramati LB, Lang E, et al. American Society of Hematology 2018 guidelines for management of venous thromboembolism: diagnosis of venous thromboembolism. Blood Adv. 2018;2(22):3226-56. PubMed PMID: 30482764. https://thrombosiscanada.ca/hcp/practice/clinical_guides?language=en-ca&guideID=DEEPVEINTHROMBOSISDIAGNOSIS https://acforum.org/web/resource_files/1772710804-36404.pdf Autres articles d’intérêt récent : Lok CE, Farkouh M, Hemmelgarn BR, Moist LM, Polkinghorne KR, Tomlinson G, et al. Fish-Oil Supplementation and Cardiovascular Events in Patients Receiving Hemodialysis. N Engl J Med. 2026;394(2):128-37. PubMed PMID: 41201837. Verma A, Birnie DH, Jiang C, Heidbuchel H, Hindricks G, Kirchhof P, et al. Antithrombotic Therapy after Successful Catheter Ablation for Atrial Fibrillation. N Engl J Med. 2026;394(4):323-32. PubMed PMID: 41211931. Wong CX, Cheung CC, Montenegro G, Oo HH, Pena IJ, Tang JJ, et al. Caffeinated Coffee Consumption or Abstinence to Reduce Atrial Fibrillation: The DECAF Randomized Clinical Trial. JAMA. 2026;335(4):317-25. PubMed PMID: 41206802. Marston NA, Bergmark BA, Alexander VJ, Prohaska TA, Kang YM, Moura FA, et al. Olezarsen for Managing Severe Hypertriglyceridemia and Pancreatitis Risk. N Engl J Med. 2026;394(5):429-41. PubMed PMID: 41211918. Navar AM, Mikhailova E, Catapano AL, Banka P, Blom DJ, Cadena A, et al. A Placebo-Controlled Trial of the Oral PCSK9 Inhibitor Enlicitide. N Engl J Med. 2026;394(6):529-39. Lee SJ, Yu HT, Lee YJ, Lee SH, Heo JH, Ahn SG, et al. Therapy for Atrial Fibrillation in Patients with Drug-Eluting Stents. N Engl J Med. 2026;394(7):658-68. PubMed PMID: 41211917. Rana AI, Zheng L, Castillo-Mancilla J, Bao Y, Sieczkarski S, Brooks KM, et al. Cabotegravir plus Rilpivirine for Persons with HIV and Adherence Challenges. N Engl J Med. 2026;394(9):858-71. PubMed PMID: 41707171. Guides de pratique : American Diabetes Association Professional Practice Committee for D. Summary of Revisions: Standards of Care in Diabetes-2026. Diabetes Care. 2026;49(1 Suppl 1):S6-S12. PubMed PMID: 41358896. Andrade JG, Joza J, Chew DS, Ayala-Paredes F, Bennett MT, Essebag V, et al. The Canadian Cardiovascular Society/Canadian Heart Rhythm Society Comprehensive Guidelines for the Selection, Implantation, and Management of Patients With Cardiac Implantable Electronic Devices. Can J Cardiol. 2026;42(1):1-68. PubMed PMID: 41539743. Babitt JL, Berns JS, Bozkurt B, Cheung Khedairy RS, Cuevas Y, Effa EE, et al. Executive Summary of the KDIGO 2026 Clinical Practice Guideline for the Management of Anemia in Chronic Kidney Disease (CKD). Kidney Int. 2026;109(1):44-56. PubMed PMID: 41485807. Mahadevan U, Seow CH, Barnes EL, Chaparro M, Flanagan E, Friedman S, et al. Global Consensus Statement on the Management of Pregnancy in Inflammatory Bowel Disease. Am J Gastroenterol. 2026;121(1):31-79. PubMed PMID: 40862489. Références du quiz clinique : Sconfienza E, Tetti M, Forestiero V, Veglio F, Mulatero P, Monticone S. Prevalence of Functioning Adrenal Incidentalomas: A Systematic Review and Meta-analysis. J Clin Endocrinol Metab. 2023;108(7):1813-1823. PubMed PMID: 36718682. Fassnacht M, Tsagarakis S, Terzolo M, Tabarin A, Sahdev A, Newell-Price J, Pelsma I, Marina L, Lorenz K, Bancos I, Arlt W, Dekkers OM. European Society of Endocrinology clinical practice guidelines on the management of adrenal incidentalomas, in collaboration with the European Network for the Study of Adrenal Tumors. Eur J Endocrinol. 2023;189(1):G1-G42. PubMed PMID: 37318239. Kebebew E. Adrenal Incidentaloma. N Engl J Med. 2021;384(16):1542-1551. PubMed PMID: 33882207. | — | ||||||
| 1/24/26 | BC 075 – Traitement médical ou par revascularisation dans la sténose carotidienne asymptomatique (étude CREST-2) | Dans cette 75e baladodiffusion, les Drs Alexandre Mutchmore et Luc Lanthier discutent du traitement de la sténose carotidienne asymptomatique, en plus de réviser la littérature médicale de décembre 2025. Quiz clinique (3 min 30), présentation principale (4 min 32), critique (32 min 22), retour sur le cas clinique (41 min 51), autres articles (45 min 57), réponse au quiz clinique (49 min 26). Référence principale : Brott TG, Howard G, Lal BK, Voeks JH, Turan TN, Roubin GS, et al. Medical Management and Revascularization for Asymptomatic Carotid Stenosis. N Engl J Med. 2026;394(3):219-31. PubMed PMID: 41269206. Articles associés : Brown MM, Bonati LH. Managing Asymptomatic Carotid Stenosis. N Engl J Med. 2026;394(3):296-97. PubMed PMID: 41269202. North American Symptomatic Carotid Endarterectomy Trial Collaborators; Barnett HJM, Taylor DW, Haynes RB, Sackett DL, Peerless SJ, Ferguson GG, Fox AJ, Rankin RN, Hachinski VC, Wiebers DO, Eliasziw M. Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis. N Engl J Med. 1991;325(7):445-53. PubMed PMID: 1852179. Randomised trial of endarterectomy for recently symptomatic carotid stenosis: final results of the MRC European Carotid Surgery Trial (ECST). Lancet. 1998;351(9113):1379-87. PubMed PMID: 9593407. Endarterectomy for asymptomatic carotid artery stenosis. Executive Committee for the Asymptomatic Carotid Atherosclerosis Study. JAMA. 1995;273(18):1421-8. PubMed PMID: 7723155. Halliday A, Mansfield A, Marro J, Peto C, Peto R, Potter J, Thomas D; MRC Asymptomatic Carotid Surgery Trial (ACST) Collaborative Group. Prevention of disabling and fatal strokes by successful carotid endarterectomy in patients without recent neurological symptoms: randomised controlled trial. Lancet. 2004;363(9420):1491-502. PubMed PMID: 15135594. Naylor R, Rantner B, Ancetti S, de Borst GJ, De Carlo M, Halliday A, et al. Editor’s Choice – European Society for Vascular Surgery (ESVS) 2023 Clinical Practice Guidelines on the Management of Atherosclerotic Carotid and Vertebral Artery Disease. Eur J Vasc Endovasc Surg. 2023;65(1):7-111. PubMed PMID: 35598721. Bushnell C, Kernan WN, Sharrief AZ, Chaturvedi S, Cole JW, Cornwell WK, 3rd, et al. 2024 Guideline for the Primary Prevention of Stroke: A Guideline From the American Heart Association/American Stroke Association. Stroke. 2024;55(12):e344-e424. PubMed PMID: 39429201. Reiff T, Eckstein HH, Mansmann U, Jansen O, Fraedrich G, Mudra H, et al; SPACE-2 Investigators. Carotid endarterectomy or stenting or best medical treatment alone for moderate-to-severe asymptomatic carotid artery stenosis: 5-year results of a multicentre, randomised controlled trial. Lancet Neurol. 2022;21(10):877-888. PubMed PMID: 36115360. Howard DPJ, Gaziano L, Rothwell PM, Oxford Vascular S. Risk of stroke in relation to degree of asymptomatic carotid stenosis: a population-based cohort study, systematic review, and meta-analysis. Lancet Neurol. 2021;20(3):193-202. PubMed PMID: 33609477. Donners SJA, van Velzen TJ, Cheng SF, Gregson J, Hazewinkel AD, Pizzini FB, et al. Optimised medical therapy alone versus optimised medical therapy plus revascularisation for asymptomatic or low-to-intermediate risk symptomatic carotid stenosis (ECST-2): 2-year interim results of a multicentre randomised trial. Lancet Neurol. 2025;24(5):389-99. PubMed PMID: 40252662. Autres articles d’intérêt récent : Nicholls SJ, Pavo I, Bhatt DL, Buse JB, Del Prato S, Kahn SE, et al. Cardiovascular Outcomes with Tirzepatide versus Dulaglutide in Type 2 Diabetes. N Engl J Med. 2025;393(24):2409-20. PubMed PMID: 41406444. Kougias P, Sharath SE, Zhan M, Carson JL, Norman LE, Mi Z, et al. Liberal or Restrictive Postoperative Transfusion in Patients at High Cardiac Risk: The TOP Randomized Clinical Trial. JAMA. 2025;334(24):2197-207. PubMed PMID: 41205227. Horn DB, Ryan DH, Kis SG, Alves B, Mu Y, Kim SG, et al. Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (ATTAIN-2): a phase 3, double-blind, randomised, multicentre, placebo-controlled trial. Lancet. 2026;406(10522):2927-44. PubMed PMID: 41275875. Xie M, Eyting M, Bommer C, Ahmed H, Geldsetzer P. The effect of shingles vaccination at different stages of the dementia disease course. Cell. 2025;188(25):7049-64 e20. PubMed PMID: 41338191. Guides de pratique : Tan DHS, Hull MW, Onyegbule SO, Ajiboye W, Arkell C, Baril JG, et al. Canadian guideline on HIV pre- and postexposure prophylaxis: 2025 update. CMAJ. 2025;197(41):E1374-E91. PubMed PMID: 41326046. Scott FI, Ananthakrishnan AN, Click B, Agrawal M, Syal G, Haydek JP, et al. AGA Living Clinical Practice Guideline on the Pharmacologic Management of Moderate-to-Severe Crohn’s Disease. Gastroenterology. 2025;169(7):1397-448. PubMed PMID: 41274746. Orman ES, Fortune BE, John BV, Asrani SK. AGA Clinical Practice Update on the Management of Ascites, Volume Overload, and Hyponatremia in Cirrhosis: Expert Review. Gastroenterology. 2025;169(7):1547-57. PubMed PMID: 41114681. Référence du quiz clinique : Rajkumar SV, Kumar S. Monoclonal Gammopathy of Undetermined Significance. N Engl J Med. 2025 Oct 2;393(13):1315-1326. PubMed PMID: 41032708. | — | ||||||
| 12/17/25 | BC 074 – Évolocumab chez les patients à risque cardiovasculaire élevé (étude VESALIUS-CV) | Dans cette 74e baladodiffusion, les Drs Alexandre Mutchmore et Luc Lanthier discutent de l’efficacité de l’évolocumab, un inhibiteur des PCSK9, chez les sujets à haut risque cardiovasculaire, en plus de réviser la littérature médicale d’octobre et novembre 2025. Quiz clinique (4 min 16), présentation principale (5 min 28), critique (27 min 19), retour sur le cas clinique (37 min 43), autres articles (40 min 32), réponse au quiz clinique (45 min 45). Référence principale : Bohula EA, Marston NA, Bhatia AK, De Ferrari GM, Leiter LA, Nicolau JC, et al; VESALIUS-CV Investigators. Evolocumab in Patients without a Previous Myocardial Infarction or Stroke. N Engl J Med. 2025 Nov 8. doi: 10.1056/NEJMoa2514428. Epub ahead of print. PubMedPMID: 41211925. Articles associés : Ibanez B, Latini R, Rossello X, Dominguez-Rodriguez A, Fernández-Vazquez F, Pelizzoni V, et al. Beta-Blockers after Myocardial Infarction without Reduced Ejection Fraction. N Engl J Med. 2025;393(19):1889-1900. PubMed PMID: 40888702. Munkhaugen J, Kristensen AMD, Halvorsen S, Holmager T, Olsen MH, Bakken A, et al. Beta-Blockers after Myocardial Infarction in Patients without Heart Failure. N Engl J Med. 2025;393(19):1901-1911. PubMed PMID: 40888716. Rossello X, Prescott EIB, Kristensen AMD, Latini R, Fuster V, Fagerland MW, et al. β blockers after myocardial infarction with mildly reduced ejection fraction: an individual patient data meta-analysis of randomised controlled trials. Lancet. 2025;406(10508):1128-1137. PubMed PMID: 40897190. Kristensen AMD, Rossello X, Atar D, Yndigegn T, Kimura T, Latini R, et al; Beta-Blocker Trialists’ Collaboration Study Group.. Beta-Blockers after Myocardial Infarction with Normal Ejection Fraction. N Engl J Med. 2025 Nov 9. doi: 10.1056/NEJMoa2512686. Epub ahead of print. PubMed PMID: 41211954. Deanfield J, Lincoff AM, Kahn SE, Emerson SS, Lingvay I, Scirica BM, et al. Semaglutide and cardiovascular outcomes by baseline and changes in adiposity measurements: a prespecified analysis of the SELECT trial. Lancet. 2025;406:2257-2268. PubMed PMID: 41138739. Ndumele CE, Blumenthal RS. VESALIUS and the Anatomy of High-Risk Prevention. N Engl J Med. 2025;393(19):eEditorial. doi:10.1056/NEJMe2515447. PubMed PMID: 41211946. Sabatine MS, Giugliano RP, Keech AC, Honarpour N, Wiviott SD, Murphy SA, et al; FOURIER Steering Committee and Investigators. Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease. N Engl J Med. 2017;376(18):1713-1722. PubMed PMID: 28304224. Schwartz GG, Steg PG, Szarek M, Bhatt DL, Bittner VA, Diaz R, et al; ODYSSEY OUTCOMES Committees and Investigators. Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome. N Engl J Med. 2018;379(22):2097-2107. PubMed PMID: 30403574. Autres articles d’intérêt récent : Kim D, Shim J, Choi EK, Oh IY, Kim J, Lee YS, et al. Long-Term Anticoagulation Discontinuation After Catheter Ablation for Atrial Fibrillation: The ALONE-AF Randomized Clinical Trial. JAMA. 2025;334(14):1246-1254. PubMed PMID: 40886309. Lemesle G, Didier R, Steg PG, Simon T, Montalescot G, Danchin N, et al. Aspirin in Patients with Chronic Coronary Syndrome Receiving Oral Anticoagulation: The AQUATIC Trial. N Engl J Med. 2025;393(16):1578-1588. PubMed PMID: 40888725. Flack JM, Azizi M, Brown JM, Dwyer JP, Fronczek J, Jones ES, et al. Efficacy and Safety of Baxdrostat in Uncontrolled and Resistant Hypertension. N Engl J Med. 2025;393(14):1363-1374. PubMed PMID: 40888730. McLaughlin VV, Hoeper MM, Badesch DB, Ghofrani HA, Gibbs JSR, Gomberg-Maitland M, et al. Sotatercept for Pulmonary Arterial Hypertension within the First Year after Diagnosis. N Engl J Med. 2025;393(16):1599-1611. PubMed PMID: 41025556. Wharton S, Aronne LJ, Stefanski A, Alfaris NF, Ciudin A, Yokote K, et al. Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment. N Engl J Med. 2025;393(18):1796-1806. PubMed PMID: 40960239. Guimarães PO, Franken M, Tavares CAM, Antunes MO, Silveira FS, Andrade PB, et al. Early Withdrawal of Aspirin after PCI in Acute Coronary Syndromes. N Engl J Med. 2025;393(21):2095-2106. PubMed PMID: 40888723. Tarantini G, Honton B, Paradies V, Lemesle G, Range G, Godin M, et al. Early Discontinuation of Aspirin after PCI in Low-Risk Acute Myocardial Infarction. N Engl J Med. 2025;393(21):2083-2094. PubMed PMID: 40888726. Fitz-Patrick D, McVinnie DS, Jackson LA, Crowther G, Geevarughese A, Cannon KD, et al; Pfizer C4781004 Trial Investigators. Efficacy, Immunogenicity, and Safety of Modified mRNA Influenza Vaccine. N Engl J Med. 2025;393(20):2001-2011. PubMed PMID: 41259756. Guides de pratique : Virani S, Zieroth S, Aleksova N, Anderson K, Clarke B, Ducharme A, Ezekowitz JA, Foroutan F, Giannetti N, Jain R, et al. Canadian Cardiovascular Society/Canadian Heart Failure Society 2025 Guideline Update for Pharmacologic Management of Heart Failure With Nonreduced Ejection Fraction (LVEF > 40%). Can J Cardiol. 2025;41(10):1857-74. PubMed PMID: 41110921. Shih AW, Schnell G, Belley-Côté E, Lett R, Peretz-Larochelle M, Tinmouth A. Canadian Cardiovascular Society and National Advisory Committee on Blood and Blood Products Joint Statement on Blood Utilization and Transfusion for Patients With Acute Coronary Syndromes. Can J Cardiol. 2025;41(10):1875–1884. PubMed PMID: 41110922. Schulz-Menger J, Collini V, Gröschel J, Adler Y, Brucato A, Christian V, Ferreira VM, Gandjbakhch E, Heidecker B, Kerneis M, et al. 2025 ESC Guidelines for the management of myocarditis and pericarditis: Developed by the task force for the management of myocarditis and pericarditis of the European Society of Cardiology (ESC) endorsed by the Association for European Paediatric and Congenital Cardiology (AEPC) and the European Association for Cardio-Thoracic Surgery (EACTS). Eur Heart J. 2025;46(40):3952-4041. PubMed PMID: 40878297. Staller K, Parkman HP, Greer KB, Leiman DA, Zhou MJ, Singh S, Camilleri M, Altayar O; AGA Clinical Guidelines Committee. AGA Clinical Practice Guideline on Management of Gastroparesis. Gastroenterology. 2025;169(5):828-61. PubMed PMID: 40976635. Kidney Disease: Improving Global Outcomes (KDIGO) IgAN and IgAV Work Group. KDIGO 2025 Clinical Practice Guideline for the Management of Immunoglobulin A Nephropathy (IgAN) and Immunoglobulin A Vasculitis (IgAV). Kidney Int. 2025;108(4S):S1–S71. PubMed PMID: 40975564. Praz F, Borger MA, Lanz J, Marin-Cuartas M, Abreu A, Adamo M, et al. 2025 ESC/EACTS Guidelines for the management of valvular heart disease. Eur Heart J. 2025;46(44):4635-4736. PubMed PMID: 40878295. Mach F, Koskinas KC, Roeters van Lennep JE, Tokgözoğlu L, Badimon L, Baigent C, Benn M, Binder CJ, Catapano AL, De Backer GG, et al. 2025 Focused Update of the 2019 ESC/EAS Guidelines for the management of dyslipidaemias. Eur Heart J. 2025;46(42):4359-78. PubMed PMID: 40878289. Wani S, Zhou MJ, Sawas T, Rubenstein JH, Eluri S, Leiman DA, Sultan S, Singh S, Inadomi J, Thrift AP, Katzka DA, Davitkov P. AGA Clinical Practice Guideline on Surveillance of Barrett’s Esophagus. Gastroenterology. 2025;169(6):1184-1231. PubMed PMID: 41125322. Référence du quiz clinique : Gallant RC, Cameron L, Mithoowani S. Copper deficiency. CMAJ. 2025;197(16):E456. PubMed PMID: 40294944. | — | ||||||
| 10/28/25 | BC 073 – Altéplase dans l’AVC ischémique aigu entre 4,5 et 24 heures (étude HOPE) | Dans cette 73e baladodiffusion, les Drs Luc Lanthier et Emmanuelle Lapointe discutent du traitement thrombolytique retardé dans l’AVC ischémique aigu, en plus de réviser la littérature médicale de juillet, août et septembre 2025. Quiz clinique (2 min 16), présentation principale (2 min 38), critique (26 min 42), retour sur le cas clinique (36 min 05), autres articles (37 min 50), réponse au quiz clinique (44 min 57) Référence principale : Zhou Y, He Y, Campbell BCV, Liebeskind DS, Yuan C, Chen H, et al. Alteplase for Acute Ischemic Stroke at 4.5 to 24 Hours: The HOPE Randomized Clinical Trial. JAMA. 2025;334(9):788-97. PubMed PMID: 40773205. Articles associés : Thomalla G, Simonsen CZ, Boutitie F, Andersen G, Berthezene Y, Cheng B, et al. MRI-Guided Thrombolysis for Stroke with Unknown Time of Onset. N Engl J Med. 2018;379(7):611-22. PubMed PMID: 29766770. Ma H, Campbell BCV, Parsons MW, Churilov L, Levi CR, Hsu C, et al. Thrombolysis Guided by Perfusion Imaging up to 9 Hours after Onset of Stroke. N Engl J Med. 2019;380(19):1795-803. PubMed PMID: 31067369. Albers GW, Jumaa M, Purdon B, Zaidi SF, Streib C, Shuaib A, et al. Tenecteplase for Stroke at 4.5 to 24 Hours with Perfusion-Imaging Selection. N Engl J Med. 2024;390(8):701-11. PubMed PMID: 38329148. Tenecteplase for Ischemic Stroke at 4.5 to 24 Hours without Thrombectomy. N Engl J Med. 2024;391(3):203-12. PubMed PMID: 38884324. Wang Z, Li J, Wang X, Yuan B, Li J, Ma Q. Tenecteplase for Acute Ischemic Stroke at 4.5 to 24 Hours: A Meta-Analysis of Randomized Controlled Trials. Stroke. 2025 Oct 13. doi: 10.1161/STROKEAHA.125.053256. PubMed PMID: 41078125. Autres articles d’intérêt récent : Aronne LJ, Horn DB, le Roux CW, Ho W, Falcon BL, Gomez Valderas E, et al. Tirzepatide as Compared with Semaglutide for the Treatment of Obesity. N Engl J Med. 2025;393(1):26-36. PubMed PMID: 40353578. Kahlmann V, Janssen Bonas M, Moor CC, Grutters JC, Mostard RLM, van Rijswijk H, et al. First-Line Treatment of Pulmonary Sarcoidosis with Prednisone or Methotrexate. N Engl J Med. 2025;393(3):231-42. PubMed PMID: 40387020. Desai AS, Karns AD, Badariene J, Aswad A, Neutel JM, Kazi F, et al. Add-On Treatment With Zilebesiran for Inadequately Controlled Hypertension: The KARDIA-2 Randomized Clinical Trial. JAMA. 2025;334(1):46-55. PubMed PMID: 40434761. Agarwal R, Green JB, Heerspink HJL, Mann JFE, McGill JB, Mottl AK, et al. Finerenone with Empagliflozin in Chronic Kidney Disease and Type 2 Diabetes. N Engl J Med. 2025;393(6):533-43. PubMed PMID: 40470996. McIntyre L, Fergusson D, McArdle T, English S, Cook DJ, Fox-Robichaud AE, et al. A Crossover Trial of Hospital-Wide Lactated Ringer’s Solution versus Normal Saline. N Engl J Med. 2025;393(7):660-70. PubMed PMID: 40503714. Davies MJ, Bajaj HS, Broholm C, Eliasen A, Garvey WT, le Roux CW, et al. Cagrilintide-Semaglutide in Adults with Overweight or Obesity and Type 2 Diabetes. N Engl J Med. 2025;393(7):648-59. PubMed PMID: 40544432. Garvey WT, Bluher M, Osorto Contreras CK, Davies MJ, Winning Lehmann E, Pietilainen KH, et al. Coadministered Cagrilintide and Semaglutide in Adults with Overweight or Obesity. N Engl J Med. 2025;393(7):635-47. PubMed PMID: 40544433. Ding D, Nguyen B, Nau T, Luo M, Del Pozo Cruz B, Dempsey PC, et al. Daily steps and health outcomes in adults: a systematic review and dose-response meta-analysis. Lancet Public Health. 2025;10(8):e668-e81. PubMed PMID: 40713949. Tonet E, Raisi A, Zagnoni S, Chiaranda G, Pasanisi G, Aschieri D, et al. Multidomain Rehabilitation for Older Patients with Myocardial Infarction. N Engl J Med. 2025;393(10):973-82. PubMed PMID: 40879431. Rosenstock J, Hsia S, Nevarez Ruiz L, Eyde S, Cox D, Wu WS, et al. Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes. N Engl J Med. 2025;393(11):1065-76. PubMed PMID: 40544435. Tao C, Liu T, Cui T, Liu J, Li Z, Ren Y, et al. Early Tirofiban Infusion after Intravenous Thrombolysis for Stroke. N Engl J Med. 2025;393(12):1191-201. PubMed PMID: 40616232. Bavendiek U, Grosshennig A, Schwab J, Berliner D, Rieth A, Maier LS, et al. Digitoxin in Patients with Heart Failure and Reduced Ejection Fraction. N Engl J Med. 2025;393(12):1155-65. PubMed PMID: 40879434. Piazza G, Bikdeli B, Pandey AK, Krishnathasan D, Khairani CD, Bejjani A, et al. Apixaban for Extended Treatment of Provoked Venous Thromboembolism. N Engl J Med. 2025;393(12):1166-76. PubMed PMID: 40888734. Florian J, Salcedo P, Burkhart K, Shah A, Chekka LMS, Keshishi D, et al. Cannabidiol and Liver Enzyme Level Elevations in Healthy Adults: A Randomized Clinical Trial. JAMA Intern Med. 2025;185(9):1070-8. PubMed PMID: 40622698. Guides de pratique : Podolanczuk AJ, Hunninghake GM, Wilson KC, Khor YH, Kheir F, Pang B, et al. Approach to the Evaluation and Management of Interstitial Lung Abnormalities: An Official American Thoracic Society Clinical Statement. Am J Respir Crit Care Med. 2025;211(7):1132-55. PubMed PMID: 40387336. Adler GK, Stowasser M, Correa RR, Khan N, Kline G, McGowan MJ, et al. Primary Aldosteronism: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2025;110(9):2453-95. PubMed PMID: 40658480. Pedersen SD, Manjoo P, Dash S, Jain A, Pearce N, Poddar M. Pharmacotherapy for obesity management in adults: 2025 clinical practice guideline update. CMAJ. 2025;197(27):E797-E809. PubMed PMID: 40789597. Thombs BD, Traversy G, Reynolds DL, Lang E, Groulx S, Wilson BJ, et al. Recommendations on interventions for tobacco smoking cessation in adults in Canada. CMAJ. 2025;197(28):E846-E61. PubMed PMID: 40854602 Writing Committee M, Jones DW, Ferdinand KC, Taler SJ, Johnson HM, Shimbo D, et al. 2025 AHA/ACC/AANP/AAPA/ABC/ACCP/ACPM/AGS/AMA/ASPC/NMA/PCNA/SGIM Guideline for the Prevention, Detection, Evaluation and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2025;152(11):e114-e218. PubMed PMID: 40811497. Référence du quiz clinique : Livingston G, Huntley J, Liu KY, Costafreda SG, Selbaek G, Alladi S, et al. Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission. Lancet. 2024;404(10452):572-628. PubMed PMID: 39096926. | — | ||||||
| 7/6/25 | BC 072 – Sémaglutide dans le traitement de la stéatohépatite liée à une dysfonction métabolique (étude ESSENCE) | Dans cette 72e baladodiffusion, les Drs Alexandre Mutchmore et Dusanka Grbic discutent du sémaglutide comme traitement de la stéatohépatite liée à une dysfonction métabolique, en plus de réviser la littérature médicale de mai et juin 2025. Quiz clinique (3 min 33), présentation principale (4 min 12), critique (29 min 25), retour sur le cas clinique (36 min 29), autres articles (39 min 00), réponse au quiz clinique (43 min 39) Référence principale : Sanyal AJ, Newsome PN, Kliers I, Ostergaard LH, Long MT, Kjaer MS, et al. Phase 3 Trial of Semaglutide in Metabolic Dysfunction-Associated Steatohepatitis. N Engl J Med. 2025;392(21):2089-99. PubMed PMID: 40305708. Articles associés : Simon TG. Semaglutide for Metabolic Dysfunction-Associated Steatohepatitis. N Engl J Med. 2025;392(21):2160-1. PubMed PMID: 40466070. Harrison SA, Bedossa P, Guy CD, Schattenberg JM, Loomba R, Taub R, et al. A Phase 3, Randomized, Controlled Trial of Resmetirom in NASH with Liver Fibrosis. N Engl J Med. 2024;390(6):497-509. PubMed PMID: 38324483. Rinella ME, Neuschwander-Tetri BA, Siddiqui MS, Abdelmalek MF, Caldwell S, Barb D, et al. AASLD Practice Guidance on the clinical assessment and management of nonalcoholic fatty liver disease. Hepatology. 2023;77(5):1797-835. PubMed PMID: 36727674. EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD). J Hepatol. 2024;81(3):492-542. PubMed PMID: 38851997. Israelsen M, Francque S, Tsochatzis EA, Krag A. Steatotic liver disease. Lancet. 2024;404(10464):1761-1778. PubMed PMID: 39488409. Sanyal AJ, Bedossa P, Fraessdorf M, Neff GW, Lawitz E, Bugianesi E, et al 1404-0043 Trial Investigators. A Phase 2 Randomized Trial of Survodutide in MASH and Fibrosis. N Engl J Med. 2024;391(4):311-319. PubMed PMID: 38847460. Loomba R, Hartman ML, Lawitz EJ, Vuppalanchi R, Boursier J, Bugianesi E, et al; SYNERGY-NASH Investigators. Tirzepatide for Metabolic Dysfunction-Associated Steatohepatitis with Liver Fibrosis. N Engl J Med. 2024;391(4):299-310. PubMed PMID: 38856224. Lin J, Huang Y, Xu B, Gu X, Huang J, Sun J, et al. Effect of dapagliflozin on metabolic dysfunction-associated steatohepatitis: multicentre, double blind, randomised, placebo controlled trial. BMJ. 2025;389:e083735. PubMed PMID: 40467095. Autres articles d’intérêt récent : Humbert M, McLaughlin VV, Badesch DB, Ghofrani HA, Gibbs JSR, Gomberg-Maitland M, et al. Sotatercept in Patients with Pulmonary Arterial Hypertension at High Risk for Death. N Engl J Med. 2025;392(20):1987-2000. PubMed PMID: 40167274. Bonaca MP, Catarig AM, Houlind K, Ludvik B, Nordanstig J, Ramesh CK, et al. Semaglutide and walking capacity in people with symptomatic peripheral artery disease and type 2 diabetes (STRIDE): a phase 3b, double-blind, randomised, placebo-controlled trial. Lancet. 2025;405(10489):1580-93. PubMed PMID: 40169145. Blockmans D, Penn SK, Setty AR, Schmidt WA, Rubbert-Roth A, Hauge EM, et al. A Phase 3 Trial of Upadacitinib for Giant-Cell Arteritis. N Engl J Med. 2025;392(20):2013-24. PubMed PMID: 40174237. Laffin LJ, Kopjar B, Melgaard C, Wolski K, Ibbitson J, Bhikam S, et al. Lorundrostat Efficacy and Safety in Patients with Uncontrolled Hypertension. N Engl J Med. 2025;392(18):1813-23. PubMed PMID: 40267417. Garrison SR, Bakal JA, Kolber MR, Korownyk CS, Green LA, Kirkwood JEM, et al. Antihypertensive Medication Timing and Cardiovascular Events and Death: The BedMed Randomized Clinical Trial. JAMA. 2025;333(23):2061-72. PubMed PMID: 40354045. Herrmann JJ, Brunner-La Rocca HP, Baltussen L, Beckers-Wesche F, Bekkers S, Bellersen L, et al. Liberal fluid intake versus fluid restriction in chronic heart failure: a randomized clinical trial. Nat Med. 2025;31(6):2062-8. PubMed PMID: 40159556. Richeldi L, Azuma A, Cottin V, Kreuter M, Maher TM, Martinez FJ, et al. Nerandomilast in Patients with Idiopathic Pulmonary Fibrosis. N Engl J Med. 2025;392(22):2193-202. PubMed PMID: 40387033. Maher TM, Assassi S, Azuma A, Cottin V, Hoffmann-Vold AM, Kreuter M, et al. Nerandomilast in Patients with Progressive Pulmonary Fibrosis. N Engl J Med. 2025;392(22):2203-14. PubMed PMID: 40388329. Lee CJ, Ihm SH, Shin DH, Jeong JO, Kim JH, Chun KH, et al. Spironolactone vs Amiloride for Resistant Hypertension: A Randomized Clinical Trial. JAMA. 2025;333(23):2073-82. PubMed PMID: 40366680. Guides de pratique : Goupil R, Tsuyuki RT, Santesso N, Terenzi KA, Habert J, Cheng G, et al. Hypertension Canada guideline for the diagnosis and treatment of hypertension in adults in primary care. CMAJ. 2025;197(20):E549-E64. PubMed PMID: 40419299 Tobe SW, Bajaj HS, Tangri N, Jain R, Pham T, Beaudin V, et al. Chronic Kidney Disease in Diabetes: A Clinical Practice Guideline. Can J Diabetes. 2025;49(2):73-86. PubMed PMID: 40382193. Mir H, Eisenberg MJ, Benowitz NL, Cowley E, Heshmati J, Jha P, et al. Canadian Cardiovascular Society Clinical Practice Update on Contemporary Approaches to Smoking Cessation. Can J Cardiol. 2025;41(5):797-812. PubMed PMID: 40340054. Osiowy C, Alvarez F, Coffin CS, Cooper CL, Fung SK, Ko HH, et al. The management of chronic hepatitis B: 2025 Guidelines update from the Canadian Association for the Study of the Liver and Association of Medical Microbiology and Infectious Disease Canada. Canadian Liver Journal. 2025;8(2):368-401. Rao SV, O’Donoghue ML, Ruel M, Rab T, Tamis-Holland JE, Alexander JH, et al. 2025 ACC/AHA/ACEP/NAEMSP/SCAI Guideline for the Management of Patients With Acute Coronary Syndromes: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. J Am Coll Cardiol. 2025;85(22):2135-237. PubMed PMID: 40013746. Rubin DT, Ananthakrishnan AN, Siegel CA, Barnes EL, Long MD. ACG Clinical Guideline Update: Ulcerative Colitis in Adults. Am J Gastroenterol. 2025;120(6):1187-224. Lichtenstein GR, Loftus EV, Afzali A, Long MD, Barnes EL, Isaacs KL, et al. ACG Clinical Guideline: Management of Crohn’s Disease in Adults. Am J Gastroenterol. 2025;120(6):1225-64. Référence du quiz clinique : Goupil R, Tsuyuki RT, Santesso N, Terenzi KA, Habert J, Cheng G, et al. Hypertension Canada guideline for the diagnosis and treatment of hypertension in adults in primary care. CMAJ. 2025;197(20):E549-E64. PubMed PMID: 40419299 | — | ||||||
| 5/28/25 | Traitement anticoagulant prolongé avec une dose réduite d’apixaban chez les patients cancéreux atteints d’une maladie thromboembolique veineuse (étude API-CAT) | Dans cette 71e baladodiffusion, les Drs Luc Lanthier et Geneviève LeTemplier discutent du traitement de la maladie thromboembolique paranéoplasique, en plus de réviser la littérature médicale d’avril 2025. Quiz clinique (2 min 04), présentation principale (2 min 29), critique (25 min 44), retour sur le cas clinique (31 min 15), autres articles (32 min 35), réponse au quiz clinique (35 min 15) Référence principale : Mahe I, Carrier M, Mayeur D, Chidiac J, Vicaut E, Falvo N, et al. Extended Reduced-Dose Apixaban for Cancer-Associated Venous Thromboembolism. N Engl J Med. 2025;392(14):1363-73. PubMed PMID: 40162636. Articles associés : Noble S. Cancer-Associated Venous Thromboembolism – Beyond 6 Months. N Engl J Med. 2025;392(14):1439-40. PubMed PMID: 40162659. Lee AY, Levine MN, Baker RI, Bowden C, Kakkar AK, Prins M, et al; Randomized Comparison of Low-Molecular-Weight Heparin versus Oral Anticoagulant Therapy for the Prevention of Recurrent Venous Thromboembolism in Patients with Cancer (CLOT) Investigators. Low-molecular-weight heparin versus a coumarin for the prevention of recurrent venous thromboembolism in patients with cancer. N Engl J Med. 2003;349(2):146-53. PubMed PMID: 12853587. Raskob GE, van Es N, Verhamme P, Carrier M, Di Nisio M, Garcia D, et al; Hokusai VTE Cancer Investigators. Edoxaban for the Treatment of Cancer-Associated Venous Thromboembolism. N Engl J Med. 2018;378(7):615-624. PubMed PMID: 29231094. Agnelli G, Becattini C, Meyer G, Munoz A, Huisman MV, Connors JM, et al. Apixaban for the Treatment of Venous Thromboembolism Associated with Cancer. N Engl J Med. 2020;382(17):1599-607. PubMed PMID: 32233112. Agnelli G, Buller HR, Cohen A, Curto M, Gallus AS, Johnson M, Porcari A, Raskob GE, Weitz JI; AMPLIFY-EXT Investigators. Apixaban for extended treatment of venous thromboembolism. N Engl J Med. 2013;368(8):699-708. PubMed PMID: 23216615. Weitz JI, Lensing AWA, Prins MH, Bauersachs R, Beyer-Westendorf J, Bounameaux H, et al; EINSTEIN CHOICE Investigators. Rivaroxaban or Aspirin for Extended Treatment of Venous Thromboembolism. N Engl J Med. 2017;376(13):1211-1222. PubMed PMID: 28316279. Lyman GH, Carrier M, Ay C, Di Nisio M, Hicks LK, Khorana AA, et al. American Society of Hematology 2021 guidelines for management of venous thromboembolism: prevention and treatment in patients with cancer. Blood Adv. 2021;5(4):927-974. PubMed PMID: 33570602. Key NS, Khorana AA, Kuderer NM, Bohlke K, Lee AYY, Arcelus JI, et al. Venous Thromboembolism Prophylaxis and Treatment in Patients With Cancer: ASCO Guideline Update. J Clin Oncol. 2023;41(16):3063-3071. PubMed PMID: 37075273. Stevens SM, Woller SC, Baumann Kreuziger L, Bounameaux H, Doerschug K, Geersing GJ, et al. Executive Summary: Antithrombotic Therapy for VTE Disease: Second Update of the CHEST Guideline and Expert Panel Report. Chest. 2021;160(6):2247-2259. PubMed PMID: 34352279. Autres articles d’intérêt récent : Kelley CF, Acevedo-Quinones M, Agwu AL, Avihingsanon A, Benson P, Blumenthal J, et al. Twice-Yearly Lenacapavir for HIV Prevention in Men and Gender-Diverse Persons. N Engl J Med. 2025;392(13):1261-76. PubMed PMID: 39602624. Choi KH, Park YH, Lee JY, Jeong JO, Kim CJ, Yun KH, et al. Efficacy and safety of clopidogrel versus aspirin monotherapy in patients at high risk of subsequent cardiovascular event after percutaneous coronary intervention (SMART-CHOICE 3): a randomised, open-label, multicentre trial. Lancet. 2025;405(10486):1252-63. PubMed PMID: 40174599. Raposeiras-Roubin S, Amat-Santos IJ, Rossello X, Gonzalez Ferreiro R, Gonzalez Bermudez I, Lopez Otero D, et al. Dapagliflozin in Patients Undergoing Transcatheter Aortic-Valve Implantation. N Engl J Med. 2025;392(14):1396-405. PubMed PMID: 40162639. Yan S, Zhou Y, Lansberg MG, Liebeskind DS, Yuan C, Yu H, et al. Alteplase for Posterior Circulation Ischemic Stroke at 4.5 to 24 Hours. N Engl J Med. 2025;392(13):1288-96. PubMed PMID: 40174223. Monto AS, Kuhlbusch K, Bernasconi C, Cao B, Cohen HA, Graham E, et al. Efficacy of Baloxavir Treatment in Preventing Transmission of Influenza. N Engl J Med. 2025;392(16):1582-1593. PubMed PMID: 40267424. Thouvenot E, Laplaud D, Lebrun-Frenay C, Derache N, Le Page E, Maillart E, et al; D-Lay MS Investigators. High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis: The D-Lay MS Randomized Clinical Trial. JAMA. 2025;333(16):1413-1422. PubMed PMID: 40063041. Guides de pratique : Rao SV, O’Donoghue ML, Ruel M, Rab T, Tamis-Holland JE, Alexander JH, et al. 2025 ACC/AHA/ACEP/NAEMSP/SCAI Guideline for the Management of Patients With Acute Coronary Syndromes: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2025;151(13):e771-e862. PubMed PMID: 40014670. Sinha SS, Morrow DA, Kapur NK, Kataria R, Roswell RO. 2025 Concise Clinical Guidance: An ACC Expert Consensus Statement on the Evaluation and Management of Cardiogenic Shock: A Report of the American College of Cardiology Solution Set Oversight Committee. J Am Coll Cardiol. 2025;85(16):1618-41. PubMed PMID: 40100174. DeSimone DC, Garrigos ZE, Marx GE, Tattevin P, Hasse B, McCormick DW, et al. Blood Culture-Negative Endocarditis: A Scientific Statement From the American Heart Association: Endorsed by the International Society for Cardiovascular Infectious Diseases. J Am Heart Assoc. 2025;14(8):e040218. PubMed PMID: 40094211. Hernandez P, Bosse Y, Bush P, Chapman KR, Maltais F, Penz ED, et al. Alpha-1-Antitrypsin Deficiency Targeted Testing and Augmentation Therapy: A Canadian Thoracic Society Meta-Analysis and Clinical Practice Guideline. Chest. 2025;167(4):1044-63. PubMed PMID: 39880301. Référence du quiz clinique : Vasan RS, Enserro DM, Beiser AS, Xanthakis V. Lifetime Risk of Heart Failure Among Participants in the Framingham Study. J Am Coll Cardiol. 2022;79(3):250-263. PubMed PMID: 35057911. | — | ||||||
| 4/29/25 | BC 070 – Sémaglutide oral et résultats cardiovasculaires chez les personnes avec diabète de type 2 à haut risque (étude SOUL) | Dans cette 70e baladodiffusion, les Drs Alexandre Mutchmore et Mathieu Labossière discutent de sémaglutide oral pour la prévention des événements cardiovasculaire chez les personnes avec diabète de type 2, en plus de réviser la littérature médicale de mars 2025. Quiz clinique (1 min 26), présentation principale (2 min 17), critique (21 min 51), retour sur le cas clinique (29 min 26), autres articles (32 min 34), réponse au quiz clinique (38 min 38) Référence principale : McGuire DK, Marx N, Mulvagh SL, Deanfield JE, Inzucchi SE, Pop-Busui R, et al. Oral Semaglutide and Cardiovascular Outcomes in High-Risk Type 2 Diabetes. N Engl J Med. 2025. Epub 2025/03/31 21:17. doi: 10.1056/NEJMoa2501006. PubMed PMID: 40162642. Articles associés : NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in diabetes prevalence and treatment from 1990 to 2022: a pooled analysis of 1108 population-representative studies with 141 million participants. Lancet. 2024;404(10467):2077-2093. PubMed PMID: 39549716. Marso SP, Bain SC, Consoli A, Eliaschewitz FG, Jódar E, Leiter LA, et al; SUSTAIN-6 Investigators. Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes. N Engl J Med. 2016;375(19):1834-1844. PubMed PMID: 27633186. Husain M, Birkenfeld AL, Donsmark M, Dungan K, Eliaschewitz FG, Franco DR, et al; PIONEER 6 Investigators. Oral Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes. N Engl J Med. 2019 ;381(9):841-851. PubMed PMID: 31185157. Autres articles d’intérêt récent : Bi Y, Li M, Liu Y, Li T, Lu J, Duan P, et al. Intensive Blood-Pressure Control in Patients with Type 2 Diabetes. N Engl J Med. 2025;392(12):1155-67. PubMed PMID: 39555827. Couturaud F, Schmidt J, Sanchez O, Ballerie A, Sevestre MA, Meneveau N, et al. Extended treatment of venous thromboembolism with reduced-dose versus full-dose direct oral anticoagulants in patients at high risk of recurrence: a non-inferiority, multicentre, randomised, open-label, blinded endpoint trial. Lancet. 2025;405(10480):725-35. PubMed PMID: 40023651. Vodstrcil LA, Plummer EL, Fairley CK, Hocking JS, Law MG, Petoumenos K, et al. Male-Partner Treatment to Prevent Recurrence of Bacterial Vaginosis. N Engl J Med. 2025;392(10):947-57. PubMed PMID: 40043236. Veltkamp R, Korompoki E, Harvey KH, Harvey ER, Fiessler C, Malzahn U, et al. Direct oral anticoagulants versus no anticoagulation for the prevention of stroke in survivors of intracerebral haemorrhage with atrial fibrillation (PRESTIGE-AF): a multicentre, open-label, randomised, phase 3 trial. Lancet. 2025;405(10482):927-36. PubMed PMID: 40023176. Guides de pratique : Advani SD, Thaden JT, Perez R, Stair SL, Lee UJ, Siddiqui NY. State-of-the-Art Review: Recurrent Uncomplicated Urinary Tract Infections in Women. Clin Infect Dis. 2025;80(3):e31-e42. PubMed PMID: 40095960. Références du quiz clinique : European Association for the Study of the Liver. EASL Clinical Practice Guidelines on haemochromatosis. J Hepatol. 2022;77(2):479-502. PubMed PMID: 35662478. Prabhu A, Cargill T, Roberts N, Ryan JD. Systematic Review of the Clinical Outcomes of Iron Reduction in Hereditary Hemochromatosis. Hepatology. 2020 Oct;72(4):1469-1482. PubMed PMID: 32500577. | — | ||||||
| 3/21/25 | BC 069 – Remplacement valvulaire aortique percutanée dans la sténose aortique sévère asymptomatique (étude EARLY TAVR) | Dans cette 69e baladodiffusion, les Drs Luc Lanthier et Alexandre Mutchmore discutent de remplacement valvulaire aortique percutané chez les sujets avec sténose aortique sévère asymptomatique, en plus de réviser la littérature médicale de janvier et février 2025. Quiz clinique (2 min 25), présentation principale (2 min 50), critique (31 min 59), retour sur le cas clinique (45 min 38), autres articles (46 min 23), réponse au quiz clinique (49 min 40) Référence principale : Genereux P, Schwartz A, Oldemeyer JB, Pibarot P, Cohen DJ, Blanke P, et al. Transcatheter Aortic-Valve Replacement for Asymptomatic Severe Aortic Stenosis. N Engl J Med. 2025;392(3):217-27. PubMed PMID: 39466903. Articles associés : Rubino F, Cummings DE, Eckel RH, Cohen RV, Wilding JPH, Brown WA, et al. Definition and diagnostic criteria of clinical obesity. Lancet Diabetes Endocrinol. 2025;13(3):221-62. PubMed PMID: 39824205. Blankenberg S. Asymptomatic Severe Aortic-Valve Stenosis – To Wait or Not to Wait. N Engl J Med. 2025;392(3):278-9. PubMed PMID: 39813648. Kang DH, Park SJ, Lee SA, Lee S, Kim DH, Kim HK, et al. Early Surgery or Conservative Care for Asymptomatic Aortic Stenosis. N Engl J Med. 2020;382(2):111-9. PubMed PMID: 31733181. Banovic M, Putnik S, Penicka M, Doros G, Deja MA, Kockova R, et al. Aortic Valve Replacement Versus Conservative Treatment in Asymptomatic Severe Aortic Stenosis: The AVATAR Trial. Circulation. 2022;145(9):648-58. PubMed PMID: 34779220. Genereux P, Banovic M, Kang DH, Giustino G, Prendergast BD, Lindman BR, et al. Aortic Valve Replacement vs Clinical Surveillance in Asymptomatic Severe Aortic Stenosis: A Systematic Review and Meta-Analysis. J Am Coll Cardiol. 2025;85(9):912-22. PubMed PMID: 39641732. Loganath K, Craig NJ, Everett RJ, Bing R, Tsampasian V, Molek P, et al. Early Intervention in Patients With Asymptomatic Severe Aortic Stenosis and Myocardial Fibrosis: The EVOLVED Randomized Clinical Trial. JAMA. 2025;333(3):213-21. PubMed PMID: 39466640. Vahanian A, Beyersdorf F, Praz F, Milojevic M, Baldus S, Bauersachs J, et al. 2021 ESC/EACTS Guidelines for the management of valvular heart disease. Eur Heart J. 2022;43(7):561-632. PubMed PMID: 34453165. Otto CM, Nishimura RA, Bonow RO, Carabello BA, Erwin JP, 3rd, et al. 2020 ACC/AHA Guideline for the Management of Patients With Valvular Heart Disease: Executive Summary: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. J Am Coll Cardiol. 2021;77(4):450-500. PubMed PMID: 33342587. Autres articles d’intérêt récent : Packer M, Zile MR, Kramer CM, Baum SJ, Litwin SE, Menon V, et al. Tirzepatide for Heart Failure with Preserved Ejection Fraction and Obesity. N Engl J Med. 2025;392(5):427-37. PubMed PMID: 39555826. Feldman WB, Suissa S, Kesselheim AS, Avorn J, Russo M, Schneeweiss S, et al. Comparative effectiveness and safety of single inhaler triple therapies for chronic obstructive pulmonary disease: new user cohort study. BMJ. 2024;387:e080409. PubMed PMID: 39797646. Piccini JP, Patel MR, Steffel J, Ferdinand K, Van Gelder IC, Russo AM, et al. Asundexian versus Apixaban in Patients with Atrial Fibrillation. N Engl J Med. 2025;392(1):23-32. PubMed PMID: 39225267. Ruff CT, Patel SM, Giugliano RP, Morrow DA, Hug B, Kuder JF, et al. Abelacimab versus Rivaroxaban in Patients with Atrial Fibrillation. N Engl J Med. 2025;392(4):361-71. PubMed PMID: 39842011. Ayus JC, Moritz ML, Fuentes NA, Mejia JR, Alfonso JM, Shin S, et al. Correction Rates and Clinical Outcomes in Hospitalized Adults With Severe Hyponatremia: A Systematic Review and Meta-Analysis. JAMA Intern Med. 2025;185(1):38-51. PubMed PMID: 39556338. Jolly SS, d’Entremont MA, Lee SF, Mian R, Tyrwhitt J, Kedev S, et al. Colchicine in Acute Myocardial Infarction. N Engl J Med. 2025;392(7):633-42. PubMed PMID: 39555823. Sapp JL, Tang ASL, Parkash R, Stevenson WG, Healey JS, Gula LJ, et al. Catheter Ablation or Antiarrhythmic Drugs for Ventricular Tachycardia. N Engl J Med. 2025;392(8):737-47. PubMed PMID: 39555820. Group E-KC, Herrington WG, Staplin N, Agrawal N, Wanner C, Green JB, et al. Long-Term Effects of Empagliflozin in Patients with Chronic Kidney Disease. N Engl J Med. 2025;392(8):777-87. PubMed PMID: 39453837. Fiorella D, Monteith SJ, Hanel R, Atchie B, Boo S, McTaggart RA, et al. Embolization of the Middle Meningeal Artery for Chronic Subdural Hematoma. N Engl J Med. 2025;392(9):855-64. PubMed PMID: 39565980. Guides de pratique : American Diabetes Association Professional Practice C. Summary of Revisions: Standards of Care in Diabetes-2025. Diabetes Care. 2025;48(1 Suppl 1):S6-S13. PubMed PMID: 39651984. Saukkonen JJ, Duarte R, Munsiff SS, Winston CA, Mammen MJ, Abubakar I, et al. Updates on the Treatment of Drug-Susceptible and Drug-Resistant Tuberculosis: An Official ATS/CDC/ERS/IDSA Clinical Practice Guideline. Am J Respir Crit Care Med. 2025;211(1):15-33. Gandhi RT, Landovitz RJ, Sax PE, Smith DM, Springer SA, Gunthard HF, et al. Antiretroviral Drugs for Treatment and Prevention of HIV in Adults: 2024 Recommendations of the International Antiviral Society-USA Panel. JAMA. 2025;333(7):609-28. PubMed PMID: 39616604. Davis JPE, Lim JK, Francis FF, Ahn J. AGA Clinical Practice Update on Management of Portal Vein Thrombosis in Patients With Cirrhosis: Expert Review. Gastroenterology. 2025;168(2):396-404. PubMed PMID: 39708000. Drazner MH, Bozkurt B, Cooper LT, Aggarwal NR, Basso C, et al. 2024 ACC Expert Consensus Decision Pathway on Strategies and Criteria for the Diagnosis and Management of Myocarditis: A Report of the American College of Cardiology Solution Set Oversight Committee. J Am Coll Cardiol. 2025;85(4):391-431. PubMed PMID: 39665703. Spooner MT, Messe SR, Chaturvedi S, Do MM, Gluckman TJ, et al. 2024 ACC Expert Consensus Decision Pathway on Practical Approaches for Arrhythmia Monitoring After Stroke: A Report of the American College of Cardiology Solution Set Oversight Committee. J Am Coll Cardiol. 2025;85(6):657-81. PubMed PMID: 39692645. Référence du quiz clinique : Rockey DC, Altayar O, Falck-Ytter Y, Kalmaz D. AGA Technical Review on Gastrointestinal Evaluation of Iron Deficiency Anemia. Gastroenterology. 2020 Sep;159(3):1097-1119. PubMed PMID: 32828801. | — | ||||||
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| 1/23/25 | BC 068 – Durée d’antibiothérapie pour les bactériémies (étude BALANCE) | Dans cette 68e baladodiffusion, les Drs Luc Lanthier et Alex Carignan discutent de durée d’antibiothérapie pour les bactériémies, en plus de réviser la littérature médicale de novembre et décembre 2024. Quiz clinique (2 min 15), présentation principale (2 min 49), critique (20 min 19), retour sur le cas clinique (26 min 26), autres articles (28 min 25), réponse au quiz clinique (33 min 18) Référence principale : BALANCE Investigators, for the Canadian Critical Care Trials Group, the Association of Medical Microbiology and Infectious Disease Canada Clinical Research Network, the Australian and New Zealand Intensive Care Society Clinical Trials Group, and the Australasian Society for Infectious Diseases Clinical Research Network; Daneman N, Rishu A, Pinto R, Rogers BA, Shehabi Y, Parke R, et al. Antibiotic Treatment for 7 versus 14 Days in Patients with Bloodstream Infections. N Engl J Med. 2024 Nov 20. doi: 10.1056/NEJMoa2404991. PubMed PMID: 39565030. Articles associés : Yahav D, Franceschini E, Koppel F, Turjeman A, Babich T, Bitterman R, et al; Bacteremia Duration Study Group. Seven Versus 14 Days of Antibiotic Therapy for Uncomplicated Gram-negative Bacteremia: A Noninferiority Randomized Controlled Trial. Clin Infect Dis. 2019;69(7):1091-1098. PubMed PMID: 30535100. von Dach E, Albrich WC, Brunel AS, Prendki V, Cuvelier C, Flury D, et al. Effect of C-Reactive Protein-Guided Antibiotic Treatment Duration, 7-Day Treatment, or 14-Day Treatment on 30-Day Clinical Failure Rate in Patients With Uncomplicated Gram-Negative Bacteremia: A Randomized Clinical Trial. JAMA. 2020;323(21):2160-2169. PubMed PMID: 32484534. Molina J, Montero-Mateos E, Praena-Segovia J, León-Jiménez E, Natera C, López-Cortés LE, et al; SHORTEN trial team. Seven-versus 14-day course of antibiotics for the treatment of bloodstream infections by Enterobacterales: a randomized, controlled trial. Clin Microbiol Infect. 2022;28(4):550-557. PubMed PMID: 34508886. Autres articles d’intérêt récent : Werring DJ, Dehbi HM, Ahmed N, Arram L, Best JG, Balogun M, et al. Optimal timing of anticoagulation after acute ischaemic stroke with atrial fibrillation (OPTIMAS): a multicentre, blinded-endpoint, phase 4, randomised controlled trial. Lancet. 2024:404(10464);1731-41. PubMed PMID: 39491870. Anker SD, Friede T, von Bardeleben RS, Butler J, Khan MS, Diek M, et al. Transcatheter Valve Repair in Heart Failure with Moderate to Severe Mitral Regurgitation. N Engl J Med. 2024;391(19):1799-809. PubMed PMID: 39216092. Cho MS, Kang DY, Ahn JM, Yun SC, Oh YS, Lee CH, et al. Edoxaban Antithrombotic Therapy for Atrial Fibrillation and Stable Coronary Artery Disease. N Engl J Med. 2024;391(22):2075-86. PubMed PMID: 39225258. Kang DY, Lee SH, Lee SW, Lee CH, Kim C, Jang JY, et al. Aspirin Monotherapy vs No Antiplatelet Therapy in Stable Patients With Coronary Stents Undergoing Low-to-Intermediate Risk Noncardiac Surgery. J Am Coll Cardiol. 2024;84(24):2380-9. PubMed PMID: 39217573. Tan J, Zhu R, Li Y, Wang L, Liao S, Cheng L, et al. Vitamin K2 in Managing Nocturnal Leg Cramps: A Randomized Clinical Trial. JAMA Intern Med. 2024;184(12):1443-7. PubMed PMID: 39466236. Hobbs FDR, McManus RJ, Taylor CJ, Jones NR, Rahman JK, Wolstenholme J, et al. Low-dose spironolactone and cardiovascular outcomes in moderate stage chronic kidney disease: a randomized controlled trial. Nat Med. 2024;30(12):3634-45. PubMed PMID: 39349629. Guides de pratique : Diabetes Canada Clinical Practice Guidelines Expert Working G, Shah BR, Bajaj HS, Butalia S, Dasgupta K, Eurich DT, et al. Pharmacologic Glycemic Management of Type 2 Diabetes in Adults-2024 Update. Can J Diabetes. 2024;48(7):415-24. PubMed PMID: 39550176. Thompson A, Fleischmann KE, Smilowitz NR, de Las Fuentes L, Mukherjee D, Aggarwal NR, et al. 2024 AHA/ACC/ACS/ASNC/HRS/SCA/SCCT/SCMR/SVM Guideline for Perioperative Cardiovascular Management for Noncardiac Surgery: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2024;150(19):e351-e442. PubMed PMID: 39316661. Yakovenko I, Mukaneza Y, Germe K, Belliveau J, Fraleigh R, Bach P, et al. Management of opioid use disorder: 2024 update to the national clinical practice guideline. CMAJ. 2024;196(38):E1280-E90. PubMed PMID: 39532476. Singh S, Loftus EV, Jr., Limketkai BN, Haydek JP, Agrawal M, Scott FI, et al. AGA Living Clinical Practice Guideline on Pharmacological Management of Moderate-to-Severe Ulcerative Colitis. Gastroenterology. 2024;167(7):1307-43. PubMed PMID: 39572132. Bushnell C, Kernan WN, Sharrief AZ, Chaturvedi S, Cole JW, Cornwell WK, 3rd, et al. 2024 Guideline for the Primary Prevention of Stroke: A Guideline From the American Heart Association/American Stroke Association. Stroke. 2024;55(12):e344-e424. PubMed PMID: 39429201. Sico JJ, Antonovich NM, Ballard-Hernandez J, Buelt AC, Grinberg AS, Macedo FJ, et al. 2023 U.S. Department of Veterans Affairs and U.S. Department of Defense Clinical Practice Guideline for the Management of Headache. Ann Intern Med. 2024;177(12):1675-94. PubMed PMID: 39467289. Référence du quiz clinique : https://cisssofil.ca/la-loi-de-vanessa/#:~:text=En%202000%2C%20une%20jeune%20fille,produits%20th%C3%A9rapeutiques%20par%20Sant%C3%A9%20Canada. | — | ||||||
| 11/20/24 | BC 067 – Tirzépatide comme traitement de l’apnée du sommeil obstructive (étude SURMOUNT-OSA) | Dans cette 67e baladodiffusion, les Drs Luc Lanthier et Alexandre Mutchmore discutent d’apnée du sommeil et de tirzépatide, en plus de réviser la littérature médicale d’octobre 2024. Quiz clinique (3 min 30), présentation principale (4 min 04), critique (25 min 00), retour sur le cas clinique (36 min 51), autres articles (38 min 45), réponse au quiz clinique (43 min 42) Référence principale : Malhotra A, Grunstein RR, Fietze I, Weaver TE, Redline S, Azarbarzin A, et al. Tirzepatide for the Treatment of Obstructive Sleep Apnea and Obesity. N Engl J Med. 2024;391(13):1193-205. PubMed PMID: 38912654. Articles associés : Patel SR. Entering a New Era in Sleep-Apnea Treatment. N Engl J Med. 2024;391(13):1248-49. PubMed PMID: 38912659. Veasey SC, Rosen IM. Obstructive sleep apnea in adults. N Engl J Med 2019; 380(15):1442-9. PubMed PMID: 30970189. Benjafield AV, Ayas NT, Eastwood PR, et al. Estimation of the global prevalence and burden of obstructive sleep apnoea: a literature-based analysis. Lancet Respir Med 2019;7(8):687-98. PubMed PMID: 31300334. Autres articles d’intérêt récent : Bekker LG, Das M, Abdool Karim Q, Ahmed K, Batting J, Brumskine W, et al. Twice-Yearly Lenacapavir or Daily F/TAF for HIV Prevention in Cisgender Women. N Engl J Med. 2024;391(13):1179-92. PubMed PMID: 39046157. Silvain J, Cayla G, Ferrari E, Range G, Puymirat E, Delarche N, et al. Beta-Blocker Interruption or Continuation after Myocardial Infarction. N Engl J Med. 2024;391(14):1277-86. PubMed PMID: 39213187. Bliddal H, Bays H, Czernichow S, Udden Hemmingsson J, Hjelmesaeth J, Hoffmann Morville T, et al. Once-Weekly Semaglutide in Persons with Obesity and Knee Osteoarthritis. N Engl J Med. 2024;391(17):1573-83. PubMed PMID: 39476339. Guides de pratique : McEvoy JW, McCarthy CP, Bruno RM, Brouwers S, Canavan MD, Ceconi C, et al. 2024 ESC Guidelines for the management of elevated blood pressure and hypertension. Eur Heart J. 2024;45(38):3912-4018. PubMed PMID: 39210715. Del Galdo F, Lescoat A, Conaghan PG, Bertoldo E, Colic J, Santiago T, et al. EULAR recommendations for the treatment of systemic sclerosis: 2023 update. Ann Rheum Dis. 2024. Epub 2024/10/12. doi: 10.1136/ard-2024-226430. PubMed PMID: 39393843. Kothari S, Afshar Y, Friedman LS, Ahn J. AGA Clinical Practice Update on Pregnancy-Related Gastrointestinal and Liver Disease: Expert Review. Gastroenterology. 2024;167(5):1033-45. PubMed PMID: 39140906. Référence du quiz clinique : Stevens DL, Bisno AL, Chambers HF, Dellinger EP, Goldstein EJ, Gorbach SL, Hirschmann JV, Kaplan SL, Montoya JG, Wade JC; Infectious Diseases Society of America. Practice guidelines for the diagnosis and management of skin and soft tissue infections: 2014 update by the Infectious Diseases Society of America. Clin Infect Dis. 2014;59(2):e10-52. PubMed PMID: 24973422. | — | ||||||
| 10/25/24 | BC 066 – Finérénone chez les sujets avec insuffisance cardiaque à fraction d’éjection préservée ou légèrement réduite (étude FINEARTS-HF) | Dans cette 66e baladodiffusion, les Drs Alexandre Mutchmore et Luc Lanthier discutent de d’insuffisance cardiaque à fraction d’éjection préservée ou légèrement réduite et finérénone, en plus de réviser la littérature médicale de septembre 2024. Quiz clinique (2 min 58), présentation principale (3 min 40), critique (32 min 55), retour sur le cas clinique (44 min 50), autres articles (46 min 57), réponse au quiz clinique (51 min 50) Référence principale : Solomon SD, McMurray JJV, Vaduganathan M, Claggett B, Jhund PS, Desai AS, et al. Finerenone in Heart Failure with Mildly Reduced or Preserved Ejection Fraction. N Engl J Med. 2024;391(16):1475-85. PubMed PMID: 39225278. Articles associés : Yusuf S, Pfeffer MA, Swedberg K, Granger CB, Held P, McMurray JJ, Michelson EL, Olofsson B, Ostergren J; CHARM Investigators and Committees. Effects of candesartan in patients with chronic heart failure and preserved left-ventricular ejection fraction: the CHARM-Preserved Trial. Lancet. 2003;362(9386):777-81. PubMed PMID: 13678871. Massie BM, Carson PE, McMurray JJ, Komajda M, McKelvie R, Zile MR, Anderson S, Donovan M, Iverson E, Staiger C, Ptaszynska A; I-PRESERVE Investigators. Irbesartan in patients with heart failure and preserved ejection fraction. N Engl J Med. 2008;359(23):2456-67. PubMed PMID: 19001508. Pitt B, Pfeffer MA, Assmann SF, Boineau R, Anand IS, Claggett B, et al; TOPCAT Investigators. Spironolactone for heart failure with preserved ejection fraction. N Engl J Med. 2014;370(15):1383-92. PubMed PMID: 24716680. Pfeffer MA, Claggett B, Assmann SF, Boineau R, Anand IS, Clausell N, et al. Regional variation in patients and outcomes in the Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist (TOPCAT) trial. Circulation. 2015;131(1):34-42. PubMed PMID: 25406305. Pfeffer MA, Claggett B. Behind the Scenes of TOPCAT – Bending to Inform. NEJM Evid. 2022 Jan;1(1):EVIDctcs2100007. PubMed PMID: 38319229. Solomon SD, McMurray JJV, Anand IS, Ge J, Lam CSP, Maggioni AP, et al. Angiotensin–Neprilysin Inhibition in Heart Failure with Preserved Ejection Fraction. N Engl J Med. 2019;381(17):1609‑20. PubMed PMID: 31475794. Anker SD, Butler J, Filippatos G, Ferreira JP, Bocchi E, Böhm M, et al; EMPEROR-Preserved Trial Investigators. Empagliflozin in Heart Failure with a Preserved Ejection Fraction. N Engl J Med. 2021;385(16):1451-1461PubMed PMID: 34449189. Solomon SD, McMurray JJV, Claggett B, de Boer RA, DeMets D, Hernandez AF, et al; DELIVER Trial Committees and Investigators. Dapagliflozin in Heart Failure with Mildly Reduced or Preserved Ejection Fraction. N Engl J Med. 2022;387(12):1089-1098. PubMed PMID: 36027570. Bakris GL, Agarwal R, Anker SD, Pitt B, Ruilope LM, Rossing P, et al. Effect of Finerenone on Chronic Kidney Disease Outcomes in Type 2 Diabetes. N Engl J Med. 2020;383(23):2219-29. PubMed PMID: 33264825. Pitt B, Filippatos G, Agarwal R, Anker SD, Bakris GL, Rossing P, Joseph A, Kolkhof P, Nowack C, Schloemer P, Ruilope LM; FIGARO-DKD Investigators. Cardiovascular Events with Finerenone in Kidney Disease and Type 2 Diabetes. N Engl J Med. 2021 Dec 9;385(24):2252-2263. PubMed PMID: 34449181. Vaduganathan M, Claggett BL, Desai AS, Jhund PS, Lam CSP, Senni M, et al. Time to Significant Benefit of Finerenone in Patients With Heart Failure. J Am Coll Cardiol. 2024. PubMed PMID: 39352338. Vaduganathan M, Claggett BL, Desai AS, Jhund PS, Lam CSP, Senni M, et al. Estimated Long-Term Benefits of Finerenone in Heart Failure: A Prespecified Secondary Analysis of the FINEARTS-HF Randomized Clinical Trial. JAMA Cardiol. 2024. PubMed PMID: 39332395. Autres articles d’intérêt récent : Ekstrom M, Andersson A, Papadopoulos S, Kipper T, Pedersen B, Kricka O, et al. Long-Term Oxygen Therapy for 24 or 15 Hours per Day in Severe Hypoxemia. N Engl J Med. 2024;391(11):977-88. PubMed PMID: 39254466. Legrand M, Falcone J, Cholley B, Charbonneau H, Delaporte A, Lemoine A, et al. Continuation vs Discontinuation of Renin-Angiotensin System Inhibitors Before Major Noncardiac Surgery: The Stop-or-Not Randomized Clinical Trial. JAMA. 2024;332(12):970-8. PubMed PMID: 39212270. Ramacciotti E, Volpiani GG, Britto KF, Agati LB, Ribeiro CM, Aguiar VCR, et al. Rivaroxaban for Patients with Intermittent Claudication. NEJM Evid. 2024;3(9):EVIDoa2400021. PubMed PMID: 39185955. Guides de pratique : Crean AM, Adler A, Arbour L, Chan J, Christian S, Cooper RM, et al. Canadian Cardiovascular Society Clinical Practice Update on Contemporary Management of the Patient With Hypertrophic Cardiomyopathy. Can J Cardiol. 2024;40(9):1503-23. PubMed PMID: 38880398. Mazzolai L, Teixido-Tura G, Lanzi S, Boc V, Bossone E, Brodmann M, et al. 2024 ESC Guidelines for the management of peripheral arterial and aortic diseases. Eur Heart J. 2024;45(36):3538-700. PubMed PMID: 39210722. Vrints C, Andreotti F, Koskinas KC, Rossello X, Adamo M, Ainslie J, et al. 2024 ESC Guidelines for the management of chronic coronary syndromes. Eur Heart J. 2024;45(36):3415-537. PubMed PMID: 39210710. Van Gelder IC, Rienstra M, Bunting KV, Casado-Arroyo R, Caso V, Crijns H, et al. 2024 ESC Guidelines for the management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS). Eur Heart J. 2024;45(36):3314-414. PubMed PMID: 39210723. Kohler TS, Kloner RA, Rosen RC, Burnett AL, Blaha MJ, Ganz P, et al. The Princeton IV Consensus Recommendations for the Management of Erectile Dysfunction and Cardiovascular Disease. Mayo Clin Proc. 2024;99(9):1500-17. PubMed PMID: 39115509. Chey WD, Howden CW, Moss SF, Morgan DR, Greer KB, Grover S, et al. ACG Clinical Guideline: Treatment of Helicobacter pylori Infection. Am J Gastroenterol. 2024;119(9):1730-53. Références du quiz clinique : Moody WE, Turvey-Haigh L, Knight D, Coats CJ, Cooper RM, Schofield R, et al. British Society of Echocardiography guideline for the transthoracic echocardiographic assessment of cardiac amyloidosis. Echo Res Pract. 2023;10(1):13. PubMed PMID: 37653443. Fine NM, Davis MK, Anderson K, Delgado DH, Giraldeau G, Kitchlu A, et al. Canadian Cardiovascular Society/Canadian Heart Failure Society Joint Position Statement on the Evaluation and Management of Patients With Cardiac Amyloidosis. Can J Cardiol. 2020;36(3):322-334. PubMed PMID: 32145862. | — | ||||||
| 9/30/24 | BC 065 – Prophylaxie d’ulcère de stress durant la ventilation mécanique (étude REVISE) | Dans cette 65e baladodiffusion, les Drs Luc Lanthier et Michaël Mayette discutent de prophylaxie d’ulcère de stress chez les sujets sous ventilation mécanique, en plus de réviser la littérature médicale de juillet et août 2024. Quiz clinique (3 min 00), présentation principale (3 min 25), critique (20 min 44), autres articles (27 min 10), réponse au quiz clinique (33 min 11) Référence principale : Cook D, Deane A, Lauzier F, Zytaruk N, Guyatt G, Saunders L, et al; REVISE Investigators. Stress Ulcer Prophylaxis during Invasive Mechanical Ventilation. N Engl J Med. 2024;391(1):9-20. PubMed PMID : 38875111. Articles associés : Gao Y, Jiang L, Pan Y, Chen W, Jing J, Wang C, et al; INSPIRES Investigators. Immediate- or Delayed-Intensive Statin in Acute Cerebral Ischemia: The INSPIRES Randomized Clinical Trial. JAMA Neurol. 2024;81(7):741-751. PubMed PMID: 38805216. Marcus MD, Link MS. Omega-3 Fatty Acids and Arrhythmias. Circulation. 2024;150(6):488-503. PubMed PMID: 39102482. Valgimigli M, Hong SJ, Gragnano F, Chalkou K, Franzone A, da Costa BR, et al. De-escalation to ticagrelor monotherapy versus 12 months of dual antiplatelet therapy in patients with and without acute coronary syndromes: a systematic review and individual patient-level meta-analysis of randomised trials. Lancet. 2024;404(10456):937-48. PubMed PMID: 39226909. Brown SM. Uncertain Answers – Proton-Pump Inhibition in the ICU. N Engl J Med. 2024;391(1):78-9. PubMed PMID: 38875100. Wang Y, Parpia S, Ge L, Heels-Ansdell D, Lai H, Esfahani MA, et al. Proton-Pump Inhibitors to Prevent Gastrointestinal Bleeding – An Updated Meta-Analysis. NEJM Evid. 2024;3(7):EVIDoa2400134. PubMed PMID: 38874580. MacLaren R, Dionne JC, Granholm A, Alhazzani W, Szumita PM, Olsen K, et al. Society of Critical Care Medicine and American Society of Health-System Pharmacists Guideline for the Prevention of Stress-Related Gastrointestinal Bleeding in Critically Ill Adults. Crit Care Med. 2024;52(8):e421-e30. PubMed PMID: 39007578. Krag M, Marker S, Perner A, Wetterslev J, Wise MP, Schefold JC, et al. Pantoprazole in Patients at Risk for Gastrointestinal Bleeding in the ICU. N Engl J Med. 2018;379(23):2199-208. PubMed PMID: 30354950. Australian PIft, New Zealand Intensive Care Society Clinical Trials Group AHSCCSCN, the Irish Critical Care Trials G, Young PJ, Bagshaw SM, Forbes AB, et al. Effect of Stress Ulcer Prophylaxis With Proton Pump Inhibitors vs Histamine-2 Receptor Blockers on In-Hospital Mortality Among ICU Patients Receiving Invasive Mechanical Ventilation: The PEPTIC Randomized Clinical Trial. JAMA. 2020;323(7):616-26. PubMed PMID: 31950977. Autres articles d’intérêt récent : Liu J, Li Y, Ge J, Yan X, Zhang H, Zheng X, et al. Lowering systolic blood pressure to less than 120 mm Hg versus less than 140 mm Hg in patients with high cardiovascular risk with and without diabetes or previous stroke: an open-label, blinded-outcome, randomised trial. Lancet. 2024;404(10449):245-55. PubMed PMID: 38945140. Lu S, Kato T, Dong X, Ahn MJ, Quang LV, Soparattanapaisarn N, et al. Osimertinib after Chemoradiotherapy in Stage III EGFR-Mutated NSCLC. N Engl J Med. 2024;391(7):585-97. PubMed PMID: 38828946. Landoni G, Monaco F, Ti LK, Baiardo Redaelli M, Bradic N, Comis M, et al. A Randomized Trial of Intravenous Amino Acids for Kidney Protection. N Engl J Med. 2024;391(8):687-98. PubMed PMID: 38865168. Miyauchi K, Iwata H, Nishizaki Y, Inoue T, Hirayama A, Kimura K, et al. Randomized Trial for Evaluation in Secondary Prevention Efficacy of Combination Therapy-Statin and Eicosapentaenoic Acid (RESPECT-EPA). Circulation. 2024;150(6):425-34. PubMed PMID: 38873793. Guides de pratique : EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD). J Hepatol. 2024;81(3):492-542. PubMed PMID: 38851997. Callum J, Skubas NJ, Bathla A, Keshavarz H, Clark EG, Rochwerg B, et al. Use of Intravenous Albumin: A Guideline From the International Collaboration for Transfusion Medicine Guidelines. Chest. 2024;166(2):321-38. PubMed PMID: 38447639. Sharma R, Kouranos V, Cooper LT, Metra M, Ristic A, Heidecker B, et al. Management of cardiac sarcoidosis. Eur Heart J. 2024;45(30):2697-726. PubMed PMID: 38923509. Umpierrez GE, Davis GM, ElSayed NA, Fadini GP, Galindo RJ, Hirsch IB, et al. Hyperglycemic Crises in Adults With Diabetes: A Consensus Report. Diabetes Care. 2024;47(8):1257-75. PubMed PMID: 39052901. Références du quiz clinique : Vinter N, Cordsen P, Johnsen SP, Staerk L, Benjamin EJ, Frost L, Trinquart L. Temporal trends in lifetime risks of atrial fibrillation and its complications between 2000 and 2022: Danish, nationwide, population based cohort study. BMJ. 2024;385:e077209. PubMed PMID: 38631726. | — | ||||||
| 7/18/24 | BC 064 – Sémaglutide dans l’insuffisance rénale chronique et le diabète type 2 (étude FLOW) | Dans cette 64e baladodiffusion, le Dr Luc Lanthier discute de l’utilisation du sémaglutide comme thérapie néphroprotectrice dans l’insuffisance rénale chronique chez les personnes avec diabète type 2, en plus de réviser la littérature médicale de juin 2024. Quiz clinique (1 min 55), présentation principale (2 min 40), critique (25 min 22), retour sur le cas clinique (35 min 04), autres articles (37 min 10), réponse au quiz clinique (40 min 17) Référence principale : Perkovic V, Tuttle KR, Rossing P, Mahaffey KW, Mann JFE, Bakris G, et al. Effects of Semaglutide on Chronic Kidney Disease in Patients with Type 2 Diabetes. N Engl J Med. 2024;391(2):109-121. PubMed PMID: 38785209. Articles associés : Herrington WG, Haynes R. Diabetic Kidney Disease – Semaglutide Flows into the Mainstream. N Engl J Med. 2024;391(2):178-179. PubMed PMID: 38986062. Mann JFE, Rossing P, Bakris G, Belmar N, Bosch-Traberg H, Busch R, et al. Effects of semaglutide with and without concomitant SGLT2 inhibitor use in participants with type 2 diabetes and chronic kidney disease in the FLOW trial. Nat Med. 2024 Jun 24. doi: 10.1038/s41591-024-03133-0. PubMed PMID: 38914124. https://kidneyfailurerisk.com https://www.ontariorenalnetwork.ca/en/kidney-care-resources/clinical-tools/primary-care-tools/kidneywise/toolkit Autres articles d’intérêt récent : Aaron SD, Vandemheen KL, Whitmore GA, Bergeron C, Boulet LP, Cote A, et al. Early Diagnosis and Treatment of COPD and Asthma – A Randomized, Controlled Trial. N Engl J Med. 2024;390(22):2061-73. PubMed PMID: 38767248. Li S, Gu HQ, Li H, Wang X, Jin A, Guo S, et al. Reteplase versus Alteplase for Acute Ischemic Stroke. N Engl J Med. 2024;390(24):2264-73. PubMed PMID: 38884332. Gibbs KW, Semler MW, Driver BE, Seitz KP, Stempek SB, Taylor C, et al. Noninvasive Ventilation for Preoxygenation during Emergency Intubation. N Engl J Med. 2024;390(23):2165-77. PubMed PMID: 38869091. Bhatt SP, Rabe KF, Hanania NA, Vogelmeier CF, Bafadhel M, Christenson SA, et al. Dupilumab for COPD with Blood Eosinophil Evidence of Type 2 Inflammation. N Engl J Med. 2024;390(24):2274-83. PubMed PMID: 38767614. McCormick N, Yokose C, Lu N, Wexler DJ, Avina-Zubieta JA, De Vera MA, et al. Sodium-Glucose Cotransporter-2 Inhibitors vs Sulfonylureas for Gout Prevention Among Patients With Type 2 Diabetes Receiving Metformin. JAMA Intern Med. 2024;184(6):650-60. PubMed PMID: 38619822. Guides de pratique : Pacheco C, Coutinho T, Bastiany A, Beanlands R, Boczar KE, Gulati M, et al. Canadian Cardiovascular Society/Canadian Women’s Heart Health Alliance Clinical Practice Update on Myocardial Infarction With No Obstructive Coronary Artery Disease (MINOCA). Can J Cardiol. 2024;40(6):953-68. PubMed PMID: 38852985. Ommen SR, Ho CY, Asif IM, Balaji S, Burke MA, Day SM, et al. 2024 AHA/ACC/AMSSM/HRS/PACES/SCMR Guideline for the Management of Hypertrophic Cardiomyopathy: A Report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines. Circulation. 2024;149(23):e1239-e311. PubMed PMID: 38718139. Gornik HL, Aronow HD, Goodney PP, Arya S, Brewster LP, Byrd L, et al. 2024 ACC/AHA/AACVPR/APMA/ABC/SCAI/SVM/SVN/SVS/SIR/VESS Guideline for the Management of Lower Extremity Peripheral Artery Disease: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2024;149(24):e1313-e410. PubMed PMID: 38743805. Références du quiz clinique : Merz LE, Story CM, Osei MA, Jolley K, Ren S, Park HS, Yefidoff Freedman R, Neuberg D, Smeland-Wagman R, Kaufman RM, Achebe MO. Absolute neutrophil count by Duffy status among healthy Black and African American adults. Blood Adv. 2023;7(3):317-320. PubMed PMID: 35994632. https://www.ncbi.nlm.nih.gov/books/NBK2271/ | — | ||||||
| 6/19/24 | BC 063 – Dé-escalade de la thérapie antiplaquettaire double avec ticagrélor seul post-syndrome coronarien aigu (étude ULTIMATE-DAPT) | Dans cette 63e baladodiffusion, les Dr Luc Lanthier et Étienne Couture discutent de l’utilisation de la thérapie antiplaquettaire post-syndrome coronarien aigu, en plus de réviser la littérature médicale de mai 2024. Quiz clinique (3 min 25), présentation principale (3 min 57), critique (27 min 00), autres articles (35 min 41), réponse au quiz clinique (38 min 12) Référence principale : Ge Z, Kan J, Gao X, Raza A, Zhang JJ, Mohydin BS, et al; ULTIMATE-DAPT investigators. Ticagrelor alone versus ticagrelor plus aspirin from month 1 to month 12 after percutaneous coronary intervention in patients with acute coronary syndromes (ULTIMATE-DAPT): a randomised, placebo-controlled, double-blind clinical trial. Lancet. 2024;403(10439):1866-1878. PubMed PMID: 38599220. Articles associés : Li X, Ge Z, Kan J, Anjum M, Xie P, Chen X, et al. Intravascular ultrasound-guided versus angiography-guided percutaneous coronary intervention in acute coronary syndromes (IVUS-ACS): a two-stage, multicentre, randomised trial. Lancet. 2024;403(10439):1855-65. PubMed PMID: 38604212. GBD 2021 Causes of Death Collaborators. Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021. Lancet. 2024;403(10440):2100-32. PubMed PMID: 38582094. Urban P, Mehran R, Colleran R, Angiolillo DJ, Byrne RA, Capodanno D, et al. Defining High Bleeding Risk in Patients Undergoing Percutaneous Coronary Intervention. Circulation. 2019;140(3):240-61. PubMed PMID: 31116032. Bainey KR, Marquis-Gravel G, Belley-Cote E, Turgeon RD, Ackman ML, et al. Canadian Cardiovascular Society/Canadian Association of Interventional Cardiology 2023 Focused Update of the Guidelines for the Use of Antiplatelet Therapy. Can J Cardiol. 2024;40(2):160-81. PubMed PMID: 38104631. Byrne RA, Rossello X, Coughlan JJ, Barbato E, Berry C, Chieffo A, et al. 2023 ESC Guidelines for the management of acute coronary syndromes. Eur Heart J. 2023;44(38):3720-826. PubMed PMID: 37622654. Lawton JS, Tamis-Holland JE, Bangalore S, Bates ER, Beckie TM, Bischoff JM, et al. 2021 ACC/AHA/SCAI Guideline for Coronary Artery Revascularization: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2022;145(3):e18-e114. PubMed PMID: 34882435. Yusuf S, Zhao F, Mehta SR, et al; Clopidogrel in Unstable Angina to Prevent Recurrent Events Trial Investigators. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N Engl J Med. 2001;345(7):494-502. PubMed PMID: 11519503. Wallentin L, Becker RC, Budaj A, Cannon CP, Emanuelsson H, Held C, et al; PLATO Investigators; Freij A, Thorsén M. Ticagrelor versus clopidogrel in patients with acute coronary syndromes. N Engl J Med. 2009;361(11):1045-57. PubMed PMID: 19717846. Mehran R, Baber U, Sharma SK, Cohen DJ, Angiolillo DJ, Briguori C, et al. Ticagrelor with or without Aspirin in High-Risk Patients after PCI. N Engl J Med. 2019;381(21):2032-42. PubMed PMID: 31556978. Kim BK, Hong SJ, Cho YH, Yun KH, Kim YH, Suh Y, et al. Effect of Ticagrelor Monotherapy vs Ticagrelor With Aspirin on Major Bleeding and Cardiovascular Events in Patients With Acute Coronary Syndrome: The TICO Randomized Clinical Trial. JAMA. 2020;323(23):2407-16. PubMed PMID: 32543684. Kim CJ, Park MW, Kim MC, Choo EH, Hwang BH, Lee KY, et al. Unguided de-escalation from ticagrelor to clopidogrel in stabilised patients with acute myocardial infarction undergoing percutaneous coronary intervention (TALOS-AMI): an investigator-initiated, open-label, multicentre, non-inferiority, randomised trial. Lancet. 2021;398(10308):1305-16. PubMed PMID: 34627490. Hong SJ, Lee SJ, Suh Y, Yun KH, Kang TS, Shin S, et al. Stopping Aspirin Within 1 Month After Stenting for Ticagrelor Monotherapy in Acute Coronary Syndrome: The T-PASS Randomized Noninferiority Trial. Circulation. 2024;149(8):562-73. PubMed PMID: 37878786. Natsuaki M, Watanabe H, Morimoto T, Yamamoto K, Obayashi Y, Nishikawa R, et al. An Aspirin-Free Versus Dual Antiplatelet Strategy for Coronary Stenting: STOPDAPT-3 Randomized Trial. Circulation. 2024;149(8):585-600. PubMed PMID: 37994553. Steiner-Gager GM, Siller-Matula JM. Abbreviated dual antiplatelet therapy after acute coronary syndrome. Lancet. 2024;403(10439):1823-5. PubMed PMID: 38599219. Autres articles d’intérêt récent : Connolly SJ, Sharma M, Cohen AT, Demchuk AM, Czlonkowska A, Lindgren AG, et al. Andexanet for Factor Xa Inhibitor-Associated Acute Intracerebral Hemorrhage. N Engl J Med. 2024;390(19):1745-55. PubMed PMID: 38749032. Blankenberg S, Seiffert M, Vonthein R, Baumgartner H, Bleiziffer S, Borger MA et al; DEDICATE-DZHK6 Trial Investigators. Transcatheter or Surgical Treatment of Aortic-Valve Stenosis. N Engl J Med. 2024;390(17):1572-1583. PubMed PMID: 38588025. Costalat V, Jovin TG, Albucher JF, Cognard C, Henon H, Nouri N, et al. Trial of Thrombectomy for Stroke with a Large Infarct of Unrestricted Size. N Engl J Med. 2024;390(18):1677-89. PubMed PMID: 38718358. Frangoul H, Locatelli F, Sharma A, Bhatia M, Mapara M, Molinari L, et al. Exagamglogene Autotemcel for Severe Sickle Cell Disease. N Engl J Med. 2024;390(18):1649-62. PubMed PMID: 38661449. Locatelli F, Lang P, Wall D, Meisel R, Corbacioglu S, Li AM, et al. Exagamglogene Autotemcel for Transfusion-Dependent beta-Thalassemia. N Engl J Med. 2024;390(18):1663-76. PubMed PMID: 38657265. Maron MS, Masri A, Nassif ME, Barriales-Villa R, Arad M, Cardim N, et al. Aficamten for Symptomatic Obstructive Hypertrophic Cardiomyopathy. N Engl J Med. 2024;390(20):1849-61. PubMed PMID: 38739079. Guides de pratique : Kaplan DE, Ripoll C, Thiele M, Fortune BE, Simonetto DA, Garcia-Tsao G, et al. AASLD Practice Guidance on risk stratification and management of portal hypertension and varices in cirrhosis. Hepatology. 2024;79(5):1180-211. PubMed PMID: 37870298. Rubio-Tapia A, McCallum R, Camilleri M. AGA Clinical Practice Update on Diagnosis and Management of Cannabinoid Hyperemesis Syndrome: Commentary. Gastroenterology. 2024;166(5):930-4. PubMed PMID: 38456869. Tjoumakaris SI, Hanel R, Mocco J, Ali-Aziz Sultan M, Froehler M, Lieber BB, et al. ARISE I Consensus Review on the Management of Intracranial Aneurysms. Stroke. 2024;55(5):1428-37. PubMed PMID: 38648283. Kan P, Fiorella D, Dabus G, Samaniego EA, Lanzino G, Siddiqui AH, et al. ARISE I Consensus Statement on the Management of Chronic Subdural Hematoma. Stroke. 2024;55(5):1438-48. PubMed PMID: 38648281. Référence du quiz clinique : Kotani Y, Turi S, Ortalda A, Baiardo Redaelli M, Marchetti C, Landoni G, Bellomo R. Positive single-center randomized trials and subsequent multicenter randomized trials in critically ill patients: a systematic review. Crit Care. 2023;27(1):465. PubMed PMID: 38017475. | — | ||||||
| 5/17/24 | BC 062 – Bêtabloquant post-infarctus du myocarde avec fraction d’éjection préservée (étude REDUCE-AMI) | Dans cette 62e baladodiffusion, le Dr Luc Lanthier discute de l’utilisation des bêtabloquants à la suite d’un infarctus du myocarde, en plus de réviser la littérature médicale d’avril 2024. Quiz clinique (1 min 52), présentation principale (2 min 20), critique (17 min 20), autres articles (23 min 44), réponse au quiz clinique (26 min 13) Référence principale : Yndigegn T, Lindahl B, Mars K, Alfredsson J, Benatar J, Brandin L, et al; REDUCE-AMI Investigators. Beta-Blockers after Myocardial Infarction and Preserved Ejection Fraction. N Engl J Med. 2024;390(15):1372-1381. PubMed PMID: 38587241. Articles associés : Steg PG. Routine Beta-Blockers in Secondary Prevention – On Injured Reserve. N Engl J Med. 2024;390(15):1434-1436. PubMed PMID: 38587255. Byrne RA, Rossello X, Coughlan JJ, Barbato E, Berry C, Chieffo A, et al. 2023 ESC Guidelines for the management of acute coronary syndromes. Eur Heart J. 2023;44(38):3720-826. PubMed PMID: 37622654. Ibanez B, James S, Agewall S, Antunes MJ, Bucciarelli-Ducci C, Bueno H, et al. 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J. 2018;39(2):119-77. PubMed PMID: 28886621. O’Gara PT, Kushner FG, Ascheim DD, Casey DE, Jr., Chung MK, de Lemos JA, et al. 2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction: executive summary: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation. 2013;127(4):529-55. PubMed PMID: 23247303. Amsterdam EA, Wenger NK, Brindis RG, Casey DE, Jr., Ganiats TG, Holmes DR, Jr., et al. 2014 AHA/ACC guideline for the management of patients with non-ST-elevation acute coronary syndromes: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation. 2014;130(25):2354-94. PubMed PMID: 25249586. Chen ZM, Pan HC, Chen YP, Peto R, Collins R, Jiang LX, et al. Early intravenous then oral metoprolol in 45,852 patients with acute myocardial infarction: randomised placebo-controlled trial. Lancet. 2005;366(9497):1622-32. PubMed PMID: 16271643. Autres articles d’intérêt récent : Foley MJ, Rajkumar CA, Ahmed-Jushuf F, Simader FA, Chotai S, Pathimagaraj RH, et al. Coronary sinus reducer for the treatment of refractory angina (ORBITA-COSMIC): a randomised, placebo-controlled trial. Lancet. 2024;403(10436):1543-53. PubMed PMID: 38604209. Moller JE, Engstrom T, Jensen LO, Eiskjaer H, Mangner N, Polzin A, et al. Microaxial Flow Pump or Standard Care in Infarct-Related Cardiogenic Shock. N Engl J Med. 2024;390(15):1382-93. PubMed PMID: 38587239. Kosiborod MN, Petrie MC, Borlaug BA, Butler J, Davies MJ, Hovingh GK, et al. Semaglutide in Patients with Obesity-Related Heart Failure and Type 2 Diabetes. N Engl J Med. 2024;390(15):1394-407. PubMed PMID: 38587233. Butler J, Jones WS, Udell JA, Anker SD, Petrie MC, Harrington J, et al. Empagliflozin after Acute Myocardial Infarction. N Engl J Med. 2024;390(16):1455-66. PubMed PMID: 38587237. Bohm F, Mogensen B, Engstrom T, Stankovic G, Srdanovic I, Lonborg J, et al. FFR-Guided Complete or Culprit-Only PCI in Patients with Myocardial Infarction. N Engl J Med. 2024;390(16):1481-92. PubMed PMID: 38587995. Meissner WG, Remy P, Giordana C, Maltete D, Derkinderen P, Houeto JL, et al. Trial of Lixisenatide in Early Parkinson’s Disease. N Engl J Med. 2024;390(13):1176-85. PubMed PMID: 38598572. Goltstein L, Grooteman KV, Bernts LHP, Scheffer RCH, Laheij RJF, Gilissen LPL, et al. Standard of Care Versus Octreotide in Angiodysplasia-Related Bleeding (the OCEAN Study): A Multicenter Randomized Controlled Trial. Gastroenterology. 2024;166(4):690-703. PubMed PMID: 38158089. Guides de pratique : Guerra PG, Simpson CS, Van Spall HGC, Writing P, Asgar AW, et al. Canadian Cardiovascular Society 2023 Guidelines on the Fitness to Drive. Can J Cardiol. 2024;40(4):500-23. PubMed PMID: 37820870. van Diepen S, Le May MR, Alfaro P, Goldfarb MJ, Luk A, Mathew R, et al. Canadian Cardiovascular Society/Canadian Cardiovascular Critical Care Society/Canadian Association of Interventional Cardiology Clinical Practice Update on Optimal Post Cardiac Arrest and Refractory Cardiac Arrest Patient Care. Can J Cardiol. 2024;40(4):524-39. PubMed PMID: 38604702. Référence du quiz clinique : Guerra PG, Simpson CS, Van Spall HGC, Writing P, Asgar AW, et al. Canadian Cardiovascular Society 2023 Guidelines on the Fitness to Drive. Can J Cardiol. 2024;40(4):500-23. PubMed PMID: 37820870. | — | ||||||
| 4/30/24 | BC 061 – Resmetirom dans le traitement de la stéatohépatite liée à une dysfonction métabolique (étude MAESTRO-NASH) | Dans cette 61e baladodiffusion, les Dr Luc Lanthier et Dusanka Grbic discutent de l’efficacité du resmetirom comme traitement de la stéatohépatite liée à une dysfonction métabolique, en plus de réviser la littérature médicale de janvier à mars 2024. Quiz clinique (2 min 32), présentation principale (2 min 56), critique (25 min 50), autres articles (33 min 00), réponse au quiz clinique (35 min 35) Référence principale Harrison SA, Bedossa P, Guy CD, Schattenberg JM, Loomba R, Taub R, et al. A Phase 3, Randomized, Controlled Trial of Resmetirom in NASH with Liver Fibrosis. N Engl J Med. 2024;390(6):497-509. PubMed PMID: 38324483. Articles associés Cusi K. Selective Agonists of Thyroid Hormone Receptor Beta for the Treatment of NASH. N Engl J Med. 2024;390(6):559-561. PubMed PMID: 38324491. Rinella ME, Lazarus JV, Ratziu V, Francque SM, Sanyal AJ, Kanwal F, et al. A multisociety Delphi consensus statement on new fatty liver disease nomenclature. Hepatology. 2023;78(6):1966-86. PubMed PMID: 37363821. Rinella ME, Neuschwander-Tetri BA, Siddiqui MS, Abdelmalek MF, Caldwell S, Barb D, et al. AASLD Practice Guidance on the clinical assessment and management of nonalcoholic fatty liver disease. Hepatology. 2023;77(5):1797-835. PubMed PMID: 36727674. Kanwal F, Shubrook JH, Adams LA, Pfotenhauer K, Wai-Sun Wong V, Wright E, et al. Clinical Care Pathway for the Risk Stratification and Management of Patients With Nonalcoholic Fatty Liver Disease. Gastroenterology. 2021;161(5):1657-69. PubMed PMID: 34602251. Byrne CD, Targher G, Tilg H. Thyroid hormone receptor-beta agonists: new MASLD therapies on the horizon. Gut. 2024;73(4):573-581. PubMed PMID: 38233199. Loomba R, Sanyal AJ, Kowdley KV, Bhatt DL, Alkhouri N, Frias JP, et al. Randomized, Controlled Trial of the FGF21 Analogue Pegozafermin in NASH. N Engl J Med. 2023;389(11):998-1008. PubMed PMID: 37356033. Sanyal AJ, Chalasani N, Kowdley KV, McCullough A, Diehl AM, Bass NM, et al; NASH CRN. Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis. N Engl J Med. 2010;362(18):1675-85. PubMed PMID: 20427778. Chaudhuri D, Nei AM, Rochwerg B, Balk RA, Asehnoune K, Cadena R, et al. 2024 Focused Update: Guidelines on Use of Corticosteroids in Sepsis, Acute Respiratory Distress Syndrome, and Community-Acquired Pneumonia. Crit Care Med. 2024;52(5):e219-e33. PubMed PMID: 38240492. Hammond J, Fountaine RJ, Yunis C, Fleishaker D, Almas M, Bao W, et al. Nirmatrelvir for Vaccinated or Unvaccinated Adult Outpatients with Covid-19. N Engl J Med. 2024;390(13):1186-1195. PubMed PMID: 38598573. Autres articles d’intérêt récent Healey JS, Lopes RD, Granger CB, Alings M, Rivard L, McIntyre WF, et al. Apixaban for Stroke Prevention in Subclinical Atrial Fibrillation. N Engl J Med. 2024;390(2):107-17. PubMed PMID: 37952132. .Gillmore JD, Judge DP, Cappelli F, Fontana M, Garcia-Pavia P, Gibbs S, et al. Efficacy and Safety of Acoramidis in Transthyretin Amyloid Cardiomyopathy. N Engl J Med. 2024;390(2):132-42. PubMed PMID: 38197816. Glal KAM, El-Haggar SM, Abdel-Salam SM, Mostafa TM. Allopurinol Prevents Cirrhosis-Related Complications: A Quadruple Blind Placebo-Controlled Trial. Am J Med. 2024;137(1):55-64. PubMed PMID: 37832758. Snyder PJ, Bauer DC, Ellenberg SS, Cauley JA, Buhr KA, Bhasin S, et al. Testosterone Treatment and Fractures in Men with Hypogonadism. N Engl J Med. 2024;390(3):203-11. PubMed PMID: 38231621. Hong SJ, Lee SJ, Suh Y, Yun KH, Kang TS, Shin S, et al. Stopping Aspirin Within 1 Month After Stenting for Ticagrelor Monotherapy in Acute Coronary Syndrome: The T-PASS Randomized Noninferiority Trial. Circulation. 2024;149(8):562-73. PubMed PMID: 37878786. Albers GW, Jumaa M, Purdon B, Zaidi SF, Streib C, Shuaib A, et al. Tenecteplase for Stroke at 4.5 to 24 Hours with Perfusion-Imaging Selection. N Engl J Med. 2024;390(8):701-11. PubMed PMID: 38329148. Collaboration NCDRF. Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults. Lancet. 2024;403(10431):1027-50. PubMed PMID: 38432237. Wood RA, Togias A, Sicherer SH, Shreffler WG, Kim EH, Jones SM, et al. Omalizumab for the Treatment of Multiple Food Allergies. N Engl J Med. 2024;390(10):889-99. PubMed PMID: 38407394. Chung DC, Gray DM, 2nd, Singh H, Issaka RB, Raymond VM, Eagle C, et al. A Cell-free DNA Blood-Based Test for Colorectal Cancer Screening. N Engl J Med. 2024;390(11):973-83. PubMed PMID: 38477985. Imperiale TF, Porter K, Zella J, Gagrat ZD, Olson MC, Statz S, et al. Next-Generation Multitarget Stool DNA Test for Colorectal Cancer Screening. N Engl J Med. 2024;390(11):984-93. PubMed PMID: 38477986. Guides de pratique Bainey KR, Marquis-Gravel G, Belley-Cote E, Turgeon RD, Ackman ML, et al. Canadian Cardiovascular Society/Canadian Association of Interventional Cardiology 2023 Focused Update of the Guidelines for the Use of Antiplatelet Therapy. Can J Cardiol. 2024;40(2):160-81. PubMed PMID: 38104631. American Diabetes Association Professional Practice Committee. Summary of Revisions: Standards of Care in Diabetes-2024. Diabetes Care. 2024 Jan 1;47(Supplement_1):S5-S10. PubMed PMID: 38078579. Matthay MA, Arabi Y, Arroliga AC, Bernard G, Bersten AD, Brochard LJ, et al. A New Global Definition of Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2024;209(1):37-47. PubMed PMID: 37487152. Qadir N, Sahetya S, Munshi L, Summers C, Abrams D, Beitler J, et al. An Update on Management of Adult Patients with Acute Respiratory Distress Syndrome: An Official American Thoracic Society Clinical Practice Guideline. Am J Respir Crit Care Med. 2024;209(1):24-36. PubMed PMID: 38032683. Jophlin LL, Singal AK, Bataller R, Wong RJ, Sauer BG, Terrault NA, et al. ACG Clinical Guideline: Alcohol-Associated Liver Disease. Am J Gastroenterol. 2024;119(1):30-54. PubMed PMID: 38174913. Joglar JA, Chung MK, Armbruster AL, Benjamin EJ, Chyou JY, Cronin EM, et al. 2023 ACC/AHA/ACCP/HRS Guideline for the Diagnosis and Management of Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2024;149(1):e1-e156. PubMed PMID: 38033089. Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Kidney Int. 2024;105(4S):S117-S314. PubMed PMID: 38490803. Tenner S, Vege SS, Sheth SG, Sauer B, Yang A, Conwell DL, et al. American College of Gastroenterology Guidelines: Management of Acute Pancreatitis. Am J Gastroenterol. 2024;119(3):419-37. Références du quiz clinique Awad K, Serban MC, Penson P, Mikhailidis DP, Toth PP, Jones SR, et al; Lipid and Blood Pressure Meta-analysis Collaboration (LBPMC) Group. Effects of morning vs evening statin administration on lipid profile: A systematic review and meta-analysis. J Clin Lipidol. 2017;11(4):972-985. PubMed PMID: 28826569. Plakogiannis R, Cohen H, Taft D. Effects of morning versus evening administration of atorvastatin in patients with hyperlipidemia. Am J Health Syst Pharm. 2005;62(23):2491-4. PubMed PMID: 16303904. | — | ||||||
| 1/22/24 | BC 060 – Thérapie antiplaquettaire double jusqu’à 72 heures après un événement vasculaire cérébral ischémique (étude INSPIRES) | Dans cette 60e baladodiffusion, le Dr Luc Lanthier discute de l’efficacité d’une thérapie antiplaquettaire double pour 21 jours débutée jusqu’à 72 heures à la suite d’un événement vasculaire cérébral ischémique, en plus de réviser la littérature médicale de décembre 2023. Quiz clinique (2 min 12), présentation principale (2 min 43), critique (26 min 05), autres articles (33 min 14), réponse au quiz clinique (36 min 46) Référence principale : Gao Y, Chen W, Pan Y, Jing J, Wang C, Johnston SC, et al. Dual Antiplatelet Treatment up to 72 Hours after Ischemic Stroke. N Engl J Med. 2023;389(26):2413-24. PubMed PMID: 38157499. Articles associés : Kim AS. Extending Dual Antiplatelet Therapy for TIA or Stroke. N Engl J Med. 2023;389(26):2478-9. PubMed PMID: 38157504. Kleindorfer DO, Towfighi A, Chaturvedi S, Cockroft KM, Gutierrez J, Lombardi-Hill D, et al. 2021 Guideline for the Prevention of Stroke in Patients With Stroke and Transient Ischemic Attack: A Guideline From the American Heart Association/American Stroke Association. Stroke. 2021;52(7):e364-e467. PubMed PMID: 34024117. Wein T, Lindsay MP, Gladstone DJ, Poppe A, Bell A, Casaubon LK, et al. Canadian Stroke Best Practice Recommendations, seventh edition: acetylsalicylic acid for prevention of vascular events. CMAJ. 2020;192(12):E302-E11. PubMed PMID: 32392513. Johnston SC, Amarenco P, Denison H, Evans SR, Himmelmann A, James S, et al. Ticagrelor and Aspirin or Aspirin Alone in Acute Ischemic Stroke or TIA. N Engl J Med. 2020;383(3):207-17. PubMed PMID: 32668111. Johnston SC, Elm JJ, Easton JD, Farrant M, Barsan WG, Kim AS, et al. Time Course for Benefit and Risk of Clopidogrel and Aspirin After Acute Transient Ischemic Attack and Minor Ischemic Stroke. Circulation. 2019;140(8):658-64. PubMed PMID: 31238700. Johnston SC, Easton JD, Farrant M, Barsan W, Conwit RA, Elm JJ, et al. Clopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA. N Engl J Med. 2018;379(3):215-25. PubMed PMID: 29766750. Wang Y, Wang Y, Zhao X, Liu L, Wang D, Wang C, et al. Clopidogrel with aspirin in acute minor stroke or transient ischemic attack. N Engl J Med. 2013;369(1):11-9. PubMed PMID: 23803136. Diener HC, Bogousslavsky J, Brass LM, Cimminiello C, Csiba L, Kaste M, et al. Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): randomised, double-blind, placebo-controlled trial. Lancet. 2004;364(9431):331-7. PubMed PMID: 15276392. Autres articles d’intérêt récent : Carson JL, Brooks MM, Hebert PC, Goodman SG, Bertolet M, Glynn SA, et al. Restrictive or Liberal Transfusion Strategy in Myocardial Infarction and Anemia. N Engl J Med. 2023;389(26):2446-56. PubMed PMID: 37952133. Rajkumar CA, Foley MJ, Ahmed-Jushuf F, Nowbar AN, Simader FA, Davies JR, et al. A Placebo-Controlled Trial of Percutaneous Coronary Intervention for Stable Angina. N Engl J Med. 2023;389(25):2319-30. PubMed PMID: 38015442. Mensah GA, Fuster V, Murray CJL, Roth GA, Global Burden of Cardiovascular D, Risks C. Global Burden of Cardiovascular Diseases and Risks, 1990-2022. J Am Coll Cardiol. 2023;82(25):2350-473. PubMed PMID: 38092509. Freund Y, Viglino D, Cachanado M, Cassard C, Montassier E, Douay B, et al. Effect of Noninvasive Airway Management of Comatose Patients With Acute Poisoning: A Randomized Clinical Trial. JAMA. 2023;330(23):2267-74. PubMed PMID: 38019968. Wilson E, Goswami J, Baqui AH, Doreski PA, Perez-Marc G, Zaman K, et al. Efficacy and Safety of an mRNA-Based RSV PreF Vaccine in Older Adults. N Engl J Med. 2023;389(24):2233-44. PubMed PMID: 38091530. Dodick DW, Goadsby PJ, Schwedt TJ, Lipton RB, Liu C, Lu K, et al. Ubrogepant for the treatment of migraine attacks during the prodrome: a phase 3, multicentre, randomised, double-blind, placebo-controlled, crossover trial in the USA. Lancet. 2023;402(10419):2307-16. PubMed PMID: 37979595. Khan SS, Coresh J, Pencina MJ, Ndumele CE, Rangaswami J, Chow SL, et al; American Heart Association. Novel Prediction Equations for Absolute Risk Assessment of Total Cardiovascular Disease Incorporating Cardiovascular-Kidney-Metabolic Health: A Scientific Statement From the American Heart Association. Circulation. 2023;148(24):1982-2004. PubMed PMID: 37947094. Guides de pratique : Humphrey MB, Russell L, Danila MI, Fink HA, Guyatt G, Cannon M, et al. 2022 American College of Rheumatology Guideline for the Prevention and Treatment of Glucocorticoid-Induced Osteoporosis. Arthritis Rheumatol. 2023;75(12):2088-102. PubMed PMID: 37845798. Singal AG, Llovet JM, Yarchoan M, Mehta N, Heimbach JK, Dawson LA, et al. AASLD Practice Guidance on prevention, diagnosis, and treatment of hepatocellular carcinoma. Hepatology. 2023;78(6):1922-65. PubMed PMID: 37199193. Références du quiz clinique : Trubiano JA, Vogrin S, Chua KYL, Bourke J, Yun J, Douglas A, Stone CA, Yu R, Groenendijk L, Holmes NE, Phillips EJ. Development and Validation of a Penicillin Allergy Clinical Decision Rule. JAMA Intern Med. 2020;180(5):745-752. PubMed PMID: 32176248. Copaescu AM, Vogrin S, James F, Chua KYL, Rose MT, De Luca J, et al. Efficacy of a Clinical Decision Rule to Enable Direct Oral Challenge in Patients With Low-Risk Penicillin Allergy: The PALACE Randomized Clinical Trial. JAMA Intern Med. 2023;183(9):944-952. PubMed PMID: 37459086. Su C, Belmont A, Liao J, Kuster JK, Trubiano JA, Kwah JH. Evaluating the PEN-FAST Clinical Decision-making Tool to Enhance Penicillin Allergy Delabeling. JAMA Intern Med. 2023;183(8):883-885. PubMed PMID: 37338869. Wijnakker R, van Maaren MS, Bode LGM, Bulatovic M, Hendriks BJC, Loogman MCM, et al. The Dutch Working Party on Antibiotic Policy (SWAB) guideline for the approach to suspected antibiotic allergy. Clin Microbiol Infect. 2023;29(7):863-875. PubMed PMID: 37068548. | — | ||||||
| 12/19/23 | BC 059 – Sémaglutide et protection cardiovasculaire chez les personnes avec obésité et maladie cardiovasculaire sans diabète (étude SELECT) | Dans cette 59e baladodiffusion, les Dr Luc Lanthier et Marie-France Langlois discutent de l’efficacité de sémaglutide pour réduire les événements cardiovasculaires chez les personnes avec obésité et maladie cardiovasculaire mais sans diabète, en plus de réviser la littérature médicale de novembre 2023. Quiz clinique (2 min 19), présentation principale (2 min 48), critique (22 min 32), autres articles (33 min 10), réponse au quiz clinique (35 min 28) Référence principale : Lincoff AM, Brown-Frandsen K, Colhoun HM, Deanfield J, Emerson SS, Esbjerg S, et al; SELECT Trial Investigators. Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes. N Engl J Med. 2023;389(24): 2221-32. PubMed PMID: 37952131. Articles associés : Khera A, Powell-Wiley TM. SELECTing Treatments for Cardiovascular Disease – Obesity in the Spotlight. N Engl J Med. 2023;389(24):2287-2288. PubMed PMID: 37952130. Wilding JPH, Batterham RL, Calanna S, Davies M, Van Gaal LF, Lingvay I, McGowan BM, Rosenstock J, Tran MTD, Wadden TA, Wharton S, Yokote K, Zeuthen N, Kushner RF; STEP 1 Study Group. Once-Weekly Semaglutide in Adults with Overweight or Obesity. N Engl J Med. 2021;384(11):989-1002. PubMed PMID: 33567185. Baig K, Dusetzina SB, Kim DD, Leech AA. Medicare Part D Coverage of Antiobesity Medications – Challenges and Uncertainty Ahead. N Engl J Med. 2023;388(11):961-963. PubMed PMID: 36912541. Autres articles d’intérêt récent : Conen D, Ke Wang M, Popova E, Chan MTV, Landoni G, Cata JP, et al. Effect of colchicine on perioperative atrial fibrillation and myocardial injury after non-cardiac surgery in patients undergoing major thoracic surgery (COP-AF): an international randomised trial. Lancet. 2023;402(10413):1627-35. PubMed PMID: 37640035. Russell-Jones D, Babazono T, Cailleteau R, Engberg S, Irace C, Kjaersgaard MIS, et al. Once-weekly insulin icodec versus once-daily insulin degludec as part of a basal-bolus regimen in individuals with type 1 diabetes (ONWARDS 6): a phase 3a, randomised, open-label, treat-to-target trial. Lancet. 2023;402(10413):1636-47. PubMed PMID: 37863084. Bendszus M, Fiehler J, Subtil F, Bonekamp S, Aamodt AH, Fuentes B, et al. Endovascular thrombectomy for acute ischaemic stroke with established large infarct: multicentre, open-label, randomised trial. Lancet. 2023;402(10414):1753-63. PubMed PMID: 37837989. Ford AC, Wright-Hughes A, Alderson SL, Ow PL, Ridd MJ, Foy R, et al; ATLANTIS trialists. Amitriptyline at Low-Dose and Titrated for Irritable Bowel Syndrome as Second-Line Treatment in primary care (ATLANTIS): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet. 2023;402(10414):1773-1785. PubMed PMID: 37858323. Mack MJ, Leon MB, Thourani VH, Pibarot P, Hahn RT, Genereux P, et al. Transcatheter Aortic-Valve Replacement in Low-Risk Patients at Five Years. N Engl J Med. 2023;389(21):1949-60. PubMed PMID: 37874020. Guides de pratique : Carson JL, Stanworth SJ, Guyatt G, Valentine S, Dennis J, Bakhtary S, et al. Red Blood Cell Transfusion: 2023 AABB International Guidelines. JAMA. 2023;330(19):1892-902. PubMed PMID: 37824153. Fitridge R, Chuter V, Mills J, Hinchliffe R, Azuma N, Behrendt CA, et al. The intersocietal IWGDF, ESVS, SVS guidelines on peripheral artery disease in people with diabetes mellitus and a foot ulcer. J Vasc Surg. 2023;78(5):1101-1131. PubMed PMID: 37724985. Références du quiz clinique : Wood E, Bright J, Hsu K, Goel N, Ross JWG, Hanson A, et al. Canadian guideline for the clinical management of high-risk drinking and alcohol use disorder. CMAJ. 2023;195(40):E1364-E79. PubMed PMID: 37844924. Maldonado JR, Sher Y, Ashouri JF, Hills-Evans K, Swendsen H, Lolak S, Miller AC. The « Prediction of Alcohol Withdrawal Severity Scale » (PAWSS): systematic literature review and pilot study of a new scale for the prediction of complicated alcohol withdrawal syndrome. Alcohol. 2014 Jun;48(4):375-90. PubMed PMID: 24657098. | — | ||||||
| 11/21/23 | BC 058 – Amikacine inhalée pour la prévention de la pneumonie acquise sous ventilation mécanique (étude AMIKINHAL) | Dans cette 58e baladodiffusion, les Dr Luc Lanthier et Michaël Mayette discutent de l’efficacité de l’amikacine inhalée pour prévenir les pneumonies sous ventilateur, en plus de réviser la littérature médicale d’aout, septembre et octobre 2023. Quiz clinique (3 min 46), présentation principale (4 min 20), critique (21 min 18), autres articles (26 min 36), réponse au quiz clinique (31 min 33) Référence principale : Ehrmann S, Barbier F, Demiselle J, Quenot JP, Herbrecht JE, Roux D, et al, Reva and CRICS-TRIGGERSEP F-CRIN Research Networks. Inhaled Amikacin to Prevent Ventilator-Associated Pneumonia. N Engl J Med. 2023 Oct 25. doi: 10.1056/NEJMoa2310307. PubMed PMID: 37888914. Articles associés : Klompas M, Branson R, Cawcutt K, Crist M, Eichenwald EC, Greene LR, et al. Strategies to prevent ventilator-associated pneumonia, ventilator-associated events, and nonventilator hospital-acquired pneumonia in acute-care hospitals: 2022 Update. Infect Control Hosp Epidemiol. 2022;43(6):687-713. PubMed PMID: 35589091. Torres A, Niederman MS, Chastre J, Ewig S, Fernandez-Vandellos P, Hanberger H, et al. International ERS/ESICM/ESCMID/ALAT guidelines for the management of hospital-acquired pneumonia and ventilator-associated pneumonia: Guidelines for the management of hospital-acquired pneumonia (HAP)/ventilator-associated pneumonia (VAP) of the European Respiratory Society (ERS), European Society of Intensive Care Medicine (ESICM), European Society of Clinical Microbiology and Infectious Diseases (ESCMID) and Asociación Latinoamericana del Tórax (ALAT). Eur Respir J. 2017;50(3):1700582. PubMed PMID: 28890434. Kalil AC, Metersky ML, Klompas M, Muscedere J, Sweeney DA, Palmer LB, et al. Executive Summary: Management of Adults With Hospital-acquired and Ventilator-associated Pneumonia: 2016 Clinical Practice Guidelines by the Infectious Diseases Society of America and the American Thoracic Society. Clin Infect Dis. 2016;63(5):575-82. PubMed PMID: 27521441. Sivapalan P, Ellekjaer KL, Jessen MK, Meyhoff TS, Cronhjort M, Hjortrup PB, Wetterslev J, Granholm A, Møller MH, Perner A. Lower vs Higher Fluid Volumes in Adult Patients With Sepsis: An Updated Systematic Review With Meta-Analysis and Trial Sequential Analysis. Chest. 2023;164(4):892-912. PubMed PMID: 37142091. Pitre T, Abdali D, Chaudhuri D, Pastores SM, Nei AM, Annane D, Rochwerg B, Zeraatkar D. Corticosteroids in Community-Acquired Bacterial Pneumonia: a Systematic Review, Pairwise and Dose-Response Meta-Analysis. J Gen Intern Med. 2023;38(11):2593-2606. PubMed PMID: 37076606. Freling S, Wald-Dickler N, Banerjee J, Canamar CP, Tangpraphaphorn S, Bruce D, et al. Real-World Application of Oral Therapy for Infective Endocarditis: A Multicenter, Retrospective, Cohort Study. Clin Infect Dis. 2023;77(5):672-679. PubMed PMID: 36881940. Conen D, Ke Wang M, Popova E, Chan MTV, Landoni G, Cata JP, et al COP-AF Investigators. Effect of colchicine on perioperative atrial fibrillation and myocardial injury after non-cardiac surgery in patients undergoing major thoracic surgery (COP-AF): an international randomised trial. Lancet. 2023;402(10413) :1627-1635. PubMed PMID: 37640035. Autres articles d’intérêt récent : Aout Garvey WT, Frias JP, Jastreboff AM, le Roux CW, Sattar N, Aizenberg D, et al. Tirzepatide once weekly for the treatment of obesity in people with type 2 diabetes (SURMOUNT-2): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial. Lancet. 2023;402(10402):613-26. PubMed PMID: 37385275. Knop FK, Aroda VR, do Vale RD, Holst-Hansen T, Laursen PN, Rosenstock J, et al. Oral semaglutide 50 mg taken once per day in adults with overweight or obesity (OASIS 1): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet. 2023;402(10403):705-19. PubMed PMID: 37385278. Aroda VR, Aberle J, Bardtrum L, Christiansen E, Knop FK, Gabery S, et al. Efficacy and safety of once-daily oral semaglutide 25 mg and 50 mg compared with 14 mg in adults with type 2 diabetes (PIONEER PLUS): a multicentre, randomised, phase 3b trial. Lancet. 2023;402(10403):693-704. PubMed PMID: 37385279. Blankestijn PJ, Vernooij RWM, Hockham C, Strippoli GFM, Canaud B, Hegbrant J, et al. Effect of Hemodiafiltration or Hemodialysis on Mortality in Kidney Failure. N Engl J Med. 2023;389(8):700-9. PubMed PMID: 37326323. Septembre Mentz RJ, Garg J, Rockhold FW, Butler J, De Pasquale CG, Ezekowitz JA, et al. Ferric Carboxymaltose in Heart Failure with Iron Deficiency. N Engl J Med. 2023;389(11):975-86. PubMed PMID: 37632463. Biscaglia S, Guiducci V, Escaned J, Moreno R, Lanzilotti V, Santarelli A, et al. Complete or Culprit-Only PCI in Older Patients with Myocardial Infarction. N Engl J Med. 2023;389(10):889-98. PubMed PMID: 37634150. Kosiborod MN, Abildstrom SZ, Borlaug BA, Butler J, Rasmussen S, Davies M, et al. Semaglutide in Patients with Heart Failure with Preserved Ejection Fraction and Obesity. N Engl J Med. 2023;389(12):1069-84. PubMed PMID: 37622681. Octobre Magnussen C, Ojeda FM, Leong DP, Alegre-Diaz J, Amouyel P, Aviles-Santa L, et al; Global Cardiovascular Risk Consortium. Global Effect of Modifiable Risk Factors on Cardiovascular Disease and Mortality. N Engl J Med. 2023;389(14):1273-1285. PubMed PMID: 37632466. Spiera RF, Unizony S, Warrington KJ, Sloane J, Giannelou A, Nivens MC, et al; SAPHYR Investigators. Sarilumab for Relapse of Polymyalgia Rheumatica during Glucocorticoid Taper. N Engl J Med. 2023;389(14):1263-1272. PubMed PMID: 37792612. Sohns C, Fox H, Marrouche NF, Crijns HJGM, Costard-Jaeckle A, Bergau L, et al; CASTLE HTx Investigators. Catheter Ablation in End-Stage Heart Failure with Atrial Fibrillation. N Engl J Med. 2023;389(15):1380-1389. PubMed PMID: 37634135. Misset B, Piagnerelli M, Hoste E, Dardenne N, Grimaldi D, Michaux I, et al. Convalescent Plasma for Covid-19-Induced ARDS in Mechanically Ventilated Patients. N Engl J Med. 2023;389(17):1590-1600. PubMed PMID: 37889107. Lee TTM, Collett C, Bergford S, Hartnell S, Scott EM, Lindsay RS, et al; AiDAPT Collaborative Group. Automated Insulin Delivery in Women with Pregnancy Complicated by Type 1 Diabetes. N Engl J Med. 2023;389(17):1566-1578. PubMed PMID: 37796241. Guides de pratique : Août Virani SS, Newby LK, Arnold SV, Bittner V, Brewer LC, Demeter SH, et al. 2023 AHA/ACC/ACCP/ASPC/NLA/PCNA Guideline for the Management of Patients With Chronic Coronary Disease: A Report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines. Circulation. 2023;148(9):e9-e119. PubMed PMID: 37471501. Rochester CL, Alison JA, Carlin B, Jenkins AR, Cox NS, Bauldoff G, et al. Pulmonary Rehabilitation for Adults with Chronic Respiratory Disease: An Official American Thoracic Society Clinical Practice Guideline. Am J Respir Crit Care Med. 2023;208(4):e7-e26. PubMed PMID: 37581410. Septembre Bourbeau J, Bhutani M, Hernandez P, Aaron SD, Beauchesne MF, Kermelly SB, et al. 2023 Canadian Thoracic Society Guideline on Pharmacotherapy in Patients With Stable COPD. Chest. 2023:S0012-3692(23)05275-3. PubMed PMID: 37690008. Octobre Morin SN, Feldman S, Funnell L, Giangregorio L, Kim S, McDonald-Blumer H, et al. Clinical practice guideline for management of osteoporosis and fracture prevention in Canada: 2023 update. CMAJ. 2023;195(39):E1333-E48. PubMed PMID: 37816527. Wood E, Bright J, Hsu K, Goel N, Ross JWG, Hanson A, et al. Canadian guideline for the clinical management of high-risk drinking and alcohol use disorder. CMAJ. 2023;195(40):E1364-E79. PubMed PMID: 37844924. Kolber MR, Klarenbach S, Cauchon M, Cotterill M, Regier L, Marceau RD, et al. Lignes directrices simplifiées de PEER sur les lipides : actualisation 2023: Prévention et prise en charge des maladies cardiovasculaires en soins primaires. Can Fam Physician. 2023;69(10):e189-e201. PubMed PMID: 37833093. McDonagh TA, Metra M, Adamo M, Gardner RS, Baumbach A, Bohm M, et al. 2023 Focused Update of the 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J. 2023;44(37):3627-39. PubMed PMID: 37622666. Delgado V, Ajmone Marsan N, de Waha S, Bonaros N, Brida M, Burri H, et al. 2023 ESC Guidelines for the management of endocarditis. Eur Heart J. 2023;44(39):3948-4042. PubMed PMID: 37622656. Byrne RA, Rossello X, Coughlan JJ, Barbato E, Berry C, Chieffo A, et al. 2023 ESC Guidelines for the management of acute coronary syndromes. Eur Heart J. 2023;44(38):3720-826. PubMed PMID: 37622654. Barbhaiya M, Zuily S, Naden R, Hendry A, Manneville F, Amigo MC, et al. The 2023 ACR/EULAR Antiphospholipid Syndrome Classification Criteria. Arthritis Rheumatol. 2023;75(10):1687-702. PubMed PMID: 37635643. Abhishek A, Tedeschi SK, Pascart T, Latourte A, Dalbeth N, Neogi T, et al. The 2023 ACR/EULAR Classification Criteria for Calcium Pyrophosphate Deposition Disease. Arthritis Rheumatol. 2023;75(10):1703-13. PubMed PMID: 37494275. Référence du quiz clinique : Fowler VG, Durack DT, Selton-Suty C, Athan E, Bayer AS, Chamis AL, et al. The 2023 Duke-International Society for Cardiovascular Infectious Diseases Criteria for Infective Endocarditis: Updating the Modified Duke Criteria. Clin Infect Dis. 2023;77(4):518-526. PubMed PMID: 37138445. | — | ||||||
| 8/29/23 | BC 057 – Pitavastatine pour la prévention de la maladie cardiovasculaire dans l’infection à VIH (étude REPRIEVE) | Dans cette 57e baladodiffusion, le Dr Luc Lanthier discute de prévention de la maladie cardiovasculaire avec une statine, la pitavastatine, chez les personnes vivant avec le VIH, en plus de réviser la littérature médicale de juin et juillet 2023. Quiz clinique (1 min 31), présentation principale (2 min 08), critique (20 min 00), autres articles (26 min 15), réponse au quiz clinique (30 min 57) Référence principale : Grinspoon SK, Fitch KV, Zanni MV, Fichtenbaum CJ, Umbleja T, Aberg JA, et al. Pitavastatin to Prevent Cardiovascular Disease in HIV Infection. N Engl J Med. 2023;389(8):687-699. PubMed PMID: 37486775. Articles associés : Freiberg MS. HIV and Cardiovascular Disease – An Ounce of Prevention. N Engl J Med. 2023;389(8):760-61. PubMed PMID: 37486752. Shah ASV, Stelzle D, Lee KK, Beck EJ, Alam S, Clifford S, et al. Global Burden of Atherosclerotic Cardiovascular Disease in People Living With HIV: Systematic Review and Meta-Analysis. Circulation. 2018;138(11):1100-12. PubMed PMID: 29967196. Hsue PY, Waters DD. Time to Recognize HIV Infection as a Major Cardiovascular Risk Factor. Circulation. 2018;138(11):1113-5. PubMed PMID: 30354392. Ntsekhe M, Baker JV. Cardiovascular Disease Among Persons Living With HIV: New Insights Into Pathogenesis and Clinical Manifestations in a Global Context. Circulation. 2023;147(1):83-100. PubMed PMID: 36576956. Feinstein MJ, Hsue PY, Benjamin LA, Bloomfield GS, Currier JS, Freiberg MS, et al. Characteristics, Prevention, and Management of Cardiovascular Disease in People Living With HIV: A Scientific Statement From the American Heart Association. Circulation. 2019;140(2). doi: 10.1161/cir.0000000000000695. PubMed PMID : 31154814. Autres articles d’intérêt récent : Simmons D, Immanuel J, Hague WM, Teede H, Nolan CJ, Peek MJ, et al. Treatment of Gestational Diabetes Mellitus Diagnosed Early in Pregnancy. N Engl J Med. 2023;388(23):2132-44. PubMed PMID: 37144983. Fischer U, Koga M, Strbian D, Branca M, Abend S, Trelle S, et al. Early versus Later Anticoagulation for Stroke with Atrial Fibrillation. N Engl J Med. 2023;388(26):2411-21. PubMed PMID: 37222476. Schrag D, Uno H, Rosovsky R, Rutherford C, Sanfilippo K, Villano JL, et al. Direct Oral Anticoagulants vs Low-Molecular-Weight Heparin and Recurrent VTE in Patients With Cancer: A Randomized Clinical Trial. JAMA. 2023;329(22):1924-33. PubMed PMID: 37266947. Brugts JJ, Radhoe SP, Clephas PRD, Aydin D, van Gent MWF, Szymanski MK, et al. Remote haemodynamic monitoring of pulmonary artery pressures in patients with chronic heart failure (MONITOR-HF): a randomised clinical trial. Lancet. 2023;401(10394):2113-23. PubMed PMID: 37220768. Lincoff AM, Bhasin S, Flevaris P, Mitchell LM, Basaria S, Boden WE, et al. Cardiovascular Safety of Testosterone-Replacement Therapy. N Engl J Med. 2023;389(2):107-17. PubMed PMID: 37326322. Bhatt SP, Rabe KF, Hanania NA, Vogelmeier CF, Cole J, Bafadhel M, et al. Dupilumab for COPD with Type 2 Inflammation Indicated by Eosinophil Counts. N Engl J Med. 2023;39(3):205-14. PubMed PMID: 37272521. Liu S, Yao C, Xie J, Liu H, Wang H, Lin Z, et al. Effect of an Herbal-Based Injection on 28-Day Mortality in Patients With Sepsis: The EXIT-SEP Randomized Clinical Trial. JAMA Intern Med. 2023;183(7):647-55. PubMed PMID: 37126332. Guides de pratique : Key NS, Khorana AA, Kuderer NM, Bohlke K, Lee AYY, Arcelus JI, Wong SL, Balaban EP, Flowers CR, Gates LE, Kakkar AK, Tempero MA, Gupta S, Lyman GH, Falanga A. Venous Thromboembolism Prophylaxis and Treatment in Patients With Cancer: ASCO Guideline Update. J Clin Oncol. 2023;41(16):3063-3071. PubMed PMID: 37075273. Chen JW, Vela MF, Peterson KA, Carlson DA. AGA Clinical Practice Update on the Diagnosis and Management of Extraesophageal Gastroesophageal Reflux Disease: Expert Review. Clin Gastroenterol Hepatol. 2023;21(6):1414-21. PubMed PMID: 37061897. Chang L, Chey WD, Imdad A, Almario CV, Bharucha AE, Diem S, et al. American Gastroenterological Association-American College of Gastroenterology Clinical Practice Guideline: Pharmacological Management of Chronic Idiopathic Constipation. Am J Gastroenterol. 2023;118(6):936-54. PubMed PMID: 37204227. Roberts ME, Rahman NM, Maskell NA, Bibby AC, Blyth KG, Corcoran JP, Edey A, Evison M, de Fonseka D, Hallifax R, Harden S, Lawrie I, Lim E, McCracken DJ, Mercer R, Mishra EK, Nicholson AG, Noorzad F, Opstad K, Parsonage M, Stanton AE, Walker S; BTS Pleural Guideline Development Group. British Thoracic Society Guideline for pleural disease. Thorax. 2023 Jul;78(Suppl 3):s1-s42. PubMed PMID: 37433578. Hoh BL, Ko NU, Amin-Hanjani S, Chou S-Y, Cruz-Flores S, Dangayach NS, et al. 2023 Guideline for the Management of Patients With Aneurysmal Subarachnoid Hemorrhage: A Guideline From the American Heart Association/American Stroke Association. Stroke. 2023;54(7):e314-e70. PubMed PMID: 37212182. Grasselli G, Calfee CS, Camporota L, Poole D, Amato MBP, Antonelli M, et al; European Society of Intensive Care Medicine Taskforce on ARDS. ESICM guidelines on acute respiratory distress syndrome: definition, phenotyping and respiratory support strategies. Intensive Care Med. 2023;49(7):727-759. PubMed PMID: 37326646. Références du quiz clinique : Agustí A, Celli BR, Criner GJ, Halpin D, Anzueto A, Barnes P, et al. Global Initiative for Chronic Obstructive Lung Disease 2023 Report: GOLD Executive Summary. Eur Respir J. 2023 Apr 1;61(4):2300239. doi: 10.1183/13993003.00239-2023. PubMed PMID: 36858443. https://goldcopd.org/2023-executive-summary/ https://www.inesss.qc.ca/publications/repertoire-des-publications/publication/maladie-pulmonaire-obstructive-chronique.html | — | ||||||
| 6/27/23 | BC 056 – Recommandations sur le dépistage pour la prévention primaire des fractures de fragilisation (lignes directrices du GÉCSSP 2023) | Dans cette 56e baladodiffusion, le Dr Luc Lanthier discute des nouvelles lignes directrices sur la prévention des fractures de fragilisation du GÉCSSP, en plus de réviser la littérature médicale d’avril et mai 2023. Quiz clinique (3 min 21), présentation principale (3 min 48), critique (26 min 23), autres articles (31 min 25), réponse au quiz clinique (33 min 00) Référence principale : Theriault G, Limburg H, Klarenbach S, Reynolds DL, Riva JJ, Thombs BD, et al. Recommendations on screening for primary prevention of fragility fractures. CMAJ. 2023;195(18):E639-E49. PubMed PMID: 37156553. Articles associés : https://frax.groupeetudecanadien.ca. https://gpevidence.org Metlay JP, Waterer GW. Time to Treat Severe Community-Acquired Pneumonia with Steroids? N Engl J Med. 2023;388(21):2001-2. PubMed PMID: 37224202. Pitre T, Abdali D, Chaudhuri D, Pastores SM, Nei AM, Annane D, et al. Corticosteroids in Community-Acquired Bacterial Pneumonia: a Systematic Review, Pairwise and Dose-Response Meta-Analysis. J Gen Intern Med. 2023:1-14. Epub 2023/04/20. doi: 10.1007/s11606-023-08203-6. PubMed PMID: 37076606. Sivapalan P, Ellekjaer KL, Jessen MK, Meyhoff TS, Cronhjort M, Hjortrup PB, et al. Lower vs Higher Fluid Volumes in Adult Patients With Sepsis: An Updated Systematic Review With Meta-Analysis and Trial Sequential Analysis. Chest. 2023. Epub 2023/05/05. doi: 10.1016/j.chest.2023.04.036. PubMed PMID: 37142091. Marcucci M, Painter TW, Conen D, Lomivorotov V, Sessler DI, Chan MTV, et al. Hypotension-Avoidance Versus Hypertension-Avoidance Strategies in Noncardiac Surgery : An International Randomized Controlled Trial. Ann Intern Med. 2023;176(5):605-14. PubMed PMID: 37094336. Gaba P, O’Donoghue ML, Park JG, Wiviott SD, Atar D, Kuder JF, et al. Association Between Achieved Low-Density Lipoprotein Cholesterol Levels and Long-Term Cardiovascular and Safety Outcomes: An Analysis of FOURIER-OLE. Circulation. 2023;147(16):1192-203. PubMed PMID: 36779348. Group RC. Higher dose corticosteroids in patients admitted to hospital with COVID-19 who are hypoxic but not requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trial. Lancet. 2023;401(10387):1499-507. PubMed PMID: 37060915. Xie Y, Bowe B, Al-Aly Z. Nirmatrelvir and risk of hospital admission or death in adults with covid-19: emulation of a randomized target trial using electronic health records. BMJ. 2023;381:e073312. PubMed PMID: 37041016. Kabore JL, Laffont B, Diop M, Tardif MR, Turgeon AF, Dumaresq J, et al. Real-World Effectiveness of Nirmatrelvir/Ritonavir on Covid-19-Associated Hospitalization Prevention: A Population-Based Cohort Study in the Province of Quebec, Canada. Clin Infect Dis. 2023. Epub 2023/05/07. doi: 10.1093/cid/ciad287. PubMed PMID: 37149726. Autres articles d’intérêt récent : Nissen SE, Lincoff AM, Brennan D, Ray KK, Mason D, Kastelein JJP, et al. Bempedoic Acid and Cardiovascular Outcomes in Statin-Intolerant Patients. N Engl J Med. 2023;388(15):1353-64. PubMed PMID: 36876740. Sorajja P, Whisenant B, Hamid N, Naik H, Makkar R, Tadros P, et al. Transcatheter Repair for Patients with Tricuspid Regurgitation. N Engl J Med. 2023;388(20):1833-42. PubMed PMID: 36876753. Bradbury AW, Moakes CA, Popplewell M, Meecham L, Bate GR, Kelly L, et al. A vein bypass first versus a best endovascular treatment first revascularisation strategy for patients with chronic limb threatening ischaemia who required an infra-popliteal, with or without an additional more proximal infra-inguinal revascularisation procedure to restore limb perfusion (BASIL-2): an open-label, randomised, multicentre, phase 3 trial. Lancet. 2023;401(10390):1798-809. PubMed PMID: 37116524. Guides de pratique : Rinella ME, Neuschwander-Tetri BA, Siddiqui MS, Abdelmalek MF, Caldwell S, Barb D, et al. AASLD Practice Guidance on the clinical assessment and management of nonalcoholic fatty liver disease. Hepatology. 2023;77(5):1797-835. PubMed PMID: 36727674. Borlaug BA, Sharma K, Shah SJ, Ho JE. Heart Failure With Preserved Ejection Fraction: JACC Scientific Statement. J Am Coll Cardiol. 2023;81(18):1810-34. PubMed PMID: 37137592. Référence du quiz clinique : Andrade JG, Aguilar M, Atzema C, Bell A, Cairns JA, Cheung CC, et al; Members of the Secondary Panel. The 2020 Canadian Cardiovascular Society/Canadian Heart Rhythm Society Comprehensive Guidelines for the Management of Atrial Fibrillation. Can J Cardiol. 2020;36(12):1847-1948. PubMed PMID: 33191198. Fanous Y, Dorian P. Lifestyle modification for the management of atrial fibrillation. CMAJ. 2020 Nov 16;192(46):E1469. PubMed PMID: 33199453. | — | ||||||
| 4/18/23 | BC 055 – Stéroïdes dans le traitement de la pneumonie acquise en communauté grave (étude CAPE COD) | Dans cette 55e baladodiffusion, les Drs Luc Lanthier et Michaël Mayette discutent de stéroïdes dans el traitement de la pneumonie acquise en communauté grave avec l’étude CAPE COD, en plus de réviser la littérature médicale de mars 2023. Quiz clinique (0 min 55), étude principale (1 min 23), critique (22 min 15), autres articles (31 min 24), réponse au quiz clinique (33 min 34) Référence principale : Dequin PF, Meziani F, Quenot JP, Kamel T, Ricard JD, Badie J, et al. Hydrocortisone in Severe Community-Acquired Pneumonia. N Engl J Med. 2023. Epub 2023/03/22. doi: 10.1056/NEJMoa2215145. PubMed PMID: 36942789. Articles associés : Metlay JP, Waterer GW, Long AC, Anzueto A, Brozek J, Crothers K, et al. Diagnosis and Treatment of Adults with Community-acquired Pneumonia. An Official Clinical Practice Guideline of the American Thoracic Society and Infectious Diseases Society of America. Am J Respir Crit Care Med. 2019;200(7):e45-e67. PubMed PMID: 31573350. Pastores SM, Annane D, Rochwerg B, Corticosteroid Guideline Task Force of S, Esicm. Guidelines for the diagnosis and management of critical illness-related corticosteroid insufficiency (CIRCI) in critically ill patients (Part II): Society of Critical Care Medicine (SCCM) and European Society of Intensive Care Medicine (ESICM) 2017. Intensive Care Med. 2018;44(4):474-7. PubMed PMID: 29090327. Meduri GU, Shih MC, Bridges L, Martin TJ, El-Solh A, Seam N, et al. Low-dose methylprednisolone treatment in critically ill patients with severe community-acquired pneumonia. Intensive Care Med. 2022;48(8):1009-23. PubMed PMID: 35723686. Saleem N, Kulkarni A, Snow TAC, Ambler G, Singer M, Arulkumaran N. Effect of Corticosteroids on Mortality and Clinical Cure in Community-Acquired Pneumonia: A Systematic Review, Meta-analysis, and Meta-regression of Randomized Control Trials. Chest. 2023;163(3):484-97. PubMed PMID: 36087797. Autres articles d’intérêt récent : Dhayat NA, Bonny O, Roth B, Christe A, Ritter A, Mohebbi N, et al. Hydrochlorothiazide and Prevention of Kidney-Stone Recurrence. N Engl J Med. 2023;388(9):781-791. PubMed PMID: 36856614. Shishehbor MH, Powell RJ, Montero-Baker MF, Dua A, Martínez-Trabal JL, Bunte MC, et al; PROMISE II Investigators. Transcatheter Arterialization of Deep Veins in Chronic Limb-Threatening Ischemia. N Engl J Med. 2023;388(13):1171-1180. PubMed PMID: 36988592. Guides de pratique : El-Hajj Fuleihan G, Clines GA, Hu MI, Marcocci C, Murad MH, Piggott T, et al. Treatment of Hypercalcemia of Malignancy in Adults: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2023;108(3):507-28. PubMed PMID: 36545746. Amin HP, Madsen TE, Bravata DM, Wira CR, Johnston SC, Ashcraft S, et al. Diagnosis, Workup, Risk Reduction of Transient Ischemic Attack in the Emergency Department Setting: A Scientific Statement From the American Heart Association. Stroke. 2023;54(3):e109-e21. PubMed PMID: 36655570. Fontana RJ, Liou I, Reuben A, Suzuki A, Fiel MI, Lee W, et al. AASLD practice guidance on drug, herbal, and dietary supplement-induced liver injury. Hepatology. 2023;77(3):1036-65. PubMed PMID: 35899384. Bass AR, Chakravarty E, Akl EA, Bingham CO, Calabrese L, Cappelli LC, et al. 2022 American College of Rheumatology Guideline for Vaccinations in Patients With Rheumatic and Musculoskeletal Diseases. Arthritis Rheumatol. 2023;75(3):333-348. PubMed PMID: 36597810. Référence du quiz clinique : Yaseen W, Auguste B, Zipursky J. Allopurinol hypersensitivity syndrome. CMAJ. 2023;195(13):E483. PubMed PMID: 37011932. FitzGerald JD, Dalbeth N, Mikuls T, Brignardello-Petersen R, Guyatt G, Abeles AM, et al. 2020 American College of Rheumatology Guideline for the Management of Gout. Arthritis Care Res (Hoboken). 2020 Jun;72(6):744-760. PubMed PMID: 32391934. Quach C, Galen BT. HLA-B*5801 Testing to Prevent Allopurinol Hypersensitivity Syndrome: A Teachable Moment. JAMA Intern Med. 2018;178(9):1260-1261. PubMed PMID: 30083702. | — | ||||||
| 3/21/23 | BC 054 – Stratégie d’hydratation dans l’hypotension provoquée par le sepsis (étude CLOVERS) | Dans cette 54e baladodiffusion, les Drs Luc Lanthier et Michaël Mayette discutent de stratégie d’hydratation dans l’hypotension septique avec l’étude CLOVERS, en plus de réviser la littérature médicale de février 2023. Quiz clinique (1 min 45), étude principale (2 min 15), critique (17 min 38), autres articles (23 min 23), réponse au quiz clinique (24 min 40) Référence principale : National Heart L, Blood Institute P, Early Treatment of Acute Lung Injury Clinical Trials N, Shapiro NI, Douglas IS, Brower RG, et al. Early Restrictive or Liberal Fluid Management for Sepsis-Induced Hypotension. N Engl J Med. 2023;388(6):499-510. PubMed PMID: 36688507. Articles associés : Meyhoff TS, Hjortrup PB, Wetterslev J, Sivapalan P, Laake JH, Cronhjort M, et al; CLASSIC Trial Group. Restriction of Intravenous Fluid in ICU Patients with Septic Shock. N Engl J Med. 2022;386(26):2459-2470. PubMed PMID: 35709019. Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, Peterson E, Tomlanovich M; Early Goal-Directed Therapy Collaborative Group. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med. 2001;345(19):1368-77. PubMed PMID: 11794169. de-Madaria E, Buxbaum JL, Maisonneuve P, Garcia Garcia de Paredes A, Zapater P, Guilabert L, et al. Aggressive or Moderate Fluid Resuscitation in Acute Pancreatitis. N Engl J Med. 2022;387(11):989-1000. PubMed PMID: 36103415. Autres articles d’intérêt récent : Wang Y, Li S, Pan Y, Li H, Parsons MW, Campbell BCV, et al. Tenecteplase versus alteplase in acute ischaemic cerebrovascular events (TRACE-2): a phase 3, multicentre, open-label, randomised controlled, non-inferiority trial. Lancet. 2023;401(10377):645-54. PubMed PMID: 36774935. Falsey AR, Williams K, Gymnopoulou E, Bart S, Ervin J, Bastian AR, et al. Efficacy and Safety of an Ad26.RSV.preF-RSV preF Protein Vaccine in Older Adults. N Engl J Med. 2023;388(7):609-20. PubMed PMID: 36791161. Papi A, Ison MG, Langley JM, Lee DG, Leroux-Roels I, Martinon-Torres F, et al. Respiratory Syncytial Virus Prefusion F Protein Vaccine in Older Adults. N Engl J Med. 2023;388(7):595-608. PubMed PMID: 36791160. Guides de pratique : Sengupta N, Feuerstein JD, Jairath V, Shergill AK, Strate LL, Wong RJ, et al. Management of Patients With Acute Lower Gastrointestinal Bleeding: An Updated ACG Guideline. Am J Gastroenterol. 2023;118(2):208-31. PubMed PMID: 36735555. Bedawi EO, Ricciardi S, Hassan M, Gooseman MR, Asciak R, Castro-Anon O, et al. ERS/ESTS statement on the management of pleural infection in adults. Eur Respir J. 2023;61(2). PubMed PMID: 36229045. Référence du quiz clinique : Ye F, Hatahet M, Youniss MA, Toklu HZ, Mazza JJ, Yale S. The Clinical Significance of Relative Bradycardia. WMJ. 2018;117(2):73-78. PubMed PMID: 30048576. | — | ||||||
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