Season 3 Episode 3 | Between Order and Chaos: Exploring the Entropic Brain

Season 3 Episode 3 | Between Order and Chaos: Exploring the Entropic Brain

From CortexCast - A Neuroscience Podcast by Oxford University

January 26, 2026 · 21 min

About this episode

This episode explores the Entropic Brain Hypothesis and its implications for understanding consciousness and mental states.

Why do psychedelics, dreams, and mental illnesses feel so different from everyday awareness? We unpack the Entropic Brain Hypothesis and what it tells us about flexibility, rigidity, and the architecture of conscious experience. Consciousness may not be a stable state, but a delicate balance between structure and freedom. In this episode, we explore the Entropic Brain Hypothesis - a framework proposing that the richness of conscious experience depends on how flexible and unpredictable brain activity becomes. Drawing on research into psychedelics, altered states, and psychiatric disorders, we discuss how shifts in brain entropy may underlie creativity, rigidity of thought, and therapeutic change, offering a new lens on the dynamics of the mind. Reference: Carhart-Harris, R.L. (2018) The entropic brain – revisited, Neuropharmacology, 142, pp. 167–178. https://doi.org/10.1016/j.neuropharm.2018.03.010

Topics covered

  • Entropic Brain Hypothesis
  • psychedelics
  • consciousness
  • mental illness
  • brain activity
  • creativity
  • rigidity of thought

Keywords

  • entropic brain
  • psychedelics
  • conscious experience
  • brain entropy
  • mental illness
  • creativity
  • rigidity

Mentioned in this episode

Organizations: Oxford University

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