Crucible Moments

Founder Matthew Rabinowitz opens up about the intensely personal journey that set him on a course to revolutionizing healthcare. A PhD in electrical engineering, he had no background in genetics or biology, but after his sister had a baby with Down syndrome that hadn’t been detected and tragically died after 6 days, Matthew dedicated himself to solving this problem. After overcoming seemingly impossible obstacles, today Natera leverages molecular biology and novel bioinformatics technology to provide prenatal screening in nearly half of U.S. pregnancies, as well as transforming oncology and organ transplants. Hear about Matthew’s vision for the future of computational biology and its profound impact on human health. Host: Roelof Botha, Sequoia Capital Featuring: Matthew Rabinowitz, Jonathan Sheena, Steve Chapman, Chitra Kotwaliwale, Sarah Elliot

DoorDash faced skeptics from the start. Grubhub, Delivery.com, and others were already addressing the restaurant delivery market when CEO Tony Xu and his co-founders started in 2013. But after talking to hundreds of local small businesses, they realized there was still an unmet need: None of the competitors solved the problem of delivery with an on-demand workforce, the way Uber had done with drivers. After struggling to raise initial funding, DoorDash found traction. But the next few years would prove tumultuous, with cash scarcity and investor skepticism putting the company perilously close to the brink. The founders’ contrarian decisions, clarity on their commitment to serve small local businesses, and ability to out-operate competitors has turned DoorDash into one the decade’s startup success stories. In this episode, Tony brings us inside their decision-making, and what DoorDash saw that others missed. Host: Roelof Botha, Sequoia Capital Featuring: Tony Xu, Keith Yandell, Miki Kuusi, Alfred Lin

Reddit is one of the largest and most culturally influential sites on the internet—and its journey is one of the most unusual company stories in internet history. College roommates Steve Huffman and Alexis Ohanian founded Reddit in 2005 and scaled it on a shoestring until Condé Nast acquired it the following year. Struggling for direction under its parent company, the founders left, and Condé Nast ultimately spun it out as an independent company once again. With Reddit buckling under user discontent in 2015, founder Steve Huffman returned as CEO to save the company and navigate the way forward. Over the following nine years, Reddit stabilized and the company’s revenue grew more than 50-fold to a successful IPO 19 years in the making. Host: Roelof Botha, Sequoia Capital Featuring: Steve Huffman, Alexis Ohanian, Chris Slowe, Jen Wong, Alfred Lin

In 2004, bankrupt after the company where he’d previously worked had imploded, Fred Luddy decided to start over as a first-time founder at age 50. His vision was to reinvent the nascent IT software field for the cloud era. What started as simple help desk replacement software would eventually become a ~$150B market cap company powering digital workflows across the enterprise—but success didn’t come easy. Initially bootstrapped and ultra-lean, the company’s infrastructure began buckling under its own success as customer demand spiked. When the legendary Frank Slootman joined as CEO to help scale the company, he describes being terrified to check his email every morning. Hear how Frank, Fred and the team stabilized the business, expanded their product offerings, and nearly made a $150B+ mistake by selling too early. Host: Roelof Botha, Sequoia Capital Featuring: Fred Luddy, Frank Slootman, Doug Leone, Pat Grady, Carl Eschenbach Transcript: https://www.sequoiacap.com/podcast/crucible-moments-servicenow/ 00:00 - Cold open 00:22 - Introduction 02:09 - Fred Luddy’s journey to coding 03:33 - Founding ServiceNow after financial ruin 07:11 - Finding product-market fit 15:16 - Finding a new CEO in Frank Slootman 22:19 - Overcoming scaling challenges 29:54 - Contemplating an acquisition offer 32:07 - Blocking the sale 38:17 - Lessons learned

Crucible Moments will be back shortly with season 2. You’ll hear from the founders of YouTube, DoorDash, Reddit, and more. In the meantime, we’d love to introduce you to a new original podcast, Training Data, where Sequoia partners learn from builders, researchers and founders who are defining the technology wave of the future: AI. The following conversation with Harrison Chase of LangChain is all about the future of AI agents—why they’re suddenly seeing a step change in performance, and why they’re key to the promise of AI. Follow Training Data wherever you listen to podcasts, and keep an eye out for Season 2 of Crucible Moments, coming soon. LangChain’s Harrison Chase on Building the Orchestration Layer for AI Agents Hosted by: Sonya Huang and Pat Grady, Sequoia Capital Mentioned: ReAct: Synergizing Reasoning and Acting in Language Models, the first cognitive architecture for agents SWE-agent: Agent-Computer Interfaces Enable Automated Software Engineering, small-model open-source software engineering agent from researchers at Princeton Devin, autonomous software engineering from Cognition V0: Generative UI agent from Vercel GPT Researcher, a research agent Language Model Cascades: 2022 paper by Google Brain and now OpenAI researcher David Dohan that was influential for Harrison in developing LangChain Transcript: https://www.sequoiacap.com/podcast/training-data-harrison-chase/

Millions of customers have explored their genome with 23andMe. But when the company started in 2006, the idea of consumer DNA testing was heresy to the medical establishment. The FDA once even ordered 23andMe to stop selling its health testing product. The company persevered to make allies out of adversaries, and became the only FDA-approved product on the market. Learn how 23andMe defined the DNA testing category, and used its success to enter the massive new field of drug discovery. Host: Roelof Botha, Sequoia Capital Featuring: Anne Wojcicki, Richard Scheller Transcript: https://www.sequoiacap.com/podcast/crucible-moments-23andMe/

Founders Brian Halligan and Dharmesh Shah reveal how they took a blog started as a hobby and turned the ideas behind it into a $20+ billion success. In 2006, HubSpot upended traditional approaches to marketing by taking advantage of the the nascent internet in a new way: By capitalizing on seach engines and social media, they offered a way to pull customers in rather than pushing ads and mailers out. They coined the new category “inbound marketing.” They continued to defy conventional wisdom, deciding to serve small businesses over big enterprises, and taking on a Goliath in a new category. As the founders explain, zigging where others zag is the key to their success. Host: Roelof Botha, Sequoia Capital Featuring: Brian Halligan, Dharmesh Shah, Pat Grady, Dannie Herzberg Transcript: https://www.sequoiacap.com/podcast/crucible-moments-hubspot/

CEO Jack Dorsey reflects on Block’s origins and defining moments with host Roelof Botha. Dorsey founded Square in 2009 with a clear vision: economic empowerment for all. Their dongle that turns iPhones into credit card readers was just the start. With Square, small business owners were able to reach more customers and better manage their companies. But when Cash App, which emerged from an internal hackathon, started to gain traction, Square had a decision to make: stick to their core focus, or risk building an unproven product for consumers? Dorsey explains how Block succeeded by weaving new products around a core vision, and how a controversial shift in strategy led them to fully deliver on their founding mission. Host: Roelof Botha, Managing Partner of Sequoia Capital Featuring: Jack Dorsey, Alyssa Henry, Brian Grassadonia