
How One Amino Acid Touches Two Aging Pathways
From Daily Value by William Wallace, Ph.D.
December 9, 2025 · 10 min
About this episode
This episode explores the unexpected effects of L-arginine on aging pathways and cognitive performance.
L-arginine is usually treated as a simple nitric-oxide precursor, a molecule with a narrow vascular role. But across multiple lines of research, it keeps appearing in places it shouldn’t: improving cerebral blood flow in older adults, shifting cognitive performance, and, most unexpectedly, altering how amyloid-β proteins aggregate in the brain. This episode unpacks why these effects are so unusual, and how they connect to the long-standing arginine paradox: the biochemical mismatch between ho...
People in this episode
Host: William Wallace
Topics covered
- aging
- cognitive performance
- vascular health
- nitric oxide
- brain health
- arginine paradox
Keywords
- L-arginine
- nitric oxide
- cerebral blood flow
- cognitive performance
- amyloid-β
- aging pathways
Mentioned in this episode
Products: L-arginine
Books & works: amyloid-β
More episodes of Daily Value
- Apigenin for Sleep and NAD+: Does It Hold Up? · June 2, 2026 · 13 min
- The Truth About Brain Magnesium · May 26, 2026 · 13 min
- Were We Wrong About Fish Oil and the Brain? · May 19, 2026 · 14 min
- The New Dietary Guidelines Controversy — Explained · January 12, 2026 · 13 min
- Fish Oil, Oxidation, and the Truth About “Rancidity” · January 5, 2026 · 9 min
- A Nutrient Mixture That Tunes Brain Signaling · December 12, 2025 · 9 min
Explore listener stats, chart rankings, contacts and more on the Daily Value podcast page.