Discovery

Have you ever been told you aren't good enough to do something, then gone ahead and proved the naysayers wrong by doing it anyway - in glorious, headline-grabbing style? That is the satisfying story of Dr Dean Lomax. Dean grew up in Doncaster with a passion for fossils but after failing various school exams, was told by teachers that he'd never make it as a palaeontologist. Undeterred by leaving school with no qualifications, Dean sold his childhood Star Wars collection to fund a fossil-hunting trip to America that changed his life - after which a chance discovery led to him publishing his first ever scientific paper at the age of just 20. Today, he’s an expert on ichthyosaurs - the massive marine reptiles that once inhabited our seas - and has discovered and named several new species, written books for both adults and children, and brought the prehistoric world to life on TV. Talking to Professor Jim Al-Khalili, Dean discusses dinosaurs as a 'gateway science', discovering the Rutland Sea Dragon and the importance of cutting out noise from nay-sayers to follow your dreams...

From humble beginnings in his native Sri Lanka, to a more than 40 year academic career at Queen’s University Belfast, Prof. AP (Amilra Prasanna) De Silva’s research into molecular photosensors has led to a pioneering career in that’s evolved from chemistry to medical diagnostics on one hand, to information processing on the other. Prof. De Silva challenged cultural expectations and overcame the lack of opportunities in chemistry that were available in Sri Lanka in the early 1970s. He first moved to Belfast to pursue research in photochemistry at Queen’s University. Inspired by his grandmother’s struggle with high blood pressure he engineered a unique sodium photosensor by marrying fluorescent molecules with chemical receptors. As a result of his international collaborations, a commercial, portable sensor was developed to detect salts and minerals in the blood. Its speed of analysis has since saved countless lives and improved healthcare around the world. AP talks to Jim Al-Khalili about his passion for engineering molecules and how his photochemical innovations have since crossed into computer science. They’ve been developed to perform molecular computations far inside the human body - where silicon microchips fear to tread. A new deeper understanding of life inside our tissues and cells beckons.

There are problems and tasks so hard and complicated that it would take today’s most powerful supercomputers millions of years to crack them. But in the next decade, we may well have quantum computers which could solve such problems in seconds.Professor Sir Peter Knight is a British pioneer in the realms of quantum optics and quantum information science. During his three decades as a researcher at Imperial College London, he has advanced our understanding of the physics which underpins how quantum computers work.Quantum optics was a new field of physics at the start of Peter Knight’s career in the early 1970s and he tells Jim Al-Khalili about the excitement and opportunities for a young scientist at the birth of a new scientific discipline. He also talks about the UK National Quantum Technologies Programme. Since his retirement in 2010, Peter Knight has been the driving force behind this £1 billion government-funded endeavour which has positioned the UK as a world leader in the development and commercialisation of quantum computing and other revolutionary quantum inventions.

The very latest developments in the world of space science with Roland Pease, recorded at the American Geophysical Union (AGU) meeting in New Orleans, where thousands of space and planetary scientists come together to promote discovery in space science for the benefit of humanity.Roland talks to Andy Rivkin, planetary astronomer at the Johns Hopkins University Applied Physics Laboratory, about planetary defence from asteroids, including the small potential for asteroid 2024 YR4 to hit the moon in 2032.We hear from Craig DeForest, principle investigator for the PUNCH mission (Polarimeter to Unify the Corona and Heliosphere), which is a constellation of four small satellites that aim to learn how the Sun's corona becomes the solar wind. And Lara Waldrop, principle investigator of the Carruthers Geocorona Observatory, discusses the Earth's exosphere which plays an important role in Earth’s response to space weather caused by the Sun.We also talk lunar earthquakes, or moonquakes, and plans to put seismometers on the moon to measure them with Philippe Lognonné, professor at Université Paris Cité and planetary seismologist at Institut de Physique du Globe de Paris, and Ceri Nunn, lunar seismologist from NASA Jet Propulsion Laboratory.Presenter: Roland Pease Producer: Jonathan Blackwell

"My ideas are often labelled as impossible, or useless, or both. Usually when people say that I'm on the right track." George Church is a geneticist, molecular engineer, and one of the pioneers of modern genomics. He's also someone who makes a habit of finding solutions to the seemingly impossible. Over the course of his career so far, George developed the first method for direct genomic sequencing, helped initiate the Human Genome Project, and founded the Personal Genome Project: making huge quantities of DNA data publicly available for research. Today, as a professor at Harvard Medical School and MIT, he’s working on some of the most headline-grabbing - and controversial - science on the planet: from the so-called "de-extinction" of woolly mammoths, to growing transplant-suitable organs in pigs, to virus-proofing humans. When inspiration strikes, there seems to be little that will slow him down - even the fact that he has narcolepsy, the neurological disorder that causes sudden sleep attacks. In fact, as George tells Professor Jim Al-Khalili, some of his best ideas come in those moments between waking and sleep...