Discovery

Imagine looking at a map of a city you thought you knew inside-out, only to discover a collection of tightly knit neighbourhoods that nobody had ever realised existed... Edith Heard has achieved something rather similar with DNA.Edith is a leading expert in epigenetics: put simply, the science around how our bodies can turn particular genes on or off without actually altering our DNA. She’s spent her career studying the mechanisms that make us who we are and transforming our understanding of how X chromosomes are expressed; notably, how female cells turn off the spare X chromosome.Talking to Professor Jim Al-Khalili, Edith discusses her journey from a shy and introverted youngster to the cutting edge of European science - including her latest role as Director of London’s prestigious Francis Crick Institute.

Here's a little fact you might have heard before: humans are around 70% water. About the same percentage as a sweet potato, incidentally. But what does that actually mean? Sure, there's blood, that accounts for some of it. And the lymphatic system has a fair amount too, sloshing around. There is water in each of our cells. But that does not add up to the full 70%, so where is the rest of it? In 2018, a scientific paper was published which gives a tantalising clue. The authors revealed for the first time that our 'interstitial spaces' - those gaps, between our bones and joints and all of our organs - spaces which are often sidelined in conventional anatomy - those spaces were full of a kind of soft, gel-like liquid. Flowing around the body. Bringing essential substances to where they are needed. Connecting all the disparate parts of us and communicating between them. They called this massive, fluid-filled system 'The Interstitium', and suggested that it might be a brand new, previously undiscovered organ. This moist, fibrous network seems to be important, in ways we still do not quite understand. It seems to have a key role in so many of our body's essential functions, from wound repair, to the maintenance of our body-clocks, to the spread of cancer from one tissue to another. And it is everywhere. Emily Knight takes a journey deep into the human body, into the ocean within us, the spaces in between the things we think of as 'us'. And discovers the way it flows, and the things that flow through it.

Design is never neutral and small choices can have a big impact. Dr Ella Hubber and journalist Katie Silver explore how consumer products marketed to women are frequently developed without fully understanding their needs. Along with expert insight, they look at everything from footwear based on male anatomy to menstrual products tested with unrealistic methods, revealing how these decisions can affect comfort, performance and even health.As awareness grows, they also ask what change can look like and whether everyday products can finally reflect women’s real needs.Presenter/producer: Ella Hubber Assistant Producer: Scarlett Victoria Researcher: Elliott Prince Editor: Ilan Goodman