Weird cfDNA Results and ISSUES: May 2026 Data

Weird cfDNA Results and ISSUES: May 2026 Data

From Dr. Chapa’s OBGYN Clinical Pearls by Dr. Chapa’s Clinical Pearls

May 6, 2026 · 25 min

About this episode

This episode reviews new findings and guidelines related to genome-wide noninvasive prenatal testing and its implications for pregnancy.

Genome-wide noninvasive prenatal testing (GW-NIPT) was introduced in 2015 and became widely available in 2019. Nonetheless, we are still learning more about this important prenatal screening test. In January 2026, the ACOG released a new PA on this, which we will also review in this episode. Our main publication ti review, however, will be the AJOG May 2026’s systematic review and meta-analysis on the finding of “genome-wide” cfDNA discordant results and what this may mean for the pregnancy. Although rare, this may lead (over a third of cases) to some adverse perinatal issues. Listen in for details. 1. ACOG PA Jan 2026: Screening for Fetal Chromosomal Abnormalities 2. AJOG May 2026: https://click.notification.elsevier.com/CL0/https:%2F%2Fwww.ajog.org%2Farticle%2FS0002-9378(25)00865-8%2Ffulltext%3Fdgcid=raven_jbs_etoc_email/1/0100019d9ec37d7b-c586438d-021a-4097-8db3-c158e6f97c9b-000000/Vq6ksekOuvTxcv8OEZZ2uBesCg_hG6qlhqU_BlCnAK4=452

People in this episode

Host: Dr. Chapa

Topics covered

  • noninvasive prenatal testing
  • cfDNA results
  • prenatal screening
  • perinatal issues
  • systematic review
  • meta-analysis

Keywords

  • cfDNA
  • prenatal testing
  • ACOG
  • AJOG
  • perinatal issues
  • genome-wide
  • discordant results

Mentioned in this episode

Organizations: ACOG

Products: GW-NIPT

Books & works: AJOG May 2026

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