Weird cfDNA Results and ISSUES: May 2026 Data

About this episode

This episode reviews new findings on genome-wide cfDNA discordant results and their implications for pregnancy.

Genome-wide noninvasive prenatal testing (GW-NIPT) was introduced in 2015 and became widely available in 2019. Nonetheless, we are still learning more about this important prenatal screening test. In January 2026, the ACOG released a new PA on this, which we will also review in this episode. Our main publication ti review, however, will be the AJOG May 2026’s systematic review and meta-analysis on the finding of “genome-wide” cfDNA discordant results and what this may mean for the pregnancy. Although rare, this may lead (over a third of cases) to some adverse perinatal issues. Listen in for details. 1. ACOG PA Jan 2026: Screening for Fetal Chromosomal Abnormalities 2. AJOG May 2026: https://click.notification.elsevier.com/CL0/https:%2F%2Fwww.ajog.org%2Farticle%2FS0002-9378(25)00865-8%2Ffulltext%3Fdgcid=raven_jbs_etoc_email/1/0100019d9ec37d7b-c586438d-021a-4097-8db3-c158e6f97c9b-000000/Vq6ksekOuvTxcv8OEZZ2uBesCg_hG6qlhqU_BlCnAK4=452

People in this episode

Host: Hector Chapa

Topics covered

• noninvasive prenatal testing
• cfDNA results
• prenatal screening
• perinatal issues
• genome-wide testing

Keywords

• cfDNA
• prenatal testing
• ACOG
• AJOG
• perinatal issues
• genome-wide
• screening

Mentioned in this episode

Organizations: ACOG

Books & works: AJOG May 2026

More episodes of Dr. Chapa's OBGYN No Spin Podcast

• 2026 Lp(a), AHA, and OBG: What Now? · June 12, 2026 · 27 min
• CS: UT in or UT out? New July 2026 Data · June 10, 2026 · 15 min
• SHOCKING: ACSs INCREASE Risk in Twins? (Listen in) · June 8, 2026 · 16 min
• 5mm v 1-cm Fascial Closure at CS: MINI EPISODE · June 6, 2026 · 3 min
• NIPT CONFIRM Test SPECIAL GUEST: Blurring the Line between Screening & Confirmation of Fetal Aneuploidy · June 5, 2026 · 23 min
• OB, ED, and STDs: Gaps Noted! · June 3, 2026 · 14 min