Generating Alpha Podcast

This week on Generating Alpha, I sat down with Christian Angermayer — serial entrepreneur, biotech pioneer, and founder of Apeiron Investment Group, one of the most unconventional private investment firms in the world.Christian grew up in a small town in Bavaria and dropped out of university at 20 to co-found Ribopharma, a biotech built on groundbreaking RNA interference technology. He sold it to Alnylam Pharmaceuticals before turning 25, and has spent the two decades since founding three unicorns, backing four more, and completing over 50 IPOs and M&A transactions across life sciences, fintech, crypto, and frontier technology.His most defining chapter has been psychedelics. At a time when psilocybin was still considered fringe science, Christian seed-funded Compass Pathways and founded atai Life Sciences — taking it public on Nasdaq at a $3.2 billion valuation — almost single-handedly transforming psychedelic medicine from a relic of the 1960s into one of the most compelling frontiers in modern psychiatry.His latest bet is just as bold. This past Friday, Enhanced Games — his performance-enhancing-drug-permitted alternative to the Olympics that doubles as a performance medicine and telehealth platform — debuted on the NYSE at a $1.2 billion valuation.In our conversation, we talked about betting on ideas before the world is ready, building and IPOing companies across entirely different industries, the science and philosophy behind the psychedelic renaissance, and what Enhanced Games is actually building beyond the headlines.It's a rare look inside the mind of a builder who keeps finding the future before anyone else does.

This week on Generating Alpha, I sat down with Fabrice Grinda — serial entrepreneur, prolific angel investor, and founding partner of FJ Labs, one of the most active venture funds in the world with over 1,100 investments across six continents.Fabrice grew up in Nice, France, the son of a doctor. He arrived at Princeton, graduated summa cum laude in economics, and was already running his first business — Princeton International Computers, exporting hardware to Europe — before he had his degree. He spent a matter of months at McKinsey before walking away at 23 to launch Aucland, a direct eBay competitor in France that became one of Europe's largest auction sites. From there he built Zingy, a mobile media company he scaled to $200 million in revenue in four years, before founding OLX in 2006 — a classified ads marketplace that grew to 350 million monthly users across 40 countries and became one of the most trafficked websites on the internet.Along the way, he tried to buy the Alibaba.com domain from an unknown Jack Ma — and ended up an early investor in Alibaba instead. Forbes later named him the #1 angel investor in the world. Today, through FJ Labs, he has made over 1,100 investments and seen more than 300 exits — backing companies like Coupang, Delivery Hero, and Rappi — all without leading rounds, taking board seats, or spending more than two calls on a decision.But what makes Fabrice genuinely singular isn't just the track record. It's the intentionality behind it. In 2012, he gave away all his possessions. He's designed his life around Turks & Caicos, New York, and Revelstoke, optimizing not for accumulation but for happiness on his own terms.In our conversation, we talked about growing up in France and catching the entrepreneurship bug early, what he learned from nearly going bankrupt and borrowing on credit cards to make payroll, the contrarian logic behind launching OLX in over 100 countries simultaneously, his pattern recognition for great marketplace businesses at the seed stage, why his two-call investment model is a feature and not a bug, and how he thinks about designing a life most people never consider.It's a rare look inside one of the most prolific and unconventional investing minds of his generation — and a masterclass in building wealth, companies, and a life entirely on your own terms.Presented by: ⁠rho.co/generatingalpha⁠

This week on Generating Alpha, I sat down with Yoni Assia, co-founder and CEO of eToro, the platform that has fundamentally changed how a generation approaches investing.Yoni's story begins in Savyon, Israel, where finance was in the air from childhood — his father founded Magic Software and would pull over the car to read stock quotes with his kids, while his mother ran a copyright law firm. After serving as a programmer in the IDF and earning dual degrees in Management and Computer Science, he got his first taste of product-building with CDRide, selling on-ride videos to people coming off roller coasters. In 2007, he co-founded eToro with his brother Ronen and friend David Ring. Then 2008 hit — and watching the global financial system freeze in real time only sharpened his conviction that markets needed to be opened up for everyone.What emerged was revolutionary. In 2010, eToro launched CopyTrader, allowing everyday investors to automatically replicate the strategies of the world's best traders. The idea helped define an entirely new category — social investing — and the platform has since grown to over 40 million registered users across more than 100 countries, going public on Nasdaq in May 2025 at a valuation of $5.64 billion. Along the way, Yoni collaborated with a young Vitalik Buterin on the Colored Coins project in 2012, years before Ethereum existed, and spent three hours at dinner with Warren Buffett in 2020 making the case for the future of finance.In our conversation, we explored that journey in full — the crises navigated, the breakthroughs earned, and what nearly two decades of building alongside his brother actually looks like. We also discussed how eToro has survived crypto winters, regulatory battles, and multiple market crashes, what Yoni took away from his dinner with Buffett, and the advice he'd give to a 16-year-old who wants to make their mark on the world.Presented by: rho.co/generatingalpha

This week on Generating Alpha, I sat down with Peter Muller, founder and CEO of PDT Partners, one of the most successful and secretive quantitative trading firms in modern finance.Pete's journey is unlike any other on Wall Street. After graduating with honors in mathematics from Princeton, he moved to California to compose music for rhythmic gymnastics teams before landing at BARRA, where he discovered his passion for quantitative finance. In 1993, he pitched Morgan Stanley with a radical idea: using quantitative models rather than human traders to manage portfolios. They gave him two years to make it work. He founded Process Driven Trading (PDT) and built it into a legendary operation that reportedly generated over $20 billion in cumulative profits before spinning out as an independent firm in 2012.What made PDT extraordinary wasn't just the returns—reportedly averaging over 20% annually through 2010—it was the culture. Pete recruited physicists, mathematicians, and unconventional thinkers who thrived in an environment valuing precision and innovation, maintaining consistent performance through multiple market cycles while staying almost entirely out of the public eye.Beyond finance, Pete is an accomplished singer-songwriter and pianist who has released six albums, performed at the Montreux Jazz Festival, and famously busked in New York City subways. He creates crossword puzzles for The New York Times, serves as a trustee of Berklee College of Music, and co-founded Math for America.In our conversation, we explored how Pete builds models that actually work, manages risk through volatile markets, and created a culture that attracts the brightest minds in finance. We also discussed the parallels between music and quantitative trading, and why the best strategies come from asking better questions.It's an extraordinary window into one of finance's most brilliant and enigmatic minds.Presented by: rho.co/generatingalpha

This week on Generating Alpha, I sat down with Keith Rabois, Managing Director at Khosla Ventures and one of the most accomplished operators and investors in Silicon Valley history.Keith's path was unconventional. After studying political science at Stanford, where he met Peter Thiel and worked on The Stanford Review, he graduated from Harvard Law School, clerked for the U.S. Court of Appeals for the Fifth Circuit, and practiced as a litigator at Sullivan & Cromwell. That legal foundation became the bedrock for an exceptional career at the intersection of building and investing.Keith started in tech as an executive at PayPal, then moved to LinkedIn as VP of Business and Corporate Development before becoming COO of Square, helping scale the company through its critical growth years. His operating experience is matched by an extraordinary investing track record. At Khosla Ventures, he led the first institutional investments in DoorDash, Affirm, and Faire, invested early in Stripe, and co-founded Opendoor. At Founders Fund, he led investments in Ramp, Trade Republic, and Aven, and made early personal investments in YouTube, Airbnb, Palantir, Lyft, and Eventbrite. He has ranked as high as number four on the Forbes Midas list in the U.S. and number eight globally. In 2021, he co-founded OpenStore, and recently returned to Opendoor's board as Chairman.In our conversation, we explored how Keith thinks about identifying asymmetric opportunities and how he evaluates talent at the earliest stages. We also discussed his framework for being a great seed investor and why the best people frame themselves as not just the best, but the only.It's a rare look at one of Silicon Valley's most influential builders and a masterclass in execution, leverage, and long-term value creation.Presented by: rho.co/generatingalpha

This week on Generating Alpha, I sat down with Ryan Tolkin — CEO of Schonfeld, a multi-billion dollar alternative asset manager that has quietly become one of the most powerful and consistent forces in the hedge fund industry.Ryan's history with the firm dates back to a high school internship, where his analytical talent was first spotted. He joined the firm as Chief Investment Officer at 27, a role he ascended to just a few years out of college, demonstrating a precocious understanding of risk and capital markets. It was under his leadership that Schonfeld transitioned from a proprietary family office to a major global player, making the pivotal decision to accept outside, third-party capital in 2016 and build the multi-strategy platform we know today.We discussed how his early experiences—from trading (perhaps even starting with baseball cards) to managing risk at a young age—shaped his systematic approach to portfolio management.In our conversation, we spoke about how Schonfeld designs its platform to maximize manager performance and minimize drawdowns, what it takes to seperate signal from noise in todays age, and the habits and mindset required to compound advantage over decades in a highly competitive industry.It’s a rare look inside the thinking of a modern hedge fund leader helping shape the next generation of top portfolio managers—and the quiet architecture behind enduring success.Presented by: rho.co/generatingalpha

This week on Generating Alpha, I sat down with Antonio Gracias — one of the few true first-principles thinkers in modern business and a key architect behind some of the most transformative companies of the 21st century.A student of physics and the human brain, Gracias began his career as an operator — stepping into distressed and underperforming businesses and engineering turnarounds through discipline, systems thinking, and relentless execution. He eventually founded Valor Equity Partners, which became one of the earliest and most influential growth investors in America.At Valor, Gracias backed a generation-defining wave of companies long before they were obvious — including Tesla, SpaceX, and other frontier-technology firms that now shape global industry. Beyond capital, he played hands-on operational roles inside several of these businesses, guiding teams through scaling challenges, manufacturing complexity, and strategic inflection points.In our conversation, we spoke about his analytical approach to problem-solving, what he learned from years spent fixing broken companies, the mental models he relies on when backing founders like Elon Musk, and how he evaluates technologies that could define the next several decades.It’s a rare look inside the mindset of an investor-operator who has quietly influenced industries from electric vehicles to space exploration — and whose first-principles approach continues to shape some of the most ambitious companies on the planet.

This week on Generating Alpha, I’m joined by Jeff Yass — founder of Susquehanna International Group, one of the most successful trading firms in the world.Jeff is a former professional poker player and horse bettor turned options trader. In 1987, he founded Susquehanna with five friends, and today it stands as one of Wall Street’s largest and most influential firms. Thanks to Susquehanna’s success and its early stake in ByteDance, Jeff is now the 26th wealthiest person in the world — yet remains one of the most private figures in finance.In one of his first-ever podcast interviews, we spent 25 minutes focused entirely on prediction markets — why Jeff believes they represent the future of truth-seeking, how firms like Susquehanna will shape their evolution, and what obstacles still stand in the way of mass participation.We also discussed whether some decisions shouldn’t be quantified, how to protect markets from manipulation, and Jeff’s advice for students on what to study in 2025.Presented By: Rho.co/generatingalpha

This week on Generating Alpha, I’m joined by Mickey Drexler — one of the most legendary figures in modern retail. Best known for transforming Gap into a global powerhouse and later reinventing J.Crew into a cultural phenomenon, Drexler has earned the nickname “The Merchant Prince” for his unparalleled ability to read consumers, build brands, and shape culture. Over decades, his vision has not only changed how America shops, but also redefined what it means to lead with instinct and creativity in business.In this first part of our conversation, Mickey reflects on his childhood in the Bronx, including his tough relationship with his father and the values that came from growing up in a working-class family. He shares how those early struggles instilled resilience, independence, and a relentless drive to prove himself — qualities that became central to his career.We trace his unlikely entry into retail, beginning with his very first job at a department store, where he developed a fascination with customers and the details of the shopping experience. From there, Mickey rose through the ranks of the fashion world, eventually becoming CEO of Ann Taylor, where he sharpened the instincts and discipline that would later serve as the foundation for his industry-defining work at Gap and J.Crew.We also dive into Mickey’s people philosophy — why he believes in being brutally honest, how he quickly assesses whether someone is the right fit, and why it rarely takes him more than a few minutes to form a judgment. His candid perspective on leadership and human behavior offers timeless lessons for anyone navigating business, management, or life.

This week on Generating Alpha, I’m joined by Larry Silverstein, one of New York’s most influential real estate developers and the Chairman of Silverstein Properties. Over the course of his career, Larry has transformed the skyline of Manhattan, developing and managing some of the city’s most iconic office and residential towers. He is best known for his pivotal role in rebuilding the World Trade Center after 9/11 — a project that became both a personal mission and a symbol of resilience for New York City.Larry’s journey is a story of perseverance and vision. From modest beginnings in Brooklyn, he built a career marked by bold deals, steady leadership, and an unwavering commitment to New York. His story spans the purchase of his very first building, the challenges and triumphs of his early ventures, and the defining moment of taking on the responsibility to rebuild Lower Manhattan in the wake of tragedy.In this conversation, we dive into Larry’s early life and career, the lessons he learned from his first projects, and the vision that has guided him for decades in real estate. We also explore how he navigated the extraordinary challenge of leading the World Trade Center redevelopment, his philosophy on resilience and leadership, and the wisdom he has drawn from a lifetime shaping the future of New York City.

This week on Generating Alpha, I’m joined by Michael Chu — Global Co-CEO of L Catterton, the world’s largest consumer-focused private equity firm with more than $35 billion under management. Over three decades, Michael has helped transform L Catterton from a boutique investor into a global powerhouse with offices across North America, Europe, Asia, and Latin America. Known for his deep understanding of consumer behavior and brand equity, he has built a reputation as one of the foremost thinkers on what makes businesses not just succeed, but endure.At L Catterton, Michael has overseen investments in some of the world’s most iconic consumer brands, including Restoration Hardware, Birkenstock, Equinox, Peloton, and Vitamin Water. His career reflects a unique blend of financial expertise and behavioral insight, giving him a front-row seat to how timeless brands are built, scaled, and kept relevant across generations.In this conversation, we explore the principles that separate enduring brands from fleeting trends, the lessons Michael has learned from scaling L Catterton into a global leader, and the challenges of maintaining cultural relevance over time. We dive into his perspective on the future of consumer investing, what he believes defines the next wave of iconic brands, and the timeless insights he’s gained about growth, resilience, and long-term success in the consumer space.

This week on Generating Alpha, I’m joined by Barry Sternlicht — founder, chairman, and CEO of Starwood Capital Group, and one of the most accomplished real estate investors ever. Since founding the firm in 1991, Barry has grown Starwood into a global powerhouse with over $100 billion in assets under management, investing across every major real estate class. He has created and managed more than 80,000 hotels, multifamily, and residential units worldwide, while launching iconic hospitality brands like W Hotels, St. Regis, and 1 Hotels, redefining the way design and brand intersect with real estate.Barry’s accomplishments extend far beyond hospitality. Under his leadership, Starwood has executed transactions totaling hundreds of billions of dollars, spanning hotels, residential, office, retail, and industrial properties. He has been recognized repeatedly as one of the most influential figures in real estate, known for his contrarian eye, his ability to anticipate market cycles, and his pioneering focus on sustainable development years before it became mainstream.In our conversation, Barry reflects on a childhood shaped by resilience and early entrepreneurial ventures, the pivotal lessons he learned working under Neil Bluhm at JMB, and the rise of Starwood Hotels. We also dive into the biggest risks and near misses of his career, his philosophy on evaluating deals and negotiation, and the timeless advice he’d give to the next generation of leaders and entrepreneurs.