
AlphaFold: Grand Challenge to Nobel Prize with John Jumper
From Google DeepMind: The Podcast by Hannah Fry
November 28, 2025 · 47 min · Episode 25
About this episode
John Jumper discusses the impact of AlphaFold on science and his experience winning the Nobel Prize.
Five years ago, AlphaFold 2 solved the protein structure prediction problem, unlocking new avenues of biological research and providing our first major proof point that AI can be a powerful tool to advance science. The profound scientific and societal value of this work was even recognized in 2024 with the Nobel Prize in Chemistry. In this episode, Hannah is joined by John Jumper, one of the most instrumental scientists behind AlphaFold. He shares stories about his Nobel win, the tool's unexpected applications, and the shift in architecture from AlphaFold 2 to the more comprehensive AlphaFold 3.
People in this episode
Host: Hannah Fry
Guest: John Jumper
Topics covered
- protein structure prediction
- AI in science
- Nobel Prize
- biological research
- AlphaFold
Keywords
- AlphaFold
- protein structure
- AI
- Nobel Prize
- biological research
- AlphaFold 2
- AlphaFold 3
Mentioned in this episode
Books & works: AlphaFold, AlphaFold 2, AlphaFold 3
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