Mast Cell Activation and Histamine Intolerance with Dr. Kelly McCann

Mast Cell Activation and Histamine Intolerance with Dr. Kelly McCann

From Healing Powers Podcast by Laura Powers

March 9, 2026 · 46 min

About this episode

Laura Powers interviews Dr. Kelly McCann about mast cell activation syndrome and histamine intolerance, discussing their impact on health and chronic symptoms.

In this episode of the Healing Powers Podcast, host Laura Michelle Powers speaks with medical doctor and functional medicine expert Dr. Kelly McCann about mast cell activation syndrome (MCAS), histamine intolerance, and the growing number of people experiencing unexplained chronic symptoms. Although mast cell activation was only first described in medical literature in 2007, research suggests that up to one in five people may be affected. Dr. McCann explains how mast cells—an important part of the immune system—can become overly reactive due to environmental toxins, mold exposure, infections, stress, and trauma. When this happens, it can trigger widespread inflammation throughout the body and lead to symptoms such as allergies, brain fog, digestive issues, insomnia, migraines, anxiety, and fatigue. Laura also shares her own experiences with mold exposure and sensitivities, highlighting how many people struggle to get answers through conventional testing. Learn more about Dr. Kelly McCann at thespringcenter.com As Dr. Kelly referenced, you can find more information and locate mold-aware professionals through the International Society for Environmentally Acquired Illness (ISEAI)…

People in this episode

Host: Laura Michelle Powers

Guest: Dr. Kelly McCann

Topics covered

  • mast cell activation
  • histamine intolerance
  • chronic symptoms
  • functional medicine
  • environmental toxins

Keywords

  • mast cell activation
  • histamine intolerance
  • chronic symptoms
  • functional medicine
  • environmental toxins
  • mold exposure
  • inflammation

Mentioned in this episode

Organizations: The Spring Center, International Society for Environmentally Acquired Illness

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