The Sequential Organ Failure Assessment (SOFA)-2 Score
From Healthy Dialogue by JAMA Network
October 29, 2025 · 16 min
About this episode
The episode discusses the SOFA-2 score and its predictive validity for ICU mortality with coauthor Mervyn Singer.
SOFA-2, validated in more than 3 million intensive care unit (ICU) patients, incorporates contemporary organ support treatments, showing strong predictive validity for ICU mortality in diverse international settings. Coauthor Mervyn Singer, MD, joins JAMA Associate Editor Christopher W. Seymour, MD, MSc, to discuss. Related Content: Rationale and Methodological Approach Underlying the Development of the Sequential Organ Failure Assessment (SOFA)–2 Score Development and Validation of the Sequential Organ Failure Assessment (SOFA)-2 Score A Revision to Organ Failure Assessment in Critically Ill Patients
People in this episode
Hosts: Christopher W. Seymour, MD, MSc, Christopher W. Seymour
Guests: Mervyn Singer, MD, Mervyn Singer
Topics covered
- ICU mortality
- organ failure assessment
- SOFA-2 score
- critical care
- predictive validity
Keywords
- SOFA-2
- ICU
- organ support
- mortality prediction
- critical illness
Mentioned in this episode
Organizations: JAMA Network
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