
Episode #47: Lean Mass Hyper-Responders
From Influenced to Death by Hannah Wright & Victoria LaFont
November 2, 2025 · 1h 13m
About this episode
The episode discusses lean mass hyper-responders and the implications of high LDL cholesterol in the context of low-carb and high-fat diets.
In this episode, Victoria & guest co-host Amanda Jones get to speak with John O’Connor, founder of Gene Food , Integrative Health Coach, and all-around excellent thinker. Today’s primary topic is lean mass hyper-responders (LMHR), a subset of lean people who, when they eat a low-carbohydrate, high-fat diet (LCHF), experience a massive increase in LDL cholesterol. Even though this group is relatively small, the concepts discussed apply to anyone interested in using a ketogenic or low-carb/high-fat diet, or any therapeutic diet (such as Carnivore, vegan, AIP, etc.), in a way that considers both the benefits and the risks. They cover: * Who are the lean mass hyper-responders and why you should care * Is unlimited saturated fat beneficial? Harmless? For everyone? * The KETO-CTA study * You can find critiques of the study on John’s website here and also a more technical but really excellent write-up from Alex Leaf here. * Saturated Fats and Health: A Reassessment and Proposal for Food-Based Recommendations: JACC State-of-the-Art Review * Why some people in the keto/low-carb community might be pushing so hard against the risk of elevated LDL cholesterol, and continue promoting and…
People in this episode
Host: Victoria LaFont
Guests: Amanda Jones, John O’Connor
Topics covered
- lean mass hyper-responders
- low-carbohydrate diet
- high-fat diet
- LDL cholesterol
- saturated fat
- keto diet
- health risks
Keywords
- lean mass hyper-responders
- LDL cholesterol
- low-carb diet
- high-fat diet
- keto
- saturated fat
- health risks
- dietary guidelines
Mentioned in this episode
Organizations: Gene Food
Books & works: Saturated Fats and Health: A Reassessment and Proposal for Food-Based Recommendations: JACC State-of-the-Art Review, KETO-CTA study
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- Episode #50: Coffee, Conspiracies, & the Cost of Certainty · January 24, 2026 · 1h 2m
- Episode #49: IV Nutrient Therapy · January 9, 2026 · 1h 15m
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