Breaking News: A Game-Changing Treatment for Pancreatic Cancer with Dr. Mark Lewis
From Knock Knock, Hi! with the Glaucomfleckens by Human Content
June 11, 2026 · 37 min
About this episode
Dr. Mark Lewis discusses a groundbreaking treatment for pancreatic cancer that has shown remarkable results.
We're dropping this bonus episode because something genuinely historic happened in oncology and we couldn't wait until our regular schedule to talk about it. Dr. Mark Lewis, GI medical oncologist, pancreatic cancer survivor, and one of our absolute favorite guests. He just got back from ASCO, the Super Bowl of oncology, where a new drug called daraxonrasib received one of only about six standing ovations in the conference's history, including applause that broke out mid-sentence when researchers showed the survival data on-screen. The drug targets a mutation that drives the vast majority of pancreatic cancer and has been considered "undruggable" for decades and it works not by attacking the mutation directly, but by cutting off the downstream signals it sends, like snipping the wire instead of fighting with the switch. The results are remarkable. In patients who had already received standard chemotherapy, daraxonrasib roughly doubled survival time and delivered it in pill form rather than an IV every two weeks, a meaningful quality-of-life difference for people who are already facing the hardest year of their lives. Mark walks us through the science, the side effects (rash…
People in this episode
Guest: Dr. Mark Lewis
Topics covered
- pancreatic cancer
- oncology
- new treatments
- survival rates
- FDA approval
Keywords
- pancreatic cancer
- daraxonrasib
- oncology
- survival data
- FDA approval
- KRAS mutations
- chemotherapy
Mentioned in this episode
Organizations: ASCO
Products: daraxonrasib
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