Polygenics and Machine SuperIntelligence; Billionaires, Philo-semitism, and Chosen Embryos – #102
From Manifold by Steve Hsu
January 1, 2026 · 1h 0m · Season 2
About this episode
The episode discusses breakthroughs in polygenic embryo screening and AI capabilities, making predictions for the future.
This is a two-part episode. The first ~30m covers the most important 2025 breakthroughs in polygenic embryo screening, while the second 30m focuses specifically on AI capabilities at the frontier of human knowledge. Both segments make predictions for 2026 and beyond. Links: Chinese billionaires, Philo-semitism, and the Chosen embryos: https://x.com/hsu_steve/status/2000206116823675078 My talk from Reproductive Frontiers 2025 in Berkeley: https://www.youtube.com/watch?v=n64rrRPtCa8 Previous episodes on frontier AI capabilities in math and theoretical physics https://www.manifold1.com/episodes/theoretical-physics-with-generative-ai-101 https://www.manifold1.com/episodes/ais-win-math-olympiad-gold-prof-lin-yang-ucla-97 Chapter Markers: (00:00) - Introduction (02:22) - Advancements in Polygenic Prediction of Human Traits (03:20) - Polygenic Risk Scores in Healthcare (08:15) - Embryo Selection and IVF (20:37) - Public Perceptions: billionaires and FOMO (31:40) - AI advances in 2025: High end capabilities and use of AI at the frontier of human knowledge (55:33) - Conclusion and predictions for 2026 – Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics…
People in this episode
Host: Steve Hsu
Topics covered
- polygenic embryo screening
- AI capabilities
- billionaires
- philo-semitism
- predictions for 2026
Keywords
- polygenic prediction
- embryo selection
- AI advancements
- billionaires
- healthcare
Mentioned in this episode
Organizations: Michigan State University, SuperFocus.ai, SafeWeb, Genomic Prediction, Othram
Places: Berkeley
More episodes of Manifold
- Letter from Beijing 2: Tsinghua University – #113 · June 4, 2026 · 1h 21m
- AI Billionaire on Existential Risk: Jaan Tallinn · May 21, 2026 · 1h 41m
- Embryo Selection and Frontier Genomics with Dr. Alex Young – #111 · May 7, 2026 · 1h 31m
- Iran War is the First Missile War (crossover with Seeking Truth From Facts podcast) – #110 · April 23, 2026 · 49 min
- Dreamers and Doomers: Our AI future, with Richard Ngo – #109 · April 9, 2026 · 1h 52m
- China, Acceleration, and Nick Land - with Matt Southey – #108 · March 26, 2026 · 1h 4m
Explore listener stats, chart rankings, contacts and more on the Manifold podcast page.