Osmosis Jones (2001)

Osmosis Jones (2001)

From Mostly Murder (But Sometimes Not) by The O'Brien Siblings

June 3, 2026 · 1h 38m · Season 1 · Episode 127

About this episode

The episode discusses the 2001 film Osmosis Jones, exploring its tonal disconnection, humor, and cultural implications.

New episode out now! We try to go viral with the 2001 partially-animated comedy Osmosis Jones . We delve into how the live action and animation feel so disconnected tonally, discuss how we did enjoy the worldbuilding and the sheer amount of puns and visual jokes, thought the music choices were not appropriate, and share how we were also just really, really, really grossed out. We talk about why children would watch this in school, despair at the racist shorthand so common in children’s media of this time, lament the parentification of Shane and wish her dad was better, and ultimately feel this was an interesting idea that was just not executed well. Katy brings up Buffy again, Carrie auditions for The Pitt , Maddy gives an interesting review of B-Dubs, and Mack has an apology to prepare for the afterlife. We also reiterate that farts are funny, learn about species-typical behavior, get excited about a hive mind, and are semi-confident in our knowledge of the human body. Listen to hear more about symptom management, Disney sequels, Laurence Fishburne, mente de gorila, the hypothalamus, mayoneggs, and scheming little brothers. And eat more fiber! Enjoy! TW: Statutory rape, racism…

People in this episode

Host: The O'Brien Siblings

Topics covered

  • animation
  • comedy
  • children's media
  • worldbuilding
  • cultural commentary

Keywords

  • Osmosis Jones
  • animation
  • comedy
  • children's media
  • cultural commentary
  • worldbuilding
  • puns
  • visual jokes

Mentioned in this episode

Books & works: Osmosis Jones

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