157: Clinical Advances and Unanswered Questions in Narcolepsy

About this episode

This episode discusses the evolution of clinical understanding of narcolepsy, including advances in diagnosis and treatment, and explores remaining gaps and misconceptions in the field.

Welcome to the NeurologyLive ® Mind Moments® podcast. Tune in to hear leaders in neurology sound off on topics that impact your clinical practice. In this episode, "Clinical Advances and Unanswered Questions in Narcolepsy," Lindsay McCullough, MD, discusses how clinical understanding of narcolepsy has evolved, where major diagnostic and treatment advances have occurred, and where important gaps remain. McCullough, assistant professor of medicine and associate program director for the sleep medicine fellowship at Rush University, reflects on progress in defining narcolepsy subtypes, the growing role of orexin biology, and how recent research in 2025 has reshaped conversations around disease-modifying approaches. The discussion also explores emerging links between sleep disorders and neurodegenerative disease, common misconceptions that continue to delay diagnosis, and how clinician education can improve recognition, safety, and long-term management of patients with narcolepsy. Looking for more Sleep Disorder discussion? Check out the NeurologyLive ® Sleep Disorder clinical focus page . Episode Breakdown: 1:05 – Advances and remaining gaps in the clinical understanding of…

People in this episode

Host: Lindsay McCullough

Guest: Lindsay Mccullough Md

Topics covered

• narcolepsy
• clinical advances
• diagnostic advances
• treatment advances
• sleep disorders
• neurodegenerative disease

Keywords

• orexin biology
• narcolepsy subtypes
• disease-modifying approaches
• clinician education

Mentioned in this episode

Books & works: Clinical Advances and Unanswered Questions in Narcolepsy, Neurology News Minute

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