Investigator-Initiated Trials in Eye Care with Dr Brad Hall
From Note to File: A Clinical Research Podcast by Brad Hightower
March 2, 2026 · 43 min
About this episode
This episode features Dr. Brad Hall discussing how independent clinicians can conduct investigator-initiated trials in eye care.
In this episode of Note to File, Denali and Brad sit down with Dr. Brad Hall, founder of Senge, a boutique CRO focused on investigator-initiated trials (IITs) in eye care. They break down how independent clinicians can turn real-world questions from daily practice into publishable clinical research. In this conversation, we cover: -Why most IITs in eye care actually happen in private practice, not academia -The biggest barriers independent clinics face (time, staff, IRB, budget) -How to start with retrospective studies and build toward prospective IITs -Funding options and how to partner with industry for real-world data -Practical pros and cons of paper vs. EDC for small IITs -Dr. Hall's LENS system from his book Idea to Impact: -Launch with focus – defining the question, protocol, and consent -Enroll with confidence – recruiting and retaining patients -Notice the insights – collecting clean data and analyzing it -Share the results – publishing and presenting your work If you're an eye care provider (or any specialist) who's ever thought, "I see this pattern in my patients—could I turn this into a study?" this episode will show you what it actually takes to go from idea to impact.
People in this episode
Host: Brad Hightower
Guest: Dr. Brad Hall
Topics covered
- investigator-initiated trials
- eye care
- clinical research
- independent clinics
- real-world data
- retrospective studies
- prospective studies
Keywords
- investigator-initiated trials
- eye care
- clinical research
- retrospective studies
- prospective studies
- real-world data
- clinical trials
- patient recruitment
- data analysis
Mentioned in this episode
Organizations: Senge
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