Conférence - Emmanuelle Passegué : Principle of Hematopoietic Stem Cell Biology and Blood Production

About this episode

Emmanuelle Passegué discusses the principles of hematopoietic stem cell biology and blood production.

Hugues de Thé Collège de France Oncologie cellulaire et moléculaire Année 2025-2026 Hematopoietic Stem Cell through the Ages: A Lifetime of Adaptation to Organismal Demands Conférence - Emmanuelle Passegué : Principle of Hematopoietic Stem Cell Biology and Blood Production Emmanuelle Passegué Directrice de la Columbia Stem Cell Initiative et professeure émérite de génétique et de développement à l'université Columbia Résumé Unlike most adult organs, the blood system regenerates continuously to maintain homeostasis in a life-long process orchestrated by a complex collection of hematopoietic stem and progenitor cells. Self-renewing HSCs reside at the apex of this hierarchy and produce all blood lineages, including the erythroid lineage that forms red blood cells, the megakaryocytic lineage that gives rise to platelets, and the myeloid and lymphoid lineages that generate cells of the innate and adaptive immune systems. Most HSCs exist in a quiescent state, dividing occasionally to self-renew and produce various lineage-biased multipotent progenitors that form a transit amplifying compartment sustaining the daily output of the blood system. We will consider how emerging concepts in…

People in this episode

Guest: Emmanuelle Passegué

Topics covered

• Hematopoietic Stem Cell Biology
• Blood Production
• Stem Cell Research

Keywords

• hematopoietic stem cells
• blood system
• self-renewal
• cell differentiation

More episodes of Oncologie cellulaire et moléculaire - Hugues de Thé

• 04 - Stress oxydant et thérapeutiques anti-tumorales : Le cas de la ferroptose · November 26, 2025 · 1h 18m
• 03 - Stress oxydant et thérapeutiques anti-tumorales : Stress oxydant et radiothérapie · November 19, 2025 · 1h 14m
• Conférence - Emmanuelle Passegué : Hematopoietic Stem Cell Aging and Adaptation to Stress · November 18, 2025 · 1h 5m
• Conférence - Emmanuelle Passegué : Adaptive and Maladaptive Myeloid Cell Production · November 13, 2025 · 57 min
• Conférence - Emmanuelle Passegué : Environmental Crosstalk and Bone Marrow Niche Regulation · November 12, 2025 · 52 min
• 02 - Stress oxydant et thérapeutiques anti-tumorales : Stress oxydant et chimiothérapie · November 12, 2025 · 1h 25m