Peptides Explained

SS-31 (Elamipretide) may be one of the most fascinating peptides ever developed.Unlike most peptides that work by activating receptors on the surface of cells, SS-31 targets the mitochondria—the cellular power plants responsible for producing energy.In this episode of Peptides Explained, we break down:✅ What mitochondria actually do✅ The role of cardiolipin in cellular energy production✅ How SS-31 works biologically✅ Why SS-31 received FDA Accelerated Approval in 2025✅ What Barth Syndrome is✅ The latest human clinical data✅ How SS-31 compares with MOTS-c✅ Whether repairing mitochondria before metabolic optimization makes biological senseWe'll separate proven science from speculation and discuss what remains investigational.This podcast is for informational purposes only and is not medical advice.Support the ShowPeptides Explained is an affiliate partner with OfflinePeptides.com. If you use my link, I may earn a commission at no additional cost to you.https://offlinepeptides.com/ref/JohnGarrett/For peptide education, provider resources, and information about compounded peptide options through licensed providers:https://peptide-solutions.info#PeptidesExplained #SS31 #Elamipretide #Forzinity #BarthSyndrome #Mitochondria #Longevity #MOTSc #Peptides

What do tanning peptides have to do with sexual medicine?More than you might think.In this episode of Peptides Explained, we explore the fascinating science behind Melanotan I, Melanotan II, and PT-141 (Bremelanotide). What began as research into skin pigmentation and UV protection unexpectedly led to the development of an FDA-approved medication for hypoactive sexual desire disorder.You'll learn:• How the melanocortin system works• The role of alpha-MSH in pigmentation and physiology• The differences between Melanotan I and Melanotan II• Why Melanotan II became known for effects beyond tanning• How PT-141 was developed from Melanotan II research• The clinical data behind pigmentation and sexual function• Potential side effects and safety considerations• The current regulatory status of these compoundsWhether you're interested in peptide science, dermatology, sexual health, or drug development, this episode highlights one of the most unexpected stories in modern peptide research.This podcast is for informational purposes only and is not medical advice.Learn more at:📍 Peptide-Solutions.infoResearch Peptide Affiliate Partner:📍 https://offlinepeptides.com/ref/JohnGarrett/Affiliate Disclosure: Peptides Explained is an affiliate partner with OfflinePeptides.com. If you use my link, I may earn a commission at no additional cost to you.#PeptidesExplained #Melanotan #Melanotan2 #Melanotan1 #PT141 #Bremelanotide #PeptideTherapy #Longevity #HealthPodcast #MedicalScience

In this episode of Peptides Explained, we take a deep dive into KPV, a three-amino-acid peptide derived from alpha-melanocyte stimulating hormone (alpha-MSH) that has generated growing interest for its potential anti-inflammatory effects.We explore the biology behind KPV, how it may influence inflammatory pathways such as NF-kB, and why researchers have studied it in models of ulcerative colitis, Crohn's disease, inflammatory bowel disease (IBD), and intestinal barrier dysfunction.You'll learn:• What KPV is and where it comes from• How KPV may reduce inflammatory signaling• The role of PepT1 transporters in the gut• What animal and laboratory studies have shown• The limitations of current human data• Why KPV has become popular in gut health discussionsWe also examine the growing interest in the KLOW Blend, a combination of:• KPV• BPC-157• TB-500• GHK-Cuand discuss the scientific rationale behind combining these peptides to target inflammation, tissue protection, cellular migration, and regeneration.As always, we separate biological mechanisms from marketing claims and review what the evidence actually shows.Peptide Solutions is owned and operated by host John Garrett and helps educate both patients and healthcare professionals about peptide science and peptide therapy pathways.Learn more at:Peptide-Solutions.infoPeptides Explained is an affiliate partner with OfflinePeptides.com.If you use the link below, I may earn a commission at no additional cost to you:https://offlinepeptides.com/ref/JohnGarrett/Healthcare providers interested in prescribing compounded peptides and individuals interested in telehealth consultation options can learn more through Peptide Solutions.Visit:Peptide-Solutions.infoDisclaimer: This podcast is for educational and informational purposes only and is not medical advice. KPV and the KLOW Blend are not FDA-approved therapies, and much of the research discussed comes from laboratory and animal studies. Always consult a licensed healthcare professional regarding medical decisions.Powered By Peptide SolutionsResearch Peptide Affiliate DisclosureCompounded Peptide Information

In this special episode of Peptides Explained, we're focusing on a topic that affects millions of women but often isn't discussed openly enough: menopause, hormonal signaling, libido, body composition, and the emerging role of peptides.Why does weight gain seem different during menopause? What causes the sudden changes in energy, sleep, skin, hair, and sexual desire? And where do peptides like Kisspeptin, PT-141 (Bremelanotide), Tesamorelin, GHK-Cu, BPC-157, and GLP-1 medications fit into the conversation?Join host John Garrett, RN, as he breaks down the science behind female hormone signaling in clear, understandable language. We'll explore the biology of menopause, the neurochemistry of desire, the "collagen cliff," metabolic changes, and the latest research on peptides being studied for women's health and aging.This episode covers:• Menopause and metabolic changes• GLP-1 medications and weight management• Kisspeptin and reproductive hormone signaling• PT-141 and female sexual desire• Tesamorelin and growth hormone pathways• GHK-Cu and collagen production• BPC-157 and recovery science• Oxytocin and emotional connection• What is evidence-based vs. what remains experimentalWhether you're navigating perimenopause, menopause, or simply interested in understanding how peptide science intersects with women's health, this episode delivers a balanced, evidence-based look at one of the most important conversations in modern medicine.Learn more:www.peptide-solutions.infoPodcast website:www.peptidesexplained.infoSupport the podcast and learn more about peptide research:offlinepeptides.com/ref/JohnGarrettAffiliate Disclosure: Peptides Explained is an affiliate partner with Offline Peptides. If you use my affiliate link, I may earn a commission at no additional cost to you.Follow Peptides Explained:• Instagram: @PeptidesExplained• Facebook: Peptides Explained• LinkedIn: Peptides Explained• Patreon: Peptides Explained• Skool: Peptides Explained CommunityIf you enjoy the show, please follow, subscribe, leave a review, and share this episode with someone who would benefit from understanding the science behind menopause, hormones, and peptide therapy.Peptides Explained is powered by Peptide Solutions, founded and operated by John Garrett, RN, providing education on peptide science and helping connect patients and clinicians with peptide-related resources.This podcast is for informational purposes only and is not medical advice.

Do growth hormone secretagogues increase cancer risk?This episode breaks down the real science behind IGF-1, cancer biology, and compounds like MK-677, Ipamorelin, Sermorelin, CJC-1295, and Tesamorelin.We review:Human IGF-1 cancer studiesAcromegaly dataTumor signaling pathwaysObservational vs causal evidenceWhat current science actually supportsThis podcast is for informational purposes only and is not medical advice.Peptides Explained is an affiliate partner with OfflinePeptides.com. If you use my link, I may earn a commission at no additional cost to you.Support the show:OfflinePeptides Affiliate Link

Tesamorelin is one of the few peptides with FDA approval—but its effects on visceral fat and growth hormone signaling have made it a major topic in metabolic health and body composition circles.In this episode of Peptides Explained, we break down:• What tesamorelin actually is• How growth hormone releasing hormone works• Why visceral fat matters metabolically• Clinical trial data and FDA-approved use• Anecdotal outcomes in real-world settings• Risks, limitations, and off-label discussionWe also explain why tesamorelin is different from traditional fat loss medications and why many users report changes in abdominal fat distribution rather than dramatic scale weight loss.This podcast is for informational purposes only and is not medical advice.Peptides Explained is an affiliate partner with Offline Peptides. If you use my link, I may earn a commission at no additional cost to you.

Retatrutide may represent the next evolution in metabolic medicine.In this deep-dive episode of Peptides Explained, we break down the science behind the investigational “triple agonist” peptide that’s generating major attention in obesity and metabolic research.Topics covered:• GLP-1 + GIP + glucagon receptor activation• How retatrutide differs from semaglutide and tirzepatide• Phase 2 clinical trial results• Fat loss vs lean mass loss• Liver fat reduction data• The emerging discussion around obesity-related cancer risk• What may happen after discontinuation• Known side effects and unanswered questionsThis episode goes beyond headlines and social media hype to explain the actual biology and human data behind retatrutide.Peptides Explained is focused on evidence, mechanism, and clarity.This podcast is for educational purposes only and is not medical advice.

A clinical deep dive into the muscle loss problem on GLP-1 medications. Semaglutide, tirzepatide, and the investigational triple agonist retatrutide all produce remarkable weight loss — but clinical trial data shows that a significant fraction of that loss is lean body mass, not fat. This episode covers the mechanism behind GLP-1-induced muscle wasting, the body composition data from STEP 1 and SURMOUNT trials, who carries the highest risk, and where the next generation of obesity pharmacology — bimagrumab combinations, pemvidutide, and retatrutide's glucagon receptor pathway — is trying to solve the problem. For clinicians, patients, and anyone paying attention to where obesity medicine is actually going.This podcast is for informational purposes only and is not medical advice.

A clinical breakdown of grey market peptide safety, including contamination risks, testing standards, and how peptide quality impacts biological effects.

A clinical deep dive into BPC-157 covering mechanism, recovery science, dosing patterns, TB-500 synergy, and why it is banned in professional sports.

MOTS-C is one of the most unique peptides being studied today — not because of what it does, but because of where it comes from.Unlike most peptides, MOTS-C is encoded inside your mitochondria, the part of the cell responsible for energy production. That makes it part of a growing category of mitochondrial signaling peptides that may play a role in metabolism, aging, and cellular energy regulation.In this episode of Peptides Explained, we break down:• What MOTS-C is and how it’s produced• How it activates AMPK, the body’s metabolic “master switch”• Why it’s being studied as a potential exercise mimetic• Its effects on insulin sensitivity and glucose metabolism• What the animal research shows vs. the current state of human data• Where it may fit in the broader peptide landscape• Risks, limitations, and why it remains experimentalThis episode focuses on the biology and clinical context behind MOTS-C — not the hype.Disclaimer: This podcast is for informational purposes only and is not medical advice. MOTS-C is not FDA-approved and is currently considered an investigational peptide. Always consult a licensed healthcare professional before considering any therapy.Peptide science is evolving — and understanding the mechanism is the first step.

In Episode 3 of Peptides Explained, we take a closer look at two of the most talked-about peptides in injury recovery circles: BPC-157 and TB-500.These compounds are often combined in what’s popularly called the “Wolverine Stack,” a nickname that reflects claims of accelerated healing and recovery. But what are these peptides actually doing in the body, and what does the science really say?In this episode, we break down the biology behind both compounds, how they interact with tissue repair pathways, and why they’ve become so popular in athletic and performance communities.We discuss:• What BPC-157 is and how it may influence angiogenesis, tendon repair, and tissue healing• What TB-500 (a fragment related to thymosin beta-4) does in terms of cell migration and tissue remodeling• The biological rationale behind combining the two peptides• What the available animal research suggests — and where human clinical data is still lacking• Why these peptides remain in a regulatory gray area• The difference between experimental compounds and FDA-approved peptide therapeuticsThe goal of Peptides Explained is clarity, not hype. In each episode we examine the mechanisms, the available data, and the real limitations of what we know today.Disclaimer:This podcast is for informational purposes only and does not constitute medical advice. Peptides discussed may have different regulatory statuses and should only be used under the guidance of licensed healthcare professionals.If you’re interested in the science behind peptides, injury recovery, metabolism, and emerging therapeutic pathways, this episode will give you a clear, evidence-based overview of one of the most talked-about peptide combinations today.

Peptides are everywhere in the health and longevity conversation right now — but most of what's out there skips the fundamentals. Before you can understand semaglutide, BPC-157, or any other compound making headlines, you need to understand what a peptide actually is at the biological level.In this episode of Peptides Explained, we lay the foundation:What peptides are and how they differ from proteins and small moleculesHow peptides function as signaling molecules in the bodyWhy the body's own peptide systems are the basis for modern therapeutic compoundsThe difference between endogenous peptides and synthetic or compounded versionsWhy understanding mechanism matters before evaluating any peptide claimThis is the episode to send someone who's heard about peptides but doesn't know where to start. No hype, no bro science — just the biology you need to make sense of everything that comes after.Disclaimer: This podcast is for informational purposes only and does not constitute medical advice. Always consult a licensed healthcare professional before considering any therapy.