Science In Action

US Health Secretary RFK Jr’s call to retract a study on childhood vaccines is resisted by the journal. Also antibiotics get designed by AI, and a new way for stars to die. A study focussing on Danish childhood vaccination data has attracted the US Secretary for Health’s anger, as RFK jr calls for the journal in which it was published, the Annals of Internal Medicine, to retract it. The Editor, Christine Laine, talk to Science in Action about the strengths and challenges of observational studies. The cuts to prestigious US federal science funded research continue, as last week it was announced that $500 million funding for future mRNA vaccines would be withdrawn. Barney Graham, one of the pioneers in the field and prominent during the Covid vaccines, argues that the research will still happen, though maybe not in the US, as mRNA has become a fundamental area of global research. Meanwhile, strides are being made in the field of synthetic biology as Jim Collins and colleagues at MIT and Harvard have used AI to design potentially viable antibiotics for two important drug-resistant superbugs. Previously, AI has been used to comb through libraries of known antibiotics. This study has gone a step further, and used generative AI to design new ones, that can then be synthesised using real chemicals. Though a long way from being prescribable drugs, the team think this could herald a new golden age of antibiotic development – something which has been lacking in recent decades. Finally, it seems astronomers may have discovered a new way for a star to die, sort of. Supernova 2023zkd was seen to explode back in 2023, found by a team looking for odd events. It didn’t seem quite like normal supernovae, in that it took a bit longer to die down. Then the team looked back, and noticed that it had also been getting slowly brighter for almost a year. At 730 million light years away, in a galaxy far, far away, it also seemed to have been stripped of all its hydrogen and even stranger yet, appeared to have exploded twice. As Ashley Villar of the Harvard Smithsonian Center for Astrophysics explains, the almost unique observation fits with a model of the huge star getting closer to a black hole, the gravity of which may have disrupted the star enough to cause it to explode. Presenter: Roland Pease Producer: Ella Hubber with Alex Mansfield Production Coordinator: Jana Bennett-Holesworth (Image: Child getting a vaccine. Credit: Luis Alvarez via Getty Images)

After most of the population of the Pacific rim sought higher ground this week, we speak with the architect of the tsunami warning technology. Also how aging Killifish might help us probe our senior moments. This week, an M8.8 earthquake near Kamchatka in the western pacific led to tsunami evacuation alerts thousands of miles away. Seismologist Judith Hubbard was writing about the area in the days leading up to it, following a M7.4 event 9 days before, which we now know to categorize as a foreshock. As she says, it’s these subduction zones between tectonic plates that give out the most energy, produce the biggest quakes, leading to the worst tsunamis. The Tsunami alarms were based on modelling developed by Vasily Titov of NOAA’s Pacific Marine Environmental Laboratory in Seattle. Having studied these phenomena for many decades, he describes the fine balance between the potential accuracy of a prediction, and the practical actionable advice authorities need to give out to save as many lives as possible. Finally, how can a short-lived African freshwater fish help scientists studying senescence? Stanford’s Judith Frydman and colleagues publish this week a study in Science that finds Killifish’s brain cells’ ability to encode proteins degrades with age, in keeping with similar patterns of older human brains. Because Killifish have such brief life cycles, yet seem to follow the brain cycles of most vertebrates, they provide an ideal model species from which to find out more, as she explains. Presenter: Roland Pease Producer: Imaan Moin and Alex Mansfield Production Coordinator: Jana Holesworth(Image Credit: Vasily Titov PMEL/NOAA)

Two black holes have collided and combined in the largest merger yet observed. Mark Hannam of Cardiff University and member of the study explains how the Interferometer Gravitational Wave Observatories (LIGO) detected this ‘violent’ event through spacetime. The lifestyle of ancient humans had an impact on their risk for infectious diseases. Astrid Iversen of the University of Oxford explains how the shift away from being hunter-gatherers played a role in the origins of human pathogens. Nitrogen fixation, or the process of organic compounds accessing nitrogen from the atmosphere via microorganisms, plays a key role in climate modelling. But prior estimations have long been missing key data to make accurate analysis. Carla Reis Ely of Oak Ridge Institute for Science and Education shares the updated facts and figures on global nitrogen fixation. How intelligent is artificial intelligence? Can AI start discovering new scientific laws in the year? Keyon Vafa of Harvard University put several AI models to the test to see if they could discover Newton’s law of gravity and understand the world around us. Presenter: Roland Pease Producer: Imaan Moin Production Coordinator: Jana Bennet-Holesworth (Image: Black Hole, digital illustration. Credit: Aaron Horowitz via Getty Images)

There's a surge in cases and deaths from H5N1 bird flu in Cambodia - we hear what's the driver and how concerned we should be. Erik Karlsson, Head of Virology at the Pasteur Institute in Phnom Penh and director of the WHO’s H5 Reference Laboratory has been watching the uptick.An interstellar interloper has been spotted entering our solar system. Most likely a comet, and possibly visible in the sky, it’s just the third such visitor we’ve ever seen. Josep Trigo of Spain’s Institute of Space Sciences (CSIC) and the Catalan Institute for Space Studies is one of many astronomers keeping his eye out.DNA from an ancient Egyptian buried in cave 2,500 BCE, the oldest to date, tell a tale of travelling ancestors, according to research led by Adeline Morez of Liverpool John Moore’s University and published in Nature.Also, Corey Allard of Harvard university has been looking at a particular type of sea slug. Published in the journal Cell, the work has been trying to work out how these slugs effectively nurture and manage stolen chloroplasts – stolen from ingested plant cells - within their own bodies. Artfully, they may use these “Kleptoplasts” to dodge periods of food shortage. Presenter: Roland Pease Producer: Alex Mansfield Production Coordinator: Jazz GeorgePhoto Credit: Institut Pasteur du Cambodge

The universe is thought to consist of 70% Dark Energy, 25% Dark Matter, and just 5% Baryonic matter which is the atoms that make up you and me. At least, that’s what the models suggest. But a well-kept secret between astronomers and cosmologists for all these years has been that they have not actually ever seen almost half of that 5% normal matter because it is thinly dispersed as gas between the galaxies and galactic clusters. This week, two studies have been published putting that right.Satisfactory model-match #1: Liam Connor of Harvard University with colleagues from Caltech have been using a mysterious phenomenon called Fast Radio Bursts (FBRs) to infer what the intergalactic medium is in between, and how much of it there is. Satisfactory model-match #2: Konstanios Migkas of Leiden University and colleagues have been looking at the very faint x-ray signal from the intergalactic medium, removing the incidental x-ray sources such as black holes, and have managed to identify some structure - in this case a mind-bendingly huge filament of ionised gas stretching between two galactic superclusters - confirming the state of “Warm Hot Intergalactic Medium” (WHIM) as predicted for much of the universe.Of course, there is not just the cosmological standard model (lambdaCDM) that these satisfy in science today. There is also the remarkably resilient Standard Model of particle physics. A report this week from the US National Academies recommends the US begins building the world’s next particle collider to follow the work of the LHC (and FCC) at Cern. It should, as University of Tennessee at Knoxville’s Tova Holmes tells us, collide not ordinary, stable, easy to manipulate particles like protons and electrons, but muons. Finally, Shana Goffredi of Occidental College in California, has found a VERY odd spider. Diving to depths in the submersible Alvin, they have found that a species of small sea-spiders, Sericosura, actually farm bacteria on their exoskeleton. Why? Because they hang around methane seeps on the ocean floor, where a specialist bacteria can metabolize methane – something the spiders themselves can’t do. Not only do the spiders then graze on the bacteria they carry around, they even pass samples of the bacteria onto their offspring by leaving bacterial lunch-boxes in their egg-sacs.Presenter: Roland Pease Producer: Alex Mansfield, with Sophie Ormiston Production co-ordinator: Jasmine Cerys George(Photo Credit: Jack Madden, IllustrisTNG, Ralf Konietzka, Liam Connor/CfA)

What is Fusarium graminearum and why were scientists allegedly smuggling it into the US? Also, Alpine Glacier collapse and an HIV capitulation.The FBI has accused two Chinese scientists of trying to smuggle a dangerous crop fungus into the US, calling it a potential agro-terrorist threat. But the fungus has long been widespread across US farms, and elsewhere, and is treatable. So what’s going on? Frédéric Suffert, Senior researcher in plant disease epidemiology at France’s National Research Institute for Agriculture, Food and Environment, gives us some insight.Last week, a glacier above the swiss village of Blatten collapsed and up to 12 million tonnes of ice and rock buried the idyllic, yet thankfully all-but evacuated, hamlet below. Daniel Farinotti of the Swiss Federal Institute of Technology explains how it was monitored more than any such event before, and maybe, despite the tragedy, could help inform the science of such events in a warming world.Amongst the latest cuts to scientific funding by the US government, two consortia working at advanced stages of a potential HIV vaccine have been told their funding will not continue. Dennis Burton of Scripps Research describes finding out.The recipient of the Royal Society Faraday Prize 2024 gave his prize lecture last week. Titled Science Under Threat: The Politics of Institutionalised Disinformation, Salim Abdul Karim’s lecture is available on YouTube. Afterwards, he was kindly able to have a chat with Science in Action about his theme. Presenter: Roland Pease Producer: Alex Mansfield Production co-ordinator: Jasmine Cerys George(Photo: A hand holding an ear of wheat. Credit: Heather Schlitz/Reuters)

This week, 124 countries agreed at the World Health Assembly in Geneva on measures aimed at preventing a future pandemic. The agreement very strongly favours a “One Health” approach, appreciating how so many potential pathogens originate in human-animal interactions. Still to agree on the terms of how to share pathogens and information with global science and vaccine researchers, eventually the treaty will need to be signed by at least 60 countries. But can the inequity between countries of the global south and north, and issues of intellectual property, be bridged?A new study on origins of the Nigerian mpox epidemic points strongly to zoonotic crossovers and mobility of wildlife in West Africa. Edyth Parker of Redeemer’s University in Nigeria describes their phylogenetic tree.Can the bovine form of H5N1 flu infect pigs, and could domestic pig populations then provide a crucible for further variants to develop? Jürgen Richt of Kansas State University and colleagues have been investigating. We need to keep up vigilance.Lucy van Dorp of University College London, working with a consortium including London’s Crick Institute, has been looking at a moment in the past when human activity provided an opportunity for a bacterial human pathogen to change its lifestyle. According to their phylogenetic tree, the bacterium Borrelia recurrentis (which causes louse-borne relapsing fever in humans) adapted and moved from ticks to human body lice around about the same time as humans started using woollen clothing.And Susan Lieberman, VP for International Policy at the Wildlife Conservation Society, was in the trenches of the Pandemic Agreement negotiations, and shares some of her hopes for its success. Image: World Health Assembly formally adopts by consensus world's first Pandemic Agreement, Geneva, Switzerland - 20 May 2025 Image Credit: Magali Girardin via EPA-EFE/ShutterstockPresenter: Roland Pease Producer: Alex Mansfield