251: Why a Single Large DoE Fails Biosimilar Glycan Optimization — And the Parallel Screening Method That Actually Works
From Smart Biotech Scientist | The CMC and Bioprocessing Podcast for Process Development and Manufacturing Leaders by David Brühlmann - CMC Development Leader, Bioprocess Expert, Business Strategist
May 12, 2026 · 18 min · Episode 251
About this episode
David Brühlmann discusses efficient compound screening methods in biosimilar development to improve quality targets.
Are you stuck screening endless compounds in biosimilar development and still not hitting your quality targets? Efficient compound screening is one of the toughest bottlenecks in biopharma, with outdated methods slowing progress and risking critical quality attributes in monoclonal antibody development. David Brühlmann breaks down a practical, parallel framework for rapid compound screening that addresses interaction effects, masking, and data quality. Methods proven in challenging biosimilar...
People in this episode
Host: David Brühlmann
Topics covered
- biosimilar development
- compound screening
- biopharma
- monoclonal antibodies
- quality attributes
Keywords
- DoE
- glycan optimization
- parallel screening
- interaction effects
- data quality
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