What Living Thing Is Most Genetically Different From Humans?

What Living Thing Is Most Genetically Different From Humans?

From Smartest Year Ever by Gordy

April 11, 2026 · 6 min · Season 2026 · Episode 12

About this episode

The episode explores which living thing is most genetically different from humans, examining genetic distance and evolutionary relationships.

Today I explore a deceptively simple question: what living thing is most genetically different from humans? At first glance, you might imagine something bizarre—deep-sea creatures, alien-looking animals, or massive organisms that seem nothing like us. But in evolutionary biology , appearances mean nothing. What actually matters is genetic distance —how far back two species share a common ancestor. In this episode, I break down how the answer changes depending on how you define the question. From microscopic life to the earliest branches of the animal kingdom , to more familiar creatures within vertebrates and mammals , this turns into a fascinating look at how all life on Earth is connected—and how far some branches have diverged. Along the way, we touch on: Domains of life and what separates humans from fundamentally different organisms The structure of eukaryotic vs prokaryotic cells The earliest diverging branches of the animal evolutionary tree How scientists define genetic relatedness and evolutionary distance Why narrowing the question completely changes the answer This is a deep dive into phylogeny , evolution , and the hidden relationships that connect every living…

People in this episode

Host: Gordy

Topics covered

  • genetic distance
  • evolutionary biology
  • phylogeny
  • animal kingdom
  • genetic relatedness

Keywords

  • genetic distance
  • evolution
  • phylogeny
  • animal evolution
  • biological diversity

Mentioned in this episode

Organizations: Zapsplat

Books & works: What Living Thing Is Most Genetically Different From Humans?

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