EP 245: Histamine, MCAS, and the Nervous System: Why Your Body Feels Stuck in Fight-or-Flight

EP 245: Histamine, MCAS, and the Nervous System: Why Your Body Feels Stuck in Fight-or-Flight

From Strong + Unfiltered: Perimenopause, Hormones, Gut Health + Hormone Optimization by Danielle Kepics

March 30, 2026 · 1h 9m · Season 1 · Episode 245

About this episode

This episode explores the role of the nervous system in histamine intolerance and chronic reactivity, featuring insights from a certified functional nutrition practitioner.

Histamine intolerance and MCAS are being talked about everywhere right now, but most conversations focus on food lists, supplements, and restriction. In this episode, Danielle sits down with a certified functional nutrition practitioner to explore a different perspective, the role of the nervous system in chronic reactivity, inflammation, and histamine-related symptoms. They discuss why some people seem to become more sensitive to foods, environments, and stress as they get older, and how nervous system state may influence everything from histamine release to sleep quality. You'll also hear a deeper conversation about why many healing approaches encourage people to disconnect from their bodies, why that can backfire, and what it actually looks like to help the body feel safe again. If you've been dealing with symptoms that feel random, overwhelming, or impossible to figure out, this episode offers a different framework for understanding what might be happening. Jennifer Parkinson is a Certified Functional Nutrition Practitioner. As the founder of EDS Nutritionist, Jennifer specializes in supporting individuals with Ehlers-Danlos Syndrome (EDS), Mast Cell Activation Syndrome…

People in this episode

Host: Danielle Kepics

Guest: Jennifer Parkinson

Topics covered

  • histamine intolerance
  • MCAS
  • nervous system
  • chronic reactivity
  • inflammation
  • food sensitivity
  • healing approaches

Keywords

  • histamine
  • MCAS
  • nervous system
  • chronic pain
  • Ehlers-Danlos Syndrome
  • POTS
  • gut dysfunction
  • inflammation

Mentioned in this episode

Organizations: EDS Nutritionist

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