The Pauling Principle

Most doctors treat you after you get sick. Professor Andrea Maier is trying to make sure you never get there. In this episode, I sit down with one of the world's leading longevity scientists, a biogerontologist who holds professorships across three continents, founded the Healthy Longevity Medicine Society, and co-founded Chi Longevity Clinics in Singapore. We explore why aging itself is becoming a treatable condition, how biological aging clocks are changing the way we think about health, and what it actually takes to bring longevity medicine out of luxury clinics and into everyday practice. This is a conversation about the science, the clinical reality, and the future of growing older on your own terms.

In this episode I sit down with Professor Hugo Verli, one of the pioneers in computational chemistry. And we discuss the past, present, and future of the field. Including some of the key challenges, like how to simulate carbohydrates and highly dynamic molecules. What simulations would YOU like to run? let me know in the comments! :)

What if aging itself is the disease we should be curing? In this episode, I sit down with Aubrey de Grey, the legendary biogerontologist who has spent decades arguing that aging is not an inevitable fate but an engineering problem with solvable components. We dive into the science behind his SENS framework, explore why the longevity field is finally gaining mainstream momentum, and debate just how close we are to adding decades of healthy life to the human lifespan. Whether you're a skeptic or a true believer, this conversation will challenge how you think about mortality, medicine, and what it means to grow old. Aubrey is also someone that I admire deeply, so I hope you find this conversation interesting!

In this episode, I sit down with Dr. Maria Marinova to uncover one of the most misunderstood frontiers in human biology: female reproductive aging. We break down why female fertility declines, what’s actually happening at the cellular level, and the emerging science that suggests this decline may be reversible. Not someday in the distant future, but now.

Is protein folding solved? Not quite, even though the progress has been tremendous since the first AlphaFold and up to last year's Nobel prize. The team behind Boltz and Boltz-2, from MIT CSAIL and Jameel Clinic, just released Boltzgen, a state of the art model for protein design. In this chat with Gabriele Corso I review the progress in the field and whats next.

Andy and his team at Vincere have been doing amazing work over years to figure out the mitochondrial mechanisms that may contribute to Parkinson's and other neurodegenerative diseases. Listen in as we discuss curing Parkinson's, using AI to find new molecules and broader drug discovery.

What if the biggest breakthroughs in health and biotechnology aren’t waiting on new ideas but on better experiments? In this episode, Michael Florea joins Javier to expose the hidden bottlenecks in animal research, the quiet revolution of automation in the lab, and the radical possibilities of treating DNA itself as medicine. This conversation peels back the curtain on how science really moves forward and why the future of drug development may look nothing like today.

Nicholas Runcie of Oxford University and I discuss whether large language models such as ChatGPT can really understand chemistry. Which of course will be essential as we try to use them to find new medicines and materials.

In this episode I talk with the amazing Reason and Mourad from Repair Bio about a cure for cardiovascular disease. Reason serves as CEO and is also a legend in the world of longevity, having run https://www.fightaging.org for a couple of decades. Mourad serves as CSO and is a celebrated researcher with stints at Harvard Medical School and Pfizer.

From AI and language models to robots, agents and using AI to automate medicine and software engineering. And even beyond: human consciousness and space exploration. This was one of the most fascinating conversations with Massimo Mascaro, AI expert and part of the CTO Office at Google.

If we want to live over 150 years and avoid cancer we will need better mechanisms to preserve our genomic integrity. Join my conversation with Benjamin Arya to learn more!

I welcome my good friend Trishan in a fascinating conversation about making healthcare accessible through technology and in particular AI.

What should we do to prevent Alzheimer's and other neurodegenerative diseases as we age? Join my conversation with Dr. Christin Glorioso from NeuroAge.