Not All Doses Are Equal: Exploring High vs. Low Dose Ketamine and the Healing Power of Discomfort

Not All Doses Are Equal: Exploring High vs. Low Dose Ketamine and the Healing Power of Discomfort

From The Psychedelic Psychiatrist by The Psychedelic Psychiatrist

November 26, 2025 · 25 min · Episode 29

About this episode

Dr. Juan Pablo Galindo discusses the differences between psycholytic and psychedelic dosing in Ketamine-Assisted Psychotherapy and their implications for therapeutic outcomes.

Send us Fan Mail In this episode, Dr. Juan Pablo Galindo breaks down the nuanced differences between psycholytic and psychedelic dosing in Ketamine-Assisted Psychotherapy (KAP)—and why the way we dose matters for therapeutic outcomes. You’ll learn how lower, talk-friendly doses (psycholytic) support emotional processing in real time, while higher, dissociative doses (psychedelic) offer deeper access to the unconscious. We discuss the therapeutic pros and cons of each approach, and how they ca...

People in this episode

Guest: Dr. Juan Pablo Galindo

Topics covered

  • Ketamine-Assisted Psychotherapy
  • psycholytic dosing
  • psychedelic dosing
  • therapeutic outcomes
  • emotional processing
  • unconscious access

Keywords

  • Ketamine
  • psychotherapy
  • dosing
  • emotional processing
  • therapeutic
  • unconscious
  • discomfort

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