Ep. 319: “Building Better iPSCs” Featuring Dr. Andrew Gaffney

About this episode

Dr. Andrew Gaffney discusses advancements in iPSC applications and challenges in the field.

Guest: Dr. Andrew Gaffney is Vice President, iPSC Platform at STEMCELL Technologies. In this episode, he discusses how his team is advancing pluripotent stem cell applications through high-quality iPSC line development, gene editing, organoid production, and GMP manufacturing for translational and clinical use. He also highlights key challenges in the field, including reproducibility, standardization, genetic diversity, and freedom-to-operate considerations, and explains how these factors impact the path from basic research to commercialization. Featured Products and Resources: Explore STEMCELL Technologies’ one-stop resource for organoids. Join us at ISSCR 2026 and be part of the global conversation shaping the future of stem cell research. The Stem Cell Science Round Up Transgene-Free Gastrulation Model – Scientists have produced a transgene-free stem cell model that recreates key features of human peri-gastrulation, including germ layer formation and early hematopoiesis. Engineering Antibody-Producing Stem Cells – CRISPR-edited hematopoietic stem cells generate B cells that produce durable, protective antibodies following vaccination. Safeguarding Chemical Reprogramming…

People in this episode

Guest: Dr. Andrew Gaffney

Topics covered

• iPSCs
• pluripotent stem cells
• gene editing
• organoid production
• GMP manufacturing
• reproducibility
• commercialization

Keywords

• iPSC
• stem cell
• gene editing
• organoid
• GMP manufacturing
• reproducibility
• standardization

Mentioned in this episode

Organizations: STEMCELL Technologies

Books & works: Transgene-Free Gastrulation Model, Engineering Antibody-Producing Stem Cells, Safeguarding Chemical Reprogramming, Targeting Barriers to Cardiac Repair

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