299 - Building Hope From Broken Systems
From Two Disabled Dudes by The Dudes
May 11, 2026 · 43 min · Season 15
About this episode
The episode discusses the intersection of smart technology and healthcare innovation through an interview with Joshua Resnikoff, focusing on the challenges faced by families with rare diseases.
Sean and Kyle kick off this episode with a conversation about smart technology, AI, and the growing tension between convenience and commercialization in everyday life. That discussion sets the stage for a powerful interview with Joshua Resnikoff , founder and CEO of Sunstone Health , whose family’s rare disease journey inspired him to tackle one of healthcare’s biggest challenges: the long and frustrating diagnostic odyssey faced by rare disease families. Josh shares how his son’s unexplained fevers and years of unanswered questions led him from biomedical research at Harvard into the world of healthcare innovation. Through Sunstone Health, Josh and his team are using AI and genome sequencing to dramatically shorten the path to diagnosis for children with rare genetic conditions—reducing a process that often takes seven years down to just weeks. Along the way, the conversation explores the hidden incentives and shortcomings within the healthcare system, the importance of purpose-driven work, and the powerful impact that determined individuals can have when they choose to “heal the world” one piece at a time. The episode closes with reflections on gratitude, community leadership…
People in this episode
Hosts: Sean, Kyle
Guest: Joshua Resnikoff
Topics covered
- smart technology
- AI
- healthcare innovation
- rare diseases
- diagnostic odyssey
- community leadership
Keywords
- smart technology
- AI
- healthcare
- rare diseases
- diagnosis
- genome sequencing
- community leadership
- innovation
Mentioned in this episode
Organizations: Sunstone Health, Harvard
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