Y Combinator Startup Podcast

One of the biggest surprises in AI over the last few years has been how well coding agents generalize beyond software. In a recent essay, MIT professor Philip Isola argued that we may be entering the era of robot-use agents: general-purpose models that can control different robots, write policies, and learn new physical tasks with little or no robot-specific training.In this episode of Decoded, we're joined by the founders of Waddle Labs and RoboCurve, two of the startups whose work helped drive this realization. They're working at the frontier of using general-purpose models to control robots, and their recent demos helped inspire the growing conversation around robot-use agents. Together, we dig into the research behind that idea, from code-as-policies and vision-language-action models to the harnesses and evals needed to make these systems work in the real world.

The best outbound starts before you automate anything. Founders need to learn who actually has the problem, what gets their attention, and what makes them reply. YC Visiting Partner Christina Gilbert recommends doing at least your first 100 outreaches by hand so you can learn those things yourself.Drawing from her experience generating and closing millions of dollars through founder-led sales at OneSchema, Christina shares eight ways founders can improve their outbound, from targeting the right people and writing emails worth reading to following up, debugging low reply rates, and using customer language to sharpen your message.

Waymo’s first autonomous demo took eighteen months. The product took fifteen years. Today, the Waymo Driver runs 500,000 trips a week — four million fully autonomous miles across fifteen cities, with 17 times fewer serious-injury crashes than human drivers.At Startup School 2026, Waymo co-CEO Dmitri Dolgov shares the seven lessons behind that journey, from bridging the gap between a demo and a real product to building systems that can safely operate in the physical world.Transcript: https://www.ycrootaccess.com/p/dmitri-dolgov-seven-lessons-from

In 2001, Jeff Dean and Sanjay Ghemawat did the math and realized Google’s entire search index would fit in RAM — then shipped it in a few days, and search got fast. In 2013, another napkin calculation showed that three minutes of daily speech recognition per user would require doubling Google’s server fleet. That one became the TPU. At Startup School 2026, Google’s Chief Scientist talks with YC’s Diana Hu through the thought experiments behind both, why inference hardware is the next specialization, and where two or three people in a room can still win.Transcript: https://www.ycrootaccess.com/p/jeff-dean-the-1-rule-for-building

In 1969, we landed on the moon and flew Concorde. Half a century later, we could do neither.Blake Scholl founded Boom Supersonic (YC W16), the startup building America’s first supersonic airliner, to change that. At Startup School 2026, he shares how a cardboard mockup with Office Depot seats became XB-1, the first independently developed jet to break the sound barrier, and why founders have to build for both the worst day and the best day.He also answers founder questions about teaching yourself hard things, breaking into hardware without the right resume, and finding work-life harmony while building something ambitious.

Fresh off the launch of Opus 5, Claude Code creator Boris Cherny joins Diana Hu at Startup School 2026 to talk about what the newest models can do, how Claude Code came to be, and what it means to build products when the underlying capabilities keep accelerating.