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Recent episodes
S3:E1 All the answers on stem cells for OA management
Feb 1, 2026
Unknown duration
S2:E10 Where does CBD fit in pain management?
Aug 8, 2025
Unknown duration
S2:E9 DogMA - keeping dogs moving
Jul 26, 2025
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S2:E8 Behaviour tools to detect maladaptive pain
Jul 2, 2025
Unknown duration
S2:E6 Let sleeping dogs (and cats) lie!
Mar 12, 2025
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| Date | Episode | Description | Length | ||||||
|---|---|---|---|---|---|---|---|---|---|
| 2/1/26 |  S3:E1 All the answers on stem cells for OA management | Stem cells are an evolving and promising option for osteoarthritis management in dogs and cats. In this podcast we talk to Dr Russell Chandler from Greenside Referrals in Scotland with all the questions you may have about stem cells. We start from the view of the vet in the consulting room with an arthritic pet in front of them. What do we say to clients, how do stem cells work, which cases are suitable. Listen to our discussion now and understand if stem cells are the right option for your patients. LinksGreenside Referralshttps://www.stemcellsscotland.co.uk/contact-usRussell’s bookhttps://5mbooks.com/product/regenerative-medicine-in-small-animal-musculoskeletal-conditionsAndrew Armitage’s paper on stem cellsEfficacy of autologous mesenchymal stromal cell treatment for chronic degenerative musculoskeletal conditions in dogs: A retrospective study.This represents the first study using “real-world” data to show that cell-based therapies, injected into multiple areas of musculoskeletal pathology in a targeted holistic approach, resulted in rapid and profound positive effects on the patient's pain state and quality of life which was maintained with repeat treatment for up to 2 years.https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2022.1014687/full | — | ||||||
| 8/8/25 | S2:E10 Where does CBD fit in pain management? | How does CBD work?Is CBD a first line option for the treatment of OA pain? And where in our second line options does CBD fit? In this episode of the Zero Pain Philosophy podcast we are joined by anaesthesia & pain specialist Dr Leon Warne to answer these questions. If your clients are asking you about CBD, then you need to listen to this. ReferencesHere is the link to the CATRAS work discussed in today’s podcast:Warne LN, Schug SA, Beths T, Brondani JT, Carter JE, Lascelles BDX, Raisis AL, Robertson SA, Steagall PVM, Taylor PM, Whittem T, Bauquier SH. Content validation of a Critical Appraisal Tool for Reviewing Analgesia Studies (CATRAS) involving subjects incapable of self-reporting pain. Pain Rep. 2018 Jul 25;3(4):e670. doi: 10.1097/PR9.0000000000000670. PMID: 30123860; PMCID: PMC6085143.These are the COAST guidelines:Cachon T, Frykman O, Innes JF, Lascelles BDX, Okumura M, Sousa P, Staffieri F, Steagall PV, Van Ryssen B. COAST Development Group's international consensus guidelines for the treatment of canine osteoarthritis. Front Vet Sci. 2023 Aug 3;10:1137888. doi: 10.3389/fvets.2023.1137888. PMID: 37601753; PMCID: PMC10436090.This is a recent review of CBD in dogs and catsMoreno-López N, Moreno-López C, Amariles P. Cannabis-based products for medicinal use in dogs and cats: a systematic review. J Small Anim Pract. 2025 Jul 14. doi: 10.1111/jsap.13913. Epub ahead of print. PMID: 40660612. | — | ||||||
| 7/26/25 | S2:E9 DogMA - keeping dogs moving | Our latest podcast discusses the newly launched DogMA app with researchers Dr Natasha Clark and Professor Eithne Comerford. Mobility issues from musculoskeletal diseases, like osteoarthritis, affect around 200,000 dogs annually, posing a significant challenge to their health and welfare. Although these diseases can affect dogs of any age, owners often miss early, subtle signs of gait abnormalities, leading to late diagnosis of osteoarthritis. The DogMA app was developed to address this by enabling early detection of mobility problems, including subtle signs of discomfort or decline often overlooked in routine care. DogMA is supported by scientific research led by Dr. Natasha Clark at the University of Liverpool, under the supervision of Professors Eithne Comerford and Karl Bates, in collaboration with Dogs Trust. By using the app for regular assessments, users can also contribute anonymized data to ongoing research at the University of Liverpool, helping to advance the understanding of canine mobility across the UK.ReferencesHere is the link to the paper discussed in today’s podcast:Clark NL, Bates KT, Harris LK, Tomlinson AW, Murray JK, Comerford EJ. GenPup-M: A novel validated owner-reported clinical metrology instrument for detecting early mobility changes in dogs. PLoS One. 2023 Dec 27;18(12):e0291035. doi: 10.1371/journal.pone.0291035. PMID: 38150469; PMCID: PMC10752556.University of Liverpool page launching DogMAhttps://www.liverpool.ac.uk/life-course-and-medical-sciences/research/dogma/Download the app for free from your app store:Android: DogMA in the Google Play StoreiOS: DogMA in the Apple App StoreThis is the paper documenting radiographic and clinical OA in 23% of dogs less than 4 years of age:Enomoto M, de Castro N, Hash J, Thomson A, Nakanishi-Hester A, Perry E, Aker S, Haupt E, Opperman L, Roe S, Cole T, Thompson NA, Innes JF, Lascelles BDX. Prevalence of radiographic appendicular osteoarthritis and associated clinical signs in young dogs. Sci Rep. 2024 Feb 3;14(1):2827. doi: 10.1038/s41598-024-52324-9. PMID: 38310147; PMCID: PMC10838335. These are the COAST guidelines:Cachon T, Frykman O, Innes JF, Lascelles BDX, Okumura M, Sousa P, Staffieri F, Steagall PV, Van Ryssen B. COAST Development Group's international consensus guidelines for the treatment of canine osteoarthritis. Front Vet Sci. 2023 Aug 3;10:1137888. doi: 10.3389/fvets.2023.1137888. PMID: 37601753; PMCID: PMC10436090. | — | ||||||
| 7/2/25 | S2:E8 Behaviour tools to detect maladaptive pain | Do you feel like to need to play detective in your behaviour cases? How many of these cases have pain as an underlying issue? Then you will love this paper! We have the pleasure of talking through the approach taken in this series of cases where the authors describe their approach to assessing pain in the behaviour case. Detection of maladaptive pain in dogs referred with behavioral complaints:challenges and opportunitieshttps://www.frontiersin.org/articles/10.3389/fnbeh.2025.1569351 | — | ||||||
| 3/12/25 | S2:E6 Let sleeping dogs (and cats) lie! | In the latest edition of The Zero Pain Philosophy podcast Matt talks to behaviour specialist Dr Carrie Tooley about sleep in dogs and cats. How many hours of sleep should dogs and cats be getting and how can sleep disturbance influence behaviour and emotional health? ShownotesWhy we sleep – Matthew WalkerLi et al review (2022): The Influence of Sleep Disturbance on Chronic Pain: https://link.springer.com/article/10.1007/s11916-022-01074-2Sleep questionnaires – only one validated for use in dogs SNoRE 3.0: https://www.nature.com/articles/s41598-023-40048-1https://www.pdsa.org.uk/what-we-do/pdsa-animal-wellbeing-report/paw-report-2024BSS (British Sleep Society)/ESRS (European Sleep Research Society) – memberships, webinars, conferencesBSS have a few podcast episodes “BSS bites” | — | ||||||
| 1/15/25 | S2:E5 Tuning into pain and emotional health | Understand how to incorporate pre visit sedation protocols with your cat or dog friendly approachThis podcast complements the pre-visit medication protocols that we have on Zero Pain PhilosophyLearn how to interpret some of the behaviours that anxious dogs are showing in the hospital and how our interactions with those pets are 90% of the solutionReview the pre-visit and hospital sedation protocols created by Dr Matt Gurney & Dr Sarah Heath first, as you listen to this podcastFind the sedation protocols at www.zeropainphilosophy.com. Please note access is limited to veterinary professionals and we are unable to answer advice queries from pet owners. Please contact your vet. For information on behavioural medicine support from Behaviour Referrals Veterinary Practice please visit https://behaviouralreferrals.co.uk/ReferencesMills, Daniel S et al. “Pain and Problem Behavior in Cats and Dogs.” Animals : an open access journal from MDPI vol. 10,2 318. 18 Feb. 2020, doi:10.3390/ani10020318Tooley, Carrie, and Sarah E Heath. “Emotional Arousal Impacts Physical Health in Dogs: A Review of Factors Influencing Arousal, with Exemplary Case and Framework.” Animals : an open access journal from MDPI vol. 13,3 465. 28 Jan. 2023, doi:10.3390/ani13030465 | — | ||||||
| 10/11/24 | S2:E4 Modifying the Microbiome to Minimise Pain | In our latest podcast, Modifying the Microbiome to Minimise Pain, Matt talks to Dr Siobhain O’Mahony, a leading academic in microbiome research. Dr O’Mahony has published work within human medicine, examining the link between the microbiome and pain outcomes after surgery. And we ask, ‘How could this translate into our field of veterinary pain management?’ We also touch upon what we should eat ourselves and ask whether we are feeding our pets correctly.References for shownotesThe gut microbiota as a key regulator of visceral pain (2017)The gut microbiota in persistent post-operative pain following breast cancer surgeryhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11137075/Stevens, Christina et al. “Gut Microbiome and Osteoarthritis: Insights From the Naturally Occurring Canine Model of Osteoarthritis.” Arthritis & rheumatology (Hoboken, N.J.), 10.1002/art.42956. 19 Jul. 2024, doi:10.1002/art.42956Stewart, H L et al. “Differences in the equine faecal microbiota between horses presenting to a tertiary referral hospital for colic compared with an elective surgical procedure.” Equine veterinary journal vol. 51,3 (2019): 336-342. doi:10.1111/evj.13010Stewart, Holly L et al. “Changes in the faecal bacterial microbiota during hospitalisation of horses with colic and the effect of different causes of colic.” Equine veterinary journal vol. 53,6 (2021): 1119-1131. doi:10.1111/evj.13389Jan S Suchodolskihttps://pubmed.ncbi.nlm.nih.gov/34514619/The Dysbiosis Index (DI) is a validated quantitative PCR assay for canine fecal samples that measures the abundance of seven important bacterial taxa and summarizes the results as one single number. The DI can be used to assess the microbiome in clinical patients over time and in response to therapy (eg, fecal microbiota transplantation). | — | ||||||
| 8/23/24 | S2:E3 Is subcutaneous methadone a thing? | Spoiler alert - you need to listen to this podcast to understand if there is a place for subcutaneous methadone in veterinary clinical practice!In this edition, Matt reviews the first paper that investigated pharmacokinetics of subcutaneous methadone and first raised the question of using this route in dogs. Matt then chats to anaesthesia specialist Aoife Ryan about a study they performed together to attempt to enhance our understanding around this topic. With Carl, we then chat through a recent publication examining this route of administration in dogs. For more on methadone, please see our pain update 'Methadone, the most versatile opioid' here https://www.zeropainphilosophy.com/post/methadone-the-most-versatile-opioidNeed more detail? You can watch this webinar on methadonehttps://www.zeropainphilosophy.com/members-webinarsReferences discussed in this podcastBini G, Vettorato E, De Gennaro C, Corletto F. A retrospective comparison of two analgesic strategies after uncomplicated tibial plateau levelling osteotomy in dogs. Vet Anaesth Analg. 2018 Jul;45(4):557-565. doi: 10.1016/j.vaa.2017.11.005. Ingvast-Larsson C, Holgersson A, Bondesson U, Lagerstedt AS, Olsson K. Clinical pharmacology of methadone in dogs. Vet Anaesth Analg. 2010 Jan;37(1):48-56. doi: 10.1111/j.1467-2995.2009.00476.x. Ryan AC, Murrell JC, Gurney MA. Post-operative nausea and vomiting (PONV) observed in a clinical study designed to assess the analgesic effects of intravenous and subcutaneous methadone in dogs. Vet J. 2022 Sep;287:105876. doi: 10.1016/j.tvjl.2022.105876. Upchurch D, Lin KTT, KuKanich B. Two doses of subcutaneous methadone for postoperative analgesia in dogs undergoing tibial plateau levelling osteotomies. J Small Anim Pract. 2024 Jun;65(6):368-375. doi: 10.1111/jsap.13728. | — | ||||||
| 7/19/24 | S2:E2 Shoe size and the wrong shaped brain | Professor Clare Rusbridge is a global thought leader in the management of syringomyelia, Chiari malformation and phantom scratching. To assist vets in treatment of these conditions, Clare has recently updated and released her 2024 treatment algorithms. In this episode, Matt discusses the new algorithms with Clare, as well as ensuring we have our diagnosis correct and also looking to the future with these diseases. You can read the treatment algorithms here:https://veterinary-neurologist.co.uk/cmsm-new-treatment-algorithm-2024/This is the link to the symptom checker:https://veterinary-neurologist.co.uk/chiari-checker/Find Clare's YouTube channel here:https://www.youtube.com/@clare-neurovetLink to Head Space project:https://www.surrey.ac.uk/research-projects/head-space-project-canine-chiari-group | — | ||||||
| 4/15/24 | S2:E1 Acute pain in cats with Prof Paulo Steagall | Meet Prof Paulo Steagall. Hear about his career, where thefeline grimace scale developed from, and what the future of the FGS is. In this episode, Matt & Carl chat through all things relating to feline pain scoring with Paulo and explore a number of questions.Where does AI fit with the future of the feline grimace scale?Can pet owners use the feline grimace scale? Are cats difficult to pain score? The podcast takes a look at how pain scoring is just onepart of the picture of enabling us to give optimal care to our feline patients.Listen to Paulo’s reflections on burprenorphine and how theuse of the FGS has enhanced our understanding Show notes below are the papers that we refer to within the podcast and you can link to the mentioned pain scale resource here Steagall PV, Robertson S, Simon B, Warne LN, Shilo-BenjaminiY, Taylor S. 2022 ISFM Consensus Guidelines on the Management of Acute Pain inCats. J Feline Med Surg. 2022 Jan;24(1):4-30. doi: 10.1177/1098612X211066268.PMID: 34937455. Steagall PV, Monteiro BP. Acute pain in cats: Recentadvances in clinical assessment. J Feline Med Surg. 2019 Jan;21(1):25-34. doi:10.1177/1098612X18808103. Epub 2018 Oct 15. PMID: 30320529. Marangoni S, Beatty J, Steagall PV. An ethogram of acutepain behaviors in cats based on expert consensus. PLoS One. 2023 Sep28;18(9):e0292224. doi: 10.1371/journal.pone.0292224. PMID: 37768967; PMCID:PMC10538801. Evangelista MC, Watanabe R, Leung VSY, Monteiro BP, O'TooleE, Pang DSJ, Steagall PV. Facial expressions of pain in cats: the developmentand validation of a Feline Grimace Scale. Sci Rep. 2019 Dec 13;9(1):19128. doi:10.1038/s41598-019-55693-8. PMID: 31836868; PMCID: PMC6911058. Steagall PV, Monteiro-Steagall BP, Taylor PM. A review ofthe studies using buprenorphine in cats. J Vet Intern Med. 2014May-Jun;28(3):762-70. doi: 10.1111/jvim.12346. Epub 2014 Mar 21. PMID:24655078; PMCID: PMC4895465. Watanabe R, Frank D, Steagall PV. Pain behaviors before andafter treatment of oral disease in cats using video assessment: a prospective,blinded, randomized clinical trial. BMC Vet Res. 2020 Apr 10;16(1):100. doi:10.1186/s12917-020-02302-w. PMID: 32272922; PMCID: PMC7146962. Watanabe R, Doodnaught G, Proulx C, Auger JP, Monteiro B,Dumais Y, Beauchamp G, Segura M, Steagall P. A multidisciplinary study of painin cats undergoing dental extractions: A prospective, blinded, clinical trial.PLoS One. 2019 Mar 1;14(3):e0213195. doi: 10.1371/journal.pone.0213195. PMID:30822336; PMCID: PMC6396900. Monteiro BP, Lee NH, Steagall PV. Can cat caregiversreliably assess acute pain in cats using the Feline Grimace Scale? A largebilingual global survey. J Feline Med Surg. 2023 Jan;25(1):1098612X221145499.doi: 10.1177/1098612X221145499. PMID: 36649089. Belli M, de Oliveira AR, de Lima MT, Trindade PHE, SteagallPV, Luna SPL. Clinical validation of the short and long UNESP-Botucatu scalesfor feline pain assessment. PeerJ. 2021 Apr 12;9:e11225. doi:10.7717/peerj.11225. PMID: 33954046; PMCID: PMC8048399.Zero Pain Philosophy is an educational resource for vet professionals.If you are a pet owner, please encourage for vet to connect with us. We areunable to offer advice direct to pet owners. | — | ||||||
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| 4/23/23 | Anti NGF questions | It's been two years since bedinvetmab was launched as a treatment for the pain associated with osteoarthritis - quickly followed by frunevetmab. During that time Matt has lectured around the world on the topic. This podcast brings together a number of questions that have been raised as part of those lectures - and we always say that if someone has a question, then 10 are people are thinking the same thing! After this podcast you will have a better understanding of the anti nerve growth factor agents. If you have questions, we would love to help. Please use the contact box to send us a message. Don't forget that we offer a telemedicine service - so for case advice, please ask for our help! Reflective learning What further questions does this podcast content raise for you? How will this understanding impact the management of your current and future patients? Learning actions Revise the mechanism of action of anti nerve growth factor agents (both references below) Review the data sheet (summary of product characteristics) for bedinvetmab (Librela/Beransa) and frunevetmab (Solensia). Practice discussion As a practice team do we feel that anti-NGF agents are a first line treatment for OA in dogs and cats? References Enomoto M, Mantyh PW, Murrell J, Innes JF, Lascelles BDX. Anti-nerve growth factor monoclonal antibodies for the control of pain in dogs and cats. Vet Rec. 2019 Jan 5;184(1):23. doi: 10.1136/vr.104590. Epub 2018 Oct 27. PMID: 30368458; PMCID: PMC6326241. Schmelz M, Mantyh P, Malfait AM, Farrar J, Yaksh T, Tive L, Viktrup L. Nerve growth factor antibody for the treatment of osteoarthritis pain and chronic low-back pain: mechanism of action in the context of efficacy and safety. Pain. 2019 Oct;160(10):2210-2220. doi: 10.1097/j.pain.0000000000001625. PMID: 31145219; PMCID: PMC6756297. | — | ||||||
| 4/16/23 | Gabapentin or pregabalin post spinal surgery? | Join Matt & Carl as we discuss the two papers here that document the difference between using pregabalin and gabapentin after spinal surgery in dogs. Reflective learning After listening to this podcast do you see a place for gabapentinoids in the management of pain following spinal surgery? How will this understanding impact the management of your current and future patients? Learning actions Watch Gwen Covey Crump's webinar on gabapentinoids. Watch Matt's webinar on descending modulation which explores the mechanism of action of gabapentinoids. Practice discussion As a practice team discuss your use of gabapentinoids. References Aghighi SA, Tipold A, Piechotta M, Lewczuk P, Kästner SB. Assessment of the effects of adjunctive gabapentin on postoperative pain after intervertebral disc surgery in dogs. Vet Anaesth Analg. 2012 Nov;39(6):636-46. doi: 10.1111/j.1467-2995.2012.00769.x. Epub 2012 Aug 10. PMID: 22882632. Almeida et al (2023) Evaluation of Gabapentin in the Treatment of Postoperative Pain after a Tibial Plateau Levelling Osteotomy in Dogs DOI https://doi.org/ 10.1055/s-0042-1751069. Crociolli GC, Cassu RN, Barbero RC, Rocha TL, Gomes DR, Nicácio GM. Gabapentin as an adjuvant for postoperative pain management in dogs undergoing mastectomy. J Vet Med Sci. 2015 Aug;77(8):1011-5. doi: 10.1292/jvms.14-0602. Epub 2015 Mar 29. PMID: 25816802; PMCID: PMC4565804. Schmierer, P. A., Tünsmeyer, J., Tipold, A., Hartnack-Wilhelm, S., Lesczuk, P., & Kästner, S. B. R. (2020). Randomized controlled trial of pregabalin for analgesia after surgical treatment of intervertebral disc disease in dogs. Veterinary Surgery, 49(5), 905–913. https://doi.org/10.1111/vsu.13411 | — | ||||||
| 3/30/22 |  Gabapentin in cats - analgesia and anxiolysis | In this episode, Matt reviews the literature on gabapentin in cats. Does the science support our use of gabapentin as an analgesic. How does gabapentin work? To end, Matt reports a recent study he conducted examining the anxiolytic benefit of gabapentin in hyperthyroid cats. Find the show notes with all references on the Pain Updates page. | — | ||||||
| 1/9/22 | CBD - en vogue or evidence based? | As a complementary supplement to Ian Self's webinar on CBD and our pain update, Matt has reviewed two of the papers on CBD in dogs. For people CBD comes with celebrity endorsement, but is this all there is to it? What does the evidence say? | — | ||||||
| 11/5/21 | OA series: intra-articular therapies | If you are thinking about intra-articular therapies, where do you start? In this episode Matt chats to the Vet Vault team about where he sees IA therapies fit with Oa management | — | ||||||
| 11/5/21 | OA series: Vet Vault podcast discussing NSAIDs & grapiprant | Continuing our OA series, the Zero Pain & Vet Vault teams chat about the role of NSAIDs and grapiprant in management of your OA cases. | — | ||||||
| 11/5/21 | OA series: Vet Vault chat about bedinvetmab (Librela) | Matt joins Hugh and Gerardo from Vet Vault to discuss bedinvetmab, in one of three podcasts on OA management. | — | ||||||
| 9/1/21 | Ketamine in chronic pain - Vet Vault chat | Earlier this year Matt joined the guys from The Vet Vault to chat all things chronic pain management. In this episode we chat about the use of ketamine subcutaneously for chronic pain. | — | ||||||
| 8/24/21 | Tramadol - review for acute pain management | Always a popular topic, we decided to go back to the literature to guide your use of tramadol for post operative pain control. | — | ||||||
| 7/1/21 | Second line in OA? | In this Vet Vault chat, Matt talks to Hubert and Gerardo about our second line options in OA. We cover amantadine and discuss is there room for tramadol? | — | ||||||
| 3/31/21 | Amantadine or memantine? | NMDA antagonists are excellent additions to chronic pain management. Why would you choose either? How do they work and what evidence do we have? In this edition of our member podcast, Matt reviews the use of these drugs and how they can help your patients. | — | ||||||
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