A Journey Through Medicine

Content covered: - Formal thought disorder - Acute psychosis, causes, differential diagnosis and treatment - Schizophrenia and related disorders - Mania - First vs second generation antipsychotics including important indications and side affects

Abdulla joins the lads as they reflect on their time in psychiatry placement, giving their thoughts and suggestions for those heading into their first psych term. We are by no means experts, but thought some people might find this useful.

Todays episode is all about stroke. What actually is a stroke? How can it happen? What are some warning signs that someone may be having a stroke? The lads discuss these questions and more as they piece together what they have learnt about cerebrovascular diseases. Content covered: - Risk factors for the development of cerebrovascular disease - Pathogenesis of cerebrovascular disease - Ischaemic vs haemorragic strokes - Clinical presentation, prognosis and sequalae of stroke - Basic principles of management

Let's break it down! Pathology and biochem wizard Jonathan joins us as we do a deep dive into diseases that affect bone integrity on a cellular and metabolic level as well as their clinical presentations. Content covered: - Osteoporosis, Type 1 and Type 2 - Osteomalacia and Ricketts - Hyperparathyroidism - Paget's Disease of Bone

TO CLARIFY: Arthralgia = the term for joint pain. Arthritis = a general term for diseases that have joint pain, leading to loss of function at the joint (+/- inflammation). Arthralgia = symptom, arthritis = diagnosis. The boys get their heads around what arthritis actually is and explore osteoarthritis (or degenerative joint diseases), one of the core MSK conditions! Content covered: - General arthritis findings - Pathophysiology of degenerative joint disease (osteoarthritis) and clinical presentation - Osteonecrosis and avascular necrosis. - Various other causes of arthritis

Today the boys were joined by the legendary Jonathan as they discuss diabetes, a common chronic disease impacting millions worldwide. Content covered: - Diabetes insipidus - Glucose homeostasis (insulin + glucagon) including some biochemistry - Pathophysiology, diagnosis, clinical features and comparisons between Type 1 & 2 diabetes mellitus - Complications of chronic hyperglycaemia (vascular, neural and immune) - Hypoglycaemia

Welcome to our 30th episode! Celebrate this milestone with us by letting out your inner Sherlock Holmes and try crack these (expertly crafted) cases of glomerulonephritis and other renal diseases. Learn about the differential diagnosis of nephritic vs nephrotic syndromes, acute vs chronic renal failure and some other related conditions.

Claire helps the boys out with the plethora of drugs that can be used to treat nausea, vomiting, reflux and more - and all their funky nuances. Topics covered in this episode include: - General causal pathways of nausea and vomiting - Drugs used to treat nausea and vomiting - including 5HT3 antagonists, dopamine antagonists (metoclopramide and prochlorperazine), domperidone, steroids, NK-1 antagonists (aprepipant and fosaprepipant), hyoscine and lorazepam - Prescribing nausea and vomiting drugs in special populations i.e. pregnancy and children - Drugs used to treat GORD and reflux symptoms - NOT EXAMINABLE: Drugs used to treat hepatic encephalopathy

Today the legendary Mike Kendall imparts some wisdom on the boys as they revise the pathogenesis, clinical features and what differentiates the inflammatory bowel diseases and other non-neoplastic conditions of the bowel. Content covered includes: - Crohn's disease and ulcerative colitis - Ischaemic colitis - Diverticular disease - Antibiotic-associated diarrhea and pseudomembranous colitis - Microscopic Colitis - Coeliac disease and its consideration in the differential diagnosis Correction: Ipilimumab can cause an Autoimmune-like enterocolitis, not GVHD.

Retrosternal chest pain only has cardiac causes... right? In this episode, the lads welcome back Ben Earner as they try to make sense of the important pathologies affecting the oesophagus and the differing signs and symptoms these could manifest as. Content covered: - Signs/symptoms of oesophageal disease such as dyspepsia, dysphagia, odynophagia, waterbrash and the dreaded retrosternal chest pains - Functional and mechanical obstructive disorders eg Achalasia and Schatzki rings - Oesophageal Varices and portal hypertension - Gastro-oesophageal reflux disease (GORD/GERD): causes and consequences - Oesophagitis - Barrett oesophagus - Oesophageal adenocarcinoma - Oesophageal squamous cell carcinoma

How does your stomach begin the digestion process without digesting itself? What structures and cells are involved in the mechanical and chemical digestive processes in the stomach? In this episode, the boys discuss the anatomy and physiology of the stomach + a little bit of the gut. Featuring a colourful diagram from Terence to help us understand transport and creation of protons across parietal cells in the stomach! Shoutout to Jarrod for the 'chief likes pepsi' memory aide.

Norm, Terence and Shaun are joined by Saud as they work their way through the anatomy of the respiratory passageway and some of the mechanics of breathing. From the nose, through the conductive tubes and to areas of gas exchange, the lads talk about the key structures and what comprise them. Content covered: - Nasal conchae and the paranasal sinuses - How air travels down the respiratory tract (and how food doesn't, hopefully) - Histological differences between conductive and respiratory structures - Innervation of the pleura and lungs - Ribs, the sternum and the sternocostal joints - Mechanics of breathing including the use of accessory muscles

The legendary Claire is back to help the boys make sense of the drug treatments clinicians should prescribe for the various pathologies that can affect the cardiovascular system. Things covered include: - Treatment of acute coronary syndromes and post MI treatment - Antiarrhythmics - Anticoagulant and antiplatelet therapy - Diuretics and antihypertensives - Lipid lowering therapies - Digoxin!