Autoimmune Alchemy

Today I'm honored to have Dr. Salome Masghati, OB-GYN and pelvic surgeon who transitioned from operating rooms to preventative medicine.Dr. Salome reveals why autoimmune diseases like Hashimoto's, lupus, and RA spike during perimenopause—estrogen is anti-inflammatory, and when it declines, cortisol dysregulates, inflammation rises, and autoimmune flares.She explains why calorie restriction backfires in midlife, worsening cortisol and weight gain, and shares practical steps: morning sunlight, protein breakfasts, resistance training, gut testing, and hormone optimization. Hormones alone aren't enough—you need proper liver detox, gut health, and anti-inflammatory diet to truly heal.Key TakeawaysAutoimmune diseases spike in perimenopause when estrogen (anti-inflammatory) declinesCortisol dysregulates when estrogen drops—overactive to compensateCalorie restriction worsens cortisol dysregulation—don't undereat in midlifeStart simple: morning sunlight, protein breakfasts, resistance training (not just cardio)Estrogen & testosterone are immune modulators—decline = autoimmune flaresHashimoto's, lupus, RA improve in pregnancy, worsen in menopauseHormones need gut health, liver detox, anti-inflammatory diet to workHeavy/painful periods, cyclical migraines = hormone-related symptomsCOVID disrupted gut microbiome—long COVID worsened autoimmuneIndividualized testing: gut, heavy metals, micronutrientsChapters & Timestamps02:00 Cortisol Clues: Exhausted Mornings, Wired Nights03:00 Why Cortisol Goes Haywire in Perimenopause05:00 Metabolic Changes: Weight Gain, Insulin Resistance07:00 Simple Starts: Sunlight, Protein, Resistance Training10:00 Autoimmune Diseases Spike When Estrogen Declines12:00 Hormones Need Gut Health & Liver Detox14:00 When Is Surgery Needed vs Lifestyle?16:00 Environmental Toxins & COVID Impact17:00 Beyond Basic BloodworkGuest DetailsSalome Masghati, MD — OB-GYN, Pelvic Surgeon & Hormone SpecialistTraining: OB-GYN, pelvic surgery, regenerative medicine, advanced hormone therapy, preventative wellnessCurrent Focus: Preventative medicine—balancing hormones to prevent surgeries, addressing root causes (gut health, environmental toxins, metabolic dysfunction)Philosophy: Individualized care. Hormones must be balanced with proper liver detox, gut microbiome, anti-inflammatory diet.Connect:Instagram: @drsalomemasghatimdWebsite: DrsalomemasghatiIndividualized Hormone Therapy for Women | Dr. Salome MasghatiAbout Your HostsMicah Yu, MD, MHA, MS, ABOIM, DipABLM, IFMCPDr. Micah Yu is a triple board-certified integrative rheumatologist who blends conventional medicine with holistic, nutrition-based healing to treat autoimmune and chronic inflammatory conditions. A patient himself, Dr. Yu brings a deeply personal perspective to his work, having reversed his own autoimmune arthritis through lifestyle and integrative medicine. He is certified in internal medicine, rheumatology, integrative medicine, lifestyle medicine, and functional medicine. As the founder of MyAutoimmuneMD and co-founder of Dr. Lifestyle Clinic, Dr. Yu empowers patients to address the root causes of illness and reclaim their health from the inside out.Melissa Mondala, MD, MHA, MS, DipABLMDr. Melissa Mondala is a dual board-certified physician in Family and Lifestyle Medicine, with advanced training in Integrative Psychiatry and Integrative Medicine. As President of Dr. Lifestyle Clinic in Newport Beach—recognized by UC Irvine as a Public Health Site of Excellence—she pioneers a holistic, patient-centered approach to chronic disease. Dr. Mondala is a nationally recognized Lifestyle Medicine Intensivist, core faculty at Loma Linda University's Preventive Medicine Department, and a passionate advocate for plant-based nutrition, mental health, and women's wellness. A sought-after speaker and educator, she combines cutting-edge science with deep compassion to empower lasting healing, especially for those silently suffering from autoimmune, mental health, and long COVID conditions. She shares practical inspiration for healthy living and cooking at @drmelissaskitchen.About AutoImmune Alchemy PodcastMission: Blending science with soul to transform autoimmune struggles into healing alchemyAutoImmune Alchemy is a podcast dedicated to the autoimmune community, offering hope, validation, and evidence-based solutions for those struggling with complex autoimmune conditions. Hosted by the dynamic duo Dr. Melissa Mondala and Dr. Micah Yu, the show features expert interviews exploring root causes like hormonal imbalances, leaky gut, and inflammation that traditional medicine often overlooks. Each episode empowers listeners to take proactive control of their health through lifestyle medicine, nutrition, and integrative approaches.Connect with AutoImmune AlchemyWebsite:MyAutoimmuneMD.comDr. Lifestyle Clinic:www.drlifestyle.orgInstagram: @myautoimmunemdFacebook: @MYAutoimmuneMDYouTube: @myautoimmunemdEmail: contact@myautoimmunemd.comSubscribe & Review: Available on Apple Podcasts, Spotify, and all major podcast platforms. If this episode helped you understand environmental toxins and autoimmune disease, please leave a 5-star review!

Show NotesIn this episode, I sit down with Dr. Tara Scott, a trailblazer in integrative hormone medicine with 23 years of experience, to reveal why birth control pills are NOT hormone replacement therapy and how bioidentical hormones transform women's health from teens to post-menopause.Dr. Scott explains when to test hormones (even on birth control or IUDs), why progesterone drops first in late 30s causing insomnia and anxiety, and how estrogen is anti-inflammatory for autoimmune patients.We discuss the groundbreaking 7 million women study showing 26% mortality reduction and 19% breast cancer reduction with transdermal hormone therapy.Key TakeawaysBirth control prevents pregnancy, NOT replaces hormonesProgesterone drops first (late 30s) = insomnia, anxiety, water retentionTest hormones during pill-free week if on birth controlEstrogen is anti-inflammatory—autoimmune flares increase in menopauseLow DHEA common in autoimmune patients—check both DHEA & DHEA-STestosterone for women requires compounding—no FDA female doseMicronized progesterone is FDA-approved bioidentical hormone7M women study: 26% mortality reduction, 19% breast cancer reduction (transdermal HRT)Vaginal DHEA safer for breast cancer survivors than estradiolLuteal phase defect = ovulation to period <14 days = low progesteroneChapters & Timestamps02:00 When Do Hormones Become Abnormal?04:00 Testing Hormones: Timing & Birth Control07:00 Can You Test on Birth Control or IUD?12:00 Low DHEA in Autoimmune Patients14:00 Progesterone Drops First: Insomnia & Anxiety18:00 Birth Control Is NOT Hormone Replacement22:00 Bioidentical Hormones: FDA-Approved Options26:00 Luteal Phase Defect & Micronized Progesterone29:00 Testosterone for Women: Compounding Solutions46:00 DHEA vs DHEA-S: Why Test Both50:00 Breast Cancer & Hormone Therapy Myths56:00 7M Women Study: 26% Mortality Reduction01:01:00 Where to Find Dr. Tara ScottGuest DetailsDr. Tara Scott, MD, FACOG — OB-GYN & Hormone SpecialistCredentials: Board-certified OB-GYN. Certified Menopause Practitioner (2006). Fellowship Functional Medicine (A4M). Board-certified Integrative Medicine (2015). 23+ years hormone specialization.Specializations: Bioidentical HRT, PCOS, perimenopause, menopause, testosterone for women, breast cancer survivors, autoimmune-hormone connection. Connect:YouTube: Your Hormone Guru / Dr. Tara ScottInstagram: @hormonegurumdWebsite:drtarascott.comAbout Your Hosts:Micah Yu, MD, MHA, MS, ABOIM, DipABLM, IFMCPDr. Micah Yu is a triple board-certified integrative rheumatologist who blends conventional medicine with holistic, nutrition-based healing to treat autoimmune and chronic inflammatory conditions. A patient himself, Dr. Yu brings a deeply personal perspective to his work, having reversed his own autoimmune arthritis through lifestyle and integrative medicine. He is certified in internal medicine, rheumatology, integrative medicine, lifestyle medicine, and functional medicine. As the founder of MyAutoimmuneMD and co-founder of Dr. Lifestyle Clinic, Dr. Yu empowers patients to address the root causes of illness and reclaim their health from the inside out.Melissa Mondala, MD, MHA, MS, DipABLMDr. Melissa Mondala is a dual board-certified physician in Family and Lifestyle Medicine, with advanced training in Integrative Psychiatry and Integrative Medicine. As President of Dr. Lifestyle Clinic in Newport Beach—recognized by UC Irvine as a Public Health Site of Excellence—she pioneers a holistic, patient-centered approach to chronic disease. Dr. Mondala is a nationally recognized Lifestyle Medicine Intensivist, core faculty at Loma Linda University’s Preventive Medicine Department, and a passionate advocate for plant-based nutrition, mental health, and women's wellness. A sought-after speaker and educator, she combines cutting-edge science with deep compassion to empower lasting healing, especially for those silently suffering from autoimmune, mental health, and long COVID conditions. She shares practical inspiration for healthy living and cooking at @drmelissaskitchen.About AutoImmune Alchemy PodcastMission: Blending science with soul to transform autoimmune struggles into healing alchemyAutoImmune Alchemy is a podcast dedicated to the autoimmune community, offering hope, validation, and evidence-based solutions for those struggling with complex autoimmune conditions. Hosted by the dynamic duo Dr. Melissa Mondala and Dr. Micah Yu, the show features expert interviews exploring root causes like hormonal imbalances, leaky gut, and inflammation that traditional medicine often overlooks. Each episode empowers listeners to take proactive control of their health through lifestyle medicine, nutrition, and integrative approaches.Connect with AutoImmune Alchemy:Website: MyautoimmunemdHome – NewInstagram: @myautoimmunemdFacebook: @MYAutoimmuneMDYouTube: @myautoimmunemdEmail: contact@myautoimmunemd.comSubscribe & Review: Available on Apple Podcasts, Spotify, and all major podcast platforms. If this episode helped you understand the hormone-autoimmune connection, please leave a 5-star review!For more information, please visit MyautoimmunemdMyAutoImmuneMD | Autoimmunity Redefined . This episode is for educational purposes only and does not constitute medical advice. Always consult with your qualified healthcare provider before starting any new treatment or making changes to your hormone therapy. Individual results may vary.

In this episode, I sit down with Dr. Roseann Capanna-Hodge, pioneering mental health expert and author of "It's Gonna Be OK," to reveal how chronic compounded stress drives nervous system dysregulation and fuels the rise of autoimmune disease.Dr. Roseann explains why "shopping cart diagnoses"—collecting labels without treating the root cause—keep patients stuck, and how regulating the nervous system through breathwork, neurofeedback, nutrition, and sleep unlocks the body's ability to heal.This conversation is a game-changer for anyone with autoimmune disease, PANS/PANDAS, ADHD, or mast cell activation who hasn't found answers despite trying everything.Key TakeawaysChronic stress = sympathetic dominance — your nervous system gets physically stuckReal or imagined stress triggers the same cortisol response — your body can't tell the difference4-7-8 breathing (inhale 4, hold 7, exhale 8) is the fastest reset to parasympathetic stateUse phone timers — minimum 3x daily breathwork to rewire nervous systemPick ONE strategy and do it consistently for 30 days before adding more90% of brain detoxification happens during sleep — prioritize before midnightRemove 1-2 inflammatory foods first — overwhelm stops progressNeurofeedback over 40 sessions/6 months reveals underlying root causes100% of complex chronic illness patients have unresolved traumaSmall deposits daily beat weekend wellness — integrate, don't isolateChapters & Timestamps01:00 Chronic Stress = Sympathetic Dominance & Stuck Nervous System02:00 "Shopping Cart Diagnoses" & Why Kids Are More Dysregulated04:00 4-7-8 Breathwork: Fastest Way to Parasympathetic State05:00 PMFT, Neurofeedback & Brain Tools for Nervous System Reset06:00 Stress Hijacks Immunity: Rise of Autoimmune & Mast Cell Activation07:00 Nervous System Dysregulation Affects Sleep, Gut & Hormones09:00 Neurofeedback Success: From Impulsive to Regulated11:00 Top 3 Strategies: Regulate, Diet & Sleep12:00 90% of Brain Detox Happens During Sleep15:00 Downtime, Workaholic Culture & Stress Deposits18:00 100% of Complex Cases Have Trauma in Their Background19:00 Programs, Podcast & Where to Find Dr. RoseannGuest DetailsDr. Roseann Capanna-Hodge, PhD Integrative Mental Health Expert, Author & FounderCredentials: Pioneered Brain Behavior Reset™ program. Founder of the Global Institute of Children's Mental Health. Author of It's Gonna Be OK and multiple books on integrative mental health. Top podcaster and one-to-one program ending 2026.Specializations: Nervous system dysregulation, ADHD, OCD, PANS/PANDAS, neurofeedback, autoimmune-mental health connection, trauma, neurodivergence, children & adult complex cases.Connect:Website: drroseann.comPodcast: Available on all platformsAbout Your HostDr. Micah Yu, DC, CFMPFunctional Medicine Practitioner & Host of AutoImmune AlchemyDr. Micah Yu is a doctor of chiropractic and certified functional medicine practitioner specializing in autoimmune conditions and chronic illness. He recognizes mold exposure as a common root cause of autoimmune disease, particularly in patients with long-haul COVID who suddenly develop mold sensitivities. Dr. Yu is passionate about educating his community on environmental toxins and bringing expert voices like John Banta to help patients understand the hidden triggers affecting their health. He practices integrative medicine with his wife, creating a dynamic team dedicated to uncovering root causes and supporting patients on their healing journey.Melissa Mondala, MD, MHA, MS, DipABLMDr. Melissa Mondala is a dual board-certified physician in Family and Lifestyle Medicine, with advanced training in Integrative Psychiatry and Integrative Medicine. As President of Dr. Lifestyle Clinic in Newport Beach—recognized by UC Irvine as a Public Health Site of Excellence—she pioneers a holistic, patient-centered approach to chronic disease. Dr. Mondala is a nationally recognized Lifestyle Medicine Intensivist, core faculty at Loma Linda University’s Preventive Medicine Department, and a passionate advocate for plant-based nutrition, mental health, and women's wellness. A sought-after speaker and educator, she combines cutting-edge science with deep compassion to empower lasting healing, especially for those silently suffering from autoimmune, mental health, and long COVID conditions. She shares practical inspiration for healthy living and cooking at @drmelissaskitchen.About AutoImmune Alchemy PodcastMission: Blending science with soul to transform autoimmune struggles into healing alchemyAutoImmune Alchemy is a podcast dedicated to the autoimmune community, offering hope, validation, and evidence-based solutions for those struggling with complex chronic conditions.Hosted by Dr. Micah Yu, the show explores root causes like mold exposure, infections, and environmental toxins that traditional medicine often overlooks. Each episode features expert interviews and cutting-edge treatments to help listeners understand the "why" behind their illness and find pathways to healing.Connect with AutoImmune Alchemy:Website: MyautoimmunemdHome – NewInstagram: @myautoimmunemdFacebook: @MYAutoimmuneMDYouTube: @myautoimmunemdEmail: contact@myautoimmunemd.comSubscribe & Review: Available on Apple Podcasts, Spotify, and all major podcast platforms. If this episode helped you understand mold's role in chronic illness, please leave a 5-star review!This episode is for educational purposes only and does not constitute medical advice. Always consult with your qualified healthcare provider before starting any new treatment or remediation. Individual results may vary.

In this episode, I sit down with Dr. Nam Lee, licensed acupuncturist, herbalist, and author, to explore how Traditional Chinese Medicine can regulate the immune system, reduce chronic inflammation, and restore energy for autoimmune patients. Dr. Lee shares accessible acupressure techniques anyone can do at home—including Large Intestine 11 for autoimmune skin conditions like psoriasis and eczema, and Stomach 36 for combating fatigue and boosting vitality. We discuss how TCM addresses autoimmune disease as a "wrong signal" in the body, treating root causes through personalized point selection, herbal medicine, breathwork, and small consistent lifestyle changes that create lasting healing.Key TakeawaysAcupressure = acupuncture you can do at home — no needles requiredLarge Intestine 11 (elbow crease) reduces autoimmune inflammation & skin flaresStomach 36 (below kneecap) is TCM's #1 point for fatigue and vitalityTCM treats autoimmune disease as "wrong signals" needing personalized rebalancingDampness in TCM = swollen, heavy, painful joints common in RA patientsAcupuncture lowers cortisol and raises endorphins — backed by researchHumming breathwork through the nose creates nitric oxide for better circulationKorean hand point stimulation activates brain function and fights fatigueSmall, consistent changes create lasting autoimmune healing — not extreme overhaulsBuild your healthcare village — ask for help and stay open-mindedChapters & Timestamps01:00 Acupressure vs. Acupuncture: Healing at Home 03:00 What to Expect at Your First Acupuncture Session 04:00 How Acupuncture Regulates Immune System & Inflammation 06:00 TCM Approach: Dampness, Heat & Personalized Autoimmune Care 08:00 Acupuncture for Fatigue & Brain Function 10:00 Key Points: Large Intestine 11 & Stomach 36 12:00 Herbs, Breathwork & Lifestyle for Resilience 15:00 Small Consistent Changes Create Big Results 16:00 Building Your Healthcare Village 18:00 Dr. Lee's Book: "Stop Calling Me Infertile" 20:00 Where to Find Dr. Nam LeeGuest DetailsDr. Nam Lee, LAc — Licensed Acupuncturist, Herbalist & AuthorCredentials: Advanced training in Oriental Medicine & Integrative Care. Specializes in Korean-style acupuncture, herbal medicine, fertility, women's health, and autoimmune disease. Author of Stop Calling Me Infertile.Practice: Newport Beach, Orange County, CaliforniaConnect:Instagram: @lee_acupunctureBook: Stop Calling Me Infertile — available nowWebsite: https://www.leeacupuncture.com/.About Your HostDr. Micah Yu, DC, CFMPFunctional Medicine Practitioner & Host of AutoImmune AlchemyDr. Micah Yu is a doctor of chiropractic and certified functional medicine practitioner specializing in autoimmune conditions and chronic illness. He recognizes mold exposure as a common root cause of autoimmune disease, particularly in patients with long-haul COVID who suddenly develop mold sensitivities. Dr. Yu is passionate about educating his community on environmental toxins and bringing expert voices like John Banta to help patients understand the hidden triggers affecting their health. He practices integrative medicine with his wife, creating a dynamic team dedicated to uncovering root causes and supporting patients on their healing journey.Melissa Mondala, MD, MHA, MS, DipABLMDr. Melissa Mondala is a dual board-certified physician in Family and Lifestyle Medicine, with advanced training in Integrative Psychiatry and Integrative Medicine. As President of Dr. Lifestyle Clinic in Newport Beach—recognized by UC Irvine as a Public Health Site of Excellence—she pioneers a holistic, patient-centered approach to chronic disease. Dr. Mondala is a nationally recognized Lifestyle Medicine Intensivist, core faculty at Loma Linda University’s Preventive Medicine Department, and a passionate advocate for plant-based nutrition, mental health, and women's wellness. A sought-after speaker and educator, she combines cutting-edge science with deep compassion to empower lasting healing, especially for those silently suffering from autoimmune, mental health, and long COVID conditions. She shares practical inspiration for healthy living and cooking at @drmelissaskitchen.About AutoImmune Alchemy PodcastMission: Blending science with soul to transform autoimmune struggles into healing alchemyAutoImmune Alchemy is a podcast dedicated to the autoimmune community, offering hope, validation, and evidence-based solutions for those struggling with complex chronic conditions.Hosted by Dr. Micah Yu, the show explores root causes like mold exposure, infections, and environmental toxins that traditional medicine often overlooks. Each episode features expert interviews and cutting-edge treatments to help listeners understand the "why" behind their illness and find pathways to healing.Connect with AutoImmune Alchemy:Website: MyautoimmunemdHome – NewInstagram: @myautoimmunemdFacebook: @MYAutoimmuneMDYouTube: @myautoimmunemdEmail: contact@myautoimmunemd.comSubscribe & Review: Available on Apple Podcasts, Spotify, and all major podcast platforms. If this episode helped you understand mold's role in chronic illness, please leave a 5-star review!This episode is for educational purposes only and does not constitute medical advice. Always consult with your qualified healthcare provider before starting any new treatment or remediation. Individual results may vary.

In this episode, I sit down with Dr. Amir Esparza, double board-certified colorectal surgeon at City of Hope, to discuss the alarming rise of colorectal cancer in patients under 45—becoming the #1 cause of cancer death in young adults.Dr. Esparza reveals warning signs often dismissed as hemorrhoids, explains why 30% of rectal cancer patients can avoid surgery through chemo/radiation alone, and shares robotic surgery breakthroughs reducing hospital stays from 7-10 days to 1-2 days.We discuss fiber's power (30g daily), why 90% of Americans are constipated, gut microbiome's impact on mood and immunity, and City of Hope's integrative approach combining surgery with acupuncture and multi-faith spiritual care.Key TakeawaysColorectal cancer becoming #1 young adult cancer death by 2030 (20% under 45)Start screening at 45 (or 10 years before family member's diagnosis)Warning signs: rectal bleeding, weight loss, stool changes, pain<20% diagnosed during screening—most symptomatic when found30% rectal cancer patients avoid surgery with chemo/radiationRobotic surgery: 7-10 days → 1-2 days hospital stayFiber: 30g daily prevents constipation, diverticulitis, cancer90% Americans constipated—fiber changes microbiome in 3-4 weeksGut microbiome (3-4 lbs) impacts mood, sleep, immunity, blood sugarCore activation during weightlifting prevents hemorrhoidsChapters & Timestamps02:00 Early Warning Signs Often Dismissed04:00 Less Than 20% Diagnosed During Screening05:00 30% Avoid Surgery with Chemo/Radiation07:00 Robotic Surgery: 1-2 Day Hospital Stays09:00 When to Get Screened: Age 45 & Family History14:00 Diverticulitis Prevention Through Fiber16:00 Why 30 Grams Daily Fiber Changes Everything20:00 Seeds & Nuts Don't Cause Diverticulitis (Myth)24:00 Gut Microbiome Controls Mood, Sleep & Immunity26:00 90% of Americans Are Constipated34:00 Best Fiber Sources: Avocados, Chia, Berries42:00 Bloating & Food Intolerances45:00 Hemorrhoid Treatment: Office vs Surgery52:00 Core Activation Prevents Hemorrhoids56:00 City of Hope's Integrative MedicineGuest DetailsAmir Esparza, MD, FACS — Colorectal & General SurgeonCredentials: Double board-certified. Administrative Chief Resident, University of Illinois Chicago. Outstanding Resident Leadership Award. City of Hope Orange County.Specializations: Robotic & minimally invasive colorectal cancer surgery, perianal disease, fecal incontinence, diverticulitis, hemorrhoids. Research: remote surgical techniques.Philosophy: Compassionate care transforms lives. Combines precision surgery with integrative medicine (acupuncture, yoga, meditation, multi-faith spiritual care).Connect:Instagram: @dr.amiresparzaYouTube: @dramiresparzaLinkedIn: dramiresparzaAbout Your HostDr. Micah Yu, DC, CFMPFunctional Medicine Practitioner & Host of AutoImmune AlchemyDr. Micah Yu is a doctor of chiropractic and certified functional medicine practitioner specializing in autoimmune conditions and chronic illness. He recognizes mold exposure as a common root cause of autoimmune disease, particularly in patients with long-haul COVID who suddenly develop mold sensitivities. Dr. Yu is passionate about educating his community on environmental toxins and bringing expert voices like John Banta to help patients understand the hidden triggers affecting their health. He practices integrative medicine with his wife, creating a dynamic team dedicated to uncovering root causes and supporting patients on their healing journey.Melissa Mondala, MD, MHA, MS, DipABLMDr. Melissa Mondala is a dual board-certified physician in Family and Lifestyle Medicine, with advanced training in Integrative Psychiatry and Integrative Medicine. As President of Dr. Lifestyle Clinic in Newport Beach—recognized by UC Irvine as a Public Health Site of Excellence—she pioneers a holistic, patient-centered approach to chronic disease. Dr. Mondala is a nationally recognized Lifestyle Medicine Intensivist, core faculty at Loma Linda University’s Preventive Medicine Department, and a passionate advocate for plant-based nutrition, mental health, and women's wellness. A sought-after speaker and educator, she combines cutting-edge science with deep compassion to empower lasting healing, especially for those silently suffering from autoimmune, mental health, and long COVID conditions. She shares practical inspiration for healthy living and cooking at @drmelissaskitchen.About AutoImmune Alchemy PodcastMission: Blending science with soul to transform autoimmune struggles into healing alchemyAutoImmune Alchemy is a podcast dedicated to the autoimmune community, offering hope, validation, and evidence-based solutions for those struggling with complex chronic conditions.Hosted by Dr. Micah Yu, the show explores root causes like mold exposure, infections, and environmental toxins that traditional medicine often overlooks. Each episode features expert interviews and cutting-edge treatments to help listeners understand the "why" behind their illness and find pathways to healing.Connect with AutoImmune Alchemy:Website: MyautoimmunemdHome – NewInstagram: @myautoimmunemdFacebook: @MYAutoimmuneMDYouTube: @myautoimmunemdEmail: contact@myautoimmunemd.comSubscribe & Review: Available on Apple Podcasts, Spotify, and all major podcast platforms. If this episode helped you understand mold's role in chronic illness, please leave a 5-star review!This episode is for educational purposes only and does not constitute medical advice. Always consult with your qualified healthcare provider before starting any new treatment or remediation. Individual results may vary.

In this episode, I sit down with James and Dahlia Marin, integrative dietitians specializing in SIBO and IBS, to explore how food relationships shape healing and why all autoimmunity begins in the gut.Dahlia shares her Hashimoto's journey—bringing antibodies from over 3,500 (off the charts) to nearly normal using food as medicine. We discuss how gut inflammation progresses to autoimmune diseases, the vagus nerve "elevator" connecting gut and brain (fight→constipation, flight→diarrhea), and practical tools like gratitude before meals and anti-inflammatory "fire extinguisher" foods that shift your microbiome with every meal.Key Takeaways- All autoimmunity begins in gut - SIBO/IBS are early warnings- Dahlia's antibodies: 3,500+ to near-normal with food- Location matters - test before taking probiotics- Anti-inflammatory foods: antioxidants, omega-3s, vitamin D, fiber- Vagus nerve connects gut-brain (fight→constipation, flight→diarrhea)- Calm nervous system before eating: gratitude, mantras, breathwork- Microbiome shifts with EVERY meal- Taste buds change to crave healthier foods over time- Repair barrier with protein, amino acids, gooey foods- Ask food relationship before giving elimination dietsChapters & Timestamps02:00 Autoimmune & Gut Health Connection04:00 Bloating to Autoimmune: The Timeline05:00 Anti-Inflammatory "Fire Extinguisher" Foods07:00 Location Matters: Don't Take Probiotics Blindly09:00 Dahlia's Hashimoto's: 3,500+ to Normal12:00 Vagus Nerve: The Gut-Brain Elevator13:00 Fight/Flight/Freeze/Fawn & GI Symptoms15:00 Sustaining Healthy Lifestyle16:00 Microbiome Shifts with Every Meal17:00 Married to Health ResourcesGuest DetailsJames & Dahlia Marin, RD - Integrative Dietitians, Married to Health FoundersCredentials: Registered Dietitians specializing in SIBO, IBS & autoimmune disease. Dahlia: Hashimoto's survivor (antibodies less than 3,500 to near-normal).Specializations: SIBO/IBS therapy, autoimmune nutrition, gut-brain connection, nervous system regulation, food relationship healing.Philosophy: "Heal with each meal, feel with each meal" - every meal shifts microbiome toward healing or harm.Connect with James & Dahlia MarinWebsite: www.marriedtohealth.com (hub for all resources)Social Media: @marriedtohealth (all platforms)Services & Programs:Private practice with 8+ specialized dietitiansGood Gut SIBO/IBS self-paced programOne-on-one nutrition sessionseBooks & educational resourcesRegenerative Nutrition & Gut Health Experience (October, Southern California in-person event)About Your HostMelissa Mondala, MD, MHA, MS, DipABLMDr. Melissa Mondala is a dual board-certified physician in Family and Lifestyle Medicine, with advanced training in Integrative Psychiatry and Integrative Medicine. As President of Dr. Lifestyle Clinic in Newport Beach—recognized by UC Irvine as a Public Health Site of Excellence—she pioneers a holistic, patient-centered approach to chronic disease. Dr. Mondala is a nationally recognized Lifestyle Medicine Intensivist, core faculty at Loma Linda University’s Preventive Medicine Department, and a passionate advocate for plant-based nutrition, mental health, and women's wellness. A sought-after speaker and educator, she combines cutting-edge science with deep compassion to empower lasting healing, especially for those silently suffering from autoimmune, mental health, and long COVID conditions. She shares practical inspiration for healthy living and cooking at @drmelissaskitchen.About AutoImmune Alchemy PodcastMission: Blending science with soul to transform autoimmune struggles into healing alchemyAutoImmune Alchemy is a podcast dedicated to the autoimmune community, offering hope, validation, and evidence-based solutions for those struggling with complex chronic conditions.Hosted by Dr. Micah Yu, the show explores root causes like mold exposure, infections, and environmental toxins that traditional medicine often overlooks. Each episode features expert interviews and cutting-edge treatments to help listeners understand the "why" behind their illness and find pathways to healing.Connect with AutoImmune Alchemy:Website: MyautoimmunemdHome – NewInstagram: @myautoimmunemdFacebook: @MYAutoimmuneMDYouTube: @myautoimmunemdEmail: contact@myautoimmunemd.comSubscribe & Review: Available on Apple Podcasts, Spotify, and all major podcast platforms. If this episode helped you understand mold's role in chronic illness, please leave a 5-star review!This episode is for educational purposes only and does not constitute medical advice. Always consult with your qualified healthcare provider before starting any new treatment or remediation. Individual results may vary.

In this episode, I sit down with Maria Lloyd, a licensed marriage and family therapist specializing in trauma-informed therapy and ketamine-assisted psychotherapy, to explore how unresolved trauma lives in the body and manifests as autoimmune disease, particularly in highly sensitive people (HSPs) who make up 20% of the population.Maria shares her personal journey with her son's gut issues and mold exposure that led to complete dysfunction until they addressed both the physical detoxification and mental health trauma through ketamine-assisted psychotherapy, ultimately leading to his full healing and return to college.We discuss how narcissistic relationships create constant fight-or-flight stress that directly impacts the nervous system and gut health, why turning toward pain with compassion (rather than running from it) calms both emotional and physical symptoms, and how creating secure attachments through therapy can rewire dysregulated nervous systems formed in childhood.Key Takeaways20% of people are highly sensitive (HSPs) - understanding this trait reduces shame and helps create supportive lifestylesTrauma lives in the body; turning toward pain with compassion calms both emotional and physical symptomsMold exposure can be like "pouring gasoline on the fire" for those with gut issues and mental health challengesKetamine-assisted psychotherapy works at a somatic level, helping people reconnect with their bodies and feel safeEarly childhood attachment patterns affect nervous system regulation and autoimmune disease riskNarcissistic relationships cause constant fight-or-flight stress that directly impacts gut health and autoimmunityHealth dramatically improves when people leave narcissistic relationships or set firm boundariesMorning and evening routines (walking, yoga, Qigong, Tai Chi, breath work) create nervous system stabilityResearch shows Qigong and yoga reduce pain and flares in lupus, rheumatoid arthritis, and fibromyalgiaIt's through relationships that we heal - secure attachments with therapists can rewire dysregulated nervous systemsChapters &amp; Timestamps00:00 Welcome: Maria Lloyd &amp; Trauma-Informed Therapy02:00 Maria's Personal Journey: Her Son's Gut Issues &amp; Mold Exposure03:00 When the Medical System Failed: The Natural Health Journey03:30 Mold Detoxification, Diet Changes &amp; Ketamine-Assisted Psychotherapy04:00 The Holistic Approach: Everything Is Connected04:30 Navigating Pain Cycles &amp; Hypervigilance in Autoimmune Flares05:00 Trauma Lives in the Body: Turning Toward Pain with Compassion06:00 Creating Secure Attachment with Ourselves07:00 Attachment Styles &amp; Their Impact on Nervous System Regulation08:00 How Early Childhood Attachment Affects the Brain &amp; Body09:00 Two Autoimmune Phenotypes: Type A Perfectionists &amp; Highly Sensitive People10:00 What Are HSPs? 20% of People Are Highly Sensitive11:00 HSPs Without Attachment: Mental Health &amp; Autoimmune Disease12:00 Reframing the Mindset: Creating Safety &amp; Boundaries12:30 Morning &amp; Evening Routines: Walking, Yoga, Qigong, Tai Chi13:00 Breath Work &amp; Meditation for Autoimmune &amp; Mental Health13:30 Research on Qigong &amp; Yoga Reducing Pain in Lupus, RA &amp; Fibromyalgia14:00 Ketamine-Assisted Psychotherapy: A Blowtorch for Getting Unstuck15:00 Narcissistic Relationships: The Toxic Impact on the Nervous System16:00 Gaslighting, Shame &amp; Confusion: Setting Boundaries or Leaving16:30 Health Improves When Leaving Narcissistic Relationships17:00 Finding Maria: Website, Podcast &amp; Resources17:30 Closing ThoughtsGuest DetailsMaria Lloyd, LMFTLicensed Marriage &amp; Family Therapist, Trauma SpecialistCredentials &amp; Training:Licensed Marriage and Family Therapist (LMFT)Certified in Ketamine-Assisted PsychotherapyTrauma-informed therapy specialistAttachment science &amp; polyvagal theory expertSomatic therapy practitionerSpecializations:Highly Sensitive People (HSPs) and empathsTrauma resolution and nervous system regulationNarcissistic relationship dynamics (home and workplace)Ketamine-assisted psychotherapy for trauma and autoimmune conditionsAttachment-based healing and secure attachment developmentSomatic therapies for body-based traumaChronic pain and autoimmune disease with trauma componentComplex PTSD and dissociationHost &amp; Educator:Host of "Catalyst for Healing" podcastFocuses on innovative breakthroughs in mental healthCovers ketamine and emerging medicine researchProvides newest information on healing modalitiesPersonal Experience: Maria's journey into holistic health began when her son developed severe gut issues from birth that worsened dramatically after mold exposure in college, leaving him completely unable to function. After the medical system failed to help, she pursued naturopathic approaches including intensive mold detoxification, dietary changes, and ketamine-assisted psychotherapy for the mental health component. Her son's complete healing and return to thriving in college inspired her to integrate these holistic approaches into her therapy practice.Clinical Approach: Maria emphasizes that trauma lives in the body and must be addressed somatically, not just cognitively. She helps clients turn toward pain with compassion rather than running from it through distraction or addiction. Her approach recognizes that 20% of people are highly sensitive (HSPs) and require different nervous system support than neurotypical individuals. She specializes in helping victims of narcissistic relationships understand the profound impact of constant gaslighting and fight-or-flight stress on physical health, often seeing dramatic health improvements when clients set boundaries or leave toxic relationships. Maria uses attachment science to help clients develop secure attachments with themselves and others, rewiring early childhood attachment wounds through therapeutic relationships.Connect with Maria LloydWebsite: www.marialloyd.comPodcast: Catalyst for Healing - www.catalystforhealing.comServices:Ketamine-assisted psychotherapyTrauma-informed individual therapySupport for highly sensitive people and empathsNarcissistic relationship recovery<span class="ql-ui"...

In this episode, Dr. Melissa Mondala sits down with Dr. Felice Gersh, an integrative OB-GYN, to explore why 80% of all autoimmune patients are women and how our two X chromosomes create a more robust immune system that can become overactive when hormones become imbalanced.Dr. Gersh explains the fascinating connection between leaky gut, hormonal dysfunction (PCOS, amenorrhea, menopause), and autoimmune diseases like Hashimoto's and rheumatoid arthritis, revealing how molecular mimicry causes antibodies against gut bacteria to cross-react with our own tissues.They discuss why rheumatologists often miss the root cause by only prescribing biologics that block immune responses without addressing leaky gut and hormone imbalances, and how early intervention with nutrition, stress management, sleep, and hormone balancing can reverse positive ANA antibodies and prevent full-blown autoimmune diseaseKey Takeaways80% of all autoimmune patients are female due to two X chromosomes with immune-related genes15% of genes on the "turned off" X chromosome stay active forever—almost all are immune-relatedWomen make more antibodies, have higher white blood cell counts, and mount stronger immune responsesEvery woman with hormonal dysfunction (PCOS, amenorrhea, menopause) develops gut dysbiosisLeaky gut allows bacteria and toxins to escape, triggering antibody production through molecular mimicryRheumatoid arthritis is linked to specific gut bacteria leaking through the intestinal barrierBiologics (Humira, Remicade) only block symptoms; they don't fix leaky gut or hormone imbalancesPositive ANA = pre-autoimmunity = leaky gut—early intervention can reverse itVegan diet high in fiber and polyphenols can reduce rheumatoid arthritis pain by 50% in one monthHormone balancing, gut repair, stress management, and nutrition work synergistically—it's all of the aboveChapters &amp; Timestamps01:00 Introduction: Dr. Felice Gersh on Women &amp; Autoimmune Disease01:30 Why Women Have More Robust Immune Systems02:00 The Two X Chromosomes &amp; Immune-Related Genes02:30 15% of X Chromosome Genes Stay Active Forever03:00 Women Make More Antibodies &amp; Have Higher White Blood Counts04:00 Estradiol &amp; Progesterone's Role in Immune Function04:30 Leaky Gut, Endotoxins &amp; Gut-Associated Lymphoid Tissue05:00 PCOS, Amenorrhea &amp; Menopause Always Cause Gut Dysbiosis06:00 Molecular Mimicry: How Antibodies Attack Your Own Organs06:30 Hashimoto's: The Most Common Autoimmune Disease in Women07:00 Rheumatoid Arthritis Linked to Specific Gut Bacteria08:00 Every Woman with Autoimmune Disease Has Leaky Gut08:30 Biologics Block Symptoms, Not Root Causes09:00 The Integrative Approach: Hormones, Gut &amp; Low Dose Naltrexone09:30 High Cortisol from Stress Causes Leaky Gut10:00 Fiber, Polyphenols &amp; Nurturing Your Gut Microbiome10:30 Why Biologics Stop Working After 2-4 Years11:00 Pre-Autoimmunity: Positive ANA Without Disease Yet11:30 Reversing Early-Stage Autoimmune Disease12:00 Terry Wahls: Reversing MS Through Diet &amp; Gut Healing12:30 Hormone Balancing at Every Life Stage13:00 Vegan Diet Reduces RA Pain by 50% in One Month13:30 It's All of the Above: Diet, Hormones &amp; Lifestyle Combined14:00 Where to Find Dr. Gersh: YouTube, Instagram &amp; Her Practice15:00 Closing &amp; ResourcesGuest DetailsDr. Felice Gersh, MD, FACOGIntegrative OB-GYN &amp; Women's Health ExpertCredentials &amp; Training:Board-certified OB-GYN (FACOG)Fellowship-trained in Integrative MedicineCombines traditional obstetrics/gynecology with functional and metabolic medicinePractices at Integrative Medical Group of Irvine, CaliforniaSpecializations:Women's hormonal health across all life stagesAutoimmune disease prevention and reversal in womenLeaky gut and gut microbiome restorationPCOS (Polycystic Ovary Syndrome)Menopause and hormone replacement therapyIntegrative approaches to rheumatoid arthritis and Hashimoto'sPre-autoimmunity intervention (positive ANA)Lifestyle medicine for chronic disease reversalAuthor &amp; Educator:Multiple published books on women's healthActive YouTube channel with educational contentStrong Instagram presence (@felicegershmd)International speaker on women's health and autoimmunityClinical Approach: Dr. Gersh practices "old-fashioned" one-on-one patient care while educating people worldwide through social media platforms. She emphasizes that women's immune systems are fundamentally different from men's due to the X chromosome's immune-related genes, making women more susceptible to autoimmune diseases when hormones become imbalanced. Her approach addresses root causes—leaky gut, gut dysbiosis, hormonal imbalances, stress, sleep, and nutrition—rather than just suppressing immune responses with biologics. She believes in proactive intervention at the pre-autoimmunity stage (positive ANA) and has successfully reversed early-stage autoimmune diseases through comprehensive lifestyle and hormonal optimization.Connect with Dr. Felice GershPractice: Integrative Medical Group of IrvineLocation: Irvine, CaliforniaSocial Media:Instagram: @felicegershmdYouTube: @FeliceGershMD (active educational channel)Website: https://integrativemgi.com/Services:One-on-one patient consultationsEducational content on women's health and autoimmunityResources and freebies available through her platformsAbout Your HostDr. Micah Yu, DC, CFMPFunctional Medicine Practitioner &amp; Host of AutoImmune AlchemyDr. Micah Yu is a doctor of chiropractic and certified functional medicine practitioner specializing in autoimmune conditions and chronic illness. He recognizes mold exposure as a common root cause of autoimmune disease, particularly in patients with long-haul COVID who suddenly develop mold sensitivities. Dr. Yu is passionate about educating his community on environmental toxins and bringing expert voices like John Banta to help patients understand the hidden triggers affecting their health. He practices integrative medicine with his wife, creating a dynamic team dedicated to uncovering root causes and supporting patients on their healing journey.About AutoImmune Alchemy PodcastMission: Blending science with soul to transform autoimmune struggles into healing alchemyAutoImmune Alchemy is a podcast dedicated to the autoimmune community, offering hope, validation, and evidence-based solutions for those struggling with complex chronic conditions.Hosted by Dr. Micah Yu, the show explores root causes like mold exposure, infections, and environmental toxins that traditional medicine often overlooks. Each episode features expert interviews and cutting-edge treatments to help listeners understand the "why" behind their illness and find pathways to healing.Connect with AutoImmune Alchemy:<span class="ql-ui"...

In this episode, Dr. Melissa Mondala sits down with Dr. Sam Ko, board-certified emergency medicine physician and medical director at Reset Ketamine, to explore how ketamine therapy is helping the 50-70% of autoimmune patients struggling with depression, anxiety, and chronic pain.They discuss how ketamine resets hypersensitized pain receptors, reduces inflammatory markers like TNF-alpha and IL-6, influences the gut-brain connection, and provides real hope for conditions like fibromyalgia, rheumatoid arthritis, MCAS, and POTS.Dr. Ko shares success stories, introduces Stellate Ganglion Block (SGB) as a complementary treatment, and reminds us that your struggle is real and there are evidence-based tools to help you reclaim functional living.Key Takeaways50-70% of autoimmune patients experience depression, anxiety, and central sensitization - there's a fascinating connection between autoimmune conditions and mood disordersKetamine resets hypersensitized pain receptors via NMDA receptors down the spinal cord, making it powerful for central sensitizationThe central nervous system and enteric nervous system share the same embryological origin (neuro crest), explaining the profound gut-brain connectionKetamine influences the gut microbiome, which in turn affects the central nervous system and moodExtended infusion protocols (80 minutes to 4 hours) are used for chronic pain conditions like fibromyalgiaKetamine reduces inflammatory markers including TNF-alpha, IL-6, and IL-10, helping to "turn down the volume" on overactive immune systemsStellate Ganglion Block (SGB) provides a "hardware reset" for the sympathetic nervous system, complementing ketamine's "software reset"Success is measured in functional improvements - getting out of bed, doing hobbies, walking 5 minutes daily - not running marathonsTeam-based care is essential, especially for patients on biologics and immunosuppressants - collaboration with rheumatologists and primary care is keyYour struggle is real, your body is wise - if a provider doesn't listen, find one who willChapters &amp; Timestamps00:00 Introduction: Ketamine for Autoimmune Depression, Anxiety &amp; Pain00:30 The Autoimmune-Mental Health Link: Why 50-70% Experience Both01:00 Central Sensitization: Resetting Hypersensitized Pain Receptors via NMDA02:30 Ketamine Beyond the ER: Treating MCAS, POTS &amp; Complex Autoimmune Conditions03:00 The Gut-Brain Connection: Embryology of Central &amp; Enteric Nervous Systems04:00 Serotonin in Gut &amp; Brain: Why "Trust Your Gut" Is Literally True04:30 How Ketamine Influences the Gut Microbiome &amp; Central Nervous System06:00 Success Stories: Fibromyalgia &amp; Extended Infusion Protocols07:00 Rheumatoid Arthritis: Visible Reduction in Joint Inflammation07:30 Reducing Inflammatory Markers: TNF-alpha, IL-6, IL-1008:30 Mind-Body Connection: Breaking the Cycle of Pain &amp; Rumination09:30 Stellate Ganglion Block (SGB): Software vs Hardware Reset11:00 Addressing Autoimmune Fatigue: Realistic Functional Improvements12:00 The Power of 1%: Micro-Habits &amp; 5-Minute Daily Walks13:00 What to Expect: Consultations &amp; Finding the Right Fit14:00 Team-Based Care: Working with Rheumatologists on Biologics14:30 Safety Protocols: Lab Monitoring &amp; Continuous Vital Signs16:00 Never Too Early or Late: Hope for Mental Health Struggles16:30 Validation: Your Struggle Is Real, Trust Your Body17:30 Finding Providers Who Listen &amp; Building Your Support Team18:00 Connect with Reset Ketamine &amp; Final ThoughtsThis episode is for educational purposes only and does not constitute medical advice. Always consult with your qualified healthcare provider before starting any new treatment. Individual results may vary.Guest DetailsDr. Sam Ko, MD Board Certified Emergency Medicine Physician &amp; Medical Director at Reset KetamineCredentials &amp; Training:Board Certified in Emergency MedicineMedical school training in embryology and the biopsychosocial paradigmExtensive experience in IV ketamine administration in ER settingsSpecialized training in ketamine therapy for mental health and chronic painCertified in Stellate Ganglion Block (SGB) proceduresSpecializations:IV Ketamine therapy for autoimmune-related depression, anxiety, and PTSDCentral sensitization and neuropathic pain syndromesFibromyalgia and rheumatoid arthritis treatmentMCAS (Mast Cell Activation Syndrome) and POTS (Postural Orthostatic Tachycardia Syndrome)Treatment-resistant mental health conditions in autoimmune patientsStellate Ganglion Block for sympathetic nervous system resetIntegrative approach to gut-brain-immune axis dysfunctionClinical Approach: Dr. Ko founded Reset Ketamine with the mission to provide evidence-based ketamine therapy specifically for patients with complex autoimmune conditions who experience overlapping mental health and pain symptoms. His approach recognizes the intimate mind-body connection and addresses both the "software" (neurological patterns through ketamine) and "hardware" (nervous system through SGB) aspects of healing. He emphasizes team-based care, working collaboratively with rheumatologists and primary care physicians to ensure safe, comprehensive treatment for patients on biologics and immunosuppressants. Dr. Ko works alongside his wife and partner, Dr. Kim, who handles social media and patient education, creating a family-centered practice dedicated to spreading knowledge about innovative treatment options.Connect with Dr. Sam Ko &amp; Reset KetamineWebsite: www.resetketamine.comLocation: Palm Springs, CaliforniaSocial Media:Instagram: @resetketamineYouTube: Reset Ketamine (500+ educational videos)LinkedIn: linkedin.com/in/samkomdmbaTikTok: @resetketamineTwitter: @resetketaminePinterest: Reset KetamineAbout Your HostsDr. Micah Yu, DC, CFMPFunctional Medicine Practitioner &amp; Co-Host of AutoImmune AlchemyDr. Micah Yu is a doctor of chiropractic and certified functional medicine practitioner specializing in autoimmune conditions. Alongside his wife Dr. Melissa Mondala, he co-hosts the AutoImmune Alchemy podcast where they blend science with soul to help patients navigate complex autoimmune journeys. Dr. Yu is passionate about integrative approaches to healing and bringing expert voices to the autoimmune community.Dr. Melissa MondalaCo-Host of AutoImmune AlchemyDr. Melissa Mondala co-hosts AutoImmune Alchemy with her husband Dr. Micah Yu, creating a dynamic duo dedicated to supporting patients and families dealing with autoimmune disease. Together, they work as a team to normalize symptoms, create safe spaces for healing, and bring experienced experts in...

In this episode of Autoimmune Alchemy, Dr. Micah Yu sits down with Dr. Robin Rose — family medicine physician, peptide specialist, and kidney health educator — to uncover a critical but often overlooked topic: early kidney decline in autoimmune disease.Dr. Rose shares her powerful personal story of surviving kidney cancer, losing a kidney, and reversing what doctors told her was irreversible kidney failure. She explains why kidney damage often begins long before standard labs change, how autoimmune inflammation quietly stresses kidney tubules, blood vessels, and mitochondria, and why many patients are told to “wait” instead of act.This conversation reframes kidney health as something proactive, reversible, and deeply connected to autoimmune disease, gut health, lifestyle, peptides, and mindset — offering hope and actionable insight for patients at every stage.TimeStamps[0:00] — Introduction: Autoimmune Disease &amp; the Forgotten Role of the Kidneys[1:20] — Dr. Robin Rose’s Story[7:40] — Why Kidney Damage Starts Before Labs Change[11:35] — How Autoimmune Disease Stresses Kidney Tubules, Blood Vessels &amp; Mitochondria[17:17] — Diet, Protein, Acidity &amp; Lifestyle Choices That Impact Kidney Health[25:20] — The Gut–Kidney–Immune Axis: Dysbiosis, Uremic Toxins &amp; Inflammation[31:00] — Early Detection Tools, Binders &amp; Proactive Kidney Protection[50:00] — Hope, Mindset &amp; Setting the Stage for Part 2 (Peptides &amp; Therapies)Key TakeawaysDiscover why autoimmune disease creates kidney vulnerability long before creatinine or GFR appear abnormal. Understand how inflammation, immune complexes, and vascular damage quietly stress kidney tubules and blood vessels. Learn why early kidney decline is often missed — and why waiting for “bad labs” delays prevention. Uncover the difference between kidney filtration (glomeruli) and reabsorption (tubules), and why tubules are damaged first. Explore how autoimmune conditions like lupus, Sjögren’s, RA, MS, and Hashimoto’s increase renal risk through inflammation and dysbiosis. Dr. Robin Rose’s story challenges the belief that kidney decline is inevitable. By understanding early warning signs, supporting the gut–immune–kidney axis, and shifting from fear to informed action, patients with autoimmune disease can protect their kidneys long before crisis occurs. Part 1 offers clarity, empowerment, and hope — reminding us that prevention begins with awareness and belief in healing.

Welcome to another episode of Autoimmune Alchemy, Dr. Micah Yu sits down with Dr. Kara Wada — board-certified allergist, immunologist, lifestyle medicine physician, Sjögren’s patient, and founder of The Immune Confidence Institute. Dr. Wada opens up about her long diagnostic journey with Sjögren’s, why so many patients are dismissed or misdiagnosed, and how clinical “gray zone” diseases like seronegative Sjögren’s, MCAS, dysautonomia, and chronic fatigue often fall through the cracks in modern medicine. She also shares the lifestyle changes, supplements, and clinical trial therapy (dazodalibep) that changed her health, plus the innovative lymph-node–targeted allergy treatment she now offers in her clinic.Time Stamps[0:00] — Welcome &amp; Introduction[1:07] — Early Symptoms &amp; Missed Red Flags[3:45] — Diagnosis Journey &amp; Lab Findings[6:12] — What Sjögren’s Really Is[7:50] — Dryness Isn’t Always the First Symptom[9:26] — Misrouted Specialists &amp; Delayed Diagnosis[9:50] — Full Symptom Breakdown[14:16] — Lifestyle Changes That Helped[15:30] — New Sjögren’s Drug Trial (Dazodalibep)[18:10] — Future Treatments &amp; Seronegative Gap[19:39] — Supplements That Helped[23:14] — “Clinical Ghosts” &amp; Why Patients Are Dismissed[27:17] — Rethinking Mast Cells &amp; MCAS[29:06] — ISLIT Protocol (Lymph-Node Immunotherapy)[30:30] — Closing &amp; Part 2 TeaserKey TakeawaysDiscover why Sjögren’s isn’t rare — only rarely diagnosed — and how normal labs can still hide the disease.Understand why dryness doesn’t always appear first and how neurological issues, fatigue, migraines, and POTS often come earlier.Learn how over-reliance on blood work leads doctors to dismiss patients whose symptoms don’t fit textbook patterns.Uncover the deep neurological involvement in Sjögren’s, including dizziness, orthostatic intolerance, and chronic headaches.Explore the lifestyle tools that helped Dr. Wada improve, including sleep optimization, stress management, and plant-forward nutrition.Autoimmune patients can be overlooked — even when the symptoms are loud and life-altering. Dr. Kara's perspective as both a physician and a patient brings clarity, compassion, and validation to a community that’s often dismissed. From redefining what Sjögren’s really looks like to exploring groundbreaking new therapies, this conversation offers hope and direction for anyone navigating immune-driven illness. #podcast #autoimmune

Women often first meet autoimmunity during hormonal transitions like perimenopause and menopause. In this conversation, in this episode, Dr. Melissa Mondala and Dr. Jennifer Roelands (OB-GYN, integrative and functional medicine) unpack how shifting estrogen and progesterone interact with the immune system, why the gut–brain–hormone axis matters for mood and symptoms, and what to do first if you are seeing new labs, new aches, or a metabolism that no longer plays by your old rules. You will hear practical ways to lower inflammation, protect bone and muscle, choose labs that actually guide care, and build “low-hanging fruit” habits that stick.Key takeawaysHormone transitions can “flip on” latent genes and unmask autoimmunity; gut health and hormone metabolism are tightly linked.Do not skip the gut: the estrobolome, serotonin production, barrier integrity, and antibodies formed in the gut influence thyroid and joint autoimmunity.Start small to beat overwhelm: stack easy “wins” such as step-ups, resistance bands, or brief “exercise snacks” while you build consistency.Protect bone and muscle: lift 2–3x weekly, add protein and fiber, and consider DEXA earlier than 65 to get a baseline.Labs that help: iron panel, vitamin D, CRP, fasting insulin, thyroid panel, and cycle-timed sex hormones; wearables or CGM can add useful data.Options exist: HRT is one path; omega-3s, fiber, magnesium (glycinate), curcumin, and targeted botanicals can also support symptoms and sleep.Perimenopause is more than hot flashes: watch for unusual signs like ear itching, body-odor changes, recurrent UTIs, libido shifts, or oral-health changes.Suggested chapters 00:00 Intro and guest background 00:26 Why autoimmunity often appears in perimenopause 00:29 Gut–hormone metabolism, estrobolome, neurotransmitters 00:31 Stress load and “low-hanging fruit” habit building 00:34 Muscle and bone loss, strength training that fits pain levels 00:36 HRT, DEXA baselines, and fracture risk context 00:39 Supplement staples: omega-3s, fiber, magnesium, curcumin 00:42 Weight and metabolism changes, personalized nutrition 00:44 Unusual symptoms of perimenopause 00:46 Early or premature menopause and risk profile 00:49 Finding the right clinician; advocating for labs 00:51 What to test and how to time hormones 00:53 Where to find Dr. Roelands and her practicePerimenopause is a whole-system transition. Pair smart medical care with gut support, resistance training, sleep, stress tools, and cycle-aware labs. Start with one easy win, get a baseline DEXA earlier, and build from there. The goal is not perfection. It is steady, sustainable progress that protects your brain, bones, and immune system.Host Bio:Dr. Melissa Mondala is a triple specialist in family medicine, lifestyle medicine, and integrative/primary care psychiatry. She is double board certified in family medicine and lifestyle medicine, completed her family medicine residency and Lifestyle Medicine Fellowship at Loma Linda University Health, and earned her MD from Chicago Medical School along with master’s degrees in Health Administration and Biomedical Science. Dr. Mondala is co-founder of Dr. Lifestyle in Newport Beach, where she provides direct primary care, integrative mental health, and lifestyle-based prevention for patients locally and via telehealth. She has served as core faculty in Preventive/Lifestyle Medicine at Loma Linda University and has contributed to national education in lifestyle medicine. She also co-hosts the Autoimmune Alchemy podcast with Dr. Micah Yu and leads the Integrative Mental Health Summit, bringing root-cause strategies for anxiety, mood, and brain health to a wider audience. Her approach blends diagnostics and conventional care with nutrition, sleep, movement, stress tools, and community to help patients reduce inflammation and build long-term resilience.

When Infections Inflame the Mind: Lyme, MS, and the Gut–Brain ConnectionDr. Darin Ingels connects the dots between chronic infections (like Lyme), the gut–brain axis, and neuroinflammation—explaining “leaky gut/leaky brain,” vagus-nerve signaling, mast-cell activation, and why mood, brain fog, and sleep often shift with immune activity. He shares practical supports—from joy practices to potent, targeted herbs—and how to vet supplement quality for safety and results. Key takeaways:Leaky gut and “leaky brain” often travel together; restoring gut function improves brain function. The vagus nerve can transmit gut signals that open the blood–brain barrier and drive neuro-inflammation. In Lyme and MS, immune cross-reactivity and mast-cell activation can inflame brain and nerves, contributing to anxiety, depression, OCD, and brain fog. Joy and regulation tools matter: music, humor, nature, and realistic activity resets help shift mental state on hard days. Herbal medicine is multi-targeted: combinations can modulate inflammation, immunity, hormones, and circulation—often at low doses with strong effects. Adaptogens to balance stress/cortisol: eleuthero (Siberian ginseng), rhodiola, holy basil, Ashwagandha—choose by symptom pattern (e.g., “tired-and-wired”). Sleep supports: lemon balm, chamomile, passionflower, kava, California poppy; nutrients like magnesium and 5-HTP/L-tryptophan help with staying asleep. Pain/inflammation options: highly bioavailable curcumin, Boswellia (frankincense), white willow bark, and devil’s claw (Harpagophytum). Quality matters: look for GMP certification and third-party testing; request Certificates of Analysis; be cautious with heat-exposed or counterfeit online products. Forms and safety: tinctures, capsules, teas, glycerites—many herbs are GRAS with low toxicity when sourced and dosed correctly. Conclusion: Integrative mental health isn’t brain-only; it’s gut, immune, nerves, and daily rhythms working together. With clearer roots (infection, mast cells, barrier integrity) and practical tools (tailored herbs, joyful resets, vetted supplements), you can calm neuro-inflammation and support steadier mood, sleep, and cognition, step by step. Host Bio:Dr. Melissa Mondala is a triple specialist in family medicine, lifestyle medicine, and integrative/primary care psychiatry. She is double board certified in family medicine and lifestyle medicine, completed her family medicine residency and Lifestyle Medicine Fellowship at Loma Linda University Health, and earned her MD from Chicago Medical School along with master’s degrees in Health Administration and Biomedical Science. Dr. Mondala is co-founder of Dr. Lifestyle in Newport Beach, where she provides direct primary care, integrative mental health, and lifestyle-based prevention for patients locally and via telehealth. She has served as core faculty in Preventive/Lifestyle Medicine at Loma Linda University and has contributed to national education in lifestyle medicine. She also co-hosts the Autoimmune Alchemy podcast with Dr. Micah Yu and leads the Integrative Mental Health Summit, bringing root-cause strategies for anxiety, mood, and brain health to a wider audience. Her approach blends diagnostics and conventional care with nutrition, sleep, movement, stress tools, and community to help patients reduce inflammation and build long-term resilience.