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On the show
Recent episodes
Red Cell Basics
May 2, 2026
49m 59s
Haemophilia B, Gene Therapy
Apr 11, 2026
50m 22s
Dilemmas in Haemophilia
Feb 8, 2026
43m 04s
Acquired Haemophilia A
Jan 25, 2026
42m 14s
Haemophilia A in Pregnancy
Jan 11, 2026
50m 16s
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| Date | Episode | Description | Length | ||||||
|---|---|---|---|---|---|---|---|---|---|
| 5/2/26 |  Red Cell Basics | Feedback Welcome to the Red Cell Series! Timestamps and notes to follow... 'Basics to Brilliance: Haematology Podcast' has been accredited for CPD credit by the Royal College of Pathologists UK. Medical professionals and clinical scientists holding career-grade positions, who are registered with any of the Royal Colleges for CPD, will be eligible to earn 1 credit for every hour of learning. Email: basicstobrilliancehaem@gmail.com Insta: BasicstoBrilliance X: @basics_2_brill Send... | 49m 59s | ||||||
| 4/11/26 |  Haemophilia B, Gene Therapy | Feedback Timestamps to follow! 'Basics to Brilliance: Haematology Podcast' has been accredited for CPD credit by the Royal College of Pathologists UK. Medical professionals and clinical scientists holding career-grade positions, who are registered with any of the Royal Colleges for CPD, will be eligible to earn 1 credit for every hour of learning. Email: basicstobrilliancehaem@gmail.com Insta: BasicstoBrilliance X: @basics_2_brill Send us your feedback! | 50m 22s | ||||||
| 2/8/26 |  Dilemmas in Haemophilia | Feedback This is a discussion about possible factors and strategies to consider and should not be used as a guideline for clinical practice. Always discuss complicated cases with the attending H&T consultant. 00:52 Intro 01:30 Case 1: 41M Severe Haemophilia A, acute MI needing PCI Try the 4 steps! Bleeding RiskAnticoagulant characteristicsIntensity of anticoagulant (prophylactic vs therapeutic)Duration of anticoagulant therapy11:20 Cardiac Disease in Haemophilia: thoughts and consideratio... | 43m 04s | ||||||
| 1/25/26 |  Acquired Haemophilia A | Feedback 00:52 Intro and chuckles 01:40 Case study: 75M, left calf swelling, put on DOAC, 24 hrs later haematoma and deep bleed on CT 06:00 General information Elderly (>65), Mortality 8-40%Common presentations: GI and UG bleeding, Retroperitoneal and muscle bleeds (compartment syndrome)Ptegnancy, TTP, Malignancy (15%), Autoimmune disease (17%)08:56 Pathogenesis and diagnosis: AutoAb against F8 *Bethesda units do not correlate with bleeding phenotype in Acquired HA- second orfer kinetics*H... | 42m 14s | ||||||
| 1/11/26 |  Haemophilia A in Pregnancy | Feedback 00:52 Intro - very important topic 02:00 Case Study: Haem/Obstetrics clinic, Family Hx Severe Haemophilia A, 12wks pregnant 04:15 Clotting changes in pregnancy Increased: FVII, FVIII, FX, VWF, FibrinogenDecreased: FXIII Protein S, Antithrombin Stable: FIX07:57 New born to 6 months clotting: FVIII (8) similar to adultFIX (9) lower and rises after 6 months09:30 GUEST STARRING Dr. William Jones MRCP FRCA St6 Anaesthetics SpR with a special interest in Obstetrics 10:25 Will s... | 50m 16s | ||||||
| 11/30/25 |  Haemophilia A: Inhibitors | Feedback 00:52 Intro 02:10 Definition Common: Alloantibody neutralizes FVIIIRare: causes increased clearance of FVIII1/3 of Severe Haemophilia A patientsMedian time 10-15 emergency dosesRF: Mutation types (INSIGHT study), <5 or >60, African/Hispanic, HIVneg, large rFVIII doses, FVIII + inflammatory stimulus07:05 Inhibitor classifications Titres: Low (<5 BU) vs. High (>5 BU)Responder: Low vs HighTime: Dependent (FVIII inh.) vs Independent (FIX inh.)09:50 Presentation in practice Tr... | 53m 59s | ||||||
| 11/16/25 |  Haemophilia A: Management Basics | Feedback 00:52 Intro 02:35 Structure of Haemophilia A care 05:10 Key aspects of management (On-demand vs prophylaxis) 07:00 Prophylaxis: reduce death rates from ICH and reducing joint bleeds - Primary prophylaxis: before the 2nd joint bleed Severe haemophiliaAny child spontaneous ICHModerate haemophilia A (1-3 IU/dL)- Secondary prophylaxis: After the 2nd joint bleedLimit joint damage and maximize long term functionESPRIT trial- Tertiary prophylaxis: If joint disease already establishedSlow p... | 1h 24m 40s | ||||||
| 11/9/25 |  Haemophilia A: Diagnosis & Investigations | Feedback 00:52 Intro 02:00 What is Haemophilia A? 03:00 Factor VIII, Pathogenesis of Haemophilia A 07:10 Structure of Factor VIII (exam pearl) 300kDHeavy (A1 A2, B) + Light Chain (A3, C1, C2) bound by a metal ions *Calcium*A subunits are 30% homologousB subunit (variable region) is cleaved by thrombin to get Factor VIIIaC1 and C2 help bind to VWFGood to r/o VWF10:55 Epidemiology and history taking- X-linked recessive Factor VIII is (mostly) feminist.....Turners syndrome, Androgen Insensitivit... | 49m 09s | ||||||
| 7/12/25 |  Factor XIII (13), Fibrinolysis & Thrombolysis | Feedback 01:45 Case: Neonate with repeated umblical bleeding. IC haemorrhage. Normal Factors (so far), Normal VW screen, Normal FBC and normal film. 05:35 Factor XIII (13): function and presentations in deficiency 09:45 Testing, testing! ELISA/Ammonia Release Assay then a Mutational Analysis Honarable mention: Clot Solubility Assay16:00 Fibrinolysis definition and pathway 21:00 Activators of Fibrinolysis: tPA vs. uPA 23:23 Inhibitors of Fibrinolysis: PAI-1, PAI-2,... | 46m 21s | ||||||
| 6/7/25 |  Inhibitors in Haemostasis | Feedback 00:52 Intro: definition and prompts 04:25 Intro to Case 1: Haemophilia B, 3rd dose of BeneFix Anaphylaxis 06:03 Intro to Case 2: Severe Haemophilia A, joint bleed, non-responsive to emergency Factor VIII 07:30 Initial screening tests NB: Inhibitors: Time Dependent vs. Immediate Acting14:54 Flash examples of Mixing Study importance 16:35 Bethesda Assay **Bethesda Studios made the Elder Scrolls and Fallout games: they Inhibit Haider from doing any work** 28:45 Bethesd... | 1h 03m 02s | ||||||
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| 5/25/25 |  Heparin & the Anti-Xa Assay | Feedback 00:52 Intro (shoutuout to the BSH anticoagulant monitoring guidelines) 02:15 Practical relevance of testing and monitoring anticoagulants 07:30 Heparin: The Basics 09:00 Unfractionated Heparin vs. Low Molecular Weight Heparin 10:24 Mechanism of action of Heparin (UfH vs. LMWH) LMWH: more Anti-Xa activityUfH Anti-IIa acitivity = Anti-Xa activity15:30 Pharmacokinetic differences (UfH vs. LMWH) 23:28 Unfractionated Heparin uses and monitoring 34:34 Anti Xa Assay 42:32 ... | 59m 29s | ||||||
| 5/18/25 |  Thrombin Time & Fibrinogen Assays | Feedback 00:54 Intro and table of contents 1:48 Case 1: pre-op, prolonged PT and ++ prolonged APTT…thrombin time done 03:44 Case 2: post-op, normal PT and prolonged APTT…thrombin time done 04:46 Thrombin Time definition and ingredients (its all about the fibrinogen!) 10:45 Differentiating causes of prolonged thrombin time- protamine, reptilase, ecarin 17:24 Case 3: Major Haemorrhage (Variceal), due OGD, Derived PT Fibrinogen normal 20:45 Clauss Fibrinogen- methodology, causes of change ... | 38m 08s | ||||||
| 4/27/25 |  Mixing Studies & Factor Assays | Feedback 0:52 Intro and table of contents 2:36 CASE 1- Infection, due surgery and a prolonged APTT ft. a refresher on APTT prolongation 08:00 Mixing studies- definition and uses ft. Hari’s exam nugget 17:00 Factor assays (1 stage, 2 stage and chromogenic assays) ft. David’s humorous humility 43:30 David applies his new-found knowledge to our first case 45:45 CASE 2- Infection, hx of weight loss and bleeding and a prolonged APTT 47:36 Summary https://practical-ha... | 51m 35s | ||||||
| 4/7/25 | Mantle Cell Lymphoma | Feedback 'Basics to Brilliance: Haematology Podcast' has been accredited for CPD credit by the Royal College of Pathologists UK. Medical professionals and clinical scientists holding career-grade positions, who are registered with any of the Royal Colleges for CPD, will be eligible to earn 1 credit for every hour of learning. Email: basicstobrilliancehaem@gmail.com Insta: BasicstoBrilliance X: @basics_2_brill Send us your feedback! | 1h 25m 06s | ||||||
| 4/5/25 |  Practical Haemostasis of the Clotting Screen | Feedback 00:00 Intro 04:25 Automated Methods of Measuring a Clot 05:50 Scenario 1 & Pre-Analytical Variables 11:50 HIL Index & Patient Factors 15:55 Blood Tube Basics 21:10 Nitty Gritties- What Happens When We Send a PT? 23:20 PT vs INR for Warfarin- Going Down The Rabbit Hole... 26:35 Heparin Neutralising Buffer 29:00 APTT 33:05 Summary (& an honorable mention) 'Basics to Brilliance: Haematology Podcast' has been accredited for CPD credit by the Royal College of Pathologi... | 34m 27s | ||||||
| 3/30/25 |  The Clotting Screen: Back to Basics | Feedback 0:00 Intro 2:45 What is Haemostasis? 3:55 Stages of Haemostasis (summary) 4:45 Primary Haemostasis 8:35 Secondary Haemostasis 11:10 The Clotting Cascade 12:20 Common + Extrinsic Pathway 13:50 Intrinsic Pathway (TwelvEleveNinEight) 14:25 Clotting Tests 16:30 Hari Pops The Bubble 18:05 In-Vivo vs. In-Vitro 22:20 Isolated PT Prolongation- causes 25:46 Isolated APTT Prolongation- causes 27:43 Paired PT/APTT Prolongation- causes 28:50 Best Test for Bleeeding (David makes Hari proud)... | 45m 19s | ||||||
| 3/17/25 | Essential Thrombocythemia (ET) | Feedback 'Basics to Brilliance: Haematology Podcast' has been accredited for CPD credit by the Royal College of Pathologists UK. Medical professionals and clinical scientists holding career-grade positions, who are registered with any of the Royal Colleges for CPD, will be eligible to earn 1 credit for every hour of learning. Email: basicstobrilliancehaem@gmail.com Insta: BasicstoBrilliance X: @basics_2_brill Send us your feedback! | 1h 11m 45s | ||||||
| 3/14/25 | Immune Thrombocytopenia (ITP) | Feedback 'Basics to Brilliance: Haematology Podcast' has been accredited for CPD credit by the Royal College of Pathologists UK. Medical professionals and clinical scientists holding career-grade positions, who are registered with any of the Royal Colleges for CPD, will be eligible to earn 1 credit for every hour of learning. Email: basicstobrilliancehaem@gmail.com Insta: BasicstoBrilliance X: @basics_2_brill Send us your feedback! | 1h 18m 24s | ||||||
| 3/11/25 | Heparin Induced Thrombocytopenia (HIT) | Feedback 'Basics to Brilliance: Haematology Podcast' has been accredited for CPD credit by the Royal College of Pathologists UK. Medical professionals and clinical scientists holding career-grade positions, who are registered with any of the Royal Colleges for CPD, will be eligible to earn 1 credit for every hour of learning. Email: basicstobrilliancehaem@gmail.com Insta: BasicstoBrilliance X: @basics_2_brill Send us your feedback! | 1h 00m 26s | ||||||
| 5/26/24 | Polycythemia Rubra Vera (PRV) | Feedback Polycythaemia- red cell # Erythrocytosis – in red cell mass Absolute Erythrocytosis - M: Hct >0.60 or >0.52 + RCM >25% of mean - F: Hct >0.56 or >0.48 + RCM >25% of mean Apparent Erythrocytosis - Men: Hct >0.52 + normal RCM - Women: Hct >0.48 + normal RCM Relative erythrocytosis -Normal RCM + Reduced plasma volume (pathological dehydration) M>F Median >60yo 2' PRV: treat underlying cause +/- venesection (higher hct threshold) Classification of Abs... | 1h 12m 33s | ||||||
| 5/12/24 | Secondary CNS Lymphoma | Feedback - Synchronous CNS and systemic lymphoma at initial presentation (treatment-naïve; TN-SCNSL) - CNS relapse without recurrent systemic lymphoma (relapsed isolated CNS lymphoma; RI-SCNSL) - Relapsed concomitant systemic and CNS disease following treatment for systemic lymphoma (RC-SCNSL) Generally hybrid disease Investigations - MRI Head w gadolinium - PET-CT - Testicular US (bl... | 37m 30s | ||||||
| 4/28/24 | Primary CNS Lymphoma | Feedback CNS Lymphomas 1% of all NHL 3% of all Brain tumours Most common subtype (90%) is DLBCL Clinical division: 1. 1* CNS lymphoma, 2. 2* CNS lymphoma - TN-SCNSL - RI-SCNSL - RC-SCNSL 3. Immune deficiency assoc- HIV; better prog. Presentation: - SOL Sx - Raised ICP: morning headaches w N+V - Neuropsych, Behavioural, Memory, Language - Focal motor + Stroke Sx - Seizures - ... | 1h 09m 06s | ||||||
| 4/14/24 | Chronic Monomyelocytic Leukemia (CMML) | Feedback Chronic MyeloMonocytic Leukemia (not CML) Persistently high monocyte count- 3 months Most frequent MDS/Myeloproliferative neoplasms – a cross between the two Median age 72 Median survival 20-40 months Transformation to AML (15-30%) WHO definition of CMML: 1. Excess monocytes- persistent over 3 months, ≥ 1 - Monocytes 10% of total WC count 2. Dysplasia: morphological difference (blood film on BMBx) O... | 41m 56s | ||||||
| 4/1/24 |  Chronic Lymphocytic Leukemia (CLL) | Feedback Chronic Lymphocytic Leukemia (CLL)- Chronic Relapsing Remitting Most common leukemia in adults Incurable but treatable *Remember Supportive Care* Median age of 72 M > F 80% incidental SLL: lymphocytes in lymph nodes and spleen instead of blood Presentation: 1) Fatigue 2) B symptoms 3) High WC 4) Cytopenias (Marrow infiltrate, AIHA, ITP, Hyposplenism) Rule out: Reactive (viral serology)- Hepatitis, HIV Investigate: 1) FBC + blood film (mature lymphocyte... | 1h 18m 33s | ||||||
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