Billion Dollar Moves™ with Sarah Chen-Spellings | Global Venture Capital

In this episode of Billion Dollar Moves, I sit down with David Berry, Co-Founder and Managing Partner of Averin Capital, for a conversation about building billion-dollar breakthroughs in healthcare. David has founded more than 30 companies, including seven valued over $1B, and has helped shape companies across biotech, AI drug discovery, microbiome therapeutics, agriculture, and health infrastructure. From losing a childhood friend to brain cancer, to asking why the hardest problems are worth pursuing, David shares how mission, science, and capital come together to create venture-scale healthcare companies. For founders, funders, and family offices investing in the future of health, this is a conversation about conviction, ethics, and building for impact at scale. Watch the full conversation and subscribe for more discussions at the intersection of capital, governance, and long-term wealth. 00:00 - Intro: Why go after the biggest problems? 01:12 - Truth vs. belief in science 03:00 - The myth that humans only use 10% of their brains 04:28 - Rethinking cancer and inherited assumptions 05:38 - How big ideas emerge from questioning “truth” 06:30 - Entrepreneur vs. investor: The N of one 08:10 - Building Seres Therapeutics and the microbiome frontier 11:00 - Turning strange science into a venture-scale company 12:20 - Why drug development does not always have to take 10–15 years 14:10 - Valo Health and AI-powered drug discovery 17:15 - Product-investor fit in biotech 20:30 - Why companies fail: Teams, resilience, and near-death moments 22:15 - Averin Capital and the transformation of health through technology 23:20 - BioLink and the future of continuous health monitoring 26:00 - Ozempic, access, and ethics in healthcare 31:10 - Women’s health, clinical trials, and bias in medical data 35:00 - David’s vision for Averin Capital 39:00 - How family offices should think about investing in health 40:00 - The next billion-dollar moves in healthcare 40:35 - Rapid fire About David Berry David is Co-Founder and Managing Partner at Averin. As an innovator and a company builder, he has been driven by the power of technology to transform industries. David has been a founder of over 30 companies, including 7 that have been valued at over $1B. David was previously a General Partner at Flagship Pioneering. He was also founder and CEO of Valo Health, where he raised over $500M and executed a transformative partnership with Novo Nordisk. David received his M.D. from Harvard Medical School and his Ph.D. from MIT through the biological engineering division, where he worked with Professors Robert Langer and Ram Sasisekharan. David works closely with Biolinq amongst other Averin companies. --- Billion Dollar Moves Podcast | The Top Global Venture & Business Podcast for Founders & Funders | Backed by HubSpot Podcast Network Conversations with billionaires, unicorn founders, and the world’s leading funders. Hosted by Sarah Chen-Spellings, Billion Dollar Moves examines how enduring companies — and the capital behind them — are built. Through long-form conversations, the show explores decision-making under uncertainty, capital allocation, and the inflection points that shape category-defining businesses. From early platform backstories to allocator frameworks used across private markets, the focus is on judgment, incentives, and long-term value creation — beyond headlines and hype. New episodes weekly. Built for those who take the long view. PODCAST INFO: Podcast website: https://billiondollarmoves.com Watch on Youtube: https://tinyurl.com/sarahchenglobal Join the community: https://sarah-chen.ck.page/billiondollarmoves FOLLOW SARAH: https://linkedin.com/in/sarahchenglobal https://instagram.com/sarahchenglobal https://x.com/sarahchenglobal

Jaclyn Johnson built Create & Cultivate into one of the most recognized platforms for women in business—scaling it to eight-figure revenue before exiting in a multi-million dollar deal. But what happens after the exit is where the real story begins. From navigating private equity, burnout, and the loss of control over the company she built… to making one of the rarest moves in business—buying it back. In this episode, we unpack: * Why selling isn’t always the win * What private equity gets wrong in community-driven businesses * The trade-offs between bootstrapping and raising capital * How to think about ownership, control, and long-term value This is a conversation about capital, consequence—and coming back with clarity. About Jaclyn Johnson With $25 million in successful exits to her name, Jaclyn has mastered the art of bootstrapping businesses, building thriving communities, and driving meaningful results. Recognized as one of Adweek's Disruptors, Forbes 30 under 30 and a WSJ Woman of note, she stands out as one of the industry's leading marketing minds. Her unwavering focus on value creation and community-first marketing has been imitated countless times, yet never truly matched. -- Billion Dollar Moves Podcast | The Top Global Venture & Business Podcast for Founders & Funders | Backed by HubSpot Podcast Network Conversations with billionaires, unicorn founders, and the world’s leading funders. Hosted by Sarah Chen-Spellings, Billion Dollar Moves examines how enduring companies — and the capital behind them — are built. Through long-form conversations, the show explores decision-making under uncertainty, capital allocation, and the inflection points that shape category-defining businesses. From early platform backstories to allocator frameworks used across private markets, the focus is on judgment, incentives, and long-term value creation — beyond headlines and hype. New episodes weekly. Built for those who take the long view. PODCAST INFO: Podcast website: https://billiondollarmoves.com Watch on Youtube: https://tinyurl.com/sarahchenglobal Join the community: https://sarah-chen.ck.page/billiondollarmoves FOLLOW SARAH: https://linkedin.com/in/sarahchenglobal https://instagram.com/sarahchenglobal

Fired at 36 from his dream job at Time Inc., Michael Loeb turned rejection into the billion-dollar spark behind Synapse and Priceline.com. A true serial entrepreneur, Michael shares how he reinvented industries—from magazine subscriptions to online travel to healthcare—and why he believes the entrepreneurial gene shows up long before the first startup pitch. In this week's episode, we unpack the mind of a founder who built and sold multiple ventures, now running Loeb.nyc, a venture collective redefining how startups are scaled. Packed with wisdom on resilience, reinvention, and legacy, this episode is a masterclass in building with capital and conviction you won't want to miss! Timestamps/Key Takeaways 0:00 - Intro 01:48 - From Firing to Fortune: Turning a corporate setback into an $800 million exit 05:12 - The Entrepreneurial Gene: Why the lemonade stand still predicts success 09:30 - Synapse to Priceline: Inside one of the internet’s most iconic startups 12:03 - Betting on Healthcare Before GoodRx: How ScriptRelief scaled to millions 14:39 - Reinventing the Model: Building The Loeb.nyc — a venture collective under one roof 17:44 - Legacy & Family: Raising entrepreneurs and building impact that lasts 20:23 - Billion Dollar Questions About Michael Loeb Michael Loeb is a serial entrepreneur and the founder and CEO of Loeb.nyc. After starting his career at Time, Inc., Michael co-founded the Synapse Group with then partner, Jay Walker. Under Michael’s direction, Synapse grew to become the largest seller of consumer magazine subscriptions worldwide, with its revolutionary and patented Continuous Service Model. Michael and Jay went on to form and incubate Priceline.com together at Synapse, leveraging a shared team of operators and capital. When Synapse Group was sold to Time Warner in 2006, Michael formed Loeb Enterprises with partner, Rich Vogel to ideate and develop new business concepts. The largest of those ventures was ScriptRelief, a pharmacy discount provider that has a membership in excess of 12 million Americans. In 2019, Loeb Enterprises rebranded to Loeb.nyc and boasts a portfolio of over 18 direct investments, most of which execute from Loeb.nyc headquarters in Manhattan. Under Michael’s visionary leadership, Loeb.nyc has established a new model for startup investments. By pairing exceptional strategic and executional talent with passionate founders, Loeb.nyc significantly de-risks startup launches. Michael sits on the board of several non-profit organizations and is an avid philanthropist. He currently resides in New York City with his wife and children. Follow Michael: LinkedIn https://www.loeb.nyc/ - Billion Dollar Moves Podcast | The Top Global VC Podcast for Founders & Funders | Backed by HubSpot Podcast Network In venture, every move can make—or break—a billion-dollar outcome. Hosted by Sarah Chen-Spellings, award-winning entrepreneur, investor, and venture insider, Billion Dollar Moves pulls back the curtain on the strategies, stumbles, and breakout moments that define the world’s most iconic companies. From boardroom power plays to investor backchannels, you’ll hear the untold stories behind iconic companies like YouTube, Canva, and Vimeo, and go inside the minds of those moving capital at firms like Sequoia, Lightspeed, and beyond. Whether you're chasing your first $10M—or your next billion—this show is your front-row seat to how the smartest founders and funders win. Think raw, unfiltered, no-BS insight—designed to help you move faster, smarter, and bolder. This isn’t just another business podcast. This is your billion-dollar playbook. PODCAST INFO: Podcast Website | Watch on Youtube | Join the Community FOLLOW SARAH: LinkedIn | Instagram | X/Twitter

The rules of private market investing are shifting; and so is the timeline for generating alpha. In this conversation from Arctic15 LP Summit earlier this year, leading allocators Selale Zaim (third-generation family business leader and venture investor) and Kim Groop (Co-Founder, First Fellow Partners) joined us to unpack how family offices and institutions are rethinking their playbooks. From compressed market cycles and delayed liquidity to the rise of co-investments, secondaries, and specialized family offices, we dive into how investors are navigating volatility, reshaping allocation strategies, and re-defining what it means to create long-term value. A must-listen for LPs, GPs, and founders who want to stay ahead in an increasingly dynamic private markets landscape. TIMESTAMPS / KEY TAKEAWAYS 0:00 - Intro 01:56 - Meet the Investors: From Family Conglomerates to Founder-Led Funds 04:43 - Returns, compression, and the shifting VC cycle 07:10 - Why family offices are splitting and specializing 09:06 - One unicorn in every 10 investments: Founder-first approach to investing 11:04 - Cracking the code on direct investments and avoiding negative selection 13:24 - Liquidity engineering: co-investments, secondaries, and partial exits 17:20 - Finland’s ecosystem and the rise of homegrown unicorns 18:42 - Cross-border collaboration among family offices 21:52 - Lessons learned: family business vs. financial returns 24:05 - AI and the new investment frontiers 26:57 - Audience Q&A final takeaways Panelists: Kim Groop, Co-Founder & Managing Partner at First Fellow Partners Selale Zaim, Board Member at Inci Holding & Head of Investment Committee at Vinci Venture Capital Hosted by: Sarah Chen-Spellings, Co-Founder & Managing Partner, Beyond The Billion - Billion Dollar Moves Podcast | The Top Global VC Podcast for Founders & Funders | Backed by HubSpot Podcast Network In venture, every move can make—or break—a billion-dollar outcome. Hosted by Sarah Chen-Spellings, award-winning entrepreneur, investor, and venture insider, Billion Dollar Moves pulls back the curtain on the strategies, stumbles, and breakout moments that define the world’s most iconic companies. From boardroom power plays to investor backchannels, you’ll hear the untold stories behind iconic companies like YouTube, Canva, and Vimeo, and go inside the minds of those moving capital at firms like Sequoia, Lightspeed, and beyond. Whether you're chasing your first $10M—or your next billion—this show is your front-row seat to how the smartest founders and funders win. Think raw, unfiltered, no-BS insight—designed to help you move faster, smarter, and bolder. This isn’t just another business podcast. This is your billion-dollar playbook. PODCAST INFO: Podcast Website | Watch on Youtube | Join the Community FOLLOW SARAH: LinkedIn | Instagram | X/Twitter

With record outflows from ESG funds and rising political scrutiny, the climate investing conversation is shifting dramatically. In this episode, we sit with Anna Herlin (KONE Family, Tiina and Antti Herlin Foundation) and Dr. Krista Halttunen (Halton Ventures) — two next-generation family office leaders driving sustainable innovation in the built environment. We asked: what comes next at the intersection of climate tech, venture capital, and LP strategies? Together, they unpack what it means to deploy patient and catalytic capital in an era of ESG fatigue; from decarbonizing steel and transforming HVAC systems to building data-driven frameworks that measure planetary boundaries. As allocators face rising pressure to balance returns, reputation, and regulation, this candid conversation explores how to future-proof portfolios and redefine value in the next economy. TIMESTAMPS / KEY TAKEAWAYS 00:00 – Intro 02:23 – ESG backlash and geopolitical landscape 05:25 – Where the capital is flowing now 08:20 – Efficiency as the new climate strategy 11:24 – Systems change vs. incremental innovation 14:12 – Building the Planetary Boundaries framework; beyond box-ticking and science-based investing 18:38 – How to spot Greenwashing & find true additionality 22:22 – Defining “Catalytic Capital for the New Economy” 25:55 – AI and Energy 28:19 – Hardware renaissance: Clean Energy, Green Steel & HVAC; “The Future Is Circular” 32:04 – Audience Q&A 37:06 – Where should Family Offices start in climate investments? Panelists: Anna Herlin, Board Member at TAH Foundation & Vice Chair at Security Trading Krista Halttunen, CEO of Halton Ventures Hosted by: Sarah Chen-Spellings, Co-Founder & Managing Partner at Beyond The Billion Video Credit: Arctic15 LP Summit 2025 - Billion Dollar Moves Podcast | The Top Global VC Podcast for Founders & Funders | Backed by HubSpot Podcast Network In venture, every move can make—or break—a billion-dollar outcome. Hosted by Sarah Chen-Spellings, award-winning entrepreneur, investor, and venture insider, Billion Dollar Moves pulls back the curtain on the strategies, stumbles, and breakout moments that define the world’s most iconic companies. From boardroom power plays to investor backchannels, you’ll hear the untold stories behind iconic companies like YouTube, Canva, and Vimeo, and go inside the minds of those moving capital at firms like Sequoia, Lightspeed, and beyond. Whether you’re chasing your first $10M—or your next billion—this show is your front-row seat to how the smartest founders and funders win. Think raw, unfiltered, no-BS insight—designed to help you move faster, smarter, and bolder. This isn’t just another business podcast. This is your billion-dollar playbook. PODCAST INFO: Podcast Website | Watch on Youtube | Join the Community FOLLOW SARAH: LinkedIn | Instagram | X/Twitter

From Wall Street to Silicon Valley's inner circle—this is the untold story behind one of tech’s most trusted capital stewards. In this episode, we sit down with Mike Anders, Partner at ICONIQ, the quiet powerhouse managing over $80B for tech’s most iconic names. Mike opens up about his activist roots, Wall Street disillusionment, and the journey to building a purpose-driven financial empire. We go behind the curtain of ICONIQ’s rise, the venture bets that paid off, the AI wave, and why collaborative philanthropy is their next big frontier. Timestamps 0:00 - Intro 02:11 - Roots & Activism: Academic upbringing and activist parents; “Start outside politics” 04:25 - Disillusionment & Reinvention: donor-advised funds (DAFs), discovering purpose in philanthropy & the pivotal first coffee with Divesh Makan 07:37 - Building ICONIQ: From Alibaba to enterprise software to data centers; the power of collective wisdom from founder clients 15:09 - Market, AI, & Culture: Surviving financial crises and market cycles; ICONIQ’s bet on AI; reflections on culture 26:31 - The Shift to Impact: The genesis of ICONIQ Impact and the CoLab model 31:06 - The Cost & The Legacy: Leadership, humility, and enduring values READ MORE: ICONIQ Impact Half a Billion Report Michael Anders | Partner, ICONIQ Michael Anders is a founding partner of ICONIQ, a global investment firm that channels ideas, talent, and capital to initiatives that advance society. Michael is also the founder and Chairman of ICONIQ Impact, which convenes ICONIQ’s extraordinary community of families, founders, and organizations to catalyze collaborative philanthropy for giving at scale. To-date, ICONIQ Impact has advised on nearly $600M in grants, tackling the world’s most urgent challenges, including climate change, education and economic mobility, ocean health and other impact areas. FOLLOW MIKE: LinkedIn | Instagram | X/Twitter Matti Navellou | Head of ICONIQ Impact, ICONIQ Matti Navellou is the Head of ICONIQ Impact, ICONIQ’s platform for collaborative philanthropy, which convenes ICONIQ’s extraordinary community of families, founders, and organizations to catalyze collaborative philanthropy for giving at scale. To-date, ICONIQ Impact has advised on nearly $900M in grants, tackling the world’s most urgent challenges, including climate change, mental health, women’s health and rights, refugee resettlement and poverty relief. Across her career, Matti has developed and launched several global human rights campaigns, including most recently at UNICEF HQ in New York, leading public advocacy campaigns for child rights. FOLLOW MATTI: LinkedIn | X/Twitter - PODCAST INFO: Podcast website: https://billiondollarmoves.com Watch on Youtube: https://tinyurl.com/sarahchenglobal Join the community: https://sarah-chen.ck.page/billiondollarmoves FOLLOW SARAH: LinkedIn: https://linkedin.com/in/sarahchenglobal Instagram: https://instagram.com/sarahchenglobal X/Twitter: https://x.com/sarahchenglobal

When Guild Education’s co-founder Rachel Romer suffered a life-threatening stroke, the company’s future rested in the hands of Bijal Shah — then on maternity leave, recovering from a traumatic birth. In this intimate and deeply strategic conversation, Guild’s now-CEO shares what it took to step up, scale a mission-driven business, and guide 70,000+ employees toward career mobility. From building slum workforce programs in India to powering skills transformation for giants like Walmart, Chipotle, and Disney—Bijal unpacks what it means to lead through adversity, design with empathy, and operate for long-term resilience. This episode is for anyone thinking about the future of workforce development, durable marketplaces, or leadership when it matters most. Timestamps / Key Takeaways 0:00 - Intro 02:11 - From Visa to slum development in India to scaling Guild 03:58 - Joining Guild: The founding vision, team conviction, and social enterprise thesis 07:51 - Evolution of the business model from content creation to a scalable marketplace 09:11 - Customer-led transformation: Meeting both employer and employee skill demands 12:41 - Workforce shifts: Aging population, AI disruption, and the half-life of skills 14:58 - Measuring impact: 70,000 learners, 2.6x retention boost, customized talent solutions 18:03 - Building long-term partnerships over short-term revenue: Walmart, Chipotle, Disney and more major clients 27:40 - Stepping into the CEO role: Permission to lead, guidance from the board, Rachel’s trust 39:45 - Billion Dollar Questions ABOUT BIJAL SHAH Bijal Shah is the CEO of Guild, a talent development company partnering with leading employers to help them build the talent needed for today and the resilient workforce of tomorrow. Guild works with organizations like Chipotle, Discover, Target, and Providence Health to provide seamless pathways for talent mobility that enhance the employee experience and activate internal talent to achieve business goals. Bijal has been named a CNBC Changemaker, and Guild has been recognized as one of TIME’s Most Influential Companies, CNBC’s Disruptor 50, LinkedIn’s Top Startups, and received Fast Company’s World Changing Ideas award. Prior to Guild, Shah held leadership roles across data analytics at Ibotta and corporate strategy at Visa. She served on the Board of Directors of Girls Inc. and was named one of Denver Business Journal’s 40 Under 40. Shah graduated from the University of Pennsylvania and the MIT Sloan School of Management. She lives in Denver with her husband and children. FOLLOW BIJAL LinkedIn | Instagram - PODCAST INFO: Podcast website: https://billiondollarmoves.com Watch on Youtube: https://tinyurl.com/sarahchenglobal Join the community: https://sarah-chen.ck.page/billiondollarmoves FOLLOW SARAH: LinkedIn: https://linkedin.com/in/sarahchenglobal Instagram: https://instagram.com/sarahchenglobal X/Twitter: https://x.com/sarahchenglobal

Named one of Forbes’ Most Powerful Women, Melinda French Gates needs no introduction. Over the last twenty years through her work at the Bill & Melinda Gates Foundation, one thing has become clear to her: If you want to lift a society up, you must invest in women. This week's replay featured Erin Harkless Moore, Senior Director of Investment for Pivotal Ventures, a Melinda French Gates company created to do exactly that. To accelerate social progress in the U.S by investing in women’s power and influence. As a member of Pivotal’s Executive Leadership Team, Erin leads the organization’s fund, and direct investment decisions, overseeing a diverse portfolio of investments that drive breakthrough innovations and drive impact for people in the US. With nearly 20 years of investment experience, building customized portfolios for endowed institutions and family offices, serving most recently as Managing Director at Cambridge Associates, we talk about everything from challenging the status quo to her investment strategy. You don’t want to miss this! TIMESTAMPS: 00:00 - Intro 02:04 - Erin's career, passion, profit, purpose 05:53 - The premium of 'track record' 07:58 - Investment in diversity initiatives under attack 10:53 - Where does the resistance come from? 12:30 - The role of consultants 16:01 - Melinda French Gates' point of impact 18:20 - Investing in women is not charity 24:24 - Getting to a 'yes' as an LP 30:22 - Cracking the patterns of history Pivotal Ventures | A Melinda French Gates Company Investing | Pivotal Ventures Breaking With Tradition | Pitchbook - PODCAST INFO: Podcast website: https://billiondollarmoves.com Watch on Youtube: https://tinyurl.com/sarahchenglobal Join the community: https://sarah-chen.ck.page/billiondollarmoves FOLLOW SARAH: LinkedIn: https://linkedin.com/in/sarahchenglobal Instagram: https://instagram.com/sarahchenglobal X/Twitter: https://x.com/sarahchenglobal

What happens when a viral creator becomes a deep tech investor—and then starts working on brain chips? In this episode, we go beyond the hype with Taryn Southern—early YouTube pioneer, Emmy-nominated filmmaker, and now a leading voice in neurotechnology and AI. From releasing the world’s first AI-generated music album to working at the frontier of brain-computer interfaces with Blackrock Neurotech, Taryn opens up about redefining creativity and investing in future-defining tech. You’ll walk away with a practical AI prompt framework, hard truths about what it takes to bet smart on deep tech—and a powerful reminder of what it really means to be human in an age of machines. Timestamps / Key Takeaways 0:00 - Intro 01:43 - From Anthropology to youtube stardom—then diving into AI & Neurotech 07:04 - The first artist to release a full AI-generated music album: why AI enhances creativity, not threatens it 12:45 - Upskilling for the AI era; The G.R.I.P.E. framework: How to prompt ChatGPT like a pro 16:18 - The science and reality behind BCI; Blackrock Neurotech’s critical technologies for ALS patients, funding and capital 26:47 - The future of AI for women; AI investment advice & the questions you should be asking 32:24 - Billion Dollar Questions with Taryn Southern About Taryn Southern "Deeply thoughtful yet boundlessly optimistic." Taryn Southern is an award-winning storyteller and creative technologist exploring the intersection of emerging tech and human potential. Her groundbreaking creative experiments offer unique insights into how technology can help us unleash creativity, joy, wellbeing and productivity. Originally from Kansas, Taryn’s first foray into entertainment began at 17 when she competed in the semi-finals of American Idol. In 2007, after obtaining degrees in journalism and anthropology, Taryn uploaded her first video onto YouTube. Ten years and 750 million views later, this early YouTuber produced more than 1500 internet videos, at the forefront of the online content revolution. In 2007, she hosted and produced a TV series documenting her travels to meet her MySpace friends and uploaded her first viral video to YouTube. Over the next decade, she created over 1500 videos garnering more than 1 billion views, served as an early advisor to YouTube, Google VR and Snapchat product teams, and consulted for companies like Conde Nast and Marriott on digital content strategy and narrative design. FOLLOW TARYN https://tarynsouthern.com/ https://www.instagram.com/tarynsouthern/ https://www.youtube.com/TarynSouthern - PODCAST INFO: ⁠Podcast website⁠ | Watch on Youtube⁠ | ⁠Join the community⁠ FOLLOW SARAH: LinkedIn | Instagram | X/Twitter