Why You Can’t Lose Weight: The Hidden Role of Insulin, Ghrelin, and Leptin

Why You Can’t Lose Weight: The Hidden Role of Insulin, Ghrelin, and Leptin

From Dr. Paika Podcast by Mohammed Paika

April 1, 2026 · 8 min · Episode 43

About this episode

Dr. Mohammed Paika discusses the hormonal factors affecting weight loss and why traditional dieting may not work.

#WeightLoss #FatLoss #HormoneHealth #ObesityMedicine #insulinresistance Why are you eating less… but still not losing weight? In this video, Dr. Mohammed Paika (Internal Medicine & Obesity Medicine) breaks down the 3 key hormones that control your weight — and why weight loss is NOT just about calories. If you’ve ever felt stuck, frustrated, or like your body is working against you… this will finally make sense. We cover: Why insulin keeps you in fat storage mode Why ghrelin makes you constantly hungry Why leptin stops you from feeling full Why diets fail even when you’re disciplined And how to actually work WITH your body This is the science behind: 👉 Weight loss plateaus 👉 Constant cravings 👉 Feeling hungry all the time And why it’s not your fault. If you’re on (or considering) GLP-1 medications like Ozempic, Wegovy, or Zepbound — this is essential to understand. TIMESTAMPS 00:00 – Why You’re Not Losing Weight (Hook) 00:32 – It’s Not About Calories 01:05 – Why People Feel Stuck 01:42 – The 3 Hormones Overview 02:10 – Insulin: The Fat Storage Switch 03:20 – Why Your Body Stores More Easily 04:05 – Ghrelin: Why You’re Always Hungry 05:15 – Why Dieting Makes Hunger Worse…

People in this episode

Host: Dr. Mohammed Paika

Topics covered

  • weight loss
  • hormones
  • insulin resistance
  • hunger
  • dieting
  • obesity medicine

Keywords

  • weight loss
  • insulin
  • ghrelin
  • leptin
  • hormone health
  • obesity medicine
  • calories
  • dieting
  • hunger

Mentioned in this episode

Products: Ozempic, Wegovy, Zepbound

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