Eczema Breakthroughs

Every parent wants to protect their baby — but what if the window to prevent lifelong allergies is smaller than anyone realized? Scientists have discovered that a newborn's immune system doesn't just work differently from an adult's; it's actually wired to overreact in ways that can set the stage for eczema and allergies before you even know it's happening. The culprit? A hormone, missing in babies, that keeps the immune system in check.In this episode, Dr. Shruti Naik reveals what's really going on beneath your baby's skin, and what it could mean for the future of allergy prevention. If you like our podcast, please consider supporting it with a tax-deductible donation.

How much influence does the gut microbiome have on developing eczema or allergies? Turns out, quite a lot. Join this special excerpt from our research symposium to learn how antibiotics in pregnancy and early childhood increases eczema risk and how adding "biotics" might prevent it in the first place. Our speakers are Dr. David Margolis (University of Pennsylvania) and Dr. Nikole Kimes (Siolta Therapeutics). If you like our podcast, please consider supporting it with a tax deductible donation.

Are you feeling lost and don’t know where to find trusted advice on managing eczema? Introducing ECZHALE, your one-stop-shop for reliable information and resources on eczema care. Join Dr. Jennifer LeBovidge, psychologist and Assistant Professor at the Atopic Dermatitis Center at Boston Children’s Hospital, and GPER’s Christine Pham Cutaran as they discuss the challenges of being an eczema caregiver and where you can turn for help. Literature mentionedMultidisciplinary interventions in the management of atopic dermatitisAtopic dermatitis: therapeutic care delivery: therapeutic education, shared decision-making, and access to careImproving patient education for atopic dermatitisResourcesECZHALE wellness hubSupport for Eczema CaregiversTreatment Navigator

Korey Capozza travels to Spain for the European Academy of Allergy and Clinical Immunology Congress where she speaks to researchers that are trying to explain the allergy epidemic and what we can do about it. Highlights: Dr. Magdalena Zemelka-Wiacek (Poland) explains microplastics cause inflammation. Tami Landau (Israel) uses “big data” to determine which children will develop eczema, and Dr Thomas Bieber (Germany) accesses the German Biobank to understand why some children go into remission.   Research MentionedMechanisms of gut epithelial barrier impairment caused by food emulsifiers polysorbate 20 and polysorbate 80 Follow-up to adolescence after early peanut introduction for allergy prevention The potential impact of nano-and microplastics on human health: Understanding human health risksBiomarkers for phenotype-endotype relationship in atopic dermatitisDevelopment of a predictive model for pediatric atopic dermatitis

Frustrated by eczema care that ignores patient priorities? New guidelines from the medical societies for allergists and immunologists may help change that. These guidelines were informed by the views of eczema patients and caregivers and based in evidence (hallelujah!). We chat with the guideline co-authors Dr. Lynda Schneider, founder and director of the Atopic Dermatitis Center at Boston Children’s Hospital, and Dr. Derek Chu, director of  the challenge clinic for allergy diagnosis, research and treatment at McMaster University, about some of the new and surprising ideas they recommend. (And if you like our podcast, consider supporting it with a tax deductible donation). Read the transcript.Research mentionedAtopic dermatitis guidelines: 2023 Is Food-Triggered Atopic Dermatitis a Form of Systemic Contact Dermatitis?

Could we cure allergies by taking probiotics or transplanting the gut microbiome from a healthy person? What does all this mean for eczema/allergy prevention? To find out, join our conversation with Dr. Rima Rachid, allergist and immunologist at Harvard Children’s Hospital, and Meenal Lele, eczema mom and author of Baby and the Biome. We discuss the promising trials with fecal microbiota transplants for food allergic children as well as the best probiotic to take for eczema and when it’s important to take it. (And if you like our podcast, consider supporting it with a tax deductible donation). Literature featured in this podcastThe microbial origins of food allergyEvaluating the Safety and Efficacy of Oral Encapsulated Microbiota Transplantation Therapy in Peanut Allergic Patients Lactobacillus rhamnosus Used in the Perinatal Period for the Prevention of Atopic Dermatitis in InfantsThe Baby and the Biome book

What are the top research discoveries of 2023 related to eczema? Tune in to learn about new, needle-free Epi-Pen alternatives, painless tests for detecting eczema before it appears, and insights about how to address anxiety and depression related to eczema. Guests include Albert Chong of University of Southern California, Dr. Ruchi Gupta of Northwestern University, Dr. Ian Myles of NIH, and Dr. Kiwako Yamamoto-Hanada of National Children's Hospital, Tokyo. P.S. If you like our podcast, consider making a donation to GPER!Research discussed in this podcastmRNAs in skin surface lipids unveiled atopic dermatitis at 1 monthPatients' and Caregivers' Preferences for Mental Health Care and Support in Atopic Dermatitis Innovations in the treatment of anaphylaxis: A review of recent data - ScienceDirectPharmacokinetics and pharmacodynamics of epinephrine sublingual film versus intra-muscular epinephrine - Journal of Allergy and Clinical ImmunologyShotgun metagenomic sequencing on skin microbiome indicates dysbiosis exists prior to the onset of atopic dermatitis

New biological therapies like dupilumab target Type 2 inflammation, but new research shows they are also modifying the skin microbiome. In this episode we discuss what Type 2 inflammation is, why it matter in eczema, and how it modifies the microbiome. Our guest is Dr. Lisa Beck (Co-Director of the Center for Allergic Disease Research, University of Rochester Medical Center, NY) who has dedicated her 35 year career to understanding why some eczema patients are susceptible to skin infections and finding safe and effective eczema treatments.Research associated with this podcastType 2 Inflammation Contributes to Skin Barrier Dysfunction in Atopic DermatitisTralokinumab treatment improves the skin microbiota by increasing the microbial diversity in adults with moderate-to-severe atopic dermatitisRapid Reduction in Staphylococcus aureus in Atopic Dermatitis Subjects Following Dupilumab Treatment