Healthy Longevity

If you've ever misplaced your keys or cell phone or forgotten the name of a friend you've known for decades, you've probably wondered, "is it early dementia?" Fear of cognitive decline is at an all-time high. A few years back, an AARP survey found that nearly half of adults over age 40 believe they will likely develop dementia. And Alzheimer's Disease International reports nearly 80% of the public is worried about the disease. Are you? Brain fog, memory loss, and dementia are among the seven common patterns of aging I write about in my new book, Invincible: Defy Your Genetic Destiny to Live Better, Longer, because so many people are concerned, and there are steps you can take today to minimize risk. On today's podcast, I'm delighted to welcome one of the leading experts in the field of brain longevity--board-certified neurologist, Dr. Sheldon Jordan, who is visiting us from Santa Monica, California where he has the private practice—Neurological Associates, The Interventional Group. Dr. Jordan is also the founder of The Regenesis Project, a clinical research initiative focused on advancing brain health, neurological regeneration, and interventions that target the biology of aging and neurodegeneration. Disclaimer: This podcast has not been approved by the FDA. The information in this presentation is for educational and informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.

Want to perform better tomorrow at anything you do? Then get a good night's sleep tonight. "Sleep plays a critical role in restoration for humans; it is the housekeeping process for our physiology that allows us to restore and start the next day," says sleep expert Sahil Chopra, MD, today's guest on Healthy Longevity with Florence Comite MD. Dr. Chopra is co-founder and chief medical officer for Empower Sleep, a virtual sleep care program that makes personalized multi-night sleep analysis and treatment accessible from home. Nearly 40% of adults report falling asleep during the day without meaning to at least once a month. Also, an estimated 50 to 70 million Americans have chronic, or ongoing, sleep disorders, according to the Centers for Disease Control and Prevention. "If people don't sleep well, the likelihood of having cardiovascular disease … is higher, the possibility of cancer is six-fold higher," says Chopra. "Growth hormone levels are lower; cortisol dysregulation is higher. Circadian rhythms, if they are misaligned, result in a compromised metabolic state. REM sleep plays a critical role in emotional stability." If you're suffering from brain fog or nodding off at your desk after lunch, you'll want to tune in to discover how to dramatically improve your health and health trajectory by improving your sleep habits. You'll learn: * Sleep debt builds slowly, so you may not recognize what it's doing to you. * Why a one-night sleep study is not an effective way to diagnose a sleep disorder. * Sleep trackers like Empower Sleep's medical-grade ring and consumer models like the Oura Ring provide patients with real-time analysis of their sleep quality in their own bed without spending a restless night in a sleep lab wired to a machine. * Poor sleep is a gut punch, affecting the gut microbiome by disrupting the GI tract's normal nightly slow-down, which allows its epithelial lining to repair and recover. * Lack of sleep compromises the immune system. Studies show that sleep-deprived people (getting four to six hours of sleep) don't respond to vaccines as well as people who get adequate sleep (seven to eight hours). * During deep sleep stages, blood flow to the brain peaks through the glymphatic system, which clears the beta amyloid and tau proteins that are believed to play a role in Alzheimer's dementia. * What to do an hour before bedtime and within 15 minutes of waking to reset a healthy circadian rhythm. * Remedies for restless leg syndrome, including new technology that stimulates nerves in the legs to make the brain think that your lower limbs are moving. * And much more! About Florence Comite, MD Dr. Comite began her medical journey at Yale University School of Medicine and continued at Yale with a residency in medicine. She completed a fellowship in Reproductive Endocrinology (multidisciplinary training incorporating pediatrics, gynecology, and andrology) at the National Institute of Child Health and Human Development. She remained at the National Institutes of Health as a senior clinical research associate before joining the Yale faculty as an associate professor in endocrinology. During her 25-year faculty tenure, Dr. Comite founded and directed Women's Health at Yale. In 2005, she launched her bespoke medical practice, Comite Center for Precision Medicine & Healthy Longevity, in New York City and subsequently expanded offices to Palo Alto and Miami Beach. Through her medical practice and decades of clinical research, Dr. Comite recognized that all humans have inherited a disorder of carbohydrate metabolism (a glucose disorder leading toward diabetes), which is accelerated by aging and the natural decline of the hormones testosterone and estrogen, which begins around age 30. Dr. Comite's podcast delivers the truth about your health—that age-related disease begins early in life at the cellular level. By slowing and even reversing the biological aging process, we can stay active and in great health for life. She interviews renowned physicians, researchers, and thought leaders offering surprising insights and practical tips that listeners can use to improve their own health trajectory.

Trouble with arousal or orgasm? Low (or no) libido? Dryness and painful intercourse? Nearly half of all women will experience sexual dysfunction or intimacy issues like these at some point in their lives. Men suffer from some of these problems, too. But it doesn't have to be that way. Advances in sexual health medicine offer exciting new solutions for these common obstacles to a healthy (and hot) sex life. Today's Healthy Longevity guest is Carolyn DeLucia, MD, a former OBGYN, who's now helping thousands of women and men rekindle their sexuality at her practice, The Secret Orchid, in Hillsborough, NJ. Dr. DeLucia uses non-surgical techniques such as laser and sound-wave therapy, platelet-rich plasma (PRP), and hormone optimization to jumpstart libido, increase vaginal lubrication, achieve more intense orgasms, and improve overall self-confidence and satisfaction. Join me as we explore the new medicine of sexual pleasure. You'll learn: · Today, women are much more open about their sexual health, thanks to social media, but there's far too much misinformation online (some of it dangerous, most of it useless). Get your advice from experts who understand the science and recognize that every human is unique. · Sexual health problems are more common than you might think. Sixty percent of women experience vaginal atrophy. A third of women suffer from urinary incontinence and 45 percent of them refrain from intimacy due to the shame. · Instead of doing thousands of Kegels every day, laser therapy and electromagnetic stimulation of the pelvic floor strengthen the muscles surrounding the bladder and improve urinary control. · In addition to boosting a woman's libido, testosterone cream applied to the back of the knee helps women put on lean muscle and lose fat. (An oral testosterone pill is currently being tested.) · Os and Ahhs: A PRP therapy called the "O-Shot," improves blood flow and lubrication, increases sex drive, heightens arousal, and makes orgasms more intense. The O-Shot involves taking a small amount of blood from the arm and processing it to concentrate platelet-rich plasma, which is injected into the numbed clitoris, labia, and G-spot. The result: improved blood flow and lubrication, increased sex drive, heightened arousal, and more intense orgasms. A similar PRP therapy, the "P-Shot," is available for male sexual dysfunction. · Part of helping women remain active and willing participants in their intimate lives is keeping their partner active, too. · An active sex life is terrific for building self-esteem and overall health. About Florence Comite, MD Dr. Comite began her medical journey at Yale University School of Medicine and continued with at Yale with a residency in medicine. She completed a fellowship in Reproductive Endocrinology (multidisciplinary training incorporating pediatrics, gynecology, and andrology) at the National Institute of Child Health and Human Development. She remained at the National Institutes of Health as a senior clinical research associate before joining the Yale faculty as an associate professor in endocrinology. During her 25-year faculty tenure, Dr. Comite founded and directed Women's Health at Yale. In 2005, she launched her bespoke medical practice, Comite Center for Precision Medicine & Healthy Longevity, in New York City and, subsequently expanded offices to Palo Alto and Miami Beach. Through her medical practice and decades of clinical research, Dr. Comite recognized that all humans have inherited a disorder of carbohydrate metabolism (a glucose disorder leading toward diabetes), which is accelerated by aging and the natural decline of the hormones testosterone and estrogen, which begins around age 30. Dr. Comite's podcast delivers the truth about your health—that age-related disease begins early in life at the cellular level. By slowing and even reversing the biological aging process, we can stay active and in great health for life. She interviews renowned physicians, researchers, and thought leaders offering surprising insights and practical tips that listeners can use to improve their own health trajectory.

Not unlike your skin, your gums, the periodontal support tissues for your teeth, act as a frontline defense against bacteria and pathogens trying to enter your body. "If your gums are not healthy, you are not healthy," says biologic dentist and periodontal surgeon Alexander Volchonok, DMD, co-founder of TetraHealth Dentistry in New York City. In this episode of Healthy Longevity with Florence Comite, MD, you'll learn that the mouth is the window into the health of your entire body. Bleeding gums, a hallmark of periodontal disease, warn of dysbiosis of the mouth's microbiome and have many downstream effects that can negatively impact the endocrine system, heart health, and even the brain. Open wide and join us on a fascinating exploration of biologic dentistry, an approach that focuses on the interconnectedness of oral health with the rest of the body. You'll learn… · Biologic dentistry uses high-tech diagnostic modalities to test saliva for markers of inflammation and to analyze the DNA of the oral microbiome. · High-definition scans can peer below the surface of the gum to the bone, uncovering hidden infections, that may be completely asymptomatic, early enough to prevent advanced disease. · Declining oral health is not inevitable with age; you can have a healthy mouth and gums for the rest of your life. · Plaques in the heart and blood vessels contain oral bacteria, which traveled there through the bloodstream from "leaky" gums. · Oral bacteria can upregulate inflammatory cytokines like interleukin-1 and interleukin-6, which can cross the blood-brain barrier and may play a role in Alzheimer's dementia. · Everyone should have a thorough oral screening and consider advanced screening and testing options. · The best way to take care of your teeth and gums, according to Volchonok: use an electric toothbrush and a water flosser (like the classic Waterpik).

As research lead for the nutrition and metabolic health company Health Via Modern Nutrition (HVMA), Latt Mansor knows more than most people about what it takes to stay fit and healthy. Still, he struggled to lose fat pounds and worried about his heart health. So, Dr. Comite invited him to come to Comite Center for a blood draw, evaluation, and recommendations for interventions based on her analysis. In this episode, Dr. Mansor returns to the center to review the results of his year-long experience as a precision medicine patient and learn how he reversed the risks that were leading him toward the cardiovascular trouble that killed his father. You'll learn… What is "reactive hypoglycemia" and why having high insulin is dangerous even if your HbA1C number is low. Why insulin, the fat-storage hormone, makes it so difficult to shed fat mass. The dietary supplements that helped Mansor lower his cholesterol risk ratio number, improve his HDL "good" cholesterol, and drop his high 200 LDL "bad" cholesterol to 110. The reason Dr. Comite advises patients like Mansor to take vitamin K2 along with vitamin D for bone and heart health. Why consistency in using testosterone or human chorionic gonadotropin is critical for maintaining muscle mass and losing weight. The change in Mansor's exercise routine that led to a dramatic improvement in his VO 2"> 22 max and potential for longevity, reducing his risk of cardiovascular death by nearly 25 percent over the next decade. How Mansor lost 22 pounds and dropped his body fat percentage from nearly 27 percent to 16.3 percent while maintaining muscle mass.

If you or someone you know has been diagnosed with cancer, the hour you spend listening to this podcast will be life-changing and, possibly, lifesaving. In this episode, Dr. Comite talks with breast cancer survivor Joelle Kaufman, author of the book Crushing the Cancer Curveball. Kaufman was a cancer caregiver (to her mother and sister) before she was a breast cancer patient herself. "The BRACA1 gene was woven into our DNA fabric like an unwanted heirloom," she says. Kaufman and Lauren Esserman, MD, director of the Breast Care Center at University of California, San Franciso School of Medicine and the surgeon who performed her double mastectomy take Dr. Comite through Kaufman's journey and share eye-opening insights and advice for newly diagnosed cancer patients and their family and friends. You'll learn… You must know your body, touch your body. Become a phenomenal body scout. Remember to do a monthly breast self-exam at the first of the month, a week after your period, or whenever you remember. Get to know what your breasts feel like because the most important thing is change. If you have a family history of cancer, bring that up every time you see a clinician. When meeting with an oncologist, always ask "can I record this," or have a friend take notes. Cancer is not an emergency You have time, and it takes time to understand the biology to have the proper care tailored to the type of tumor you have. Everyone's cancer can be unique. Avoid accepting lots of advice from people who don't know the nuances of your cancer. Give yourself permission to rage. It's OK to feel all the emotions you're feeling. If you resist, it persists. Consider "cold cap" therapy, which can potentially reduce hair loss by limiting the amount of chemotherapy reaching the hair follicles. You need community. Start a caring bridge that let friends know what help you need. Love with abandon; the love will come back to you.

Hormone optimization, often referred to as HRT or hormone replacement therapy, has the power to transform women's lives—but despite its benefits, many women remain hesitant to pursue it due to unfounded fears. In Part II of her guest appearance on Healthy Longevity, gastroenterologist and long-COVID expert Robin Rose, MD, shares real-life case studies that reveal the tangible impact of hormone optimization. Combined with insights from Dr. Comite's decades of endocrinology experience, these patient stories demonstrate how personalized treatment, regular monitoring, and education can make all the difference in a woman's health journey. You'll Learn… The reasons why so many women hesitate to embrace bioidentical hormone optimization therapies yet will take synthetic hormones for birth control without thinking twice. The biggest misconceptions about estrogen, progesterone, and testosterone—and what the science actually says. Real-life case studies that showcase the power of personalized hormone management. How long COVID (and even the COVID vaccine) can throw hormones off balance, especially in young women. The critical role of tracking hormone levels and making precise adjustments over time. How hormone optimization can reverse biological aging and protect your heart, brain, and bones.

"Weight gain is not about lack of willpower; it's biology," says obesity doctor and GLP-1 expert Alexandra Sowa, MD. In this episode, the author of the new book The Ozempic Revolution: A Doctor's Proven Plan for Success to Help You Reverse Obesity, End Yo-Yo Dieting, Protect Yourself from Disease, cuts through the confusion surrounding GLP-1 medications and tells listeners what her most successful and happiest patients do to reap the full health benefits of these game-changing peptides. Dr. Sowa is the founder of the telehealth clinic SoWell Health. You'll learn… Why "try harder" is terrible medical advice. The differences between GLP-1 drugs like Ozempic, Wegovy, Monjuro and Zepbound. How GLP-1s quiet the "food noise" in your brain. Are GLP-1s right for you? How to get your prescription covered. How to eat and exercise to minimize symptoms and gain the best results. The future of GLP-1s and how they may help eliminate chronic disease. Dr. Comite began her medical journey at Yale University School of Medicine and continued with at Yale with a residency in medicine. She completed a fellowship in Reproductive Endocrinology (multidisciplinary training incorporating pediatrics, gynecology, and andrology) at the National Institute of Child Health and Human Development. She remained at the National Institutes of Health as a senior clinical research associate before joining the Yale faculty as an associate professor in endocrinology. During her 25-year faculty tenure, Dr. Comite founded and directed Women's Health at Yale. In 2005, she launched her bespoke medical practice, Comite Center for Precision Medicine & Healthy Longevity, in New York City and, subsequently expanded offices to Palo Alto and Miami Beach. Through her medical practice and decades of clinical research, Dr. Comite recognized that all humans have inherited a disorder of carbohydrate metabolism (a glucose disorder leading toward diabetes), which is accelerated by aging and the natural decline of the hormones testosterone and estrogen, which begins around age 30. Dr. Comite's podcast delivers the truth about your health—that age-related disease begins early in life at the cellular level. By slowing and even reversing the biological aging process, we can stay active and in great health for life. She interviews renowned physicians, researchers, and thought leaders offering surprising insights and practical tips that listeners can use to improve their own health trajectory.

Peptides are becoming more and more popular, not only among biohackers, but people who just want to boost their health a notch or two. What are peptides? In short, they're chains of amino acids that can be combined to form proteins that trigger specific beneficial cellular functions, such as reducing inflammation, improving skin health, and growing muscle. In this episode of Healthy Longevity, Dr. Comite interviews Neil Paulvin, DO, a Manhattan physician specializing in anti-aging and regenerative medicine who's known as "Dr. Peptide" for his expertise in peptide therapy. You'll learn… How Dr. Paulvin combines personalized functional medicine, peptide and hormone therapy, and biohacking techniques to help patients improve their healthspan and perform at their best. Dr. Paulvin's three favorite peptides for longevity. The free, in-home health hack that will dramatically improve anyone's energy, mood, and cognitive function. Best peptides for weight loss, brain health, inflammation, healing gut lining. and more. The skin rejuvenating benefits of GHK Copper

Lorenzo Thione is an entrepreneur, expert in Artificial Intelligence, a celebrated storyteller. and Broadway producer four-times nominated for and twice winner of Tony Awards. For someone so busy, it's remarkable he finds the time to stay as laser focused on his health as he appears. But is he really doing all he could to optimize his body? In this episode of Healthy Longevity, Dr. Comite analyzes Thione's recent blood work to see if his biomarkers reveal he's as healthy on the inside as he looks on the outside. You'll learn… How Thione, a technology expert and self-quantifier, uses wearable devices and other health data point to inform his lifestyle decisions. How testosterone optimization therapy improved Thione's energy, libido, and more! Dr. Comite's recommendations for improving his low levels of magnesium, a mineral that's essential for gut and brain and plays a role in over 300 critical functions in the body. Insights about homocysteine and why some people need methylated forms of vitamin B12. Why family health history has been called a poor man's genetic test.

Don't try to manage menopause alone as your mother did. Actively seeking help and resources to comprehend and navigate perimenopause and menopause is the new plan for women to manage symptoms and improve their health. Join Dr. Comite in an open conversation about how to embrace this significant life phase with Jessica Shepherd, MD, a board-certified OB/GYN and author of the new book Generation M: Living Well in Perimenopause and Menopause. You'll learn… How participating in open dialogues with other women and your partner will facilitate understanding of changes, alleviate symptoms, and reduce feelings of isolation or shame. Why prepping your body for perimenopause as you would train for a 10K race will help you master the marathon of menopause. How hormone therapy can ease symptoms, reduce the risk of heart disease, and reverse biological aging. That incorporating mindfulness through meditation, yoga, or other methods, contributes to positive health outcomes during menopause.

Amy B. Killen, M.D., was an emergency room doctor for more than 10 years. And she was tired of treating the same people over and over again. "I'd see the same patients with the same problems, and I thought "there has to be a better way." In this episode of Healthy Longevity with Florence Comite, M.D., Dr. Killen describes how she came to the realization that she could prevent the chronic diseases that were bringing patients to the E.R. "if we could only get to them sooner." She also admits that she worried she could become one of those patients in the E.R. waiting room if she didn't change her own unhealthy lifestyle habits. Drs. Comite and Killen discuss the need to shift from conventional medicine's reactive methods to a more proactive, personalized, preventive approach to healthcare. They explore ways individuals can play a more active role in optimizing their health for life. You'll learn: What Dr. Killen saw in the E.R. that drove her to switch from conventional to proactive longevity medicine. Why sleep is so critical to every function in your body and brain. The challenges and solutions for treating hypothyroid symptoms. The #1 change you can make in your life today to be healthier tomorrow. And much more!