Episode #45: MTHFR

Episode #45: MTHFR

From Influenced to Death by Hannah Wright & Victoria LaFont

October 22, 2025 · 1h 45m

About this episode

The episode discusses the MTHFR gene and its potential health impacts, featuring insights from guest hosts and research studies.

In this episode, guest host Amanda Jones and Victoria speak with Sara Russell about the MTHFR gene (the gene that leads to the creation of the methylenetetrahydrofolate reductase enzyme) and the different variants that might (emphasis on MIGHT) impact your health. Be prepared before you dive in…this is a longer discussion that covers many aspects of MTHFR, both hypothetical (primarily what we’ve seen in influence-y spaces like social media) and actual (what we’ve read in research studies and seen in clinical practice). We discuss the role of MTHFR variants in autism spectrum disorders, infertility, and other diagnoses, as well as the use of methylated B vitamins versus folic acid and folinic acid. Some of the studies Amanda, Victoria, and Sara reference include: * Overview of MTHFR and variant biochemistry * Basic write-up on MTHFR variants from the CDC * Connection to autism - here , here , and here * The connection between one variant (C677T) and blood folate levels * Homocysteine in disease * Helpful overview of homocysteine and why low levels might also be problematic * The connection between homocysteine and infertility * Genetic Biomarkers of Metabolic Detoxification for…

People in this episode

Host: Victoria LaFont

Guests: Amanda Jones, Sara Russell

Topics covered

  • MTHFR gene
  • health impact
  • autism spectrum disorders
  • infertility
  • methylated B vitamins
  • folic acid

Keywords

  • MTHFR
  • methylenetetrahydrofolate reductase
  • autism
  • infertility
  • methylated B vitamins
  • folic acid
  • homocysteine

Mentioned in this episode

Organizations: CDC

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